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International Journal of Radiation Biology Volume 75, 1999 - Issue 12
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Research Article

Biomarkers of exposure, sensitivity and disease

Antone L. Brooks
Pages 1481-1503 | Published online: 03 Jul 2009

  • AKIYAMA, M., UMEKI, S., KUSUNOKI, Y., KYOIZUMI, S. NAKAMURA, N., MORI, T., ISHIKAWA, Y., YAMAKIDO, M., OHAMA, K. KODAMA, T. ENDO, K. and COLOGNE, J. B., 1995, Somatic-cell mutations as possible predictor of cancer risk. Health Physics, 6, 643-649.
  • ALBERTINI, R. J., 1985, Somatic gene mutations in moo as indicated by 6-thioguanine resistant T-lymphocytes in human blood. Mutation Research, 150, 411-422.
  • ANDERSSON, M., VYBERT, M., VISFELDT, J., CARSTENSEN, B. and STORM. H. H., 1994. Primary liver tumors among Danish patients exposed to thorotrast. Radiation Research, 137, 262-273.
  • AWA, A. A., NAKANO, M., OHTAKI, K., KODAMA, Y., LUCAS, J. and GRAY, J., 1992, Factors that determine the in moo dose-response relationship for stable chromosome aberrations in A-bomb survivors. Journal of Radiation Research (Tokyo), 33(suppl.), 206-214.
  • AZZAM, E. I., DE TOLEDO, S. M., GOODING, T. and LITTLE, J. B., 1998, Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiation Research, 150, 497-504.
  • BAO, S., HARWOOD, P. W., CHRISLER, W. B., GROCH, K. M. and BROOKS, A. L., 1997, Comparative clastogenic sensitivity of respiratory tract cells to gamma rays. Radiation Research, 148, 90-97.
  • BAUCHINGER, M., SALASSIDIS, K., BRASELMANN, H., VOZILOVA, A., PRESSL, S., STEPHAN, G., SNIGIRYOVA, G., KOZHEUROV, V. P. and AKLEYEV, A., 1998a, FISH-based analysis of stable translocations in the Techa River population. International Journal of Radiation Biology, 73, 605-612.
  • BAUCHINGER, M. and SCHMID, E., 1997, Is there reliable experimental evidence for a chromosomal 'fingerprint' of exposure to densely ionizing radiation? Radiation Research, 147, 506-510.
  • BAUCHINGER, M. and SCHMID, E., 1998b, LET dependence of yield ratios of radiation-induced intra- and interchromosomal aberrations in human lymphocytes. International Journal of Radiation Biology, 74, 17-25.
  • BENDER, M. A., 1964, Chromosome aberrations in irradiated human subjects. Annals of the New York Academy of Science, 114, 249-251.
  • BENDER, M. A., AWA, A. A., BROOKS, A. L., EVANS, H. J., GROER, P. G., LITTLEFIELD, L. G., PERIRA, C., PRESTON, R. J. and WACHHOLZ, B. W., 1988, Current status of cytogenetic procedures to detect and quantify previous exposures to radiation. Mutation Research, 196, 103-159.
  • BENDER, M. A. and GOOCH, P. C., 1966, Somatic chromosome aberrations induced by human irradiation: the 'recuplex' critically accident. Radiation Research, 29, 568-582.
  • BENDER, M. A., RARY, J. M. and KALE, R. P., 1985, G2 chromosomal radiosensitivity in ataxia-telangiectasia lymphocytes. Mutation Research, 152, 39-47.
  • BISSELL, M. J., 1996, The central role of extracellular-matrix (ECM) in integration of growth, differentiation and apoptosis. FASEB Journal, 10, N6, P2431.
  • BISSELL, M. J., 1998, Glandular structure and gene expression. Lessons from the mammary gland. Annuals of the New York Academy of Science, 842, 1-6.
  • BLANCHARD, A. P. and HOOD, L., 1996, Sequence to array: probing the genome's secrets. Nature, Biotechnology, 14, 1649-1649.
  • BODMER, W. F., BISHOP, T. and KARRAN, P., 1994, Genetic steps in colorectal cancer. Nature, Genetics, 6, 217-219.
  • BOGAN, K. T., 1993, Reassessment of human peripheral T-lymphocyte lifespan deduced from cytogenetic and cytotoxic effects of radiation. International Journal of Radiation Biology, 64, 195-204.
  • BONGARZONE, I., FUGAZZOLA, L. VIGNERI, P., MARIANI, L., MONDELLINI, P., PACINI, F., BASOLO, F., PINCHERA, A., PILOTTI, S. and PIEROTTI, M. A., 1996, Age-related activation of the tyrosine kinase receptor protooncogenes RET and NTRKI in papillary thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism, 81, 2006-2009.
  • BOOTHMAN, D. A., MEYERS, M., ODEGAARD, E. and WANG, M., 1996, Altered G1 checkpoint control determines adaptive survival responses to ionizing radiation. Mutation Research, 358, 143-153.
