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Research Article

Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation

Pages 145-150 | Published online: 03 Jul 2009

References

  • BECH-HANSE NN. T., BLATTNER, W. A., SELL, B. M., McKEE, E. A., LAMPKIN, B. C., FRAUMENI, J. F. and PATERSON, M. C., 1981, Transmission of in vitro radioresistance in a cancer-prone family. Lancet, i, 1335–1337.
  • BIRCH, J. M., HARTLEY, A. L., SANTIBANEZ-KOREF, M. F., TRICKER, K. J., PROSSER, J., CONDIE, A., KELSEY, A. M., HARRIS, M., MORRIS JONES, P. H., BINCHY, A., CRowTHER, D., CRAFT, A. W., EDEN, 0. B., EVANS, D. G. R., THOMPSON, E., MANN, J. R. and MARTIN, J., 1994, Prevalence and diversity of constitutional muta-tions in the p53 gene among 21 Li—Fraumeni families. Cancer Research, 54, 1298–1304.
  • BURNET, N. G., NYMAN, J., TURESSON, I., WURM, R., YARNOLD, J. R. and PEACOCK, J. H., 1994, The relationship between cellular radiation sensitivity and tissue response may provide the basis for individualising radiotherapy schedules. Radiotherapy and Oncology, 33, 228–238.
  • CHANG, E. H., PIROLLO, K. F., Zou, Q. Z., CHEUNG, H-Y, LAWLER, E. L., GARNER, R., WHITE, E., BERNSTEIN, W. B., FRAUMENI, J. W. and BLATTNER, W. A., 1987, Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family. Science, 237, 1036–1038.
  • CHEN, J. R., 1977, In situ detection of mycoplasma contamina-tion in cell cultures by fluorescent Hoechst 33258 stain. Experimental Cell Research, 104, 255–262.
  • Cox, R., 1982, A cellular description of the repair defect in ataxia-telangiectasia. In: Ataxia-Telangiectasia. A Cellular and Molecular Link Between Cancer, Neuropathology and Immune Deficiency. Edited by: B. A. Bridges and D. G. Harnden (Wiley, Chichester), pp. 141–153.
  • DI-LEONARDO, A., LINKE, S. P., CLARKIN, K. and WAHL, G. M., 1994, DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip-1 in normal human fibroblasts. Genes and Development, 8, 2540–2551.
  • FAN, S., EL-DEIRY, W. S., BAE, I., FREEMAN, J., JONDLE, D., BHATIA, K., FORNACE, A. J., MAGRATH, I., KoHN, K. W. and O'CONNOR, P. M., 1994, p53 gene mutations are associated with decreased sensitivity of human lym-phoma cells to DNA damaging agents. Cancer Research, 54, 5824–5830.
  • FLoRES-ROZAS, H., KELMAN, Z., DEAN, F. B., PAN, Z-Q., HARPER, J. W., ELLEDGE, S. J., O'DONNELL, M. and HURWITZ, J., 1994, Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhi-bits DNA replication catalysed by DNA polymerase holoenzyme. Proceedings of the National Academy of Sciences USA, 91, 8655–8659.
  • FoRD, J. M. and HANAWALT, P. C., 1995, Li—Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance. Proceedings of the National Academy of Sciences USA, 92, 8876–8880.
  • FRITSCHE, M., HAESSLER, C. and BRANDNER, G., 1993, Induction of nuclear accumulation of the tumour-suppressor protein p53 by DNA-damaging agents. Oncogene, 8, 307–308.
  • GEARA, F. B., PETERS, L. J., ANG, K., WIKE, J. L., SWON, S. S., GUTTENBERGER, R., CALLENDAR, D. L., MALAISE, E. P. and BROCK, W. A., 1992, Intrinsic radiosensitivity of normal human fibroblasts and lymphocytes after high- and low-dose-rate irradiation. Cancer Research, 52, 6348–6352.
  • HAO, M., FINLAY, C. A. and LOZANO, G., 1993, A functionally inactive p53 Li—Fraumeni syndrome mutant. Oncogene, 8, 299–306.
  • KASID, U., PFEIFER, A., WEICHELSBAUM, R. R., DRITSCHILO, A. and MARK, G. E., 1987, The Raf oncogene is associated with a radiation-resistant human laryngeal cancer. Science, 237, 1039–1041.
  • KASTAN, M. B., ONEYEKWERE, 0., SIDRANSKY, D., VoGELSTEIN, B. and CRAIG, R. W., 1991, Participation of p53 in the cellular response to DNA damage. Cancer Research, 51, 6304–6311.
  • KUERBITZ, S. J., p LUNKETT, B. S., WALSH, W. V. and KASTAN, M. B., 1992, Wild-type p53 is a cell cycle checkpoint determi-nant following irradiation. Proceedings of the National Academy of Sciences USA, 89, 7491–7495.
  • LANE, D. P., 1992, Cancer. p53, guardian of the genome. Nature, 358, 15–16.
  • LEE, J. M. and BERNSTEIN, A., 1993, p53 mutations increase resistance to ionising radiation. Proceedings of the National Academy of Sciences USA, 90, 5742–5746.
