A Major Component of Radiation Action: Interference with Intracellular Control of Differentiation

References

• Aller P., Rius C., Mata F., Zorrilla A., Cebanas C., Bellón T., Bernabeu C. Camptothecin induces differentiation and stimulates the expression of differentiation-related genes in U-937 human promonocytic leukemia cells. Cancer Research 1992; 52: 1245–1251
   PubMedGoogle Scholar
• Barath Z., Kuntzel H. Cooperation of mitochondrial and nuclear genes specifying the mitochondrial genetic apparatus in Neuropora crassa. Proceedings of the National Academy of Sciences, USA 1972; 69: 1371–1374
   PubMed Web of Science ®Google Scholar
• Baugnet-Mathieu L., Goutier R., Baes C. Comparative sensitivity of nuclear and mitochondrial DNA synthesis to X-irradiation and to the administration of sulfhydryl radio-protector (AET). Biophysics 1970; 6: 357–366
   Google Scholar
• Bayreuther K., Rodemann H.P., Francz I., Maier K. Differentiation of fibroblast stem cells. Journal of Cell Science 1988; 10: 115–130, (Suppl.)
   Google Scholar
• Bedford J.S., Hall E.J. Chromosome constitution and gamma-ray sensitivity: a possible correlation in hamster cells cultured in vitro. Radiation Research 1967; 31: 679–692
   Web of Science ®Google Scholar
• Beer J.Z. Heritable lesions affecting proliferation of irradiated mammalian cells. Advances in Radiation Biology, J.T. Lett, H. Adler. Academic, New York 1979; 8: 363–417, In
   Google Scholar
• Ben-Baruch N., Reinhold W.C., Alexandrova N., Ichinose I., Blake M., Trepel J.B., Zajac-Kaye M. c-myc down-regulation in suramin-treated HL60 cells precedes growth inhibition but does not trigger differentiation. Molecular Pharmacology 1994; 46: 73–78
   Google Scholar
• Bennett D.C. Differentiation in mouse melanoma cells: Initial reversibility and an on-off stochastic model. Cell 1983; 34: 445–453
   Google Scholar
• Berry R.J. Quantitative studies of relationships between tumor cell ploidy and dose response to ionizing radiation in vivo. Radiation Research 1963; 18: 236–245
   Web of Science ®Google Scholar
• Bloch A. Antineoplastic agents and cancer cell differentiation. Cancer Biology and Therapeutics, J.G. Cory, A. Szentivanyi. Plenum, New York 1987; 217–221, In
   Google Scholar
• Bond V.P., Fliedner T.M., Archambeau J.O. Mammalian Radiation Lethality, a Disturbance in Cellular Kinetics. Academic, New York 1965
   Google Scholar
• Brach M.A., Hass R., Sherman M.L., Gunji H., Weichselbaum R., Kufe D. Ionizing radiation induces expression and binding of the nuclear factor κB. Journal of Clinical Investigation 1991; 88: 691–695
   PubMed Web of Science ®Google Scholar
• Brelvi Z.S., Studzinski G.P. Inhibition of DNA synthesis by an inducer of differentiation of leukemic cells, 1 alpha, 25 dihydroxy vitamin D3, precedes down regulation of the c-myc gene. Journal of Cellular Physiology 1986; 128: 171–179
   PubMed Web of Science ®Google Scholar
• Briggs R., King T.J. Nucleocytoplasmic interaction in eggs and embryos. The cell, J. Brachet, A.E. Mirsky. Academic, New York 1959; 1: 537–612, In
   Google Scholar
• Brühl P., Mergenthaler H.-G., Dörmer P. Haemopoetic inductive capacity of irradiated stromal cell layers in human micro long-term bone marrow cultures. Cell and Tissue Kinetics 1988; 31: 411–417
   Google Scholar
• Burki H.J., Carrano A.V. Relative radiosensitivities of tetraploid and diploid Chinese hamster cells in culture exposed to ionizing radiation. Mutation Research 1973; 17: 277–282
   PubMedGoogle Scholar
• Chase J.W. Mitochondrial RNAs in eggs and embryos of Xenopus. Carnegie Institute Washington, Yearbook 1971; 69: 578–580
   Google Scholar
• Clark A.M., Mitchell C.J. Effect of X-rays upon haploid and diploid embryos of Habrobracon. Biological Bulletin 1952; 103: 170–177