  • BOS, J. L., 1989, ras oncogenes in human cancer: a review. Cancer Research, 49, 4682-4689.
  • BOUFFLER, S.D., BRECKON, G. and COX, R., 1996, Chromosomal mechanisms in murine radiation acute myeloid leukemogenesis. Carcinogenesis, 17, 655-659.
  • BRANDOM, W. F., BLOOM, A. D., ARCHER, P. G., ARCHER, V. E., BISTLINE, R. W. and SACCOMANNO, G., 1978, Somatic cell genetics of uranium miners and plutonium workers: a biological dose-response indicator. In Late Biological Effects of Ioniang Radiation, I. STI/PUB/489 (Vienna: International Atomic Energy Agency), pp. 507-518.
  • BRENNER, D. J., 1994, The significance of dose-rate in assessing the hazards of domestic radon exposure. Health Physics, 67, 76-79.
  • BRENNER, D. J. and SACHS, R. K., 1994, Chromosomal 'fingerprints' of prior exposure to densely ionizing radiation. Radiation Research, 140, 123-142.
  • BROOKS, A. L., 1975, Chromosome damage in liver cells from low dose-rate alpha, beta and gamma irradiation: derivation of RBE. Science, 190, 1090-1092.
  • BROOKS, A. L., 1980, Low dose and low dose-rate effects on cytogenetics. In R. E. Meyn and H. R. Withers (eds), Radiation Biology in Cancer Research (New York: Raven), pp. 263-276.
  • BROOKS, A. L., BAO, S., HARWOOD, P. W., WOOD, B. H., CHRISLER, W. B, GIES, R. A. and CROSS, F. T., 1997, Induction of micronuclei in respiratory tract following radon inhalation. International Journal of Radiation Biology, 72, 485-495.
  • BROOKS, A. L., BENJAMIN, S. A., HAHN, F. F., BROWNSTEIN, D. G., GRIFFITY, W. C. and MCCLELLAN, R. O., 1983, The induction of liver tumors by 239Pu citrate or 239PuO2 particles in the Chinese hamster. Radiation Research, 96, 135-151.
  • BROOKS, A. L., GUILMETTE, R. A., HAHN, F. F., HALEY, P. J., MUGGENBURG, B. A., MEWHINNEY, J. A. and MCCLELLAN, R. O. 1992, Distribution and biological effects of inhaled 239Pu(NO3)4 in Cynomolgus monkeys. Radiation Research, 130, 79-87.
  • BROOKS, A. L., MCCIELLAN, R. O. and BENJAMIN, S. A., 1972, The effects of 144Ce-144Pr on the metaphase chromosomes of the Chinese hamster liver cells in vino. Radiation Research, 52, 481-498.
  • BROOKS, A. L., MCDONALD, K. E., MlTCHELL, C., DAGLE, G. E. and YANG, W. K., 1994, Role of plutonium-induced chromosome alterations and mutated Ki-v-ras oncogene during liver cancer induction in Chinese hamsters and mice. In G. van Kaick, A. Karaoglou and A. M. Kellerer (eds), Health Effects of Internally Deposited Radionuclides: Emphasis on Radium and Thorium (Singapore: World Scientific), pp. 397-402.
  • BROOKS, A. L., MIICK, R., BUSCHBOM, R. L., MURPHY, M. K. and KHAN, M. A., 1995, The role of dose-rate on the induction of micronuclei in deep-lung fibroblasts in vivo after exposure to Co gamma rays. Radiation Research, 144, 114-118.
  • BROOKS, A. L., RETHERFORD, J. C. and MCCLELLAN, R. O., 1974, Effect of 239-plutonium oxide particle number and size on the frequency and distribution of chromosome aberrations in the liver of the Chinese hamster. Radiation Research, 59, 693-709.
  • BYRNE, J. L., CARTER, G. I., DAVIES, J. M., HAYNES, A. P., RUSSELL, N. H. and CROSS, N. C., 1998, A novel BCRABL fusion gene (e2/1a) in a patient with Philadelphiapositive chronic myelogenous leukemia and an aggressive clinical course. British Journal of Hematology, 103, 791-794.
  • CARRANO, A. V. and HEDDLE, J. A., 1973, The fate of chromosome aberrations. Journal of Theoretical Biology, 38, 289-304.
  • CHEN, D. and WEI, L., 1991, Chromosome aberrations, cancer mortality and hermetic phenomena among inhabitants in areas of high background radiation in China. Journal of Radiation Research, Tokyo, 32 (suppl. 2), 46-53.
  • CONGER, A. D. and CURTIS, H. J., 1968. Abnormal anaphases in regenerating mouse livers. Radiation Research, 33, 150-161.
