131
Views
83
CrossRef citations to date
0
Altmetric
Research Article

Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells

Pages 721-735 | Published online: 03 Jul 2009

  • and types of DNA lesions that respond to protection
  • implies that the underlying mechanism has a broad Alper, T. 1975, C ell S urvival after L ow D oses of R adiati on: T heoretical
  • remit. Since the protection is prevented by agents and C linica l I m plicati ons. (London: Wiley).
  • Azzam, E. I., Raaphorst, G. P. and Mitchel, R. E. J., 1994,that inhibit DNA repair and protein synthesis, the Radiation-inducedadaptiveresponseforprotectionbalance of evidence favours an inducible protective against m icronucleus form ation and neoplastic trans-
  • repair process, most likely involving DNA. The simil-form ation in C3H 10T1/2 m ouse embryo cells. R adiatio n
  • arities between HRS/IRR after single doses and R esearch, 138, S28-S31.
  • after priming treatments and the adaptive response
  • Azzam, E. I., de Toledo, S. M., Raaphorst, G. P. and Mitchel, R. E. J., 1992, Radiation-induced radioresist-seen in human lymphocytes are therefore many and ance in a normal human skin fibroblast cell line. In L owhave been addressed in a review by Joiner et al. (1996). D ose I rradiation and B iological D efence M echanism s, edited by T. Sugahara, L. A. Sagan and T. Aoyama (Oxford: Elsevier Science Publishers), pp. 291-294.12. Conclusions
  • Bartelink, H., Kallman, K. F., Rapacchietta, D. and Hart, G. A. M., 1986, Therapeutic enhancement in m ice byThe existence of hypersensitivity and increased clinically relevant dose fractionation schedules of cis-radioresistance after single doses of ionizing radiation diamminedichloroplatinum (II). R adiotherapy and O ncology,
  • in radioresistant and repair competent hamster and 6, 61-74.
  • human cells is now well established. Intrinsic radio-Bedford, J. S. and Griggs, H. G., 1975, The estim ation of
  • resistance may re¯ ect IRR but the underlying mech-survival at low doses and the limits of resolution of the single-cell-plating technique. In C ell S urvival after L ow D oses
  • anismthatcontrolstheseeåectsisnotfully ofR adiati on:T heoreticalandC linica lI m plicati onsedited by
  • characterized. Circumstantial evidenceimplicates T. Alper (London: Wiley) pp. 34-39.
  • DNA damage and repair in the process of IRR. In Begg, A. C., 1986, Radiosensitization by cisplatin of RIF1
  • human tumour cells the evidence also supports the tumour cells in vitro. I nternational J ournal of R adiati on B iology,
  • hypothesis that the intrinsic radioresistance at high 50, 871- 884. Benjamin, R. C. and Gill, D. M., 1980, Poly(ADP-ribose)
  • doses re¯ ects the extent of the IRR response and synthesis in vitro programmed by damaged DNA: a com -
  • therefore that a significant component of radioresist-parison of DNA m olecules containing diåerent types of
  • ance is induced rather than constitutive. Clearly, the strand breaks. J ournal of B iological C hem istry, 255, 10502-
  • idea of radioresistance as a static property of cells 10508.
  • which can be explained in terms of a fixed parameter
  • Boag, J. W., 1975, The statistical treatment of cell survival data. In C ell S urvival after L ow D oses of R adiati on: T heoretical andlike a or D0 must now be discarded. Rather, the
  • C linica lI m plicati onsedited by T. Alper (London: Wiley)Ikushima, T., 1987, Chromosomal responses to ionizing radiation reminiscent of an adaptive response in cultured Chinese
  • pp. 40-53. hamster cells. M utation R esearch, 180, 215 -221.Boothman, D. A., Bouvard, I. and Hughes, E. N., 1989, Ikushima, T., 1995, Radio-adaptive response: enhanced repair
  • Identification and characterization of X-ray-induced proof radiation-induced DNA strand breaks in adapted cells,
  • teins in human cells. C ancer R esearch, 49, 2871 -2878. In R adiati on R esearch C ongress A b stracts: 1 0 th I C R R W uÈrz b erg,Boothman, D. A., Davis, T. W. and Sahijdak, W. M., 1994, edited by U. H agen, H. Jung and C. Streåer pp. 306.