   Google Scholar
• Clark A.M., Rubin M.A. The modification by X-rays of the life span of haploids and diploids of the wasp Habrobracon species. Radiation Research 1961; 15: 224–253
   Google Scholar
• Clarke A.R., Purdie C.A., Harrison D.J., Morris R.G., Bird C.C., Hooper M.L., Wyllie A.H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993; 362: 849–852
   PubMed Web of Science ®Google Scholar
• Conger A.D., Johnston A.H. Polyploidy and radiosensitivity. Nature 1956; 178: 271–271
   Web of Science ®Google Scholar
• Conger A.D., Sparrow A.H., Schwemmer S.S., Klug E.E. Relation of nuclear volume and radiosensitivity to ploidy level (haploid to 22-ploid) in the higher plants and a yeast. Environmental and Experimental Botany 1982; 22: 57–74
   Google Scholar
• Davies D.R., Evans H.J. The role of genetic damage in radiation-induced cell lethality. Advances in Radiation Biology, L.G. Augenstein, R. Mason, M. Zelle. Academic, New York 1966; 2: 243–353, In
   Google Scholar
• Dexter T.J., Bennett D.C. Differentiation apparently repressed by the nucleus. Rapidly-induced pigmentation of enucleated melanoma cells. Experimental Cell Research 1987; 168: 255–264
   Google Scholar
• Etoh H., Taguchi Y.H., Tabachnick J. Cytokinetics of regeneration in β-irradiated Guinea-pig epidermis. Radiation Research 1977; 71: 109–118
   PubMedGoogle Scholar
• Evans H.J. Chromatid aberrations induced by gamma irradiation. I. The structure and frequency of chromatid interchanges in diploid and tetraploid cells of Vicia faba. Genetics 1961; 46: 257–275
   PubMedGoogle Scholar
• Fantoni A., Ghiara L., Pozzi L.V. Arrest of cell division and hemoglobin synthesis in differentiating yolk sac erythroid cells. Biochimica et Biophysica Acta 1972; 269: 141–152
   PubMedGoogle Scholar
• Fibach E., Rachmilewitz E.A. Stimulation of erythroid progenitors by high concentrations of erythropoietin results in normoblasts arrested in G2 phase of the cell cycle. Experimental Hematology 1993; 21: 184–188
   Google Scholar
• Fischer-Lindahl K., Hermel E., Loveland B.E., Wang C.-R. Maternally transmitted antigen of mice: a model transplantation antigen. Annual Review of Inmmunology 1991; 9: 351–372
   Google Scholar
• Francis G.E. Growth and differentiation control. Cancer Chemotherapy and Biological Response Modifiers, H.M. Pinedo, D.L. Longo, B.A. Chabner. Elsevier. 1993; 284–329, ch. 15,
   Google Scholar
• Gamba-Vitalo C., Blair O.C., Keyes S.R., Sartorelli A.C. Differentiation of WEHI-3 d+ monomyelocytic leukemia cells by retinoic acid and aclacinomycin A. Cancer Research 1986; 46: 1189–1194
   PubMed Web of Science ®Google Scholar
• Gerharz C.D., Gabbert H.E., Engers R., Ramp U., Mayer H., Biesalski H.K., Luley C. Heterogeneous response to differentiation induction in different clonal subpopulations of a rat rhabdomyosarcoma cell line (BA-HAN-1). Cancer Research 1989; 49: 7132–7140
   Google Scholar
• Glücksmann A. Histological features in the local radiocurability of carcinomas. The Biological and Clinical Basis of Radiosensitivity, M. Friedman. C. C. Thomas, Springfield 1974; 203–218, In
   Google Scholar
• Gualtieri R.J. Consequences of extremely high doses of irradiation on bone marrow stromal cells and the release of hematopoietic growth factors. Experimental Hematology 1987; 15: 952–957
   PubMedGoogle Scholar
• Haber A.H., Foard D.E. Further studies of gamma-irradiated wheat and their relevance to use of mitotic inhibition for development studies. American Journal of Botany 1964; 51: 151–159
   Google Scholar
• Hass R. Retrodifferentiation—an alternative biological pathway in human leukemia cells. European Journal of Cell Biology 1992; 58: 1–11
   PubMed Web of Science ®Google Scholar