  • COWELL, J. K. and HOGG, A., 1992, Genetics and cytogenetics of retinoblastoma. Cancer Genetics and Cytogenetics, 64, 1-11.
  • COX, R. D., 1994, Human cancer predisposition and the implications for radiological protection. International Journal of Radiation Biology, 66, 643-647.
  • COX, R. D., 1997, The mechanisms and genetics of radiation tumorigenesis: recent developments in animal models. In Health Effects of Low Dose Radiation (London: British Nuclear Energy Society), pp. 33-35.
  • COX, R. D., 1998, The multi-step nature of carcinogenesis and the implications for risk analysis. International Journal of Radiation Biology, 73, 373-376.
  • COX, R. D. and BRECKON, G., 1991, Chromosomal changes: radiation sensitive sites on chromosome 2 and their role in radiation myeloid leukaemogenesis in the mouse. Radiation and Environmental Biophysics, 30, 177-179.
  • COX, R. D., MEIER-EWERT, S., ROSS, M., LARIN, Z., MONACO, A. P. and LEHRACH, H., 1993, Genome mapping and cloning of mutations using yeast artificial chromosomes. Methods of Enzymology, 225, 637-653.
  • CROCE, C. M., 1987, Role of chromosome translocation in human neoplasia. Cell, 49, 155-156.
  • CROSS, F. T., 1994a, Evidence of cancer risk from experimental animal radon studies. In Radiation and Public Perception (American Chemical Society), pp. 79-87.
  • CROSS, F. T., 1994b, Invited commentary: residential radon risks from the perspective of experimental animal studies. American Journal of Epidemiology, 140, 333-339.
  • CROSS, F. T., PALMER, R. F., BUSCH, R. H., FILIPY, R. E. and STUART, B. O., 1981, Development of lesions in Syrian golden hamsters following exposure to radon daughters and uranium ore dust. Health Physics, 41, 135-153.
  • DA CRUZ, A. D., MCARTHUR, A. G., SILVA, C. C., CURADO, P. P. and GLICKMAN, B. W., 1994, Human micronucleus counts are correlated with age, smoking and cesium-137 dose in the Goiânia (Brazil) radiological accident. Mutation Research, 313, 57-68.
  • DALLA-FAVERA, R., BREGNI, M., ERIKSON, J., PATTERSON, D., GALLO, R. C. and CROCE, C. M., 1982, Human c-myc one gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proceedings of the National Academy of Sciences, USA, 79, 7824-7827.
  • DESHPANDE, A., GOODWIN, E.H., BAILEY, S. M., MARRONE, B. L. and LEHNERT, B. E., 1996, Alpha-particle-induced sister chromatid exchange in normal human lung fibroblasts: evidence for an extranuclear target. Radiation Research, 145, 260-267.
  • DIKOMEY, E., DAHM-DAPHI, J., BRAMMER, I., MARTENSEN, R. and KAINA, B., 1998, Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines. International Journal of Radiation Biology, 73, 269-278.
  • DU MANOIR, S., SPEICHER, M. R., JOOS, S. SCHROCK, E., POPP, S., DOHNER, H., KOVACS, G., ROBERT-NICOUD, M., LICHTER, P. and CREMER, T., 1993, Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization. Human Genetics, 90,590-610.
  • DURANTE, M., GEORGE, K. and YANG, T. C. 1997, Biodosimetry of ionizing radiation by selective painting of prematurely condensed chromosomes in human lymphocytes. Radiation Research, 148, S45-50.
  • DURANTE, M., FURUSAWA, Y. and GOTOH, E., 1998, Technical Report A simple method for simultaneous interphasemetaphase chromosome analysis in biodosimetry. International Journal Radiation Biology, 74, 457-462.
  • EDWARDS, A. A., 1997, The use of chromosomal aberrations in human lymphocytes for biological dosimetry. Radiation Research, 148, S39-44.
  • ELKIND, M. M., 1992, Enhanced neoplastic transformation by protracted exposures of high-LET radiations: a cellkinetic model based upon a G2/M-phase window of sensitivity. In T. Aoyama (ed.), International Conference on Low Dose Irradiation and Biological Defense Mechanisms (Amsterdam: Elsevier), pp. 29-35.
  • EVANS, H. J., BUCKTON, K. E., HAMILTON, G. E. and CAROTHERS, A., 1979, Radiation-induced chromosome aberrations in nuclear-dockyard workers. Nature, 277, 521-534.
  • FENECH, M. and MORELY, A. A., 1985, Measurement of micronuclei in lymphocytes. Mutation Research, 147, 29-36.
  • FINNON, P., LLOYD, D. C. and EDWARDS, A. A., 1995, Fluorescence in situ hybridization detection of chromosomal aberrations in human lymphocytes: applicability to biological dosimetry. International Journal of Radiation Biology, 68, 429-435.
