DNA double-strand break distributions in X-ray and alpha-particle irradiated V79 cells: evidence for non-random breakage

References

• AGER, D. D. and DEwEy, W. C., 1990, Calibration of pulsed-field gel electrophoresis for measurements of DNA double-strand breaks. International Journal of Radiation Biology, 58, 249–259.
   PubMed Web of Science ®Google Scholar
• BLAZEK, E. R., SAWHNEY, B. K. and LANAIS, A. J.7 1993, DNA double strand breaks produced in cells by fast neutrons are clustered compared to those produced by gamma radiation. Abstracts of the 4 I st Annual Meeting of the Radiation Research Society, Abstract P25-12 (Dallas, Texas, Radiation Research Society).
   Google Scholar
• BLOCHER, D., 1990, In CHEF electrophoresis a linear induction of dsb corresponds to a non-linear fraction of extracted DNA with dose. International Journal of Radiation Biology, 57, 7–12.
   PubMed Web of Science ®Google Scholar
• BODNAR, J. W., 1988, A domain model for eukaryotic DNA organization: a molecular basis for cell differentiation and chromosome evolution. Journal of Theoretical Biology, 132, 479–507.
   PubMed Web of Science ®Google Scholar
• BRENNER, D. J. and WARD, J. F., 19927 Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks. International Journal of Radiation Biology, 61, 737–748.
   Google Scholar
• CEDERVALL, B. and KALLMAN, P., 1994, Randomly distributed DNA double strand breaks as measured by pulsed field gel electrophoresis: a series of explanatory calculations. Radiation and Environmental Biophysics, 33, 9–21.
   PubMed Web of Science ®Google Scholar
• CEDERVALL, B., WONG, R., ALBRIGHT, N., DYNLACHT, J., LAMBIN, P. and DEWEY, W. C., 1995, Methods for the quantification of DNA double-strand breaks determined from the distribution of DNA fragment sizes measured by pulsed-field gel electrophoresis. Radiation Research, 143, 8–16.
   PubMed Web of Science ®Google Scholar
• CHARLTON, D. E., NIKJOO, H. and Humm, J. L., 1989, Calculation of initial yields of single and double strand breaks in cell nuclei from electrons, protons and alpha-particles. International Journal of Radiation Biology, 56, 1–19.
   PubMed Web of Science ®Google Scholar
• CHATTERJEE, A. and HOLLEY, W. R" 1992, Biochemical mechan-isms and clusters of damage for high-LET radiation. Advances in Space Research, 12, 33–43.
   Google Scholar
• COOK, V. E. and MORTIMER, R. K., 1991, A quantitative model of DNA fragments generated by ionizing radiation, and possible experimental applications. Radiation Research, 125, 102–106.
   PubMed Web of Science ®Google Scholar
• ELIA, M. C. and NicHoLs, W. W., 1993, Application of pro-grammable autonomously controlled electrode (PACE) technology to the development of an improved pulsed field gel electrophoresis assay for DNA double-strand breaks in mammalian Cells. International J ournal of Radiation Biology, 63, 7–11.
   PubMed Web of Science ®Google Scholar
• ERIXON, K. and CEDERVALL, B., 1995, Linear induction of DNA double-strand breakage with X-ray dose as determined from DNA fragment size distribution. Radiation Research, 142, 153–162.
   PubMed Web of Science ®Google Scholar
• FRANKENBERG, D., FRANKENBERG-SCHWAGER, M., BLOCHER, D., and HARBICH, R., 1981, Evidence for DNA double strand breaks as the critical lesions in yeast cells irradiated with sparsely or densely ionizing radiation under oxic or anoxic Conditions. Radiation Research, 88, 524–532.
   PubMed Web of Science ®Google Scholar
• GooDHEAD, D. T. and NIKJOO, H., 1989, Track structure analysis of ultrasoft X-rays compared to high and low LET radiations. International Journal of Radiation Biology, 55, 513–529.
   PubMed Web of Science ®Google Scholar
• HEILMANN, J., RINK, H., TAUCHER-SCHOLZ, G. and KRAFT, G" 1993, DNA strand break induction and rejoining and cellular recovery in mammalian cells after heavy-ion irradiation. Radiation Research, 135, 46–55.
