- can be hypothesized that the contribution of the Alper, T. and Bryant, P. E., 1974, Reduction in oxygen
- PLD-like component of STLD depends on the rate enhancement ratio with increase in LET: tests of two
- of proliferation of critical cells in tissues. Late hypotheses. I nternational J ournal of R adiati on B iology, 26,
- responding tissues contain a large fraction of non-203-208.
- cycling cells and are generally characterized by low
- Alper, T., Gillies, N. E. and Elkind, M. M., 1960, The sigmoid survival curve in radiobiology. N ature, 186,a1/a2 ratios, possibly associated with a low a1, due 1062-1063.to a more eæ cient repair of the PLD component of
- Barendsen, G. W., 1962, Dose-survival curves of human cells
- the linear term. A smaller contribution of PLD would in tissue culture irradiated with alpha-, beta-, 20 kV X-
- also be expected to yield a higher R B E. This hypo-and 200 kV X-radiation. N ature, 193, 1153 -1155.
- thesis is consistent with the observation that R B E of
- Barendsen, G. W., 1964, Impairment of the proliferative capacity of human cells in culture by alpha-particles offast neutrons for damage to late-responding tissues diåerent linear energy transfer. I nternational J ournal ofare generally larger than for early responding tissues. R adiati on B iology, 8, 453-466.In late-responding tissues many cells are non-cycling
- Barendsen, G. W., 1967, Mechanisms of action of diåerent
- or have a long life span, associated with ample time ionizing radiations on the proliferative capacity of m am -
- available for repair of PLD. m alian cells. In A dvances in T heoretical and E xperim ental B iophy sics, edited by A. Cole, Ed., vol. 1 (New York:
- A large contribution of PLD or PLD-like damage Marcel Dekker), pp. 167-231.could also be responsible for low R B E of fast neutrons Barendsen, G. W., 1979, In¯ uence of radiation quality on the
- for responses of some types of tumours. For slow-eåectiveness of small doses for induction of reproductive
- growing tumours frequently high R B E were obtained death and chromosom e aberrations in m amm alian cells.
- in clinical studies (Battermann et al. 1981). If the I nternational J ournal of R adiati on B iology, 36, 49-63. Barendsen, G. W., 1982, Dose fractionation, dose rate and iso-
- hypothesis is correct that in slow growing tumours eåect relationships for normal tissue responses. I nternational
- the high R B E of fast neutrons is due to a large J ournal of R adiati on O ncology, B iology, P hy sics, 8, 1981 -1997.
- component of non-cycling cells which repair PLD Barendsen, G. W., 1990, Mechanisms of cell reproductive death
- eæ ciently, than an important suggestion can be and shapes of radiation dose-survival curves of m amm a-
- derived with respect to the application of fast neut-lian cells. I nternational J ournal of R adiati on B iology, 57, 885-896.
- rons. In several types of tumours an increased rate Barendsen, G. W., 1993, Sublethal damage and DNA double-
- of repopulation of surviving cells has been suggested strand breaks have sim ilar R B E -LET relationships: evid-
- to start after a number of dose fractions has induced ence and implications. I nternational J ournal of R adiati on
- suæ cient cell death to evoke a proliferative response B iology, 63, 325-330.
- (Fowler 1989). In these rapidly proliferating cells less
- Barendsen, G. W., 1994a, The relationships between R B E and LET for diåerent types of lethal damage in m amm alianrepair of PLD might occur and as a consequence of cells: biophysical and m olecular m echanism s. R adiatio nthe large component of PLD remaining eåective, the R esearch, 139, 257-270.
- R B Eof high-LET radiations might be lower. Thus Barendsen, G. W., 1994b, R B E -LET relationships for diåerent
- the application of high-LET radiation might be more types of lethal radiation damage in m amm alian cells:
- beneficial in the first few weeks of a protracted com parison with DNA dsb and an interpretation of diåerencesinradiosensitivity.I nternationalJ ournalof
- treatment, when more cells are in a resting state, R adiati on B iology, 66, 433-436.
- than in the later weeks. A further suggestion which Barendsen, G. W., Beusker, T. L. J., Vergroesen, A. J. and
- can be derived from the identification of two compon-Budke, L., 1960, Eåects of diåerent ionizing radiations
- ents contributing to STLD, is of interest with respect on human cells in tissue culture. R adiati on R esearch, 13,
- to the application of predictive testing for radiosensit-841-849. Barendsen, G. W., Walter, H. M. D., Fowler, J. F. and
- ivity to standard treatments with low -LET radiations,
- Bewley, D. K., 1963, Eåects of diåerent ionizing radi-DNA lesions susceptible to fixation. I nternational J ournal of R adiati on B iology, 53, 541-584.
- ations on human cells in tissue culture. III. Experiments Jones, G. D. D., Ward, J. F., Limoldi, C. L., Moyer, D. J.
- with cyclotron accelerated alpha-particles and deuterons. and Aguilera, J. A., 1995, Mechanisms of radiosensitiza-
- R adiati on R esearch, 18, 106-119. tion in iododeoxyuridine-substituted cells. I nternationalBattermann, J. J., Breur, K., Hart, A. A. M. and Van J ournal of R adiati on B iology, 67, 647-653.