  • FORD, J.R., MARSDEN, S.J., STCVENS, D.L., TOWNSEND, K.M.S.and GOODHEAD, D. T., 1997, The 'bystander' effect and expression of p53 in irradiated rat tracheal epithelial cells. Abstract from the 16th Radiation Research Society, 3-7 May 1997, Rhode Island, P15-306.
  • GADBOIS, D. M., CRISSMAN, H. A., NASTASI, A., HABBERSETT, R., WANG, S., CHEN, D. and LEHNERT, B. E., 1996, Alterations in the progression of cells through the cell cycle after exposure to alpha particles or gamma rays. Radiation Research, 146, 414-424.
  • GAVRILIN, Y. I., KHROUGH, V. T., SHINKAREV, S. M., KRYSENKO, N. A., SKRYABIN, A. M., BOUVILLE, A. and ANSPAUGH, L. R., 1999, Chernobyl accident: reconstruction of thyroid dose for the inhabitants of the Republic of Belarus. Health Physics, 76, 105-119.
  • GEARD, C. R., 1985, Chromosomal aberration production by track segment charged particles as a function of linear energy transfer. Radiation Protection Dosimetry, 13, 1 -4.
  • GEESMAN, D. P., 1968, An analysis of the carcinogenic risk from an insoluble alpha-emitting aerosol deposited in deep respiratory tissue. Report No. UCRL-50387 Addendum (Livermore: Lawrence Radiation Laboratory). (Available from the National Technical Information Service, Springfield, VA 22161, USA.)
  • GILBERT, E. S., GRIFFITH, W. C., BOECKER, B. B., DAGLE, G. E., GUILMETTE, R. A., HAHN, F. F., MUGGENBURG, B. A., PARK, J. F. and WATSON, C. R., 1998, Statistical modeling of carcinogenic risks in dogs that inhaled 238PuO2. Radiation Research, 150, 66-82.
  • COULD, M. N., WANG, B. and MOORE, C. J., 1989, Modulation of mammary carcinogenesis by enhancer and suppressor genes. In N. H. Colbum (ed.), Genes and Signal Transduction in Multistage Carcinogenesis (New York: Marcel Dekker), pp. 19-38.
  • GUO, G. Z., SASAI, K., OYA, N., TAKAGI, T., SHIBUYA, K. and HIRAOKA, M., 1998, Simultaneous evaluation of radiation-induced apoptosis and micronuclei in five cell lines. International Journal Radiation Biology, 73, 297-302.
  • HARRIS, C. C. and M. HOLLSTCIN, 1993, Clinical implications of the p53 tumor-suppressor gene. New England Journal of Medicine, 329, 1318-1327.
  • HAYATA, I. SEKI, M., YOSHIDA, K., HIRASHIMA, K., SADO, T., YAMAGIWA, J. and ISHIHARA, T., 1983, Chromosomal aberrations observed in 52 mouse myeloid leukemias. Cancer Research, 43, 367-373.
  • HEDDLE, J. A., 1973, A rapid in vino test for chromosome damage. Mutation Research, 18, 187-190.
  • HEDDLE, J. A., HITE, M., KIRKHART, B. MAVOURNIN, K., MACGREGOR, J. T., NEWELL, G. W. and SALAMONE, M. F., 1983, The induction of micronuclei as a measure of genotoxicity: A report of the US Environmental Protection Agency Gene-Tox Program. Mutation Research, 123, 61-118.
  • HEI, T. K., WU, L.-J. LIU, S.-X., VANNAIS, D., WALDREN, C. A. and RANDERS-PHERSON, G., 1997, Mutagenic effects of a single and an exact number of alpha particles in mammalian cells. Proceedings of the National Academy of Sciences, USA, 94, 3765-3770.
  • HICKMAN, A. W., JARAMILLO, R. J., LECHNER, J. F. and JOHNSON, N. F., 1994, Alpha particle-induced p53 protein expression in a rat lung epithelial cell strain. Cancer Research, 54, 5797-5800.
  • HILL, C. K., BUONAGURO, F. M., MYERS, C. P., HAN, A. and ELKIND, M. M., 1982, Fission-spectrum neutrons at reduced dose-rates enhance neoplastic transformation. Nature, 298, 67-69.
  • HOLLSTEIN, M., D. SIDRANSKY, B. VOGELSTEIN, C. and HARRIS, C., 1991, p53 mutations in human cancers. Science, 253, 49-53.
  • INTERNATIONAL COMMISSION ON RADIOLOGICAL PROTECTION (ICRF), 1991, 1990 Recommendations of the International Commission on Radiological Protection. Publication no. 60. Amah of the ICRP 21 (Oxford: Pergamon).
  • ICRP, 1995, Age Dependent Dose to Members of the Public from Intake of Radionuclides, Part 3. Publication no. 69 (Oxford: Pergamon).
  • ISHII, K. and WATANABE, M., 1996, Participation of gapjunctional cell communication on the adaptive response in human cells induced by low doses of X-rays. International Journal of Radiation Biology, 69, 291-299.
