Tumour Oxygenation, Radiosensitivity, and Necrosis before and/or after Nicotinamide, Carbogen and Perflubron Emulsion Administration

References

• Chaplin D.J., Horsman M.R., Aoki D.S. Nicotinamide, Fluosol-DA and carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vitro. British Journal of Cancer 1991; 63: 109–113
   PubMed Web of Science ®Google Scholar
• Chaplin D.J., Horsman M.R., Siemann D.W. Further evaluation of nicotinamide and carbogen as a strategy to reoxygenate hypoxic cells in vivo: importance of nicotinamide dose and pre-irradiation breathing time. British Journal of Cancer 1993; 68: 269–273
   PubMed Web of Science ®Google Scholar
• Chaplin D.J., Horsman M.R., Trotter M.J. Effect of nicotinamide on the microregional heterogeneity of oxygen delivery within a murine tumor. Journal of the National Cancer Institute 1990; 82: 672–676
   PubMedGoogle Scholar
• Dische S., Saunders M.I., Bennet M.H., Dunphy E.P., Des Rochers C., Stratford M.R.L., Minchinton A.I., Wardman P. A comparison of the tumour concentrations obtainable with misonidazole and Ro 03-8799. British Journal of Radiology 1986; 59: 911–917
   PubMed Web of Science ®Google Scholar
• El Gamoussi R., Threadgill M.D., Prade M., Stratford I.J., Guichard M. Relationship between the melanin content of a human melanoma cell line, its radiosensitivity and uptake of pimonidazole. Cancer and Chemical Pharmacology 1993; 31: 277–282
   PubMed Web of Science ®Google Scholar
• Evans R.G., Kimler B.F., Morantz R.A., Vats T.S., Gener L.S., Liston V., Lowe N. A phase I/II of the use of Fluosol as an adjuvant to radiation therapy in the treatment of primary high-grade brain tumors. International Journal of Radiation Oncology, Biology and Physics 1990; 19: 415–420
   PubMed Web of Science ®Google Scholar
• Falk S.J., Ward R., Bleehen N.M. The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised pO2 histography. British Journal of Cancer 1992; 66: 919–924
   PubMed Web of Science ®Google Scholar
• Gatenby R.A., Kessler H.B., Rosenblum J.S., Coia L.R., Moldofsky P.J., Hartz W.H., Broder G.J. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. International Journal of Radiation Oncology, Biology and Physics 1988; 14: 831–838
   PubMed Web of Science ®Google Scholar
• Guichard M. Comparison of the radiobiological properties of human tumour xenografts and rodent tumours. International Journal of Radiation Biology 1989; 56: 583–586
   PubMed Web of Science ®Google Scholar
• Guichard M., Dertinger H., Malaise E.P. Radiosensitivity of four human tumor xenografts. Influence of hypoxia and cell-cell contact. Radiation research 1983; 95: 602–609
   PubMed Web of Science ®Google Scholar
• Guichard M., Gosse C., Malaise E.P. Survival curve of a human melanoma in nude mice. Journal of the National Cancer Institute 1977a; 58: 1665–1669
   PubMedGoogle Scholar
• Guichard M., Lachet B., Malaise E.P. Measurements of RBE, OER and recovery of potentially lethal damage of a 645 MeV Helium Ion Beam using EMT6 cells. Radiation research 1977b; 71: 413–420
   PubMed Web of Science ®Google Scholar
• Hasegawa T., Rhee J.G., Levitt S.H., Song C.W. Increase in tumor pO2 by perfluorochemicals and carbogen. International Journal of Radiation Oncology, Biology and Physics 1987; 13: 569–574
   PubMed Web of Science ®Google Scholar
• Hockel M., Knoop C., Schlenger K., Vorndran B., Baussmann E., Mitze M., Knapstein P.G., Vaupel P. Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiotherapy and Oncology 1993; 26: 45–50
