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Research Article

Apoptosis and mitotic cell death: their relative contributions to normal-tissue and tumour radiation response

Pages 709-719 | Published online: 03 Jul 2009

References

  • AIHARA, M., SCARDINO, P. T., TRUONG, L. D., WHEELER, T. M., GOAD, J. R., YANG, G. and THOMPSON, T. C., 1995, The frequency of apoptosis correlates with the prognosis of Gleason grade 3 adenocarcinoma of the prostate cancer, 75, 522–529.
  • ALPER, T., 1973, The relevance of experimental radiobiology to radiotherapy British Medical Bulletin, 29, 3–6.
  • ARENos, M., McGREooR, A. H., WYLLIE, A. H., 1994, Apoptosis is inversely related to necrosis and determines net growth in tumours bearing constitutively expressed myc, ras and HPV oncogenes American Journal of Pathology, 144, 1045–1057.
  • BAIRD, M. C., HENDRY, J. H. and TESTA, N. G, 1990, Radiosensitivity increases with differentiation status of murine haemopoietic progenitor cells selected using enriched marrow subpopulations and recombinant growth factors Radiation Research, 123, 292–298.
  • BARDESY, N., FALKOFF, D., PETRUZZI, M. J., NOWAK, N., ZABEL, B., ADAM, M., AGUIAR, M. C., GRUNDY, P., SHOW, S. T.7 and PELLETIER, J.7 1994, Anaplastic Wilm's tumours, a subtype displaying poor prognosis, harbours p53 gene mutations. Nature Genetics, 7, 91–97.
  • BENTZEN, S. M., THAMES, H. D. and OVERGAARD, J.7 1990, Does variation in the in vitro cellular radiosensitivity explain the shallow clinical dose-control curve for malig-nant melanoma? International Journal of Radiation Biology, 57, 117–126.
  • BENTZEN, S. M., 1992, Steepness of the clinical dose-control curve and variation in the in vitro radiosensitivity of head and neck squamous cell carcinoma International Journal of Radiation Biology, 61, 417–423.
  • BOWEN, I. D. and BOWEN, S. M., 1990, Programmed cell death in tumours and tissues. (Chapman and Hall, London).
  • BRACHMAN, D. G., BECKETT, M., GRAVES, D., HARAF, D., VOICES, E. and WEICHSELBA UM, R. R., 1993, p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines Cancer Research, 53, 3667–3669.
  • MusTow, R. G. and HILL, R. P., 1990, Comparison between in vitro radiosensitivity and in vivo radioresponse in murine tumor cell lines II: In vivo radioresponse following fraction-ated treatment and in vitro/ in vivo correlations International Journal of Radiation Oncology, Biology and Physics, 18, 331–345.
  • CHEN, F-D. and HENDRY, J. FI.7 1988a, Residual skin injury after repeated irradiation: more injury observed with healing and macro colony endpoints than with micro colonies. International Journal of Radiation Oncology Biology and Physics, 15, 943–948.
  • CHEN, F-D. and HENDRY, J. H., 1988b, Re-irradiation of mouse skin: similarity of dose-reductions for healing and colony endpoints. Radiotherapy Oncology, 11, 152–160.
  • DI LEONARDO, LINKE, S. P. and WAHL, G. M.7 1994, DNA damage triggers a prolonged p53-dependent G1 arrest and long-term inductio of Cip 1 in normal human fibroblasts. Genes and Development, 8, 2540–2551.
  • DONEHOWER, L. A., HARVEY, M., SLAGLE, B. L., MCARTHUR, M. J., MONTGOMERY, C. A., BUTEL, J. S. and BRADLEY, A.7 1992, Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature, 356, 215–221.
  • DUBRAY, B., DELIC, J., BRETON, C., FOURQUET, A., MAGDELENAT, H. and COSSET, J. M.7 1996, Apoptosis as a predictive assay of tumor response in human lymphomas. Abstracts of the 44th Annual Meeting of the Radiation Research Society, p158.
  • FERTIL, B. and MALAIS EE. P.719817 Inherent Cellular radiosens-itivity as a basic concept for human tumor radiotherapy. International Journal of Radiation Oncology, Biology and Physics, 7, 621–629.