  • LI, F. P. and FRACMENI, J. F., 1969, Soft tissue sarcomas, breast cancer and other neoplasms: a familial syndrome. Annals of Internal Medicine, 71, 747–752.
  • LITTLE, J. B. and NAGASAWA, H., 1985, Effect of confluent holding on potentially lethal damage repair, cell cycle progression, and chromosomal aberrations in human normal and ataxia-telangiectasia fibroblasts. Radiation Research, 101, 81–93.
  • LITTLE, J. B., NOVE, J., DAHLBERG, W. K., TROILO, P., NicHoLs, W. W. and STRONG, L. C., 1987, Normal cytotoxic response of skin fibroblasts from patients with Li—Fraumeni familial cancer syndrome to DNA damaging agents in vivo. Cancer Research, 47, 429–434.
  • LOWE, S. W., SCHMITT, E. M., SMITH, S. W., OSBORNE, B. A. and JACKS, T., 1993, p53 is required for radiation-induced apoptosis in mouse lymphocytes. Nature, 362, 847–849.
  • MALKIN, D., LI, F. P., STRONG, J. F. FRAUMENIJR, J. F., NELSON, C. E., Km, D. H., KASSEL, J., GRYKA, M. A., BiscHOFF, F. Z., TAINSKY, M. A. and FRIEND, S. H., 1990, Germline p53 mutations in a familial syndrome of breast cancer, sarcoma and other neoplasms. Science, 250, 1233–1238.
  • MCKENNA, W. G., WEISS, M. C., FNDLICH, B., LING, C. C., BAKANANSKAS, V. J., KELSTEN, M. U. and MUSCHEL, R. J., 1990, Synergistic effect of the v-myc oncogene with H-ras on radioresistance. Cancer Research, 50, 97–102.
  • MERRITT, A. J., pOTTEN, C. S., KEMP, C. J., HICKMAN, J. A., BALMAIN, A., LANE, D. P. and HALL, P. A., 1994, The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Research, 54, 614–617.
  • MILNER, J. and MEDCALF, E. A., 1991, Cotranslation of activated mutant p53 with wildtype drives the wildtype p53 protein into the mutant configuration. Cell, 65, 765–774.
  • MIRZAYANS, R., AUBIN, R. A., BOSNICH, A., BLATTNER, W. A. and PATERSON, M. C., 1995, Abnormal pattern of post-y-ray DNA replication in radioresistant fibroblast strains from affected members of a cancer-prone family with Li—Fraumeni syndrome. British Journal of Cancer, 71, 1221–1230.
  • O'CONNOR, P. M., JACKMAN,J., JONDLE, D., BHATIA, K., MAGRATH, I. and KOHN, K. W., 1993, Role of the p53 tumour suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines. Cancer Research, 53, 4776–4780.
  • ROBERTS, S. A., 1990, DRFIT: A program for fitting radiation survival models. International Journal of Radiation Biology, 57, 1243–1246.
  • SLICHENMYER, W. J., NELSON, W. G., SLEBOS, R. J. and KASTAN, M. B., 1993, Loss of p53-associated G1 check-point does not decrease cell survival following DNA damage. Cancer Research, 53, 4164–4168.
  • SMITH, M. L., CHEN, I. T., ZHAN, Q., BAE, I., CHEN, C. Y, GILMER, T. M., KASTAN, M. B., O'CONNOR, P. M. and FORNACE, A. J., 1994, Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science, 266, 1376–1380.
  • SRIVASTAVA, S., ZOU, Z., PIROLLO, K., BLATTNER, W. and CHANG, E. H., 1990, Germ-line transmission of mutated p53 gene in a cancer-prone family with Li—Fraumeni syndrome. Nature, 348, 747–749.
  • SRIVASTAVA, S., WANG, S., TONG, Y A., PIROLLO, K. and CHANG, E. H., 1993, Several mutant p53 proteins detected in cancer-prone families with Li—Fraumeni syndrome exhibit transdominant effects on the bio-chemical properties of the wild-type p53. Oncogene, 8, 2449–2456.
  • STEEL, G. G., MCMILLAN, T. J. and PEACOCK, J. M., 1989, The picture has changed in the 19802s. InternationalJournal of Radiation Biology, 56, 525–537.
  • WANG, X. W., YED, H., ScHARYFER, L. and 10 others, 1995, p53 modulation of TFIIH-associated nucleotide excision repair activity. Nature Genetics, 10, 188–195.
  • WEEKS, D. E., PATERSON, M. C., LANGE, K., ANDRAIS, B., DAVIS, R. C., YODER, F. and GATTI, R. A., 1991, Assessment of chronic L) radiosensitivity as an in vitro assay for heterozygote identification of ataxia-telangiectasia. Radiation Research, 128, 90–99.
  • WEST, C. M. C., ELYAN, S. A. G., BERRY, p., COWAN, R. and SCOTT, D., 1995, A comparison of the radiosensitivity of lymphocytes from normal donors, cancer patients, individuals with ataxia-telangiectasia (A-T) and A-T heterozygotes. International Journal of Radiation Biology, 68, 197–203.

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