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Original Article

Glutathione Manipulation and the Radiosensitivity of Human Tumour and Fibroblast Cell Lines

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Pages 413-419 | Received 06 Apr 1995, Accepted 08 Jun 1995, Published online: 03 Jul 2009

References

  • Aguilera J.A., Newton G.L., Fahey R.C., Ward J.F. Thiol uptake by Chinese hamster V79 cells and aerobic radioprotection as a function of the net charge on the thiol. Radiation Research 1992; 130: 194–204
  • Alper T. The modification of damage caused by primary ionization of biological targets. Radiation Research 1956; 5: 573–586
  • Alper T., Howard-Flanders P. Role of oxygen in modifying the radiosensitivity of E. coli B. Nature 1956; 178: 978–979
  • Arlett C.F., Green M.H.L., Priestley A., Harcourt S.A., Mayne L.V. Comparative human cellular radiosensitivity. 1. The effect of SV40 transformation and immortalization on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes. International Journal of Radiation Biology 1988; 54: 911–928
  • Blaglow J.E., Varnes M.E., Astor M., Hall E.J. Non-protein thiols and cellular response to drugs and radiation. International Journal of Radiation, Oncology, Biology and Physics 1982; 8: 719–723
  • Biaglow J.E., Varnes M.E., Clark E.P., Epp E.R. The role of thiols in cellular response to radiation and drugs. Radiation Research 1983; 95: 437–455
  • Biaglow J.E., Varnes M.E., Epp E.R., Clark E.P., Astor M. Factors involved in depletion of glutathione from A549 human lung carcinoma cells: implications for radiotherapy. International Journal of Radiation, Oncology, Biology and Physics 1984; 10: 1221–1227
  • Biaglow J.E., Varnes M.E., Epp E.R., Clark E.P., Tuttle S.W., Held K.D. Role of glutathione in the aerobic radiation response. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1311–1314
  • Britten R.A., Warenhius H.M., White R., Browning P.G.W., Green J.A. Melphalan resistant human ovarian tumour cells are cross-resistant to photons, but not to high LET neutrons. Radiotherapy and Oncology 1990; 18: 357–363
  • Bump E.A., Brown J.M. Role of glutathione in the radiation response of mammalian cells in vitro and in vivo. Pharmacological Therapeutics 1990; 47: 117–136
  • Bump E.A., Yu N.Y., Brown J.M. The use of drugs which deplete intracellular glutathione in hypoxic cell radiosensitization. International Journal of Radiation Oncology, Biology and Physics 1982; 8: 439–442
  • Clark E.P., Epp E.R., Biaglow J.E., Mores-Gaudio M., Zachgo E. Glutathione depletion, radiosensitization and misonidazole potentiation in hypoxic Chinese hamster ovary cells by buthionine sulfoximine. Radiation Research 1984; 108: 370–380
  • Clark E.P., Epp E.R., Morse-Gaudio M., Biaglow J.E. The role of glutathione in the aerobic radioresponse. I. Sensitization and recovery in the absence of intracellular glutathione. Radiation Research 1986; 108: 238–250
  • Deacon J.M., Wilson P.A., Peckham M.J. The radiobiology of human neuroblastoma. Radiotherapy and Oncology 1985; 3: 201–209
  • Debieu D., Deschavanne P.J., Midander J., Larsson A., Malaise E.P. Survival curves of glutathione synthetase deficient human fibroblasts: correlation between radiosensitivity in hypoxia and glutathione synthetase activity. International Journal of Radiation Biology 1985; 48: 525–543
  • Dethmers J.K., Meister A. Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivy to irradiation. Proceedings of the National Academy of Sciences, USA 1981; 78: 7492–7496
  • Griffith O.W., Meister A. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). Journal of Biological Chemistry 1979; 254: 7558–7560
  • Held K.D., Epp E.R., Awad S., Biaglow J.E. Post-irradiation sensitization of mammalian cells by the thiol-depleting agent dimethyl fumarate. Radiation Research 1991; 127: 75–80
  • Issels R.D., Nagelf A., Eckert K.-G., Wilmanns W. Promotion of cysteine uptake and its utilization for glutathione biosynthesis induced by cysteamine and n-acetylcysteine. Biochemical Pharmacology 1988; 37: 881–888
