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International Journal of Radiation Biology Volume 73, 1998 - Issue 3
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Research Article

Radiation-induced micronucleus formation in human skin fibroblasts of patients showing severe and normal tissue damage after radiotherapy

U. NACHTRAB U. OPPITZ M. FLENTJE H. STOPPER Departments of Toxicology; Radiation Therapy, University of Wurzburg, Versbacher StraBe, 97078 Wurzburg Germany
Pages 279-287 | Published online: 03 Jul 2009

  • ARLETT, C. F. and PRIESTLY, A., 1985, An assessment of the radiosensitivity of ataxia-telangiectasia heterozygotes. In Ataxia Telangiectasia: Genetics, Neuropathology, and Immunology of a Degmerative Disease of Childhood, edited by R. A. G. a. M. Swift (New York: Alan R. Liss).
  • BENTZEN, S. M., 1997, Potential clinical impact of normal-tissue intrinsic radiosensitivity testing. Radiotherapy and Oncology, 43, 121-131.
  • CHAMPION, A. R., HANSON, J. A., VENABLBS, S. E., MCGREGOR, A. D. and GAFFNEY, C. C., 1997, Determination of radiosensitivity in established and primary squamous cell carcinoma cultures using the micronucleus assay. European Journal of Cancer, 33(3), 453-462.
  • FENECH, M., 1993, The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutation Research, 285, 35-44.
  • GEARD, C. R. and CHEN, C. Y., 1990, Micronuclei and cIonogenicity following low- and high-dose-rate gamma irradiation Of normal human fibroblasts. Radiation Research, 124 (Suppl. 1), S56-S61.
  • JONES, L. A., SCOTT, D., COWAN, R. and ROBERTS, S. A., 1995, Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: chromosome aberrations after low doserate irradiation. International Journal of Radiation Biology, 67, 519-528.
  • JORGENSBN, T. J. and SHILOH, Y., 1996, The ATM gene and the radiobiology of ataxia-telangiectasia. international Journal of Radiation Biology, 69, 527-537.
  • MILLER, B., LOCHER, F., SEELBACH, A., STOPFER, H., UTESCH, D. and MADLE, S., 1997, Evaluation of the in vitro micronucleus test (MNT) as an alternative to the in vitro chromosomal aberration assay (CA): position of the GUM working group on the in vitro micronucleus test. Mutation Research, in press.
  • MORGAN, J. L., HOLCOMB, T. M. and MORRISSEY, R. W., 1968, Radiation reactions in ataxia telangiectasia. American Journal of Diseases of Childhood, 116, 557-558.
  • MOLLER, W. U., STREFFER, C. and WUTTKE, K., 1995, Micronucleus determination as a means to assess radiation exposure, stem Cells, 13, 199-206.
  • MOLLER, W. U., NOSSE, M., MILLER, B. M., SLAVOTINEK, A., VIAGGI, S. and STREFFBR, C., 1996, Micronuclei: a biological indicator of radiation damage. Mutation Research, 366, 163-169.
  • OSANTO, S., THIISSEN, J. C., WOLDERING, V. M., VAN RUN, J. L., NATARAIAN, A. T. and TATES, A. D., 1991, Increased frequency of chromosomal damage in peripheral blood lymphocytes up to nine years following curative chemotherapy of patients with testicular carcinoma. Environmental and Molecular Mutagenesis, 17, 71-78.
  • RIGAUD, O., GUBDENEY, G., DURANTON, I., LEROY, A., DOLOY, M. T. and MAGDELENAT, H., 1990a, Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. I. Chromosome aberrations induced in vivo. Mutation Research, 242, 17-23.
  • RIGAUD, O., GUEDBNEY, G., DURANTON, I., LEROY, A., DOLOY, M. T. and MAGDELENAT, H., 1990b, Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. II. Alteration of DNA repair and chromosome radiosensitivity. Mutation Research, 242, 25-35.
  • RUDAT, V., DIETZ, A., CONRADT, C., WEBER, K.-J. and FLENTJE, M., 1997, in vitro radiosensitivity of primary human fibroblasts. Lack of correlation with acute radiation toxicity in patients with head and neck cancer. Radiotherapy and Oncology, 43, 181-188.
  • SCOTT, D., HU, Q. and ROBERTS, S. A., 1996, Dose-rate sparing for micronucleus induction in lymphocytes of controls and ataxia-telangiectasia heterozygotes exposed to 60Co gamma-irradiation in vitro. International Journal of Radiation Biology, 70, 521-527.
  • SHIBAMOTO, Y., STREFFER, C., FUHRMANN, C. and BUDACH, V., 1991, Tumor radiosensitivity prediction by the cytokinesis-block micronucleus assay. Radiation Research, 128, 293-300.
  • STOPPER, H. and MÜLLER, S. O., 1997, A mini review: micronuclei as biological endpoints for genotoxicity. Toxicology in Vitro, in press.
  • TAYLOR, A. M., BYRD, P. J., MCCONVILLE, C. M. and THACKER, S., 1994, Genetic and cellular features of ataxia telangiectasia. International Journal of Radiation Biology, 65, 65-70.
  • TUCKER, S. L., GEARA, F. B., PETERS, L. J. and BROCK, W. A., 1996, How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity? Radiotherapy and Oncology, 38, 103-113.
  • WENNERBERG, J., 1996, Predicting response to therapy of squamous cell carcinoma of the head and neck (Review). Anticancer Research, 16, 2389-2396.

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