   PubMed Web of Science ®Google Scholar
• Hockel M., Schlenger K., Knoop C., Vaupel P. Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements. Cancer Research 1991; 51: 6098–6102
   PubMed Web of Science ®Google Scholar
• Horsman M.R., Chaplin D.J., Brown J.M. Tumor radiosensitization by nicotinamide; a result of improved perfusion and oxygenation. Radiation research 1989a; 118: 139–150
   PubMed Web of Science ®Google Scholar
• Horsman M.R., Hansen P.V., Overgaard J. Radiosensitization by nicotinamide in tumors and normal tissues: the importance of tissue oxygenation status. International Journal of Radiation Oncology, Biology and Physics 1989b; 16: 1273–1276
   PubMed Web of Science ®Google Scholar
• Horsman M.R., Hoyer M., Honess D.J., Dennis I.F., Overgaard J. Nicotinamide pharmacokinetics in humans and mice: a comparative assessment and the implications for radiotherapy. Radiotherapy and Oncology 1993a; 27: 131–139
   PubMed Web of Science ®Google Scholar
• Horsman M.R., Khalil A.A., Nordsmark M., Grau C., Overgaard J. Relationship between radiobiological hypoxia and direct estimates of tumour oxygenation in a mouse tumour model. Radiotherapy and Oncology 1993b; 28: 69–71
   PubMed Web of Science ®Google Scholar
• Horsman M.R., Wood P.J., Chaplin D.J., Brown J.M., Overgaard J. The potentiation of radiation damage by nicotinamide in the SCCVII tumour in vivo. Radiotherapy and Oncology 1990; 18: 49–57
   PubMed Web of Science ®Google Scholar
• Jonsson G.G., Kjellen E., Pero R.W., Cameron R. Radiosensitization effects of nicotinamide on malignant and normal mouse tissue. Cancer research 1985; 45: 3609–3614
   PubMed Web of Science ®Google Scholar
• Kjellen E., Joiner M.C., Collier J.M., Johns H., Rojas A. A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-rays treatments. Radiotherapy and Oncology 1991; 22: 81–91
   PubMed Web of Science ®Google Scholar
• Lartigau E., Lespinasse F., Vitu L., Guichard M. Does the direct measurement of oxygen tension in tumors have any adverse effects?. International Journal of Radiation Oncology, Biology and Physics 1992; 22: 949–951
   PubMed Web of Science ®Google Scholar
• Lee I., Cunningham W.P., Levitt S.H. Improvement in RBC flux, acidosis and oxygenation in tumour microregions by Fluosol-DA 20%. International Journal of Radiation Biology 1991; 60: 695–705
   PubMed Web of Science ®Google Scholar
• Lee I., Levitt S.H., Song C.W. Improved tumour oxygenation and radiosensitization by combination with nicotinamide and pentoxifylline. International Journal of Radiation Biology 1993; 64: 237–244
   PubMed Web of Science ®Google Scholar
• Lespinasse F., Thomas Ch., Bonnay M., Malaise E.P., Guichard M. Ro 03-8799: preferential relative uptake in human tumor xenografts compared to a murine tumor: comparison with SR-2508. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1105–1109
   PubMed Web of Science ®Google Scholar
• Martin L., Thomas C.D., Guichard M. Nicotinamide and carbogen: relationship between pO2 and radiosensitivity in three tumour lines. International Journal of Radiation Biology 1994; 65: 379–386
   PubMed Web of Science ®Google Scholar
• Moulder J.E., Rockwell S. Tumor hypoxia: its impact on cancer therapy. Cancer Metastasis Review 1987; 5: 313–341
   PubMed Web of Science ®Google Scholar
• Ono K., Masunaga S., Akuta K., Akaboshi M., Abe M. Radiosensitization of SCCVII tumours and normal tissues by nicotinamide and carbogen: analysis by micronucleus assay. Radiotherapy and Oncology 1993; 28: 162–167