• Hatfill S.J., LaCock C.J.R., Laubscher R., Downing T.G., Kirby R. A role for mitochondrial DNA in the pathogenesis of radiation-induced myelodysplasia and secondary leukemia. Leukemia Research 1993; 17: 907–913
   PubMed Web of Science ®Google Scholar
• Hay E. Dedifferentiation and metaplasia in vertebrate and invertebrate regeneration. The Stability of the Differentiated State, H. Ursprung. Springer, Berlin 1968; 85–108, In
   Google Scholar
• Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Experimental Cell Research 1961; 25: 585–621
   PubMed Web of Science ®Google Scholar
• Heller D.P., Raaphorst G.P. Inhibition of potentially lethal damage recovery by altered pH, glucose utilization and proliferation in plateau growth phase human glioma cells. International Journal of Radiation Biology 1994; 66: 41–47
   PubMed Web of Science ®Google Scholar
• Hendry J.H. Review: Survival curves for normal-tissue clonogenes: a comparison of assessments using in vivo, transplantation, or in situ techniques. International Journal of Radiation Biology 1985a; 47: 3–16
   Web of Science ®Google Scholar
• Hendry J.H. The cellular basis of long-term marrow injury after irradiation. Radiotherapy and Oncology 1985b; 3: 331–338
   PubMed Web of Science ®Google Scholar
• Hendry J.H., Cowie F.G., Wangenheim K.-H.v. The reversion phenomenon in irradiated fern prothalli: effects of acute or chronic anoxia and LET. Radiation and Environmental Biophysics 1985; 24: 45–56
   Google Scholar
• Hendry J.H., Scott D. Loss of reproductive integrity of irradiated cells, and its importance in tissues. Perspectives on Mammalian Cell Death, C.S. Potten. Oxford University Press, Oxford 1987; 160–183, In
   Google Scholar
• Herzberg N.H., Zwart R., Wolterman R.A., Ruiter J.P.N., Wanders R.J.A., Bolhuis P.A., Van den Bogert C. Differentiation and proliferation of respiration-deficient human myoblasts. Biochimica et Biophysica Acta 1993; 1181: 63–67
   PubMedGoogle Scholar
• Hetzel F.W., Kolodny G.M. Radiation-induced giant cell formation: the influence of conditions which enhance repair of potentially lethal damage. Radiation Research 1976; 68: 490–498
   PubMed Web of Science ®Google Scholar
• Hofer K.G., van Loon N., Schneiderman M.H., Dalrymple G.V. Targets for radiation-induced cell death: target replication during the cell cycle evaluated in cells exposed to X-rays or 125I decays. International Journal of Radiation Biology 1993; 64: 205–216
   PubMed Web of Science ®Google Scholar
• Jackson R.C. Biological effects of folic acid antagonists with antineoplastic activity. Cell Cycle Effects of Drugs, L.A. Dethlefsen. International Encyclopedia of Pharmacology and Therapeutics, Section 121, Pergamon, Oxford 1986; 112–135, In
   Google Scholar
• Joshi G.P., Nelson W.J., Revell S.H., Shaw C.A. X-ray-induced chromosome damage in live mammalian cells, and improved measurements of its effects on their colony-forming ability. International Journal of Radiation Biology 1982; 41: 161–181
   Web of Science ®Google Scholar
• Kaneko T., Watanabe T., Oishi M. Effect of mitochondrial protein synthesis inhibitors on erythroid differentiation of mouse erythroleukemia (Friend) cells. Molecular and Cellular Biology 1988; 8: 3311–3315
   PubMed Web of Science ®Google Scholar
• Kobayashi S., Amikura R., Okada M. Presence of mitochondrial large ribosomal RNA outside mitochondria in germ plasm of Drosophila melanogaster. Science 1993; 260: 1521–1524
   PubMed Web of Science ®Google Scholar
• Koeffler H.P. Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood 1983; 62: 709–721
   PubMed Web of Science ®Google Scholar
• Kondo K., Tsuneizumi K., Watanabe T., Oishi M. Induction of in vitro differentiation of mouse embryonal carcinoma (F) cells by inhibitors of topoisomerases. Cancer Research 1991; 51: 5398–5404
