30
Views
18
CrossRef citations to date
0
Altmetric
Research Article

Interpretation of inverse dose-rate effects for mutagenesis by sparsely ionizing radiation

Pages 447-458 | Published online: 03 Jul 2009

  • AMUNDSON, S. A. and CHEN, D. J., 1996, Inverse dose-rate effect for mutation induction by c-rays in human lym phoblasts. International Journal of Radiation Biology, 69, 555 -564.
  • BHATTACH ARYA, R. N. and WAYMIRE, E. C., 1990, Stochastic Processes with Applications (New York: Wiley).
  • BARENDSEN, G. W., 1985, Do fast neutrons at low dose rate enhance cell transformation in vitro? A basic problem of microdosimetry and interpretation. International Journal of Radiation Biology, 47, 731 -734.
  • BRENNER, D. J., 1994, The signifi cance of dose rate in assessing the hazards of domestic radon exposure. Health Physics, 66, 76 -79.
  • BRENNER, D. J. and H ALL, E. J., 1990, The inverse dose rate effect for oncogenic transformation by neutrons and charged particles. A plausible interpretation consistent with published data. International Journal of Radiation Biology, 58, 745 -758.
  • BRENNER, D. J., HLATKY, L. R., H AHNFELDT, P. J., H ALL, E. J. and SACHS, R. K., 1995, A convenient extension of the linear-quadratic model to include redistribution and reoxygenation. International Journal of Radiation Oncology, Biology, Physics, 32, 379 -390.
  • BRENNER, D. J., H UANG, Y. and H ALL, E. J., 1991, Fractionated high dose-rate versus low dose-rate regimens for intra-cavitary brachytherapy of the cervix: equivalent regimensforcombinedbrachytherapyandexternal irradiation. International Journal of Radiation Oncology, Biology, Physics, 21, 1415 -1423.
  • BURKI, H. J., 1980, Ionizing radiation-induced 6-thioguanine-resistant clones in synchronous CHO cells. Radiation Research, 81, 76 -84.
  • CHUANG, Y. and LIBER, H. L., 1995, Cell cycle effects on x-ray mutagenesis at the thymine kinase locus in hum an lym phoblastoid cell line. Abstract in 43rd Annual Meeting of the Radiation Research Society, San Jose, CA.
  • CROMPTON, N. E. A., BARTH, B. and KIEFER, J., 1990, Inverse dose-rate effect for the induction of 6-thioguanine-resistant m utants in Chinese hamster V79-S cells by 60Co c-rays. Radiation Research, 124, 300 -308.
  • CURTIS, S. B., 1986, Lethal and potentially lethal lesions induced by radiation -- a unified repair model. Radiation Research, 106, 252 -270.
  • ELKIND, M. M., 1994, Radon-induced cancer: a cell-based model of tumorigenesis due to protracted exposures. International Journal of Radiation Biology, 66, 649 -653.
  • EVANS, H. H., H O RNG, M. F., MENCL, J., GLAZIER, K. G. and BEER, J. Z., 1985, The in¯ uence of dose rate on the lethal and mutagenic effects of X-rays in proliferating L5178Y cells differing in radiation sensitivity. International Journal of Radiation Biology, 47, 553 -62.
  • EVANS,H. H., NIELSEN,M., M ENCL,J.,H ORNG,M. F. and RICANATI, M., 1990, The effect of dose rate on x-radiation-induced mutant frequency and the nature of DNA lesions in mouse lym phoma L5178Y cells. Radiation Research, 122, 316 -325.
  • FURUNO-FUKUSHI, I., UENO, A. M. and M ATSUDAIRA, H., 1988, Mutation induction by very low dose rate c-rays in cultured mouse leukemiacells L5178Y. Radiation Research, 115, 273 -280.
  • H AHNFELDT, P. and H LATKY, L. R., 1996, Resensitization due to redistribution of cells in the phases of the cell cycle during arbitrary radiation protocols. Radiation Research, 145, 134 -43.
  • H AHNFELDT, P. and SACHS, R. K., 1996, Radiation damage to a dynamic cell population. In Proceedings of the Fourth International Conference on Population Dynamics, edited by O. Arino (in press).
  • H ILL, C. K., BUONAGURO, F. M., M YERS, C. P., H AN, A. and ELKIND, M. M., 1982, Fission-spectrum neutrons at reduceddoseratesenhanceneoplastic transformation. Nature, 298, 67 -69.
  • H LATKY, L. R., H AHNFELDT, P. and SACHS, R. K., 1994, The in¯ uence of time-dependent, stochastic heterogeneity on the radiation response of a cell population. Mathematical Biosciences, 122, 201 -220.
  • JOSTES, R. F., B USH NELL, K. M. and D EWEY, W. C., 1980, X-ray induction of 8-azaguanine-resistant mutants in synchronousChinesehamsterovarycells.Radiation Research, 83, 146 -161.
  • KAMIYA, K., YASU KAWA-BARNES, J., MITCHEN, J. M., GO ULD, M. N. and CLIFTON, K., 1995, Evidence that carcinogenesis involvesanimbalancebetweenepigenetichigh-frequency initiation and suppression of promotion. Proceedings of the National Academy of Sciences, USA, 92, 1332-1336.