  • Enhanced expression of thymidine kinase in human cells Joiner, M. C., 1994, Induced radioresistance: an overview and
  • following ionising radiation. I nternational J ournal R adiati on,
  • historical perspective. I nternationalJ ournalofR adiati on
  • O ncology, B iology and P hy sics, 30, 391- 398. B iology, 65, 79-84.
  • Boothman, D. A., Wang, M. and Lee, S. W., 1991, Induction Joiner, M. C., Denekamp, J. and Maughan, R. L., 1986, The
  • of tissue-type plasminogen activator by ionising radiation use of top-up experiments to investigate the eåects of
  • in human m alignant m elanoma cells. C ancer R esearch, 51, very small doses per fraction in m ouse skin. I nternational
  • 5587-5595. J ournal of R adiati on B iology, 49, 565- 580.
  • Boreham, D. R. and Mitchel, R. E. J., 1991, DNA lesions that Joiner, M. C. and Johns, H., 1988, Renal damage in the m ouse:
  • signal the induction of radioresistance and DNA repair the response to very small doses per fraction. R adiatio n
  • in yeast. R adiati on R esearch, 128, 19-28. R esearch, 114, 385- 398.
  • Boreham, D. R., Trivedi, A., Weinberger, P. and Mitchel, Joiner, M. C., Lambin, P., Malaise, E. P., Robson, T., Arrand,
  • R. E. J., 1990, The involvement of topoisomerases and J.E.,Skov,K.A.andMarples,B.,1996,
  • DNA polymerase I in the m echanism of induced thermal H ypersensitivity to very-low single radiation doses: its
  • and radiation resistance in yeast. R adiati on R esearch, 123, relationship to the adaptive response and induced radio-
  • 203-212. resistance. M utation R esearch, 358, 171 -183.
  • Bryant, P. E., 1972, Changes in sensitivity of cells during Koch, C. J. and Giandomenico, A. R., 1994, The alkaline
  • exposure to radiation at low dose-rate. I nternational J ournal elution technique for m easuring DNA single strand
  • of R adiati on B iology, 22, 67-73.breaks: increased reliability and sensitivity. A naly tical
  • Durand, R. E., 1986, Use of a cell sorter for assays of cell B iochem istry, 220, 58-65.
  • clonogen icity. C ancer R esearch, 46, 2775 -2778. Koval, T. M., 1988, Enhanced recovery from ionising radiation
  • Durkacz, B. W., Omidiji, O., Gray, D. A. and Shall, S.,damage in a lepidopteran insect cell line. R adiati on R esearch,
  • 1980, (ADP-ribose)n participates in excision repair. N ature,115, 413- 420.
  • 283, 593 -596.Lambin, P., Malaise, E. P. and Joiner, M. C., 1996, M ight
  • Eastman, A., 1987, The form ation, isolation and characterizationintrinsic radioresistance of human tumour cells be induced
  • of DNA adducts produced by anticancer platinum com by radiation? I nternational J ournal of R adiati on B iology, 69,
  • plexes. In P harm aceutical T herapy, edited by L. C. Erickson279-290.
  • (Oxford: Pergamon Journals Ltd.) pp. 155-166.Lambin, P., Marples, B., Fertil, B., Malaise, E. P. and Joiner,
  • Eichholtz-Wirth, H. and Heitel, B., 1994, Cisplatin resistanceM. C., 1993a, Low dose radiation response of human tumour cell lines of diåerent intrinsic radiosensitivity. Inin m ouse fibrosarcoma cells after low-dose irradiation in P redictionofR esponseinR adiotherapy :R adiosensitivityandvitro and in vivo. B ritish J ournal of C ancer, 70, 579- 584. R epopulation, edited by B. R. Paliwal, T. J. Kinsella and
  • Eichholtz-wirth, H., Reidel, G. and Heitel, B., 1993, J. F. Fowler. (New York: New York Institute of Physics),Radiation-induced transient cisplatin resistance in m urine pp. 311-319.fibrosarcoma cells associated with elevated m etallothi on-Lambin, P., Marples, B., Fertil, B., Malaise, E. P. and Joiner,
  • ein content. B ritish J ournal of C ancer, 67, 1001 -1006. M. C., 1993b, H ypersensitivity of a human tumour cell
  • Fraval, H. N. A. and Roberts, J. J., 1979, Excision repair of line to very low radiation doses. I nternational J ournal ofcis-diamm inedichloroplatinum (II)-induced damage to R adiati on B iology, 63, 639- 650.DNA of Chinese hamster cells. C ancer R esearch, 39, Lehnert, S. and Chow, T. Y. K., 1995a, M echanisms of cross-
  • 1793-1797. resistance between cis-platinum and ionising radiation.