   PubMed Web of Science ®Google Scholar
• Krystal G., Lam V., Dragowska W., Takahashi C., Appel J., Gontier A., Jenkins A., Lam H., Quon L., Lansdorp P. Transforming growth factor β1 is an inducer of erythroid differentiation. Journal of Experimental Medicine 1994; 180: 851–860
   PubMed Web of Science ®Google Scholar
• Lamy R., Muller H.J. Evidence of the non-genetic nature of the lethal effect of radiation on Drosphila embryos. Proceedings of the 7th International Congress of Genetics. Journal of Genetics. 1939; 180–181, (Suppl.),
   Google Scholar
• Lange C.S. Studies on the cellular basis of radiation lethality V. A survival curve for the reproductive integrity of the planarian neoblast and the effect of polyploidy on the radiation response. International Journal of Radiation Biology 1969; 15: 51–64
   Google Scholar
• Liao X., Butow R.A. RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell 1993; 72: 61–71
   PubMed Web of Science ®Google Scholar
• Liebermann D.A., Hoffman B. Differentiation primary response genes and protooncogenes as positive and negative regulators of terminal hematopoietic cell differentiation. Stem Cells 1994; 12: 352–369
   PubMedGoogle Scholar
• Littlefield J.W. Variation, Senescence, and Neoplasia in Cultured Somatic Cells. Harvard University Press, Cambridge, MA 1976
   Google Scholar
• Lord B.I. Proliferation regulators in haemopoiesis. Cellular Dynamics of Haemopoiesis, L.G. Lajtha. Saunders, Philadelphia 1979; 8: 435–451, Clinics in Haematology
   Google Scholar
• Lord B.I. Haemopoietic stem cells. Stem Cells, C.S. Potten. Churchill Livingstone, Edinburgh 1983; 118–154, In
   Google Scholar
• Lowe S.W., Schmitt E.M., Smith S.W., Osborne B.A., Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993; 362: 847–849
   PubMed Web of Science ®Google Scholar
• Maity A., McKenna W.G., Muschel R.J. The molecular basis for cell cycle delays following ionizing radiation: a review. Radiotherapy and Oncology 1994; 31: 1–13
   PubMed Web of Science ®Google Scholar
• Mann J.D., Storey W.B. Rapid action of carbamate herbicides upon plant cell nuclei. Cytologia 1966; 31: 203–207
   Web of Science ®Google Scholar
• Marks P.A., Sheffery M., Rifkind R.A. Induction of transformed cells to terminal differentiation and the modulation of gene expression. Cancer Research 1987; 47: 659–666
   PubMed Web of Science ®Google Scholar
• Meinzer H.P., Sandblad B., Baur H.J. Generation-dependent control mechanisms in cell proliferation and differentiation—the power of two. Cell Proliferation 1992; 25: 125–140
   Google Scholar
• Metalli P., Ballardin E. Radiobiology of artemia: radiation effects and ploidy. Currents Topics in Radiation Research Quarterly 1970–72; 7: 181–240
   Google Scholar
• Metcalf D. The molecular control of proliferation and differentiation in hemopoietic cells. Comptes Rendus de l'Academie des Sciences Paris, Sciences de la vie/Life sciences 1993; 316: 860–870
   Google Scholar
• Michalowski A. Effects of radiation on normal tissues: hypothetical mechanisms and limitations of in situ assays of clonogenicity. Radiation and Environmental Biophysics 1981; 19: 157–172
   PubMed Web of Science ®Google Scholar
• Millar B.C., Millar J.L. The effect of ploidy on the modification of the shoulder region of hypoxic cell-survival curves by the biradical, Ro. 03-6061. International Journal of Radiation Biology 1977; 31: 355–363
   Google Scholar
• Mitchison J.M. The Biology of the Cell Cycle. Cambridge University Press, Cambridge 1971
   Google Scholar
• Muller H.J. Some present problems in the genetic effects of radiation. Journal of Cellular and Comparative Physiology 1950; 35: 9–70, (Suppl.)