  • KENNEDY, A. R., 1985, Evidence that the fi rst step leading to carcinogen induced malignant transformation is a high frequency, common event. In Carcinogenesis: A Comprehensive Survey-- Mechanisms of Carcinogenesis and Assays for Carcinogens, edited by J. C. Barrett and R. W. Tennant (New York: Raven).
  • KIRKPATRICK, S., GELATT, C. D. and VECCI, M. P., 1983, Optimization by simulated annealing. Science, 22, 671 -680.
  • KOÈNIG, F. and K IEFER, J., 1988, Lack of dose-rate effect for mutation induction by c-rays in human TK6 cells. International Journal of Radiation Biology, 54, 891 -897.
  • LEA, D. E. and CATCHESIDE, D. G., 1942, The mechanism of the induction by radiation of chromosome aberrations in Tradescantia. Journal of Genetics, 44, 216 -245.
  • LORENZ, R., LEUNER, K., DEUBEL, W., GO LLNER, T. and H EMPEL, L., 1993, Normal and reverse dose-rate effect for the induction of m utants in somatic cells by ionizing radiation. Toxicology Letters, 67, 353 -363.
  • LUBIN, J. H., BOICE, J. D. Jr., H ORNUNG, R. W., EDLING, C., H ORNUNG, R. W., H OW E, G., KUNZ, E., KUSIAK, R. A., M ORRISON,H.I.,RADFORD,E.P.,SAMET,J.M., TIRMARCHE, M., W OO DWA RD, A. and YAO, S. X., 1995, Radon-exposedundergroundminersandinverse dose-rate (protraction enhancement) effects. Health Physics, 69, 494 -500.
  • M ILLER, R. C., BRENNER, D. J., GEARD, C. R., KOMATSU, K., M ARINO, S. A. and H ALL, E. J., 1988, Oncogenic transformation by fractionated doses of neutrons. Radiation Research, 114, 589 -598.
  • M ILLER, R. C., GEARD, C. R., M ARTIN, S. G., M ARINO, S. A. and H ALL, E. J., 1995, Neutron-induced cell cycle-dependent oncogenic transformation of C3H10T1/2 cells. Radiation Research, 142, 270 -185.
  • N AKAMURA, N. and O KADA, S., 1981, Dose rate effects of gamma-ray-induced mutations in cultured mammalian cells. Mutation Research, 83, 127 -35.
  • O FTEDAL, P. A., 1968, A theoretical study of mutant yield and cell killing after treatm ent of heterogeneous cell populations. Hereditas, 60, 177-210.
  • PAZZAG LIA, S., SARAN, A., PARISET, L., REBESSI, S., DI M AJO, V., CO PPOLA, M. and COVELLI, V., 1996, Sensitivity of C3H10T1/2 cells to radiation-induced killing and neoplastic transformation as a function of cell cycle. International Journal of Radiation Biology, 69, 57 -66.
  • REDPATH, J. L., ANTONIONO, R. J., SUN, C., GERSTENBERG, H. M. and BLAKELY, W. F., 1995, Late mitosis/early G1 phase and mid-G1 phase are not hypersensitive cell cycle phases for neoplastic transformation of HeLa ´ skin fi broblast human hybrid cells induced by fi ssion-spectrum neutrons. Radiation Research, 141, 37 -43.
  • ROSSI, H. H. and KELLERER, A. M., 1986, The dose rate dependence of oncogenic transformation by neutrons may be due to variation of response during the cell cycle. International Journal of Radiation Biology, 50, 353-361.
  • SACHS, R. K. and BRENNER, D. J., 1993, Effect of LET on chromosomalaberrationyields. I. Dolong-lived, exchange-prone double-strand breaks play a role? International Journal of Radiation Biology, 64, 677 -688.
  • SCHULTHEISS, T. E., ZAGARS, G. K. and PETERS, L. J., 1987, An explanatory hypothesis for early- and late-effect parameter values in the LQ model. Radiotherapy and Oncology, 9, 241 -8.
  • SELVANAYAGAM, C. S., DAVIS, C. M., CO RNFORTH, M. N. and U LLRICH, R. L.,1995,Latentexpressionofp53 mutations and radiation-induced mam mary cancer. Cancer Research, 55, 3310 -3317.
  • STEEL, G. G., 1977, Growth Kinetics of Tumours: Cell Population Kinetics in Relation to the Growth and Treatment of Cancer (Oxford: Clarendon).
  • THACKER, J. and STRETCH, A., 1983, Recovery from lethal and mutagenic damage during postirradiation holding and low-dose-rate irradiations of cultured ham ster cells. Radiation Research, 96, 380 -92.
  • THAMES, H. D. and HENDRY, J. H., 1987, Fractionation in Radiotherapy, (London: Taylor & Francis).
  • TRAVIS, E. L. and TUCKER, S. L., 1987, Iso-effect models and fractionated radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 13, 283 -287.
  • WATANABE, M. and HO RIKAWA, M., 1980, Analyses of different sensitivities of synchronized HeLa S3 cells to radiation and chemical carcinogens during the cell cycle. V. Radiation- and chemical carcinogen-induced mutagenesis. Mutation Research, 71, 219 -31.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.