  • Freyer, J. P., Wilder, M. E. and Raju, M. R., 1984, Coulter In R adiati on R esearch 1 8 9 5 - 1 9 9 5, C ongress A b stracts, 1 0 th
  • volume cell sorting to improve the precision of radiation I C R R S ociety, W uÈrz b erg, edited by U. H agen, H. Jung and
  • survival assays. R adiati on R esearch, 97, 608 -614. C. Streåer p. 229.
  • Gupta, S. S. and Bhattacharjee, S. B., 1988, Induction of Lehnert, S. and Chow, T. Y. K., 1995b, Low doses of ionising
  • repair functions by hydrogen peroxide in Chinese hamster radiation induce nuclear activity catalyzing double strand
  • cells. I nternational J ournal of R adiati on B iology, 53, 935 -942. homologous DNA recombination [abstract]. 4 4 th A nnual
  • Hendry, J. H., 1986, Radioresistance induced in fern spores by m eeting oftheR adiati onR esearchS ociety, C hicago,I L, 199 6,
  • prior irradiation. R adiati on R esearch, 106, 396- 400. pp. 14-262.
  • Hill, B. T., 1990, I n vitro drug-radiation interactions using Marples, B., Adomat, H., Koch, C. J. and Skov, K. A., 1996,
  • fractionated x-irradiation regim ens. In A ntitum our D rug-Response of V79 cells to low doses of x-rays and negative
  • R adiati on I nteractions, edited by B. T. H ill and A. S. Bellamypi-mesons: clonogen ic survival and DNA strand breaks.
  • (Boca Raton: CRC Press) pp. 207-224. I nternational J ournal of R adiati on B iology, 7, 429 -436.
  • Horsley, R. J. and Laszlo, A., 1971, Unexpected additional Marples, B. and Joiner, M. C., 1993, The response of Chinese
  • recovery following a first X-ray dose to synchronous cellhamster V79 cells to low radiation doses: evidence of
  • culture.I nternationalJ ournalofR adiati onB iology, 12,enhanced sensitivity of the whole cell population. R adiatio n
  • 210-208.R esearch, 133, 41-51.
  • Horsley, R. J. and Laszlo, A., 1973, Additional recovery inMarples, B. and Joiner, M. C., 1995, The elim ination of low-
  • X-irradiated oedogonium cardiacum can be suppresseddose hypersensitivity in Chinese hamster V79-379A cells
  • by cyclohexim ide. I nternational J ournal of R adiati on B iology, by pretreatment with X rays or hydrogen peroxide. R adiati on R esearch, 141, 160 -169.
  • 23, 210 -204.
  • Marples, B., Joiner, M. C. and Skov, K. A., 1992, An X-rayShadley, J. D., 1994, Chromosomal adaptive response in human lymphocytes. R adiati on R esearch, 138, S9-S12.
  • inducible repair response: evidence from high resolution
  • survival m easurem ents in air and hypoxia. In L ow D oseShall, S., 1994, The function of poly (ADP-ribosylation) in DNAbreakageand rejoining. M olecular and C ellular
  • I rradiationandB iologicalD efenceM echanism s, edited by
  • T. Sugahara, L. A. Sagan and T. X. Aoyama (Elsevier),B iochem istry, 138, 71-75. Singh, B., Arrand, J. E. and Joiner, M. C., 1994, H ypersensitive
  • pp. 295-298.
  • Marples, B., Joiner, M. C. and Skov, K. A., 1994b, The eåectresponse of normal human lung epithelial cells at low radiation doses. I nternational J ournal of R adiati on B iology, of oxygen on low-dose hypersensitivity and increased
  • radioresistance in Chinese hamster V79-379Acells.65, 457- 464. Skarsgard, L. D., Harrison, I. and Durand, R. E., 1991, The
  • R adiati on R esearch, 138, S17-S20.