   Google Scholar
• Ng C.E., Bussey A.M., Raaphorst G.P. Inhibition of potentially lethal and sub-lethal damage repair by camptothecin and etoposide in human melanoma cell lines. International Journal of Radiation Biology 1994; 66: 49–57
   PubMed Web of Science ®Google Scholar
• Nias A.H.W. An Introduction to Radiobiology. Wiley, Chichester 1990
   Google Scholar
• Nicoletti G., De Giovanni C., Landuzzi L., Simone G., Rocchi P., Nanni P., Lollini P.L. Induction of myogenic differentiation in human rhabdomyosarcoma cells by ionising radiation, N,N-dimethylformamide and their combination. British Journal of Cancer 1992; 65: 519–522
   PubMed Web of Science ®Google Scholar
• Nijhof W., Wierenga P.K. Characterization of a cycling murine pluripotent stem cell population. European Journal of Cell Biology 1985; 39: 136–141
   PubMedGoogle Scholar
• Oleinick N.L., Rustad R.C. Interrelationships between ionizing radiation, protein synthesis, and the physiological expressions of radiation damage. Advances in Radiation Biology, J.T. Lett, H. Adler. Academic, New York 1976; 6: 107–160, In
   Google Scholar
• Padmanaban G., Venkateswar V., Rangarajan P.N. Haem as a multifunctional regulator. Trends in Biology and Science 1989; 14: 492–496
   PubMed Web of Science ®Google Scholar
• Painter R.B. Similarities and differences between UV and ionizing radiation death. 4th International Congress of Radiation Research, Evian, 1970, Abstract No. 644.
   Google Scholar
• Painter R.B. Similarities and differences between UV and ionizing radiation death. Advances in Radiation Research, J.F. Duplan, A. Chapiro. Gordon & Breach, New York 1973; 1: 411–419, Physics and Chemistry, part 2, Biology and Medicine
   Google Scholar
• Pallavicini M.G. Cytosine arabinoside: molecular, pharmacokinetic and cytokinetic considerations. Cell Cycle Effects of Drugs, L.A. Dethlefsen. International Encyclopedia of Pharmacology and Therapeutics, Section 121, Pergamon, Oxford 1986; 136–169, In
   Google Scholar
• Pedersen P.L. Tumor mitochondria and the bioenergetics of cancer cells. Progress in Experimental Tumor Research 1978; 22: 190–274
   PubMedGoogle Scholar
• Peterson H.-P., Feldges A., Wangenheim K.-H.v., Feinendegen L.E. Preleukemic proliferative changes in murine bone marrow after single and multiple 7,12-dimethyl-benz(a)anthracene (DMBA)-applications. Leukemia Research 1993; 17: 43–49
   Google Scholar
• Peterson H.-P., Wangenheim K.-H.v., Feinendegen L.E. Persisting radiation effect on murine 7-day and 12-day CFU-S. Experimental Hematology 1986; 14: 776–781
   Google Scholar
• Peterson H.-P., Wangenheim K.-H.v., Feinendegen L.E. Early and late effects in the bone marrow of mice following 2Gy (6MeV) neutron irradiation. Radiation and Environmental Biophysics 1989; 28: 291–302
   Google Scholar
• Philbrick D.A. Radiation induced reproductive death as function of mammalian cell ploidy. University of California, Berkeley 1976, PhD thesis (LBL-4783),
   Google Scholar
• Pierce G.B., Shikes R., Fink L.M. Cancer, a problem of development biology. Foundations of Developmental Biology Series, C.L. Markert. Prentice-Hall, Englewood Cliffs 1978
   Google Scholar
• Ploemacher R.E., Brons N.H.C. In vivo proliferative and differential properties of murine bone marrow cells separated on the basis of rhodamine-123 retention. Experimental Hematology 1988; 16: 903–907
   PubMedGoogle Scholar
• Potten C.S. Radiation and Skin. Taylor & Francis, London 1985
   Google Scholar
• Potten C.S. A comprehensive study of the radiobiological response of the murine (BDF1) small intestine. International Journal of Radiation Biology 1990; 58: 925–973
   PubMed Web of Science ®Google Scholar
• Potten C.S., Merritt A., Hickman J., Hall P., Farada A. Characterization of radiation-induced apoptosis in the small intestine and its biological implications. International Journal of Radiation Biology 1994; 65: 71–78