  • GILBERT, C. W., 1974, A double minus transformation of mortality probabilities International Journal of Radiation Biology, 25, 633–634.
  • GRAEBER, T. G., OSMANIAN, T. J., MOUSMAN, D. E., KOCH, C. J., LOWE, S. W. and GIACCIA, A. J., 1996, Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours Nature, 379, 88–91.
  • HAMILTON, E., 1979, Cell proliferation and aging in mouse colon. I. Repopulation after repeated X-ray injury in young and old mice Cell and Tissue Kinetics, 11, 423.
  • HENDRY, J. H., 1984, Correlation of the dose-relationships for epidermal colony-forming units, skin reactions and hea-ling in the X-irradiated mouse tail British Journal of Radiology, 57, 909–918.
  • HENDRY, J. H., 1992, Treatment acceleration in radiotherapy: the relative time factors and dose-response slopes for tumours and normal tissues Radiotherapy Oncology, 25, 3098–3120.
  • HENDRY, J. H., ADEEKO, A., POTTEN, C. S., MORRIS, I. D.71996, p53 deficiency produces fewer regenerating spermatog-enic tubules after irradiation. International Journal of Radiation Biology (in press).
  • HENDRY, J. H., CAI, W. B., ROBERTS, S. A. and POTTEN, C. S., 1997, p53 deficiency sensitises clonogenic cells to irradi-ation in the large but not the small intestine. Radiation Research (in press).
  • HENDRY, J. H. and LORD, B. I., 1983, The analysis of the early and late response to cytotoxic insults in the haemopoietic cell hierarchy. In C ytoto xi c Insult to Tissue: Ejects on Cell Lineages, edited by C. S. Potten, J. H. Hendry (Edinburgh: Churchill Livingston) pp. 1–66.
  • HENDRY, J. H., POTTEN, C. S., GHAFOOR, A., MOORE, J. V., ROBERTS, S. A. and WILLIAMS, P. C.7 1989, The response of murine intestinal crypts to short-range 147Pm )3-irradi-ation: deductions concerning clonogenic cells Radiation Research, 118, 364–374.
  • HENDRY, J. H., POTTEN, C. S. and ROBERTS, N. P.7 1983a, The gastrointestinal syndrome and mucosal clonogenic cells: relationships between target cell sensitivities Radiation Research, 96, 100–112.
  • HENDRY, J. H. and ROBERTS, S. A.7 1990, Analysis of dose-incidence relationships for marrow failure in different species, in terms of radiosensitivity of tissue-rescuing units Radiation Research, 122, 155–160.
  • HENDRY, J. H., ROBERTS, S. A. and POTTEN, C. 5.7 1992, The clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination. Radiation Research, 132, 115–119.
  • HENDRY, J. H. and WEST, C., 1995, The implications of delayed reproductive death (lethal mutations/genomic instability) for the interpretation of tissue responses International Journal of Radiation Biology, 68, 363–368.
  • HENDRY, J. H., WEST, C. M. L., MOORE, J. V. and POTTEN, C. S., 1994, Tumour stem cells: the relevance of predictive assays for tumour control after radiotherapy. Radiotherapy Oncology, 30, 11–16.
  • HENDRY, J. H., Xu, C. X. and TESTA, N. G.7 1983b, A cellular analysis of residual haemopoietic deficiencies in mice after four repeated doses of 4.5 gray International Journal of Radiation Oncology, Biology and Physics, 9, 1641–1646.
  • JUNG, M., NOTARIO, V. and DRITSCHILO, A.7 19927 Mutations in the p53 gene in radiation-sensitive and -resistant human squamous carcinoma cells. Cancer Research, 52, 6390–6393.
  • KALLMAN, P., AGREN, A. and BRAHME, A.7 1991, Tumour and normal tissue responses to fractionated non-uniform dose delivery. International Journal of Radiation Biology, 62, 249–262.
  • KERR, J. F. R., WINTERFORD, C. M. and HARMON, B. V.7 1994, Apoptosis: its significance in cancer and cancer therapy. Cancer, 73, 2013–2026.
