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International Journal of Radiation Biology Volume 73, 1998 - Issue 6
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Research Article

Effectiveness of 0.28 keV carbon K ultrasoft X-rays at producing simple and complex chromosome exchanges in human fibroblasts in vitro detected using FISH

C.S GRIFFIN MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxon OX11 0RD, UK.
,
M.A HILL MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxon OX11 0RD, UK.
,
D.G PAPWORTH MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxon OX11 0RD, UK.
,
K. M. S. TOWNSEND MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxon OX11 0RD, UK.
,
J.R.K SAVAGE MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxon OX11 0RD, UK.
&
D.T. GOODHEAD MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxon OX11 0RD, UK.
Pages 591-598 | Published online: 03 Jul 2009

  • BOTCHWAY, S. W., STEVENS, D. L., HILL, M. A., JENNER, T. J. and O'NEILL, P., 1997, Induction and rejoining of DNA double-strand breaks in Chinese hamster V79-4 cells irradiated with characteristic aluminum K and copper LUltrasoft X-rays. Radiation Research, 148, 317-324.
  • CARPENTER, S., CORNFORTH, M. N., HARVEY, W. F., RAJU, M. R., SCHILLACI, M. E., WILDER, M. E. and GOODHEAD, D. T., 1989, Radiobiology of ultrasoft X-rays. IV. Flatand round-shaped hamster cells (CHO-10B.HS-23).Radiation Research, 119, 523-533.
  • CHADWICK, K. M. and LEENHOUTS, H. P., 1978, The rejoining of DNA double strand breaks and a model for the formation of chromosomal aberrations, international journalof Radiation Biology, 33, 517-529.
  • CORNFORTH, M. N., 1990, Testing the notion of the one hitexchange. Radiation Research, 121, 21-27.
  • CORNFORTH, M. N., SCHILLAO, M. E., GOODHBAD, D. T., CARPENTER, S. G., WILDER, M. E., SEBRING, R. J. and RAJU, M. R., 1989, Radiobiology of ultrasoft X-rays III. Normal human fib rob lasts and the significance of terminal track structure in cell inactivation. Radiation Research, 119, 511-522.
  • DURANTE, M., GEORGE, K., Wu, H. and YANG, T. C., 1996, Rejoining and misrejoining of radiation-induced chromatin breaks. 1. Experiments with human lymphocytes.Radiation Research, 145, 274-280.
  • FRANKENBERG, D., GOODHEAD, D. T., FRANKENBERGSCHWAGER, M., HARBICH, R., BANCE, D. A. and WILKINSON, R. E., 1986, Effectiveness of l.5 keV aluminium and 0.3 keV carbon K characteristic X-rays at inducing DNA double strand breaks in yeast cells.International Journal of Radiation Biology, 50, 727-741.
  • FRANKENBERG, D., KUHN, H., FRANKENBERG-SCHWAGER, M., LENHARD, W. and BECKONERT, S., 1995, 0.3 keV carbon K ultrasoft X-rays are four times more effective than 7-rays when inducing oncogenic cell transformation atlow doses. International Journal of Radiation Biology, 68,593-601.
  • GOODHEAD, D. T., 1994, Soft X-ray radiobiology and synchrotron radiation. In Synchrotron Radiation in Biosciences, editedby B. Chance et ai. (Oxford Science Publ., Oxford: Clarendon Press), pp. 683-705.
  • GOODHEAD, D. T. and NIKIOO, H., 1989, Track structure analysis of ultrasoft X-rays compared to high- and low-LETradiations, international Journal of Radiation Biology, 55,513-529.
  • GOODHEAD, D. T. and NIKIOO, H., 1990, Current status of ultrasoft X-rays and track structure analysis as tools for testing and developing biophysical models of radiationaction. Radiation Protection Dosimetry, 31, 343-350.
  • GOODHEAD, D. T. and THACKBR, J., 1977, Inactivation and mutation of cultured mammalian cells by aluminium characteristic ultrasoft X-rays I. Properties of aluminium X-rays and preliminary experiments with Chinese hamster Cells. International Journal of Radiation Biology, 31,541-559.