  • ITO, T., SEYAMA, T., MIZUNO, T., TSUYAMA, N. HAYASHI, Y., DOHI, K., NAKAMURA, N. and AKIYAMA, M., 1993, Genetic alterations in thyroid tumor progression: association with p53 gene mutations. Japan Journal of Cancer Research, 84, 526-531.
  • JANATIPOUR, M., TRAINOR, K. J., KUTLACA, R., BENNETT, G., HAY, J., TURNER, D. R. and MORLEY, A. A., 1988, Mutations in human lymphocytes studied by an HLA selection system, Mutation Research, 198, 221-226.
  • JENSEN, R. H., LANGLOIS, R. G., BIGBEE, W. L., GRANT, S. G., MOORE, D. II, PILINSKAYA, M, VOROBTSOVA, I. and PLESHANOY, P., 1995, Elevated frequency of glycophorin A mutations in erythrocytes from Chernobyl accident victims. Radiation Research, 141, 129-135.
  • JOHANSEN, J., STGREFFER, C., FUHRMANN, C., BENTZEN, S. M., STAUSBOL-GRON, B. and OVERGAARD, M., 1998, Radiosensitivity of normal fibroblasts from breast cancer patients assessed by the micronucleus and colony assays. International Journal of Radiation Biology, 73, 671-678.
  • JOHNSON, R. T. and RAO, P. N., 1970, Mammalian cell fusion: induction of premature condensation in interphase nuclei. Nature, 226, 717-722.
  • KADHIM, M. A., LORIMORE, S. A., HEPBURN, M. D. and GOODHEAD, D. T., 1994, Alpha-particle-induced chromosomal instability in human bone marrow cells. Lancet, 344, 987-988.
  • KADHIM, M. A., MACDONALD, D. A., GOODHEAD, D. T., LORIMORE, S. A., MARSDEN, S. J. and WRIGHT, E. G., 1992, Transmission of chromosomal instability after plutonium alpha-particle irradiation. Nature, 355, 738-740.
  • KALLIONIEMI, O. P., KALLIONIEMI, A., KURISU, W. THOR, A., CHEN, L. C., SMITH, H. S., WALDMAN, F. M., PINKEL, D. and GRAY, J. W., 1992, ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. Proceedings of the National Academy of Sciences, USA, 89, 5321-5325.
  • KASTEN, M. B, ZHAN, Q., EL-DEIRY, W. S., CARRIER, F., JACKS, T., WALSH, W. V., PLUNKETT, B. S., VOGELSTEIN, B. and FORANCE, A. J., JR, 1992, A mammalian cell cycle checkpoint pathway utilizing p53 and GADD55 is defective in ataxia-telangiectasia. Cell, 71, 587-597.
  • KHAN, M. A., CROSS, F. T., BUSHBOM, R. L. and BROOKS, A. L., 1995, Inhaled radon-induced genotoxicity in Wistar rat, Syrian hamster and Chinese hamster deep-lung fibroblasts in vino. Mutation Research, 334, 131-137.
  • KHAN, M. A., CROSS, F. T., JOSTES, R.F., HUI, E., MORRIS, J. E. and BROOKS, A. L., 1994, Micronuclei induced by radon and its progeny in deep-lung fibroblasts of rats in vino and in vitro. Radiation Research, 139, 53-59.
  • KLEINERMAN, R. A., LITTLEFIELD, L. G., TARONE, R. E., SAYER, A. M., HILDRETGH, N. G., POTTER, L. M., MACHADO, S.G. and BOICE, JR, J. D., 1990, Chromosome aberrations in relation to radiation dose following partialbody exposure in three populations. Radiation Research, 123, 93-101.
  • KLÜGBAUER, S., LENGFELDER, E., DEMIDCHIK, E. P. and RABES, H. M., 1995, High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident. Oncogene, 11, 2459-2467.
  • KLÜGBAUER, S., LENGFELDER, E., DEMIDCHIK, E. P. and RABES, H. M., 1996, A new form of RET rearrangement in thyroid carcinomas of children after the Chernobyl reactor accident. Oncogene, 13, 1099-1102.
  • KNEHR, S., ZITZELSBERGER, H. and BAUCHINGER, M., 1998, FISH-based analysis of radiation-induced chromosomal aberrations using different nomenclature systems. International Journal of Radiation Biology, 73, 135-141.
  • KNUDSON, A. G., 1985, Hereditary cancer, oncogenes and antioncogenes. Cancer Research, 45, 1437-1443.
  • KNUDSON, A. G., 1991, Overview: Genes that predispose to cancer. Mutation Research, 247, 185-190.
  • KUERBITZ, S. J., PLUNKETT, B. S., WALSH, W. V. and KASTAN, M. B., 1992, Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proceedings of the National Academy of Sciences, USA, 89, 7491-7495.