  • LEONCINI, L., DEL VECCHIO, M. T. and MEGHA, T. 1993, Correlations between apoptotic and proliferative indices in malignant non-Hodgkin's lymphomas American Journal of Pathology, 142, 755–763.
  • LEVINE, E. L., RENEHAN, A., GOSSIEL, R., DAVIDSON, S. E., ROBERTS, S. A., CHADWICK, C., WILKS, D. P., POTTEN, C. S., HENDRY, J. H., HUNTER, R. E. and WEST, C. M. L.7 1995, Apotosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma Radiotherapy Oncology, 37, 1–9.
  • LEVINE, E. L., DAVIDSON, S. E., ROBERTS, S. A., CHADWICK, C. A., POTTEN, C. S. and WEST, C. M. L., 1994, Apoptosis as predictor of response to radiotherapy in cervical carcin-oma The Lancet, 344, 472.
  • LOGSDON, M. D., MCDONALD, T. J., PUGH, W. C., BESA, P. C., Cox, J. D., CABANILLAS, F. F., STEPHENS, L. C. and MEYN, R. C., 1996, Apoptosis, bc1-2, and bax as pre-dictors of tumor response in stage I and II follicular lymphoma. Abstracts of the 44th Annual Meeting of the Radiation Research Society p156.
  • MEISTRICH, M. L., 1993, Effects of chemotherapy and radio-therapy on spermatogenesis European Urology, 23, 136–142.
  • MEYN, R. E., STEPHENS, L. C. and HENDRY, J. H., 1994, Workshop report: Radiation-induced apoptosis, 5-8 May 19947 Round Top, Texas International Journal of Radiation Biology, 66, 655–659.
  • MEYN, R. E., STEPHENS, L. C., ANG, K. K., HUNTER, N. R., BROCK, W. A., MILAS, L. and PETERS, L. J.7 1993, Heterogeneity in the development of apoptosis in irradi-ated murine tumours of different histologies International Journal of Radiation Biology, 64, 583–591.
  • MICHALOWSKI, A., 1981, Effects of radiation on normal tissues: hypothetical mechanisms of limitations of in situ assays of clonogen icity Radiation Environmental Biophysics, 19, 157–192.
  • MUNRO, T. R. and GILBERT, C. W., 1961, The relation between tumour lethal doses and the radiosensitivity of tumour cells British Journal of Radiology, 34, 246–51.
  • NOTHDURFT7 1991, Bone marrow. In Radiopathology of Organs and Tissues, edited by E. Schere, C. Streffer, K-R. Trott (Springer-Verlag), pp. 113–170.
  • OAKBERG, E. F., 1971, A new concept of spermatogonial stem cell renewal in the mouse and its relationship to genetic effects Mutation Research, 11, 1.
  • O'CONNOR, P. M., JACKMAN, J., JONDLE, D., BHATIA, K., MAGRATH, I. and KOHN, K. W., 1993, Role of the p53 tumor supressor gene in cell cycle arrest and radiosensitiv-ity of Burkitt's lymphoma cell lines. cancer Research, 53, 4776–4780.
  • PLOEMACHER, R. E., VAN Os, R., VAN BUERDEN, C. A. J.7 and DOWN, J. D., 1992, Murine haemopoietic stem cells with long term engraftment and marrow repopulatin gability are less radiosensitive than are spleen colony-forming cells. International journal of Radiation Biology, 61, 489–499.
  • POTTEN, C. S. (ed), 1996, Stem Cells (London: Academic Press).
  • POTTEN, C. S. and HENDRY, J. H., 1985, Cell clones. In Manual of Mammalian Cell Techniques, edited by C. S. Potten, J. H. Hendry (Edinburgh: Churchill-Livingstone), pp. 235
  • Q1, D. Y., HENDRY, J. H. and TESTA, N. A., 1991, Interactions in recovery and in residual injury from sequential treat-ments of mouse haemopoietic and stromal marrow cell populations, using X-rays, cyclophosphamide and busul-phan. Radiotherapy and Oncology, 20, 46–52.
  • RADFORD, I. R., MURPHY, T. K., RADLEY, J. M. and ELLIS, S. L., 1994, Radiation response of mouse lymphoid and myeloid cell lines. Part II. Apoptotic death is shown by all lines examined International J ournal of Radiation Biology, 65, 217–227.
