21
Views
27
CrossRef citations to date
0
Altmetric
Original Article

Mechanism of Radiosensitization by Halogenated Pyrimidines: The Contribution of Excess DNA and Chromosome Damage in BrdU Radiosensitization may be Minimal in Plateau-phase Cells

, &
Pages 133-142 | Received 13 Dec 1993, Accepted 29 Mar 1994, Published online: 03 Jul 2009

References

  • Albright N. Computer programs for the analysis of cellular survival data. Radiation Research 1987; 112: 331–340
  • Blocher D. In CHEF electrophoresis a linear induction of dsb corresponds to a nonlinear fraction of extracted DNA with dose. International Journal of Radiation Biology 1990; 57: 7–12
  • Boothman D.A., Greer S., Pardee A.B. Potentiation of halogenated pyrimidine radiosensitizers in human carcinoma cells by beta-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtol[1,2-b]pyran-5,6-dione), a novel DNA repair inhibitor. Cancer Research 1987; 47: 5361–5366
  • Buxton G.V., Greenstock C.L., Helman W.P., Ross A.B. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (*OH/*O-) in aqueous solution. Journal of Physical Chemical Reference Data 1988; 17: 513–886
  • Cornforth M.N., Bedford J.S. X-ray-induced breakage and rejoining of human interphase chromosomes. Science 1983; 222: 1141–1143
  • Dewey W.C., Humphrey R.M. Increase in radiosensitivity to ionizing radiation related to replacement of thymidine in mammalian cells with 5-bromodeoxyuridine. Radiation Research 1965; 23: 538–553
  • Freifelder D., Freifelder D.R. Mechanism of X-ray sensitization of bacteriophage T7 by 5-bromouracil. Mutation Research 1966; 3: 177–184
  • Goz B. The effects of incorporation of 5-halogenated deoxyuridines into the DNA of eukaryotic cells. Pharmacological Reviews 1978; 29: 249–272
  • Hittelman W.N., Rao P.N. Premature chromosome condensation. I. Visualization of X-ray-induced chromosome damage in interphase cells. Mutation Research 1974; 23: 251–258
  • Iliakis G. Radiation-induced potentially lethal damage: DNA lesions susceptible to fixation. International Journal of Radiation Biology 1988; 53: 541–584
  • Iliakis G. The role of DNA double strand breaks in ionizing radiation-induced killing of eukaryotic cells. BioEssays 1991; 13: 641–648
  • Iliakis G.E., Cicilioni O., Metzger L. Measurement of DNA double-strand breaks in CHO cells at various stages of the cell cycle using pulsed field gel electrophoresis: calibration by means of 125I decay. International Journal of Radiation Biology 1991b; 59: 343–357
  • Iliakis G., Kurtzman S. Keynote Address: Application of non-hypoxic cell sensitizers in radiobiology and radiotherapy: rationale and future prospects. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1235–1241
  • Iliakis G., Kurtzman S. Mechanism of radiosensitization by halogenated pyrimidines: bromodeoxyuridine and β-arabinofuranosyladenine affect similar subsets of radiation-induced potentially lethal lesions in plateau-phase Chinese hamster ovary cells. Radiation Research 1991; 127: 45–51
  • Iliakis G., Kurtzman S., Pantelias G., Okayasu R. Mechanism of radiosensitization by halogenated pyrimidines: effect of BrdU on radiation induction of DNA and chromosome damage and its correlation with cell killing. Radiation Research 1989; 119: 286–304
  • Iliakis G.E., Metzger L., Denko N., Stamato T.D. Detection of DNA double-strand breaks in synchronous cultures of CHO cells by means of asymmetric field inversion gel electrophoresis. International Journal of Radiation Biology 1991a; 59: 321–341