  • KNUUTILA, S., BIORKQKVIST, A. M., AUTIO, K., TARKKANEN, M., WOLF, M., MONNI, O., SZYMANSKA, J., LARRAMENDY, M. L., TAPPER, J., PERE, H., EL-RIFAI, W., HEMMER, S., WASENIUS, V.M., VIDGREN, V. and ZHU, Y., 1998, DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies. American Journal of Pathology, 152, 1107-1123.
  • KYOIZUMI, S., AKIYMA, M. HIRAI, Y., KUSUNOKI, Y., TANA, K. and UMIKI, S., 1990, Spontaneous loss and alterations of antigen receptor expression in mature CD4+ cells. Journal of Experimental Medicine, 71, 1988-1999.
  • LABAUVE, R. J., BROOKS, A. L., MAUDERLY, J. L., HAHN, F. F., REDMAN, H. C., MACKEN, C., SLAUSON, D. O., MEWHINNEY, J. A. and MCCLELLAN, R. O., 1980, Cytogenetic and other biological effects of 239PuO2 inhaled by Rhesus monkeys. Radiation Research, 82, 310-335.
  • LAMBIN, P., MALAISE, E. P. and JOINER, M. C., 1996, Might intrinsic radioresistance of human tumour cells be induced by radiation? International Journal of Radiation Biology, 69, 279-290.
  • LANE, D., 1993, A death in the life of p53. Nature, 362, 786-787.
  • LANGLOIS, R. G., AKIYAMA, M., KUSUNOKI, Y., DUPONT, B. R., MOORE, D. H., II, BIGBEE, W. L., GRANT, S. G. and JENSEN, R. H., 1993, Analysis of somatic cell mutations at the glycophorin A locus in atomic bomb survivors: a comparative study of assay methods. Radiation Research, 136, 111-117.
  • LANGLOIS, R. G., BIGBEE, W. L. and JENSEN, R. H., 1986, Measurements of the frequency of human erythrocytes with gene expression loss phenotypes at the glycophorin A locus. Human Genetics, 74, 353-362.
  • LAPIERRE, J. M., CAHEUX, V., DASILVA, F, COLLOT, N., HERVY, N., WISS, J. and TACHDJIAN, G., 1998, Comparative genomic hybridization: technical development and cytogenetic aspects for routine use in clinical laboratories. Annals of Genetics, 41, 56-62.
  • LE, X. C., XING, J. Z., LEE, J., LEADON, S.A. and WEINFELD, M., 1998, Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage. Science, 280, 1066-1069.
  • LEHNERT, B. E. and GOODWIN, E. H., 1997, Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells. Cancer Research, 57, 2164-2171.
  • LI, S., THOMPSON, S. A., KAVANAGH, T. J. and WOODS, J. S., 1996, Localization by in situ hybridization of gammaglutamylcysteine synthetase mRNA expression in rat kidney following acute methyl mercury treatment. Toxicology of Applied Pharmacology, 141, 59-67.
  • LITTLE, M. P. and MUIRHEAD, C. R., 1998, Curvature in the cancer mortality dose-response in Japanese atomic bomb survivors: absence of evidence of threshold. International Journal of Radiation Biology, 74, 471-480.
  • LITTLEFIELD, L. G., JOINER, E. E., COLYER, S. P., RICKS, R. C., LUSHBAUGH, C. C. and HURADO-MONROY, R., 1991, The 1989 San Salvador Co radiation accident: cytogenetic dosimetry and follow-up evaluation in three accident victims. Radiation Protection Dosimetry, 35, 115-123.
  • LITTLEFIELD, L. G., MCFEE, A. F., SALOMAA, S. I., TUCKER, J. D., INSKIP, P. D., SAYER, A. M., LINDHOLM, C., MAKINEN, S., MUSTONEN, R., SORENSEN, K., TEKKEL, M., VEIDEBAUM, T. AUVINEN, A. and BOICE, J. D., JR, 1998, Do recorded doses overestimate true doses received by Chernobyl cleanup workers? Results of cytogenetic analyses of Estonian workers by fluorescence In Situ hybridization. Radiation Research, 150, 237-249.
  • LIVINGSTON, C. K., JENSEN, R. H., SILBERSTEIN, E. B., HINNEFELD, J. D., PRATT, G., BIGBEE, W. L., LANGLOIS, R. G., GRANT, S. G. and SHUKLA, R., 1997, Radiobiological evaluation of immigrants from the vicinity of Chernobyl. International Journal of Radiation Biology, 72, 703-713.
  • LLOYD, D. C., PURRETT, R. J., DOLPHIN, G. W. and EDWARDS, A. A. 1976. Chromosomal aberrations induced in human lymphocytes by neuron irradiation. International Journal of Radiation Biology, 29, 169-182.
