13
Views
28
CrossRef citations to date
0
Altmetric
Research Article

Intrinsic radiosensitivity of healthy donors and cancer patients as determined by the lymphocyte micronucleus assay

Pages 693-701 | Published online: 03 Jul 2009

References

  • BURNET, N. G., NYMAN, J., TURESSON, I., WURM, R., YARNOLD, J. R. and PEACOCK, J. H., 1994, The relationship between cellular radiation sensitivity and tissue response may provide the basis for individualising radiotherapy sched-ules. Radiotherapy and Oncology, 33, 228–238.
  • BURNET, N. G., WURM, R. and PEACOCK, J. F1.7 1996, Low dose-rate fibroblast radiosensitivity and the prediction of patients response to radiotherapy. International Journal of Radiation Biology, 70, 289–300.
  • CATENA, C., CONTI, D., DEL NERO., A. and RIGHT, E.7 19927 Inter-individual differences in radiation response shown by an in vitro micronucleus assay: effects of 3-aminobenzamide on X-ray treatment. International Journal of Radiation Biology, 62, 687–694.
  • CATENA, C., CONTI, D., PARASACCHI, P., MARENCO, P., BORTOLATO, B., BOTTURI, M., LEONI, M., PORTALURI, M., PALEANI-VETTORI, P. G. and RIGHI, E.7 1996, Micronuclei in cytokinesis-blocked lymphocytes may pre-dict patient response to radiotherapy. International j ournal of Radiation Biology, 70, 301–308.
  • DI GIORGIO, C., DE MEO, M. P., LAGET, M., GUIRAUD, H., BOTTA, A. and DUMENIL, G., 1994, The micronucleus assay in human lymphocytes: screening for interindividual variability and application to biomonitoring. carcinogenesis, 15, 313–317.
  • DUNST, J. and GEBHART, E.7 1995, Unexpected tumor response, radiation myelitis and increased in vitro-radiosensitivity of lymphocytes in a patient with non-small lung cancer. Radiotherapy and Oncology, 36, 158.
  • DURAN, R. 0. and ODELL, P. L., 1974, Cluster Analysis (Berlin: Springer).
  • ELLARD, S. and PARRY, E. M., 1993, A modified protocol for the cytochalasin B in vitro micronucleus assay using whole human blood or separated lymphocyte cultures. M utagenesis, 8, 317–320.
  • FENECH, M., 1993, The cytokinesis-block micronucleus tech-nique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutation Research, 285, 35–44.
  • FENECH, M. and MORLEY, A. A., 1986, Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low dose X-irradiation. Mutation Research, 161, 193–198.
  • FLOYD, D. N. and CASSONI, A. M., 1994, Intrinsic radiosensitivity of adult and cord blood lymphocytes as determined by the micronucleus assay. European Journal of Cancer, 30A, 615–620.
  • GEARA, F. B., PETERS, L. J., ANG, K. K., WIKE, J. L. and BROCK, W. A., 1993, Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radio-therapy patients. International Journal of Radiation Oncology, Biology and Physics, 27, 1173–1179.
  • GENTNER, N. E. and MORRISON, D. P., 1989, Determination of the proportion of persons in the population-at-large who exhibit abnormal sensitivity to ionising radiation. In Low Dose Radiation: Biological Basis of Risk Assessment (London: Taylor & Francis), pp. 253–262.
  • GORDON, A. D., 1981, Classification: Methods for the Exploratory Analysis of Multivariate Data (London: Chapman & Hall).
  • HANSON, J. A., 1994, The Association for Radiation Research First Workshop: Report. Normal cell radiosensitivity: clinical application in predicting response to radiotherapy and cancer predisposition. 21–23 March 1994, Westlakes Research Institute, Cumbria, UK.
  • HUBER, R., BRASELMANN, H. and BAUCHINGER, M., 19927 Infra-and interindividual variation of background and radi-ation-induced micronucleus frequencies in human lymphocytes. International Journal of Radiation Biology, 61, 655–661.
  • JOHANSEN, J., BENTZEN, S. M., OVERGAARD, J. and OVERGAARD, M., 1996, Relationship between the in vitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia, and skin erythema after radio-therapy. Radiotherapy and Oncology, 40, 101–109.
  • JONES, L. A., SCOTT, D., COWAN, R. and ROBERTS, S. A., 1995, Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: chromosome aberrations after low dose-rate irradiation. International Journal of Radiation Biology, 67, 519–528.
  • KAGAN, A. R., 1988, The importance of genetics for the optimiza-tion of radiation therapy. American Journal of Clinical Oncology, 11, 84–88.
  • LITTLEFIELD, L. G., SAYER, A. M. and FROME, E. L., 1989, Comparisons of dose—response parameters for radiation-induced acentric fragments and micronuclei observed in cytokinesis-arrested lymphocytes. M utagenesis, 4, 265–270.