  • REYNAUD, A. and TRAVIS, E. L., 1984, Late effects of irradiation of mouse jejunum International Journal of Radiation Biology, 49, 125–34.
  • ROBERTS, S. A., HENDRY, J. and POTTEN, C. 5.71995, Deduction of the clonogen content of intestinal crypt: A direct comparison of two-dose and multiple dose methodologies. Radiation Research, 141, 303–308.
  • ROBINSON, C. V., 1968, Relationship between animal and stem Cell dose—survival curves Radiation Research, 35, 318–44.
  • SAEGUSA, M., TAKANO, Y., OKAYASU, 1.7 1995, Bc1-2 expression and its correlation with apoptosis, p53 immunoreactivity and cell proliferation in human gastric carcinomas. j ournal of Cancer Research and Clinical Oncology, 121, 357–363.
  • STEPHENS, L. C., HUNTER, N. R., ANG, K. K., MILAS, L. and MEYN, R. E., 1993, Development of apoptosis in irradi-ated murine tumors as a function of time and dose Radiation Research, 135, 75–80.
  • TAKANO, Y., SAEGUSA, M., IKENAGA, M., MITOMI, H. and OKAYASU, I., 1996, Apoptosis of colon cancer: comparison with Ki-67 proliferative activity and expression of p53 journal of Cancer Research and Clinical Oncology, 122, 166–170.
  • TAUCHI, H. and SAWADA, 5.71994, Analysis of mitotic cell death caused by radiation in mouse leukaemia L51 78Y cells: apoptosis is the ultimate form of cell death following mitotic failure. International journal of Radiation Biology, 65, 449–455.
  • THAMES, H. D., HENDRY, J. H., MooRE, J. V., ANG, K. K. and TRAVIS, E. L., 1989, The high steepness of dose-response curves for late-responding normal tissues Radiation Oncology, 15, 49–53.
  • TUCKER, S. L. and HENDRY, J. H., 1990, redicted dose-latency relationships for early and late-responding hierarchical tissues International J ournal of Radiation Biology, 57, 163–184.
  • VESALAINEN, S., LIPPONEN, P., TALJA, M. and SYRJANEN, 1(.7 1994, Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma. European Journal of Cancer, 30A, 1797–1803.
  • WANG, L., CUT, Y., LORD, B. I., ROBERTS, S. A., POTTEN, C. S. and SCOTT, D. S., 1996, Gamma ray induced cell killing chromosome abnormalities in p53-deficient mice Radiation Research, 146, 259–266.
  • WEST, C. M. L., 1995, Invited review: intrinsic radiosensitivity as a predictor of patient response to radiotherapy British Journal of Radiology, 68, 827–837.
  • WEST, C. M. L., DAVIDSON, S. E., ROBERTS, S. A. and HUNTER, R. D., 1993, Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix. British Journal of Cancer, 68, 819–823.
  • WEST, C. M. L. and HENDRY, J. H., 19927 Intrinsic radiosensitivity as a predictor of patient response to radiotherapy. British Journal of Radiology Supplement, 24, 146–152.WHEELER, J. A., STEPHENS, L. C., TORNOS, C., EIFEL, P. J.,
  • ANG, K. K., MILAS, L., ALLEN, P. K. and MEYN, R. E.,1995, ASTRO fellowship: apoptosis as a predictor of tumor response to radiation in stage lb cervical carcin-oma International Journal of Radiation Oncology, Biology and Physics, 32, 1487–1493.
  • WHELDON, T. E., MICHALOWSKI, A. and KIRK, J.7 1982, The effect of irradiation on function in self-renewing normal tissues with differing proliferature organisation. British Journal of Radiology, 55, 759–766.
  • WITHERS, H. R., TAYLOR, J. M. G., MACIEJEWSKI, B., 1988, Treatment volume and tissue tolerance. International J ournal of Radiation Biology, 14, 751–759.
  • YAES, R. J. and KALEND7 A, 1988, Local stem cell depletion model for radiation myelitis. International J ournal of Radiation Oncology, Biology and Physics, 14, 1247–1259.

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