  • LOCKHART, D. J., DONG, H. L., BYRNE, M. C., FOLLETTIE, M. T., GALLO, M. V., CHEE, M. S., MITTMAN, M., WANG, C. W., KOBAYASHI, M., HORTON, H. and BROWN, E. L., 1996, Expression monitoring by hybridization to highdensity oligonucleotide arrays. Nature Biotechnology, 14, 1675.
  • LORIMORE, S. A., K ADHIM, M. A., POCOCK, D. A., PAPWORTH, D., STEVENS, D. L., GOODHEAD, D. T. and WRIGHT, E. G., 1998, Chromosomal instability in the descendants of unirradiated surviving cells after alpha-particle irradiation. Proceedings of the National Academy of Sciences, USA, 95, 5730-5733.
  • LUBIN, J. H., BOICE, J. D., EDLING, C., HORNUNG, R. W, HOWE, G., KUNZ, E., KUSIAK, R. A., MORRISON, H. I., RADFORD, E. P., SAMET, J. M., TIRMARCHE, M., WOODWARD, A. and YAO, S. X. 1995, Radon exposed underground miners and inverse exposure-rate (protraction enhancement) effects. Health Physics, 69, 494-500.
  • LUCAS, J. N. and SACHS, R. K., 1993, Using three-color chromosome painting to test chromosome aberration models. Proceedings of the National Academy of Sciences, USA, 90, 1484-1487.
  • LUCAS, J. N., TEJIN, T., STRAUME, T., PINKEL, D., MOORE, D., II, LITT, M. and GRAY, J., 1989, Rapid human chromosome aberration analysis using florescence in situ hybridization. International Journal of Radiation Biology, 56, 35-44.
  • LUCUS, J. N., 1997, Dose reconstruction for individuals exposed to ionizing radiation using chromosome painting. Radiation Research, 148, S33-38.
  • LUCUS, J. N., 1998, Cytogenetic signature for ionizing radiation. International Journal of Radiation Biology, 73, 15-20.
  • LUKE, S. and SHEPELSKY, M., 1998, FISH: Recent advances and diagnostic aspects. Cell, 5, 49-53.
  • MALINS, D. C. and GUNSELMAN, S. J., 1994, Fourier-transform infrared spectroscopy and gas chromatography-mass spectrometry reveal a remarkable degree of structural damage in the DNA of wild fish exposed to toxic chemicals. Proceedings of the National Academy of Sciences, USA, 91, 13039-13041.
  • MALINS, D. C., POLISSAR, N. L., GARNER, M. M. and GUNSELMAN, S. J., 1996, Mutagenic DNA base modifications are correlated with lesions in non-neoplastic hepatic tissue of the English Sole carcinogenesis model. Cancer Research, 56, 5563-5565.
  • MALINS, D. C., POLISSAR, N. L. and GUNSLEMAN, S. J., 1997a, Models of DNA structure achieve almost perfect discrimination between normal prostate, benign prostatic hyperplasia (BPH) and adenocarcinoma and have a high potential for predicting BPH and prostrate cancer. Proceedings of the National Academy of Sciences, USA, 94, 259-264.
  • MALINS, D. C., POLISSAR, N. L. and GUNSELMAN, S. J., 1997b, Infrared spectral models demonstrate that exposure to environmental chemicals leads to new forms of DNA. Proceedings of the National Academy of Sciences, USA, 94, 3611-3615.
  • MALINS, D. C., POLISSAR, N. L., SCHAEFER, S., SU, Y. and VINSON, M., 1998, A unified theory of carcinogenesis based on order-disorder transitions in DNA structure as studied in the human ovary and breast. Proceedings of the National Academy of Sciences, USA, 95, 7637-7642.
  • MICHAELIS, J., 1998, Recent epidemiological studies on ionizing radiation and childhood cancer in Germany. International Journal of Radiation Biology, 73, 377-381.
  • MIKI, Y., SWENSEN, J., SHATTUCK-EIDENS, D., FUTREAL, P. A., LARSHMAN, K. I., TAVTIGIAN, S., LIU, Q., COCHRAN, C., BENNET, L. M., DING, W., BELL, R., ROSENTHRAL, J., HUSSEY, C., TRAN, T., MCCLURE, M., FRYE, C., HATTIER, T., PHELPS, R., HAUGEN-STRANO, A., KATCHER, H., YAKUMO, K., GHOLAMI, Z., SHAFFER, D., STONE, S., BAYER, S., WRAY, C., BOGDEN, R., DAYANANTH, J., WARD, P., TONIN, S., NAROD, P. K., BRISTOW, F. H., NORRIS, L., HELVERING, P., MORRISON, P., ROSTECK, P., LAI, M., BARRETT, J. C., LEWIS, C., NEUHAUSEN, S., CANNON-ALBRIGHT, L., GOLDGAR, D., WISEMAN, R., KAMB, A. and SKOLNICK, M. H., 1994, A strong candidate for the breast and ovarian cancer susceptibility gene BRCAl. Science, 266, 66-71.