   Google Scholar
• HEILMANN, J., TAUCHER-SCHOLZ, G. and KRAFT, G" 1995, Induction of DNA double-strand breaks in CHO-Kl cells by carbon ions. International Journal of Radiation Biology, 68, 153–162.
   Google Scholar
• HOFER, K. G., VAN LOON, N., SCHNEIDERMAN, M. Fl" and CHARLTON, D. E., 1992, The paradoxical nature of DNA damage and cell death induced by 141 decay. Radiation Research, 130, 121–124.
   Google Scholar
• HOLLEY, W. R. and CHATTERJEE, A" 1996, Clusters of DNA damage induced by ionizing radiation: Formation of short DNA fragments I. Theoretical Modelling. Radiation Research, 145, 188–199.
   Google Scholar
• JENNER, T. J., BELLI, M., GOODHEAD, D. T., IANZINI, F.,
   Google Scholar
• SIMONE, G. and TABOCCHINI, M. A" 1992, Direct com-parison of biological effectiveness of protons and alpha-particles of the same LET. III. Initial yield of DNA double-strand breaks in V79 cells. International Journal of Radiation Biology, 61, 631–7.
   Google Scholar
• JENNER, T. J., DE LARA, C. M., O'NEILL, P. and STEVENS, D. L., 1993, Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following r and a-irradiation. International Journal of Radiation Biology, 64, 265–273.
   Google Scholar
• KAMW, G. and EicHHoRN, K., 1983, DNA strand breakage by different radiation qualities and relations to cell killing: Further results after the influence of alpha-particles and carbon ions. S tudia B iophysica, 93, 17–26.
   Google Scholar
• KYSELA, B. P., ARRAND, J. E. and MICHAEL, B. D., 1993, Relative contributions of levels of initial damage and repair of double-strand breaks to the ionizing radiation-sensitive phenotype of the Chinese hamster cell mutant XR-V15B. Part II Neutrons. International Journal of Radiation, 64, 531–538.
   PubMed Web of Science ®Google Scholar
• LEHMANN, A. R. and ORMEROD, M. G" 1970, Double-strand breaks in the DNA of a mammalian cell after X-irradiation. B iochimica et B iophysica Acta, 217, 268–277.
   Google Scholar
• LJUNGMAN, M.7 1991, The influence of chromatin structure on the frequency of radiation-induced DNA strand breaks: a study using nuclear and nucleoid monolayers. Radiation Research, 126, 58–64.
   PubMed Web of Science ®Google Scholar
• LJUNGMAN, M., NYBERG, S., NYGREN, N. Y. G., ERIKSSON, M" and AHNSTROM, G., 1991, DNA-bound proteins contrib-ute much more than soluble intracellular compounds to the intrinsic protection against radiation-induced DNA strand breaks in human cells. Radiation Research, 127, 171–176.
   Google Scholar
• LOBRICH, M., COOPER, P. K. and RYDBERG, B" 1996, Non-random distribution of DNA double-strand breaks induced by particle irradiation. International Journal of Radiation Biology, 70, 493–503.
   Google Scholar
• LOBRICH, M., IKPEME, S., HAUB, P., WEBER, K.-J.7 and KIEFER, J., 1993, DNA double-strand break induction in yeast by X-rays and a-particles measured by pulsed-field gel-electrophoresis. International Journal of Radiation Biology, 64, 539–546.
   Google Scholar
• LOBRICH, M., RYDBERG, B. and COOPER, P. K" 1994a, DNA double-strand breaks induced by high-energy Neon and Iron ions in Human fibroblasts. 2. Probing individual Not I fragments by hybridisation. Radiation Research, 139, 142–151.
   Google Scholar
• LOBRICH, M., IKPKEME, S. and KIEFER, J.7 1994b, DNA double-strand break measurement in mammalian cells by pulsed-field gel electrophoresis: an approach using restriction enzymes and gene probing. International J ournal of Radiation Biology, 65, 623–630.
   Google Scholar
• McMANus, J., PERRY, P., SUMNER, A. T., WRIGHT, D. M., THomsoN, E. J., ALLsHIRE, R. C., HAsim, N. D. and BICICVIORE, W. A., 1994, Unusual chromosome structure of fission yeast DNA in mouse cells. Journal of Cell Science, 107, 469–486.