   PubMed Web of Science ®Google Scholar
• Prasad K.N. Differentiation of neuroblastoma cells in culture. Biological Reviews 1975; 50: 129–265
   PubMed Web of Science ®Google Scholar
• Radford I.R., Hodgson G.S. Effect of ploidy on the response of V79 cells to ionizing radiation. International Journal of Radiation Biology 1987; 51: 765–778
   Web of Science ®Google Scholar
• Reiss M., Gamba-Vitalo C., Sartorelli A.C. Induction of tumor cell differentiation as a therapeutic approach: preclinical models for hematopoietic and solid neoplasms. Cancer Treatment Reports 1986; 70: 201–218
   PubMedGoogle Scholar
• Revell S.H. Relationships between chromosome damage and cell death. Radiation-induced Chromosome Damage in Man, T. Ishihara, M.S. Sasaki. Riss, New York 1983; 215–233, In
   Google Scholar
• Rèvèsz L., Norman U. Cellular and macroscopic damage in relation to cytological observation. Radiation Effects in Physics, Chemistry and Biology, M. Ebert, A. Howard. North Holland, Amsterdam 1963; 136–139, In
   Google Scholar
• Rijke R.P.C., Plaisier H., Hoogeveen A.T., Lamerton L.F., Galjaard H. The effect of continuous irradiation on cell proliferation and maturation in small intestinal epithelium. Cell Tissue Kinetics 1975; 8: 441–453
   PubMedGoogle Scholar
• Ritzl F., Spooner-Hart R., Johnson S., Wheen G. Gamma-irradiation effects on haploid and diploid eggs of honey bee Apis mellifera. 10th International Congress of Radiation Research, Würzburg, 1995, Abstract (submitted).
   Google Scholar
• Rizzino A. Understanding the roles of growth factors in carcinogenesis: modulation of autocrine growth control by differentiation. International Journal of Developmental Biology 1993; 37: 61–65
   Google Scholar
• Rocchi P., Ferreri A.M., Simone G., Granchi D., Nanni P., Frau A., Paolucci P., Paolucci G. Gamma radiation-induced differentiation on human neuroblastoma cells in culture. Anticancer Research 1993; 13: 419–422
   Google Scholar
• Rodemann H.P., Peterson H.-P., Schwenke K., Wangenheim K.-H.v. Terminal differentiation of human fibroblasts is induced by radiation. Scanning Microscopy 1991; 5: 1135–1142
   PubMedGoogle Scholar
• Sachs L. The cellular and molecular environment in leukemia. Blood Cells 1993; 19: 709–726
   Google Scholar
• Scher W., Friend C. Breakage of DNA and alterations in folded genomes by inducers of differentiation in Friend erythroleukemic cells. Cancer Research 1978; 38: 841–849
   PubMed Web of Science ®Google Scholar
• Schneiderman M.H., Braby L.A., Roesch W.C. Division delay after low X-ray doses and treatment with cycloheximide. Radiation Research 1977; 70: 130–140
   PubMed Web of Science ®Google Scholar
• Schwartz D., Bay C. Further studies on the reversal in the seedling height dose curve at very high levels of ionizing radiations. American Naturalist 1956; 90: 323–327
   Web of Science ®Google Scholar
• Schwenke K. Modulation von Differenzierungsprozessen hämatopoetischer Zellen: Zur Biologie des Strahlenschadens und zellulärer Kontrollmechanismen. University of Bonn. 1993, PhD thesis
   Google Scholar
• Schwenke, K., Peterson, H.-P., Wangenheim, K.-H.v., Feinendegen, L.E. Induction of differentiation in erythroleukemic K562 cells by γ-irradiation. Leukemia Research, in press, 1995
   Google Scholar
• Scott R.E., Tzen C.-Y., Witte M.M., Blatti S., Wang H. Regulation of differentiation, proliferation and cancer suppressor activity. International Journal of Developmental Biology 1993; 37: 67–74
   Google Scholar
• Silini G., Hornsey S. Studies on cell-survival of irradiated Ehrlich ascites tumour III. A comparison of the X-ray survival curves obtained with a diploid and a tetraploid strain. International Journal of Radiation Biology 1962; 5: 147–153
   Web of Science ®Google Scholar
