Advanced search
Publication Cover
International Journal of Radiation Biology Volume 73, 1998 - Issue 6
Submit an article Journal homepage
10
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Automated fluorescence microscopic measurement of apoptosis frequency following ionizing radiation exposure in cultured mammalian cells

J.B Matthews Cancer Imaging Department and Advanced Therapeutics, BC Canc er Research Centre, 601 West 10th Ave., Vancouver, BC V5Z 1L3, Canada.
,
A Harrison Oncometrics Imaging Corp. Suite 505, 601 West Broadway, Vancouver, BC V5Z 4C2, Canada.
,
B. Palcic Cancer Imaging Department and Advanced Therapeutics, BC Canc er Research Centre, 601 West 10th Ave., Vancouver, BC V5Z 1L3, Canada.
&
K Skov Oncometrics Imaging Corp. Suite 505, 601 West Broadway, Vancouver, BC V5Z 4C2, Canada.
Pages 629-639 | Published online: 03 Jul 2009

  • BEDFORD, J. and MITCHELL, J., 1977, Mitotic accumulation of HeLa cells during continuous irradiation. Radiation Research. 70, 173-180.
  • BEDFORD, J. S. and GRIGGS, H. G., 1975, The estimation of survival at low doses and the limits of resolution of the single-cell-plating technique. In Ceil Survival after LOW Doses of Radiation: Theoretical and Clinical Implications, edited by T. Alper (London: Wiley), pp. 34-39.
  • BOAG, J. W., 1975, The statistical treatment of cell survival data. In Cell Survival after Low Doses of Radiation: Theoretical and Clinical impiictions, edited by T. Alper (London: Wiley), pp. 40-53.
  • CHEN, C. H., ZHANG, J. and LING, C. C., 1994, Transfected c-myc and c-Ha-ras modulate radiation-induced apoptosis in rat embryo Cells. Radiation Research, 139, 307-315.
  • COLLINS, R. J., HARMON, B. V., GOBE, G. C. and KERR, J. F., 1992, Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis. international j ommai of Radiation Biology, 61, 451-453.
  • DEWEY, W. C., LING, C. C. and MEYN, R. E., 1995, Radiationinduced apoptosis: relevance to radiotherapy, international Journal of Radiation Oncology. Biology. Physics, 33, 781-796.
  • DOUDKINE, A., MACAULAY, C., POULIN, N. and PALCIC, B., 1995, Nuclear texture measurements in image cytometry. Pathologica, 87, 286-299.
  • ELKIND, M., HAN, A. and VOLZ, K., 1963, Radiation response of mammalian cells grown in culture. IV. Dose dependence of division delay and post-irradiation growth of surviving and non-surviving Chinese hamster cells. J ommai of the National Cancer Institute, 30, 705-711.
  • GAFFNEY, E. F., O'NEILL, A. and STAUNTON, M. J., 1995, In situ end-labelling, light microscopic assessment and ultrastructure of apoptosis in lung caarcinoma, y ournai of clinica Pathology, 48, 1017-1021.
  • JAGGI, B., DEEN, M. J. and PALCIC, B., 1989, Design of a solid State microscope. Optical Engineering, 28, 675-687.
  • KERR, J., WINTERFORD, C. and HARMON, B., 1994, Morphological criteria for identifying apoptosis. In Ceil Biology: E Laboratory Handbook (New York: Academic Press), pp. 319-329.
  • KERR, J. F. R., WYLLIB, A. H. and CURRIE, A. R., 1972, Apoptosis: a basic biological phenomenon with wideranging implications in tissue kinetics. British j ournai of Cancer, 26, 239-257.
  • MARPLES, B. and JOINER, M. C., 1993, The response of Chinese hamster V79 cells to low radiation doses: evidence of enhanced sensitivity of the whole cell population. Radiation Research, 133, 41-51.
  • MATTHEWS, J. B., 1997, Characterisation of the apoptotic response due to low doses of radiation using automated image cytometry. PhD Thesis, University of British Columbia, 'Vancouver, BC, Canada.
  • OLIVE, P. L., FRAZER, G. and BANATH, J. P., 1993, Radiationinduced apoptosis measured in TK6 human B lymphoblaSt Cells USing the COmet assay. Radiation Research, 136,130-136.
  • PALCIC, B., BROSING, J., LAM, G. and SKARSGARD, L., 1983, The requirement of survival measurements at low doses. In Proceedings. Berkeley Conference in Honour of Jerry Neyman and jack Kiefer, edited by L. C. Olshen (New York: Wadsworth), pp. 331-342.
  • RADFORD, I. R. and MURFHY, T. K., 1994, Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage. International Journai of Radiation Biology, 65, 229-239.
  • SKOV, K. A., KOCH, C. J. and MARFLES, B., 1994a, Effect of etanidazole on absolute sensitivity and increased radioresistance in hypoxic cells at low doses. Radiation Oncology Investigations, 2, 164-170.
  • SKOV, K. A., MACPHAIL, H. S. and MARPLES, B., 1994b, The effect of radiosensitizers on the survival response of hypoxic mammalian cells: the low X-ray dose region, hypersensitivity and induced radioresistance. Radiation Research, 138, Sl 13-116.
  • UMANSKY, S., 1991, Apoptotic process in the radiation-induced death of lymphocytes. In ApopUais: The Molecular Basis of Cell Death, edited by L. T. Cope (New York: Cold Spring Harbour Laboratory Press), pp. 193-208.
  • VIDAIR, C., CHBN, C., LING, C. and DBWEY, W., 1996, Apoptosis induced by X-irradiation of rec-myc cells is postmitotic and not predicted by the time after irradiation or behaviour of Sister Cells. Cancer Research, 56, 4116-4118.
  • WARTERS, R. L., 1992, Radiation-induced apoptosis in a murine t-cell hybridoma. Cancer Research, 52, 883-890.
  • WOUTERS, B. G. and SKARSGARD, L. D., 1994, The response of a human tumor cell line to low radiation doses: evidence of enhanced sensitivity. Radiation Research, 138, S76-80.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.