   PubMed Web of Science ®Google Scholar
• MICHALIK, V.7 1992, Model of DNA damage induced by radi-ations of various qualities. International J ournal of Radiation Biology, 62, 9–20.
   PubMed Web of Science ®Google Scholar
• PIENTA, K. J. and COFFEY, D. 5" 1984, A structural analysis of the role of the nuclear matrix and DNA loops in the organisation of the nucleus and chromosome. Journal of Cell Science, 1, 123–135.
   Google Scholar
• PRISE, K. M., 1994, Use of radiation quality as a probe for DNA lesion complexity. International Journal of Radiation Biology, 65, 43–48.
   PubMed Web of Science ®Google Scholar
• PRISE, K. M., DAVIES, S. and MICHAEL, B. D" 1987, The relationship between radiation-induced DNA double-strand breaks and cell kill in hamster V79 fibroblasts irradiated with 250KVp X-rays, 2.3 MeV neutrons or 233Pu a-particles. International Journal of Radiation Biology, 52, 893–902.
   Google Scholar
• PRISE, K. M., FOLKARD, M., NEWMAN, H. C. and MICHAEL, B. D., 1994, The effect of radiation quality on lesion Complexity in Cellular DNA. International J ournal of R adiation Biology, 66, 537–542.
   PubMed Web of Science ®Google Scholar
• PRISE, K. M., FOLKARD, M., VOJNOVIC, B., DAVIES, S., ROPER, M. J. and MICHAEL, B. D., 1990, The irradiation of V79 mammalian cells by protons with energies below 2MeV. Part II: Measurement of oxygen enhancement ratios and DNA damage. International Journal of Radiation Biology, 58, 261–277.
   PubMed Web of Science ®Google Scholar
• RADFORD, I. R., 1985, The level of induced DNA double-strand breakage correlates with cell killing after X-irradiation. International Journal of Radiation Biology, 48, 45–54.
   Web of Science ®Google Scholar
• RADFORD, I. R. and HODGSON, G. S., 1987, Effect of ploidy 011 the response of V79 cells to ionizing radiation. International Journal of Radiation Biology, 51, 765–778.
   Web of Science ®Google Scholar
• RYDBERG, B., 1996, Clusters of DNA damage induced by ionizing radiation: formation of short DNA fragments II. Experimental detection. Radiation Research, 145, 200–209.
   Google Scholar
• RYDBERG, B., LOBRICH, M. and COOPER, P. 1(.7 1994, DNA double-strand breaks induced by high-energy Neon and Iron ions in human fibroplasts.l.Pulsed-field gel electro-phoresis method. Radiation Research, 139, 133–141.
   Google Scholar
• RUIZ DE ALMODDVAR, J. M., STEEL, G. G., WHITAKER, J. M., and MCMILLAN, T. J., 1994, A comparison of methods for calculating DNA double-strand break induction fre-quency in mammalian cells by pulsed-field gel electro-phoresis. International Journal of Radiation Biology, 65, 641–649.
   PubMed Web of Science ®Google Scholar
• SAK, A., STUSCHKE, M., STAPPER, N. and STREFFER, C., 1996, Induction of DNA double-strand breaks by ionizing radi- ation at the c- my c locus compared with the whole genome: a study using pulsed-field gel electrophoresis and gene probing. International Journal of Radiation Biology, 69, 679–685.
   PubMed Web of Science ®Google Scholar
• WARD, J., 1981, Some biochemical consequences of the spatial distribution of radiation-produced free radicals. Radiation Research, 86, 185–195.
   PubMed Web of Science ®Google Scholar
• WARD, J. F., 1990, The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review. International Journal of Radiation Biology, 57, 1141–1150.
   PubMed Web of Science ®Google Scholar
• WARD, J. F., MILLIGAN, J. R., JONES, G. D. D., and FAHEY, R. C., 1995, Multiply damaged sites. In Radiation Damage in DNA: Structure/Function Relationships at Early Times. Edited by (A. F. Fuciarelli and J. D. Zimbrik (Columbus, Ohio: Battelle Press), pp. 45–53.
   Google Scholar
• WEBER, K. and FLENTJE, M.7 1993, Lethality of heavy ion-induced DNA double-strand breaks in mammalian cells. International Journal of Radiation Biology, 64, 169–178.
   Google Scholar