• Sohal R.S., Allen R.G., Nations C. Oxygen free radicals play a role in cellular differentiation: an hypothesis. Journal of Free Radicals in Biology and Medicine 1986; 2: 175–181
   PubMedGoogle Scholar
• Sparrow A.H. Comparisons of the tolerances of higher plant species to acute and chronic exposures of ionizing radiation. Journals of Genetics 1964; 40: 12–37
   Google Scholar
• Storrs E.E., Williams R.J. A study of monozygous. Proceedings of the National Academy of Sciences, USA 1968; 60: 910–914
   Google Scholar
• Stubbe W. Die Plastiden als Erbträger. Probleme der Biologischen Reduplikation, P. Sitte. Springer, Berlin 1966; 237–288, In
   Google Scholar
• Suzuki S., Eguchi-Kasai K., Kosaka T., Watanabe I., Ohara H., Kaneko I. Time-lapse microscopy and DNA double-strand breakage of Chinese hamster cells under conditions promoting or preventing PLD repair after irradiation with 60Co γ-rays. International Journal of Radiation Biology 1990; 58: 769–779
   PubMed Web of Science ®Google Scholar
• Tandler B., Hutter R.V.P., Erlandson R.A. Ultrastructure of oncocytoma of the parotid gland. Laboratory Investigation 1970; 23: 567–580
   PubMed Web of Science ®Google Scholar
• Tauchi H., Sawada S. Analysis of mitotic cell death caused by radiation in mouse leukaemia L5178Y cells: apoptosis is the ultimate form of cell death following mitotic failure. International Journal of Radiation Biology 1994; 65: 449–455
   PubMed Web of Science ®Google Scholar
• Terada M., Epner E., Nudel U., Salmon J., Fibach E., Rifkind R.A., Marks P.A. Induction of murine erythroleukemia differentiation by actinomycin D. Proceedings of the National Academy of Sciences, USA 1978; 75: 2795–2799
   PubMed Web of Science ®Google Scholar
• Terada M., Fried J., Nudel U., Rifkind R.A., Marks P.A. Transient inhibition of initiation of S-phase associated with dimethyl sulfoxide induction of murine erythroleukemia cells to erythroid differentiation. Proceedings of the National Academy of Sciences, USA 1977; 74: 248–252
   PubMedGoogle Scholar
• Testa N.G., Hendry J.H., Molineux G. Long-term bone marrow damage in experimental systems and in patients after radiation or chemotherapy. Anticancer Research 1985; 5: 101–110
   PubMed Web of Science ®Google Scholar
• Thames H.D., Withers R., Mason K.A., Reid B.O. Dose survival characteristics of mouse jejunal crypt cells. International Journal of Oncology and Biological Physics 1981; 7: 1591–1597
   PubMed Web of Science ®Google Scholar
• Tobey R.A. Different drugs arrest cells at a number of distinct stages in G2. Nature 1975; 254: 245–247
   PubMed Web of Science ®Google Scholar
• Underbrink A.G., Pond V. Cytological factors and their predictive role in comparative radiosensitivity: a general summary. Current Topics in Radiation Research Quarterly 1976; 11: 251–306
   Google Scholar
• Van Pelt F.N., Hassing I.G.A.M., Stelling M.A., Seinen W., Blaauboer B.J. Induction of terminal differentiation in cultured human keratinocytes by polychlorinated aromatic hydrocarbons as measured by cell size analysis. Toxicology and Applied Pharmacology 1992; 113: 240–245
   PubMedGoogle Scholar
• Van't Hoff J. The duration of chromosomal DNA synthesis, of the mitotic cycle, and of meiosis of higher plants. Handbook of Genetics, R.C. King. Plenum, New York 1974; 2: 363–377, In
   Google Scholar
• Visser J.W.M., Bauman J.G.J., Mulder A.H., Eliason J.F., de Leeuw A.M. Isolation of murine pluripotent hemopoietic stem cells. Journal of Experimental Medicine 1984; 59: 1576–1590
   Google Scholar
• Walters R.A., Enger M.D. Effect of ionizing radiation on nuclei acid synthesis in mammalian cells. Advances in Radiation Biology, J.T. Lett, H. Adler. Academic, New York 1976; 6: 1–48, In
   Google Scholar