  • GOODHEAD, D. T., THACKBR, J. and Cox, R., 1979, Effectiveness of 0.3 keV carbon ultrasoft X-rays for the inactivation and mutation of cultured mammalian cells, internationalJournal of Radiation Biology, 36, 101-114.
  • GOODHEAD, D. T., THACKER, J. and Cox, R., 1981, Is selective absorption of ultrasoft X-rays biologically important inmammalian cells? Physics in Medicine and Biology, 26,1115-1127.
  • GOODHEAD, D. T., THACKER, J. and Cox, R., 1993, Effects of radiations of different qualities on cells: molecular mechanisms Of damage and repair. International Journal of Radiation Biology, 63, 543-556.
  • GOODHEAD, D. T., VIRSIK, R. P., HARDER, D., THACKER, J., Cox, R. and BLOHM, R., 1980, Ultrasoft X-rays as a tool to investigate radiation-induced dicentric chromosomeaberrations. Proceedings of the Seventh Symposium onM icrodosimetry, Oxford, September 1980, edited by J. Booz, H. G. Ebert and H. D. Hartfiel (Harwood AcademicPublishers for the Commission of the European Communities (EUR 7147)), pp. 1275-1285.
  • GREINERT, R., DETZLER, E., VOLKMER, B. and HARDER, D., 1995, Kinetics of the formation of chromosome aberrations in X-irradiated human lymphocytes: analysis by premature chromosome condensation with delayedfusion. Radiation Research, 144, 190-197.
  • GRIFFIN, C. S., MARSDBN, S. J., STEVENS, D. L., SIMPSON, P. and SAVAGE, J. R. K., 1995, Frequencies of complex chromosome exchange aberrations induced by 239Pu aparticles and detected by fluorescence in situ hybridization using single chromosome specific probes, internationalJournal of Radiation Biology, 67, 431-439.
  • GRIFFIN, C. S., STEVENS, D. L. and SAVAGE, J. R. K., 1996, Ultrasoft l.5 keV A1K X-rays are efficient producers of complex chromosome exchange aberrations as revealedby fluorescent in situ hybridization. International J ournal of Radiation Biology, 146, 144-150.
  • HENKE, B. L., GULLIKSON, E. M. and DAVIS, J. C., 1993, X-ray interactions: photoabsorption, scattering, transmission, and reflection at £ =50-30 000 eV, X = 1-92. Atomic Dataand Nuclear Data tables, 54, 181-342.
  • HOSHI, M., GOODHEAD, D. T., BRENNER, D. J., BANCE, D. A., CHMIBLEWSKI, J. J., PACIOTTI, M. A. and BRADBURY, J. N., 1985, Dosimetry comparison and characterisation of an A1K ultrasoft X-ray beam from an MRC coldcathode Source. Physics in Medicine and Biology, 30,1029-1041.
  • ICRP, 1975, Reference Man: Anatomical, Physiological and MetabolicCharacteristics, Publication 23 (Oxford: Pergamon).
  • LICHTER, P., CREMER, T., BORDEN, J., MANUELIDIS, L. and WARD, D. C., 1988, Delineation of individual human chromosomes in metaphase and interphase cells by in situ hybridization using recombinant DNA libraries. HumanGenetics, 80, 224-238.
  • MOISEENKO, V. V., EDWARDS, A. A., NIKIOO, H. and PRESTWICH, W. V., 1997, The influence of track structure on the understanding of relative biological effectiveness for the induction of chromosomal exchanges in human lymphocytes. Radiation Biology, 147, 208-214.
  • MORRIS, T. and THACKBR, J., 1993, Formation of large deletions by illegitimate recombination in the HPRT gene ofprimary human fib rob lasts. Proceedings of the National Academy of Sciences, USA, 90, 1392-1396.
  • NIKJOO, H. and GOODHEAD, D. T., 1991, Track structure analysis illustrating the prominent role of low-energy electrons in radiobiological effects of low-LET radiations. Physics inMedicine and Biology, 36, 229-238.