  • Iliakis G., Okayasu R., Varlotto J., Shernoff C., Wang Y. Hypertonic treatment during premature chromosome condensation allows visualization of interphase chromosome breaks repaired with fast kinetics in irradiated CHO cells. Radiation Research 1993; 135: 160–170
  • Iliakis G., Pantelias G., Kurtzman S. Mechanism of radiosensitization by halogenated pyrimidines: Effect of BrdU on cell killing and interphase chromosome breakage in radiation-sensitive cells. Radiation Research 1991c; 125: 56–64
  • Iliakis G., Wang Y., Pantelias G., Metzger L. Mechanism of radiosensitization by halogenated pyrimidines: Effect of BrdU on repair of DNA breaks, interphase chromatin breaks and potentially lethal damage in plateau-phase CHO cells. Radiation Research 1992; 129: 202–211
  • Iliakis G., Wright E., Ngo F.Q.H. Possible importance of PLD repair in the modulation of BrdUrd and IdUrd-mediated radiosensitization in plateau-phase C3H10T1/2 mouse embryo cells. International Journal of Radiation Biology 1987a; 51: 541–548
  • Iliakis G., Wright E., Ngo F.Q.H. Repair and fixation of potentially lethal damage (PLD) as demonstrated by delayed plating or incubation with araA in contact inhibited refed plateau-phase C3H mouse embryo 10T1/2 cells grown in the presence of BrdUrd. Radiation and Environmental Biophysics 1987b; 26: 47–62
  • Johnson R.T., Rao P.N. Mammalian cell fusion: induction of premature chromosome condensation in interphase nuclei. Nature 1970; 226: 717–722
  • Kaplan H.S. DNA-strand scission and loss of viability after X-irradiation of normal and sensitized bacterial cells. Proceedings of the National Academy of Sciences, USA 1966; 55: 1442–1446
  • Kaplan H.S., Smith K.C., Tomlin P. Effect of halogenated pyrimidines on radiosensitivity of E. coli. Radiation Research 1967; 16: 98–113
  • Kinsella T.J., Mitchell J.B., Russo A., Mostryn G., Glatstein E. The use of halogenated thymidine analogs as clinical radiosensitizers: rationale, current status, and future prospects: non-hypoxic cell sensitizers. International Journal of Radiation Oncology, Biology and Physics 1984; 10: 1399–1406
  • Kinsella T.J., Dobson P.P., Mitchell J.B., Fornace A.J., Jr. Enhancement of X-ray induced DNA damage by pre-treatment with halogenated pyrimidine analogs. International Journal of Radiation Oncology, Biology and Physics 1986; 13: 733–739
  • Krasin F., Hutchinson F. Double strand breaks from single photochemical events in DNA containing 5-bromouracil. Biophysics Journal 1978; 24: 645–656
  • Lawrence T.S., Davis M.A., Maybaum J., Stetson P.L., Ensminger W.D. The effect of single versus double stranded substitution on halogenated pyrimidine-induced radiosensitization and DNA strand breakage in human tumor cells. Radiation Research 1990; 123: 192–198
  • Lawrence T.S., Davis M.A., Maybaum J., Mukhopadhyay S.K., Stetson P.L., Normolle D.P., McKeever P.E., Ensminger W.D. The potential superiority of bromodeoxyuridine to iododeoxyuridine as a radiation sensitizer in the treatment of colorectal cancer. Cancer Research 1992; 52: 3698–3704
  • Lawrence T.S., Davis M.A., McKeever P.E., Maybaum J., Stetson P.L., Normolle D.P., Ensminger W.D. Fluorodeoxyuridine-mediated modulation of iododeoxyuridine incorporation and radiosensitization in human colon cancer cells in vitro and in vivo. Cancer Research 1991; 51: 3900–3905
  • Lett J.T., Caldwell I., Little J.G. Repair of X-ray damage to the DNA in Micrococcus radiodurans: the effect of 5-bromodeoxyuridine. Journal of Molecular Biology 1970; 48: 395–408
  • Lett J.T., Parkins G., Alexander P. Mechanisms of sensitization to X-rays of mammalian cells by 5-bromodeoxyuridine. Nature 1964; 203: 593–596