• Wangenheim K.-H.v. Entwicklungsphysiologische Untersuchungen über die Beteiligung nukleärer und extranukleärer Erbträger an der Phänogenese. Berichte der Deutschen Botanischen Gesellschaft 1967; 80: 228–236
   Google Scholar
• Wangenheim K.-H.v. Genetische Defekte und Strahlenschädigung. Radiation Botany 1970a; 10: 469–490
   Google Scholar
• Wangenheim K.-H.v. Different effect of polyploidy on radiation response and on aging of differentiated cells. Radiation Botany 1970b; 10: 345–350
   Google Scholar
• Wangenheim K.-H.v. A major component of the radiation effect: Interference with endocellular control of cell proliferation and differentiation. International Journal of Radiation Biology 1975; 27: 7–30
   Google Scholar
• Wangenheim K.-H.v. A mechanism for the endocellular control of cell differentiation and cell proliferation. Journal of theoretical Biology 1976; 59: 205–222
   PubMedGoogle Scholar
• Wangenheim K.-H.v. Induction of early differentiation as a means of cell sterilization. Radiation Biology and Chemistry: Research Developments, H.E. Edwards, S. Navaratnam, B.J. Parsons, G.O. Phillips. Studies in Physical and Theoretical Chemistry Series, Elsevier, Amsterdam 1979; 6: 217–225, In
   Google Scholar
• Wangenheim K.-H.v. Cell death through differentiation. Potential immortality of somatic cells: a failure in control of differentation. Perspectives on Mammalian Cell Death, C.S. Potten. Oxford University Press, Oxford 1987; 129–159, In
   Google Scholar
• Wangenheim K.-H.v., Howard A. Different modes of cell sterilization: cell killing and early differentiation. Radiation Research 1978; 73: 288–302
   Web of Science ®Google Scholar
• Wangenheim K.-H.v., Siegers M.P., Feinendegen L.E. Repopulation ability and proliferation stimulus in the hematopoietic system of mice following gamma-irradiation. Experimental Hematology 1980; 8: 694–701
   PubMed Web of Science ®Google Scholar
• Wangenheim K.-H.v., Walther F., Kern H. DNA-Synthesis nach Bestrahlung mit hohen Röntgendosen und Spindelhemmung. Zeitschrift für Pflanzenzüchtung 1970; 64: 6–19
   Google Scholar
• Wareing P.F., Phillips I.D.J. The Control of Growth and Differentiation in Plants. Pergamon, Oxford 1973
   Google Scholar
• Watanabe T., Kondo K., Oishi M. Induction of in vitro differentiation of mouse erythroleukemia cells by genistein, an inhibitor of tyrosine protein kinases. Cancer Research 1991; 51: 764–768
   PubMed Web of Science ®Google Scholar
• Weeks D.L., Melton D.A. A maternal mRNA localized to the animal pole of Xenopus eggs encodes a subunit of mitochondrial ATPase. Proceedings of the National Academy of Sciences, USA 1987; 84: 2798–2802
   PubMedGoogle Scholar
• Weiss M.J., Orkin S.H. GATA transcription factors: key regulators of hematopoiesis. Experimental Haematology 1995; 23: 99–107
   PubMed Web of Science ®Google Scholar
• Wenisch T. Redundanz genetischer Information als kritische Determinante des Zellüberlebens nach Einwirkung ionisierender Strahlung. University of Frankfurt, Main 1989, PhD thesis,
   Google Scholar
• Wu C., Lajtha L.G. Haemopoietic stem-cell kinetics during continuous irradiation. International Journal of Radiation Biology 1975; 27: 41–50
   Web of Science ®Google Scholar
• Xu C.X., Hendry J.H., Testa N.G. Residual deficiencies in hemopoietic precursor cell populations after repeated irradiation of mice with X-rays or neutrons: dose response relationships. Experimental Hematology 1986; 14: 230–233
   PubMedGoogle Scholar
• Yoshida H., Takase M., Bando T., Shirakami T., Yura Y. Emergence of a smooth-muscle phenotype and apoptosis by treatment with etoposide, an inhibitor of DNA topoisomerase-II, in a neoplastic human salivary intercalated duct cell-line. Cancer Journal 1993; 6: 220–228
   Google Scholar
• Zetsche K. Regulation der zeitlichen Aufeinanderfolge von Differentzierungsvorgängen bei Acetabularia. Zeitschrift für Naturforschung 1966; 21b: 375–379
   Google Scholar