- Peperzeel, H. A., 1981, Observations on pulmonary Kaplan, H. S. and Moses, L. E., 1964, Biological com plexity
- m etastastases in patients after single doses and m ultiple and radiosensitivity. S cience, 145, 21-25.
- fractions of fast neutrons and Cobalt-60 gam ma rays. Kellerer, A. M. and Rossi, H. H., 1972, The theory of dual
- E uropean J ournal of C ancer, 17, 539-545.
- radiationaction.C urrentT opicsinR adiati onR esearchBertsche, U. and Iliakis, G., 1987, Modifications in repair and
- Q uarterly, 8, 85-158.expression of potentially lethal damage (alpha-PLD) as Lohman, P. H. M., Cox, R. and Chadwick, K. H., 1995, Role
- m easured by delayed plating or treatment with beta-araA of m olecular biology in radiation biology. I nternational
- in plateau-phase Ehrlich ascites tumor cells after exposure J ournal of R adiati on B iology, 68, 331-340.
- to charged particles of various specific energies. R adiatio n McNally, N. J., de Ronde, J. and Folkard, M., 1988,
- R esearch, 111, 26- 46. Interaction between X-ray and alpha-particle damage in
- Bird, R. P., Zaider, M., Rossi, H. H., Marino, N., Rohrig, N. V79 cells. I nternational J ournal of R adiati on B iology, 53,
- and Hall, E. J., 1983, The sequential irradiation of 917-920.
- m amm alian cells with X-rays and charged particles of Miller, E. M., Fowler, J. F. and Kinsella, T. J., 1992, Linear-
- high LET. R adiati on R esearch, 93, 444-452. quadratic analysis of radiosensitization by halogen ated
- Charlton, D. E., Nikjoo, N. and Humm, J. L., 1989, Calculation pyrimidines. 1. Radiosensitization of human colon cancer
- of initial yields of single- and double-strand breaks in cells by iododeoxyuridine. R adiati on R esearch, 131, 81-89.
- DNA of cell nuclei from electrons, protons and alpha Phillips, R. A. and Tolmach, L. J., 1966, Repair of potentially
- particles. I nternational J ournal of R adiati on B iology, 56, 1 -19. lethal damage in X-irradiated H eLa cells. R adiatio n
- Cox, R., 1982, A cellular description of the repair defect in R esearch, 29, 413-432.
- ataxia-telangiectasia. In A txia - telangiectasia: A C ellular and Puck, T. T. and Marcus, P. I., 1956, Action of X-rays on
- M olecularL inkB etw eenC ancer,N europathologyand m amm alian cells. J ournal of E xperim ental M edicine, 103,
- I m m unedeficiency, edited by B.A. Bridges and D.G. H arden 653-666.
- (London: Wiley), pp. 141-153. Radford, I. R., 1986, Evidence for a general relationship
- Elkind, M. M. and Sutton, H., 1960, X-ray damage and between the induced level of DNA double strand breakage
- recovery in m amm alian cells in culture. N ature, 184, and cell-killing after X-irradiation of m amm alian cells.
- 1293-1295. I nternational J ournal of R adiati on B iology, 49, 611-620.
- Elkind, M. M. and Whitmore, G. F., 1967, T he R adiob iology of Rydberg, B., 1996, Clusters of DNA damage induced by ionizing
- C ultured M am m alian C ells (New York: Gordon & Breach). radiation: form ationofshortDNAfragments.11.
- Fertil, B., Deschavanne, P. J., Debieu, D. and Malaise, E. P., Experimental detection. R adiati on R esearch, 145, 200-209.
- 1988, Correlation between PLD repair and survival curves Szybalski, W., 1974, X-ray sensitization by halopyrimidines.
- of human fibroblasts in exponential growth phase: analysis C ancer C hem otherapy R eports, 58, 975-982.
- in terms of several parameters. R adiati on R esearch, 116, Terzi, M., 1961, Comparative analysis of inactivation eæ ciency
- 74-88. of radiation on diåerent organisms. N ature, 191, 461-462.
- Fowler, J. F., 1989, The linear-quadratic form ula and progressWard, J. F., 1990, The yield of DNA double-strand breaks
- in fractionated radiotherapy. B ritish J ournal of R adiology, produced intra-cellularly by ionizing radiation: a review.
- 62, 679-694. I nternational J ournal of R adiati on B iology, 57, 1141 -1150.
- Goodhead, D. T., 1989, The initial physical damage producedWeischelbaum, R. R., 1984, The role of DNA repair processes
- by ionizing radiations. I nternational J ournal of R adiati onin the response of human tumours to fractionated radio-
- B iology, 56, 623-634.therap y. I nternational J ournal of R adiati on O ncology, B iology,
- Hall, E. J., 1972, Radiation dose-rate: a factor of importanceP hy sics, 10, 1127 -1134.
- inradiobiologyandradiotherapy. B ritishJ ournalofYang, T. C., Craise, L. M., Mei, M. T. and Tobias, C. A.,
- R adio logy, 45, 81-97.1985, Neoplastic cell transformation by heavy charged particles. R adiati on R esearch, 104, S177 -187.
- Iliakis, G., 1988, Radiation-induced potentially lethal damage:
Parameters of linear-quadratic radiation dose-effect relationships: dependence on LET and mechanisms of reproductive cell death
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.