  • NIKIOO, H., O'NEILL, P., GOODHEAD, D. T. and TERRISSOL, M.,1997, Computational modelling of low energy electrons induced DNA damage by early physical and chemicalevents. InternationalJ ournal of Radiation Biology, 71, 467-483.
  • PANDITA, T. K. and GEARD, C. R., 1996, Chromosome aberrations in human fib rob lasts induced by monoenergetic neutrons. 1. Relative biological effectiveness. RadiationResearch, 45, 730-739.
  • PRETLOW, T. G., WEIR, E. and ZETTERGREN, J. G., 1975, Problems connected with the separation of different kindsOf Cells. In International Review of Experimental Pathology,edited by G. W. Richter and M. A. Epstein (Academic Press), 14, 91-204.
  • RABBITTS, T. H., 1994, Chromosomal translocations in human cancer. Nature, 372, 143-149.
  • RAJU, M. R., CARPENTER, S. G., CHMIBLEWSKI, J. J., SCHILLAQ, M. E., WILDER, M. E., FRYER, J. P., JOHNSON, N. F., SCHOR, P. L., SEBRING, R. J. and GOODHBAD, D. T., 1987, Radiobiology of ultrasoft X-rays. 1. Cultured hamster Cells (V79). Radiation Research, 110, 396-412.
  • SACHS, R. K., CHEN, A. M. and BRENNER, D. J., 1997, Review: proximity effects in the production of chromosome aberrations by ionising radiation. International Journal of Radiation Biology, 71, 1-19.
  • SAVAGE, J. R. K. and SIMPSON, P., 1994, On the scoring of FISH-'painted' chromosome exchange aberrations.Mutation Research, 307, 345-353.
  • SCHILLACI, M. E., CARPENTER, S., RAJU, M. R., SEBRING, R. J., WILDER, M. E. and GOODHEAD, D. T., 1989, Radiobiology of ultrasoft X-rays. II. Cultured C3H mouseCells (1OT1/2). Radiation Research, 119, 83-92.
  • SIMPSON, P. and SAVAGE, J. R. K., 1995, Estimating the true frequency of X-ray-induced complex chromosome exchanges using fluorescence in situ hybridization.International Journal of Radiation Biology, 67, 37-45.
  • SIMPSON, P. and SAVAGE, J. R. K., 1996, Dose-reponse curves for simple and complex chromosome aberrations induced by X-rays and detected using fluorescence in situ hybridization. International Journal of Radiation Biology, 69,429-436.
  • THACKER, J., WILKINSON, R. E. and GOODHEAD, D. T., 1986, The induction of chromosome exchange aberrations by carbon ultrasoft X-rays in V79 hamster cells, internationalJournal of Radiation Biology, 49, 645-656.
  • TOWNSBND, K. M. S., STRETCH, A., STEVENS, D. L. and GOODHEAD, D. T., 1990, Thickness measurements on V79-4 cells: a comparison between laser scanning confocal microscopy and electron microscopy, internationalJournal of Radiation Biology, 58, 499-508.
  • VIRSIK, R. P., SCHAFER, C. H., HARDER, D., GOODHEAD, D. T., Cox, R. and THACKER, J., 1980, Chromosome aberrations induced in human lymphocytes by ultrasoft Alx andCK X-rayS. International Journal of Radiation Biology, 38,545-557.
  • VIRSIK-PEUCHERT, P., RAVE-FRANK, M., LANGEBRAKB, U. and SCHMIDBBRGER, H., 1997, Differences in the yields of dicentrics and reciprocal translocations observed in the chromosomes of irradiated human skin fibroblasts and blood lymphocytes from the same healthy individuals.Radiation Research, 148 209-215.
  • WILKINSON, R. E., GOODHEAD, D. T. and THACKBR, J., 1985, Induction of chromosome aberrations by very short tracks at different stages of the cell cycle. Radiation ProtectionDosimetry, 13, 161-165.

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