  • Marples, B., Lam, G. K. Y., Zhou, H. and Skov, K. A., 1994a,radiation response of asynchronous cells at low dose: evidence of substructure. R adiati on R esearch, 127, 248 -256.The response of Chinese hamster V79-379A cells exposed
  • to negative pi-mesons: evidence that increased radioresist-Skarsgard, L. D., Wilson, D. J. and Durand, R. E., 1993, Survival at low doses in asynchronous and partially
  • ance is dependent on linear energy transfer. R adiatio n
  • R esearch, 138, S81-S84.synchronised Chinese hamster V79-171 cells. R adiatio n R esearch, 133, 102- 107.Marples, B. and Skov, K. A., 1996, Small doses of high-linear
  • energy transfer radiation increase the radioresistance ofSkov, K. A., Koch, C. J. and Marples, B., 1995, Further investigations into the nature of the trigger of increased
  • Chinese hamster V79 cells to subsequent X irradiation.
  • R adiati on R esearch, 146, 382 -387.radioresistance: the eåect of14C and3H thymidine incorporation on low dose hypersensitivity. P roceedings of w orkshopMeyn, R. E., Jenkins, S. F. and Thompson, L. H., 1982,
  • Defective removal of DNA cross-links in a repair-deficienton`R adiati onD am ageinD N A :R elationshipsatearlytim es‚, edited by J. Zimbrick and A. Fucarielli (Ohio Columbus:
  • m utant of Chinese hamster cells. C ancer R esearch, 42,
  • 3106-3110.Batelle Publishing), pp. 441-447. Skov, K. A. and Marples, B., 1995, Increased radioresistance
  • Musk, S. R. and Steel, G. G., 1990, The inhibition of cellular
  • recovery in human tumour cells by inhibitors of topoiso-at clinical doses: investigations from the survival perspective. R adiati on O ncology I nvestigati ons, 2, 201- 211.
  • m erase. B ritish J ournal of C ancer, 62, 364- 367.
  • Olivieri, G., Bodycote, J. and Wolff, S., 1984, AdaptiveSkov, K. A., Marples, B., Matthews, J. B., Joiner, M. C. and Zhou, H., 1994b, A preliminary investigation into the
  • response of human lymphocytes to low concentrations of
  • radioactive thymidine. S cience, 223, 594 -597.extentofincreasedradioresistanceorhyper-radiosensitivity in cells of hamster cell lines known to beOsmak, M. and Perovic, S., 1989, M ultiple fractions of gam ma
  • rays induced resistance to cis-diamm inedichloroplatinumdeficientinDNArepair.R adiati onR esearch,138, S126-129.
  • (II) and m ethatrexate in human H eLa cells. I nternational
  • J ournalR adiati onO ncology, B iologyandP hy sics,16,Skov, K. A., Zhou, H. and Marples, B., 1994a, The eåect of two topoisomerase inhibitors on low-dose hypersensitivity
  • 1537-1541.
  • Palcic, B., Brosing, J. W. and Skarsgard, L. D., 1982, Survivaland increased radioresistance in Chinese hamster V79 cells. R adiati on R esearch, 138, S117 -20.m easurem ents at low doses: oxygen enhancement ratio.
  • B ritish J ournal of C ancer, 46, 980- 984.Spadinger, I., Marples, B., Matthews, J. and Skov, K. A., 1994, Can colony size be used to detect low-dose eåects?
  • Palcic, B. and Jaggi, B., 1986, The use of solid state sensor
  • technology to detect and characterize live m amm alianR adiati on R esearch, 138, S21-S24. Spadinger, I. and Palcic, B., 1992, The relative biological
  • cells growing in tissue culture. I nternational J ournal of
  • R adiati on B iology, 50, 345 -352.eåectiveness of60Co gam ma-rays, 55 kVp X-rays, 250 kVp X-rays, and 11 M eV electrons at low doses. I nternational
  • Palcic, B. and Skarsgard, L. D., 1984, Reduced oxygen
  • enhancement ratio at low doses of ionising radiation.J ournal of R adiati on B iology, 61, 345- 353. Spadinger, I. and Palcic, B., 1993, Cell survival m easurem ents
  • R adiati on R esearch, 100, 328 -39.