  • Kato T., Irwin R.J., Prout G.R. Cell cycles in two cell lines of human bladder carcinoma. Tohoku Journal of Experimental Medicine 1977; 121: 157–164
  • Koch C.J., Howell R.J. Combined radiation-protective and radiation-sensitizing agents. II. Radiosensitivity of hypoxic or aerobic Chinese hamster fibroblasts in the presence of cysteamine and misonidazole: implications for the ‘oxygen effect’ (with appendix on calculation of dose-modifying factors). Radiation Research 1981; 87: 265–283
  • Lehnert S., Greene D., Batist S. Radiation response of drug-resistant variants of a human breast cancer cell line: the effect of glutathione depletion. Radiation Research 1990; 124: 208–215
  • Mason R.P. Free radical metabolites of foreign compounds and their toxological significance. Reviews in Biochemical Toxicology, E. Hodgson, J.R. Bend, R.M. Philpot. Elsevier, Amsterdam 1979; 151–200, In
  • Masters J.R.W., Hepburn P.J., Walker L. Tissue culture models of transitional cell carcinoma: characterization of 22 human urothelial cell lines. Cancer Research 1986; 46: 3630–3636
  • McMillan T.J., Holmes A. The isolation and partial characterization of a radiation-sensitive clone of a human bladder carcinoma cell line. Radiation Research 1991; 128: 302–305
  • Mitchell J.B., Russo A. The role of glutathione in radiation and drug induced cytotoxicity. British Journal of Cancer 1987; 55: 96–104
  • Mitchell J.B., Russo A., Biaglow J.E., McPherson S. Cellular glutathione depletion by diethylmaleate or buthionine sulfoximine: no effect of glutathione depletion on the oxygen enhancement ratio. Radiation Research 1983; 96: 422–428
  • Paffenholz V., Ebener U., Kornhuber B. Uptake and release of iodine-labelled m-iodobenzylguanine in a neuroblastoma cell culture system and its importance in neuroblastoma therapy. Journal of Cancer Research and Clinical Oncology 1989; 115: 269–275
  • Prise K.M., Davies S., Michael B.D. A comparison of the chemical repair rates of free radical precursors of DNA damage and cell killing in Chinese hamster V79 cells. International Journal of Radiation Biology 1992; 61: 721–728
  • Radford I.R. The level of induced DNA double-strand breakage correlates with cell killing after X-irradiation. International Journal of Radiation Biology 1985; 48: 45–54
  • Radford I.R. Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after X-irradiation of mammalian cells. International Journal of Radiation Biology 1986; 49: 611–620
  • Saunders E.L., Meredith M.J., Eisert D.R., Freeman M.L. Depletion of glutathione after γ-irradiation modifies survival. Radiation Research 1991; 125: 267–276
  • Schulte-Frohlinde D., von Sonntag C. Radiolysis of DNA and model systems in the presence of oxygen. Oxidative Stress, H. Sies. Academic, London 1985; 11–40, In
  • Sies H., Wahllander A., Waydhas C., Soboll S., Hoberle D. Functions of intracellular glutathione in hepatic hydroperoxide and drug metabolism and the role of extracellular glutathione. Advances in Enzyme Research 1980; 18: 303–320
  • Tieize F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Analytical Biochemistry 1969; 27: 502–522
  • van Der Schans G.P., Vos O., Roos-Verhey W.S.D., Lohman P.H.M. The influence of oxygen on the induction of radiation damage in DNA in mammalian cells afger sensitization by intracellular glutathione depletion. International Journal of Radiation Biology 1986; 50: 453–465
  • von Sonntag C. The Chemical Basis of Radiation Biology. Taylor & Francis, London 1987
  • Vos O., van der Schans G.P., Roos-Verhey W.S.D. Effects of BSO and DEM on thiol-level and radiosensitivity in HeLa cells. International Journal of Radiation, Oncology, Biology and Physics 1984; 10: 1249–1253
  • Whitaker S.J., Ung Y.C., McMillan T.J. DNA double-strand break induction and rejoining as determinants of human tumour cell radiosensitivity. A pulsed-field gel electrophoresis study. International Journal of Radiation Biology 1995; 67: 7–18
  • Willson R.L. Free radical repair mechanisms and the interactions of glutathione and vitamins C and E. Radioprotectors and Anticarcinogens, O.F. Nygaard, M.G. Simic. Academic, New York 1983; 1–22, In

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