   PubMed Web of Science ®Google Scholar
• Riess J.G. Overview of progress in the fluorocarbon approach to in vivo oxygen delivery. Biomaterials, Artificial Cells and Immobilizing Biotechnology 1992; 20: 183–202
   PubMed Web of Science ®Google Scholar
• Riess J.G. Highly fluorinated systems for oxygen transport, diagnosis and drug delivery. Colloids and Surfaces A: Physicochemical and Engineering Aspects 1994; 84: 33–48
   Web of Science ®Google Scholar
• Rockwell S., Fischer J.J., Martin D.F., Teicher B.A. Artificial blood substitutes as adjuncts to cancer therapy. Cells and Tissue Kinetics 1983; 16: 612–612
   Google Scholar
• Rockwell S., Kelley M., Irvin C.G., Hughes C.S., Porter E., Yabuki H., Fisher J.J. Modulation of tumor oxygenation and radiosensitivity by a perfluorooctylbromide emulsion. Radiotherapy and Oncology 1991; 22: 92–98
   PubMed Web of Science ®Google Scholar
• Rockwell S., Moulder J.E. Hypoxic fractions of human tumors xenografted into mice: a review. International Journal of Radiation Oncology, Biology and Physics 1990; 19: 197–202
   PubMed Web of Science ®Google Scholar
• Simon J.M., Lartigau E., Guichard M. Nicotinamide and carbogen: major effect on the radiosensitivity of EMT6 and HRT18 tumours. Radiotherapy and Oncology 1993; 28: 203–207
   PubMed Web of Science ®Google Scholar
• Teicher B.A., Herman T.S., Holden S.A., Liu S., Menon K. Effect of dose, schedule and rate of administration on radiosensitization by a high-concentration perflubron emulsion/carbogen. Radiotherapy and Oncology Investigations 1993; 1: 14–19
   Google Scholar
• Teicher B.A., Rose C.M. Perfluorochemical emulsions can increase tumor radiosensitivity. Science 1984; 223: 934–936
   PubMed Web of Science ®Google Scholar
• Thomas C.D., Chavudra N., Martin L., Guichard M. Correlation between radiosensitivity, percent hypoxic cells and pO2 measurements in three tumor cell lines. Radiation Research 1994; 139: 1–8
   PubMed Web of Science ®Google Scholar
• Thomas C., Reiss J., Guichard M. Influence of the 100%w/v perfluorooctyl bromide (PFOB) emulsion dose on tumour radiosensitivity. International Journal of Radiation Biology 1991; 59: 433–445
   PubMed Web of Science ®Google Scholar
• Thomlinson R.H., Gray L.H. The histological structure of some human lung cancers and the possible implications for radiotherapy. British Journal of Cancer 1995; 9: 539–549
   Google Scholar
• Tremper K.K., Friedman A.E., Levine E.M., Lapin R., Camarillo D. The preoperative treatment of severely anemic patients with a perfluorochemical oxygentransport fluid, fluosol-DA. New England Journal of Medicine 1982; 307: 277–283
   PubMed Web of Science ®Google Scholar
• Vaupel P. Oxygenation of human tumors. Strahlentherapie und Onkologie 1990; 166: 377–386
   PubMed Web of Science ®Google Scholar
• Vaupel P., Okunieff P., Kallinowski F., Neuringer L.J. Correlations between 31P-NMR spectroscopy and tissue O2 tension measurements in a murine fibrosarcoma. Radiation Research 1989; 120: 477–493
   PubMed Web of Science ®Google Scholar
• Vaupel P., Schlenger K., Knoop C., Hockel M. Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Research 1991; 51: 3316–3322
   PubMed Web of Science ®Google Scholar
• Vitu-Loas L., Thomas C., Chavaudra N., Guichard M. Radiosensitivity, blood perfusion and tumour oxygenation after perflubron emulsion injection. Radiotherapy and Oncology 1993; 27: 149–155
   PubMed Web of Science ®Google Scholar