  • Popoff, S. C., Beck, D. J. and Rupp, W. D., 1987, Repair ofat low doses using an automated image cytom etry device. I nternational J ournal of R adiati on B iology, 63, 183- 189.plasmid DNA damaged in vitro with cis- and trans-
  • diamminedichloroplatinum(II). M utatati on R esearch, 183,Ward, J. F., 1985, Biochemistry of DNA lesions. R adiatio n R esearch, 104, S103 -S111.
  • Power, M. O., Wilson, G. D. and Joiner, M. C., 1996, CellWard, J. F., Blakely, W. F. and Joner, E. I., 1995, M ammalian cells are not killed by DNA single-strand breaks caused
  • cycle delay, apoptosis and survival in irradiated human
  • tumour cell lines [abstract]. B ritish J ournal of R adiology, by hydroxyl radicals from hydrogen peroxide. R adiatio n R esearch, 103, 383- 92.
  • 69, 582.
  • Puck, T. T. and Marcus, P. I., 1956, Action of X-rays onWang, J. C., 1985, DNA topoisomerases. A nnual R eview of B iochem istry, 54, 665 -697.
  • m amm alian cells. J ournal of E xperim ental M edicine, 103,
  • 653-666.Watts, M. E., Hodgkiss, R. J., Jones, N. R. and Fowler, J. F., 1986, Radiosensitization of Chinese hamster cells byRevesz, L. and Palcic, B., 1985, Radiation dose dependence
  • of the sensitization by oxygen and oxygen m imic sensit-oxygen and m isonidazole at low X-ray doses. I nternational J ournal of R adiati on B iology, 50, 1009 -1021.
  • izers. A cta R adiologica, 24, 209.
  • Robson, T., Lohrer, H., Hirst, D. G., Joiner, M. C. andWojewodzka, M., Wojcik, A., Szumiel, I. and Streffer, C., 1995, In R adiati on R esearch 1 8 9 5 - 1 9 9 5, C ongress A b stracts,
  • Arrand, J., 1995, M odulation of gene expression by low
  • dose ionising radiation. R adiati on R esearch, 141, 112 -113.1 0 th I C R R S ociety, W uÈrz b erg, edited by U. H agen, H. Jung and C. Streåer, p. 307.Santier, S., Gilet, R. and Malaise, E. P., 1985, Induced
  • radiation resistance during low-dose-rate gam ma irradi-Wolff, S., 1992, Failla M emorial Lecture. Is radiation all bad? Thesearchforadaptation. R adiati onR esearch,131,
  • ation in plateau phase Chlorella cells. R adiati on R esearch,
  • 104, 224 -233.117-123.
  • Wolff, S., Wiencke, J. K., Afzal, V., Youngblom, J. andWouters, B. G. and Skarsgard, L. D. 1994, The response of a human tumor cell line to low radiation doses: evidence
  • Cortes, F., 1989, The adaptive response of human
  • lymphocytes to very low doses of ionizing radiation: aof enhanced sensitivity. R adiati on R esearch, 138, S76-80. Wouters, B. G., Sy, A. M. and Skarsgard, L. D., 1996, Low
  • case of induced chromosom al repair with the induction
  • of specific proteins. In L ow D ose R adiati on: A case of I nduceddose hypersensitivity and increased radioresistance in a panel of human tumor cell lines with diåerent radiosensit-
  • C hrom osom al R epair w ith the I nduction of S pecific P roteins, edited
  • by K. F. Baverstock and J. W. Stather (London: Taylorivity. R adiati on R esearch, 146, 399 -413. Zwelling, L. A., Anderson, T. and Kohn, K. W., 1979, DNA-
  • & Francis), pp. 446-454.
  • Woloschak, G. E., Chang Liu, C-M., Jones, P. S. and Jounes,protein and DNA interstrand cross-linking by cis- and trans-platinum(II) diamminedichloride in L1210 m ouseC. A., 1990, M odulation of gene expression in Syrian
  • hamster embryo cells following ionising radiation. C ancerleukemia cells and relation to cytotoxicity. C ancer R esearch, 39, 365- 369.
  • R esearch, 50, 339- 344.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.