  • MALCOLMSON, A. M., DAVIES, G., HANSON, J. A., DEELEY, J. 0. T., GAFFNEY, C. C., McGREooR, A. D. and KERBY, I. J., 1995, Determination of radiation-induced damage in lymphocytes using the micronucleus and microgel electro-phoresis 'comet' assays. European Journal of Cancer, 31A, 2320–2323.
  • MILL, A. J., WELLS, J., HALL, S. C. and BUTTER, A., 1996, Micronucleus induction in human lymphocytes: compar-ative effects of X rays, alpha particles, beta particles and neutrons and implications for biological dosimetry. Radiation Research, 145, 575–585.
  • MITCHELL, J. C. and NORMAN, A., 1987, The induction of micronuclei in human lymphocytes by low doses of radiation. International Journal of Radiation Biology, 52, 527–535.
  • OCHI-LOHMANN, T. H., OKAZAKI, K., MADRUGA, M. R., DE B. PEREIRA, C. A. and RABELLO-GAY, M., 1996, Radiosensitivity of blood lymphocytes from basocellular carcinoma patients, as detected by the micronucleus assay. Mutation Research, 357, 97–106.
  • PROSSER, J. S., MOQUET, J. E., LLOYD, D. C. and EDWARDS, A. A., 1988, Radiation induction of micronuclei in human lymphocytes. Mutation Research, 199, 37–45.
  • RACHED, E., BEER, K. T., SCHINDLE RR. and GREINER., R. F1.7 1996, Can the micronucleus (MNC)-assay be used to discriminate patients with severe acute reactions? Radiotherapy and Oncology, 40 (suppl. 1), S67.
  • SAVAGE, J. R. K., 1970, Sites of radiation induced chromosome exchanges. Current Topics on Radiation Research, 6, 129–194.
  • SCOTT, D., Hu, Q. and ROBERTS, S. A., 1996, Dose-rate sparing for micronucleus induction in lymphocytes of controls and ataxia-telangiectasia heterozygotes exposed to 60Co y-irradiation in vitro. International J ournal of Radiation Biology, 70, 521–527.
  • STEEL, G. G., DOWN, J. D., PEACOCK, J. H. and STEPHENS, T. C., 1986, Dose rate effects and the repair of radiation damage. Radiotherapy and Oncology, 5, 321–331.
  • SURRALLES, J., CARBONELL, E., MARCOS, R., DEGRASSSI, F., ANTOCCIA, A. and TANZARELLA, C., 1992, A Collaborative study on the improvement of the micronucleus test in cultured human lymphocytes. M utagenesis, 7, 407–410.
  • TANZARELLA, C., DEGRASSSI, F., ANTOCCIA, A., BATTISTONI, A., SURRALLES, J., CARBONELL, E. and MARCOS, R., 1992, Validation of the micronucleus test in cultured human lymphocytes: a collaborative study. mutagenesis, 7, 379.
  • THIERENS, H., VRAL, A. and DE RIDDER, L., 1991, Biological dosimetry using the micronucleus assay for lymphocytes: interindividual differences in dose—response. Health Physics, 61, 623–630.
  • THIERENS, H., VRAL, A., VAN EIJKEREN, M., SPELEMAN, F. and DE RIDDER, L., 1995, Micronucleus induction in peri-pheral blood lymphocytes of patients under radiotherapy treatment for cervical cancer or Hodgkin's disease. International journal of Radiation Biology, 67, 529–539.
  • TUCKER, S. L., GEARA, F. B., PETERS, L. J. and BROCK, W. A., 1996, How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity? Radiotherapy and Oncology, 38, 103–113.
  • TURESSON, I., 1990, Individual variation and dose dependency in the progression rate of skin telangiectasia. International Journal Radiation Oncology, Biology and Physics, 19, 1569–1574.
  • TURESSON, I., NYMAN, J., HOLMBERG, E. and ODEON, A., 1996, Prognostic factors for acute and late skin reactions in radiotherapy patients. International Journal Radiation Oncology, Biology and Physics, 36, 1065–1075.
  • VRAL, A., THIERENS, H. and DE RIDDER, L., 1996, Micronucleus induction by 60Co 7-rays and fast neutrons in ataxia telangiectasia lymphocytes. International Journal of Radiation Biology, 70, 171–176.
  • VRAL, A., VERHAEGEN, F., THIERENS, H. and DE RIDDER, L., 1994, Micronuclei induced by fast neutrons versus 60Co 7-rays in human peripheral blood lymphocytes. International Journal of Radiation Biology, 65, 321–328.
  • WARD, J. H., 1963, Hierarchical grouping to optimise an object-ive function. Journal of the American Statistical Association, 58, 236–244.
  • WEST, C. M. L., ELYAN, S. A. G., BERRY, P., COWAN, R. and SCOTT, D., 1995, A comparison of the radiosensitivity of lymphocytes from normal donors, cancer patients, indi-viduals with ataxia-telangiectasia (A-T) and A-T heterozygotes. International journal of Radiation Biology, 68, 197–203.
  • WEST, C. M. L., SCOTT, D. and PEACOCK, J. F1.7 1994, The Association for Radiation Research First Workshop: Report. Normal cell radiosensitivity: clinical application in predicting response to radiotherapy and cancer predis-position. 21–23 March 1994, Westlakes Research Institute, Cumbria, UK.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.