  • Ling L.L., Ward J.F. Radiosensitization of Chinese hamster V79 cells by bromodeoxyuridine substitution of thymidine: Enhancement of radiation-induced toxicity and DNA strand break poduction by monofilar and bifilar substitution. Radiation Research 1990; 121: 76–83
  • Lohman P.H.M., Bootsma D., Hey A.H. The influence of 5-bromodeoxyuridine on the induction of breaks in the deoxyribonucleic acid of cultivated human cells by x-irradiation and ultraviolet light. Radiation Research 1972; 41: 617–641
  • Mitchell J.B., Russo A., Cook J.A., Straus K.L., Glatstein E. Radiobiology and clinical application of halogenated pyrimidine radiosensitizers. International Journal of Radiation Biology 1989; 56: 827–836
  • Mitchell J.B., Russo A., Kinsella T.J., Glatstein E. The use of non-hypoxic cell sensitizers in radiobiology and radiotherapy. International Journal of Radiation Oncology, Biology and Physics 1986; 12: 1513–1518
  • Okayasu R., Iliakis G. Ionizing radiation induces two forms of interphase chromosome breaks in Chinese hamster ovary cells that rejoin with different kinetics and show different sensitivity to treatment in hypertonic medium or β-araA. Radiation Research 1993; 136: 262–270
  • Phillips T.L., Bodell W.J., Uhl V., Ross G.Y., Rasmussen Y., Mitchell J.B. Correlation of exposure time, concentration and incorporation of IdUrd in V-79 cells with radiation response. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1251–1255
  • Roots R., Okada S. Protection of DNA molecules of cultured mammalian cells from radiation-induced single-strand scissions by various alcohols and SH compounds. International Journal of Radiation Biology 1972; 21: 329–342
  • Sawada S., Okada S. Effects of BUdR-labelling on radiation-induced DNA breakage and subsequent rejoining in cultured mammalian cells. International Journal of Radiation Biology 1972; 21: 599–602
  • Shipley W.U., Elkind M.M. DNA damage and repair following irradiation: the effect of 5-bromodeoxyuridine in cultured Chinese hamster cells. Radiation Research 1971; 48: 86–94
  • Szybalski W. X-ray sensitization by halopyrimidines. Cancer Chemotherapy Reports, Part 1 1974; 58: 539–557
  • Waldren C.A., Johnson R.T. Analysis of interphase chromosome damage by means of premature chromosome condensation after x- and ultra-violet irradiation. Proceedings of the National Academy of Sciences, USA 1974; 71: 1137–1141
  • Wang Y., Iliakis G. Effects of 5′ iododeoxyuridine on the repair of radiation induced potentially lethal damage interphase chromatin breaks and DNA double-strand breaks in Chinese hamster ovary cells. International Journal of Radiation Oncology, Biology and Physics 1992; 23: 353–360
  • Ward J.F. DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, repairability. Progress in Nucleic Acids and Molecular Biology 1988; 35: 95–125
  • Webb C.F., Jones G.D.D., Ward J.F., Moyer D.J., Aguilera J.A., Ling L.L. Mechanisms of radiosensitization in bromodeoxyuridine substituted cells. International Journal of Radiation Biology 1993; 64: 695–705
  • Zimbrick J.D., Ward J.F., Myers L.S., Jr. Studies on the chemical basis of cellular radiosensitization by 5-bromouracil substitution in DNA. I. Pulse-and steady-state radiolysis of 5-bromouracil and thymine. International Journal of Radiation Biology 1969a; 16: 505–523
  • Zimbrick J.D., Ward J.F., Myers L.S., Jr. Studies on the chemical basis of cellular radiosensitization by 5-bromouracil substitution in DNA. II. Pulse-and steady-state radiolysis of bromouracil-substituted and unsubstituted DNA. International Journal of Radiation Biology 1969b; 16: 525–534

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.