  • MILLER, R.C., RANDERS-PEHRSON, G., GEARD, C. R., HALL, E. J. and BRENNER, D. J., 1999, The oncogenic transforming potential of the passage of single alpha particles through mammalian cell nuclei. Proceedings of the National Academy of Sciences, USA, 96, 19-22.
  • MILLER, R. C., RANDERS-PEHRSON, G., HIEBER, L., MARINO, S. A., RICHARDS, M. and HALL, E. J., 1993, The inverse dose-rate effect for oncogenic transformation by charged particles is dependent on linear energy transfer. Radiation Research, 133, 360-364.
  • MOORE, D. H., TUCKER, J. D., JONES, I. M., LANGLOIS, R. G., PLESHONOV, P., VOROBTSOVA, I. and JENSEN, R., 1997, A study of the effects of exposure on cleanup workers at the Chernobyl nuclear reactor accident using multiple endpoints. Radiation Research, 148, 463-475.
  • MORRISON, B. W. and LEDER, P., 1994, neu- and ras- initiate murine mammary tumors that share genetic markers generally absent in C-myc and int-2-initiated tumors. Oncogme, 9, 43417-43426.
  • MUGGENBURG, B. A., GUILMETTE, R. A., MEWHINNEY, J. A., GILLETT, N. A., MAUDERLY, J. L., GRIFFITH, W. C., DIEL, J. H., SCOTT, B. R., HAHN, F. F. and BOECKER, B. B., 1996, Toxicity of inhaled 238PuO2 in beagle dogs. Radiation Research, 145, 361-381.
  • NACHTRAB, U., OPPITZ, U., FLENTJE, M. and STOPPER, H., 1998, Radiation-induced micronucleus formation in human skin fibroblasts of patients showing severe and normal tissue damage after radiotherapy. International Journal of Radiation Biology, 73, 279-287.
  • NAGASAWA, H. and LITTLE, J. B., 1992, Induction of sister chromatid exchanges by extremely low doses of alpha particles. Cancer Research, 52, 6394-6396.
  • NAKAMURA, N., MIYAZAWA, C., SAWADA, S., AKIYAMA, M. and AWA, A. A., 1998, A close correlation between electron spin resonance (ESR) dosimetry from tooth enamel and cytogenetic dosimetry from lymphocytes of Hiroshima atomic-bomb survivors. International Journal of Radiation Biology, 73, 619-629.
  • NARAYANAN, P. K., GOODWIN, E. H. and LEHNERT, B. E., 1997, Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Research, 57, 3963-3971.
  • NATIONAL RESEARCH COUNCIL (NRC), 1990, Committee on the Biological Effects of Ionizing Radiations, Health Effects of Exposure to Low Levels of Ionizing Radiation (BEIR V) (Washington, DC: National Academy Press).
  • NRC, 1998, Committee on Biological Effects of Ionizing Radiations. Health Effects of Exposure to Radon (BEIR VI) (Washington, DC: National Academy Press).
  • NATIONAL COUNCIL ON RADIATION PROTECTION and MEASUREMENTS (NCRP), 1980, Influence of Dose and its Distribution in Time on Dose-Response Relationships for LowLET Radiations. Report no. 64 (Bethesda: NCRP).
  • NCRP, 1990, The Relative Biological Effictiveness of Radiations of Different Quality. Report no. 104 (Bethesda: NCRP).
  • NCRP, 1991, Some Aspects of Strontium Radiobiology. Report no. 110 (Bethesda: NCRP).
  • NCRP, 1993, Risk Estimates for Radiation Protection. Report no. 115 (Bethesda: NCRP).
  • NCRP, 1997, Deposition, Retention and Dosimetry of Inhaled Radioactive Substances. Report no. 125 (Bethesda: NCRP).
  • NELSON, J. M., BROOKS, A. L., METTING, N. F., KHAN, M. A., BUSCHBOM, R. L., DUNCAN, A., MIICK, R. and BRABY, L. A., 1996, Clastogenic effects of defined numbers of 3.2MeV alpha particles on individual CHO-K1 cells. Radiation Research, 145, 568-574.
  • NIKIFOROV, Y. and GNEPP, D. R., 1994, Pediatric thyroid cancer after the Chernobyl disaster. Pathomorphologic study of 84 cases (1991-1992) from the Republic of Belarus. Cancer, 74, 748-766.
  • NORMAN, A. and SASAKI, M. S., 1966, Chromosome aberrations in human lymphocytes, International Journal of Radiation Biology, 11, 321-328.
  • NOWELL, P. C., 1990, Cytogenetics of tumor progression. Cancer, 65, 2172-2177.
  • OLIVIERI, G., BODYCOTE, J. and WOLFF, S., 1984, Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. Science, 223, 594-597.
  • OU, Y. C., THOMPSON, S. A., KIRCHNER, S. C., KAVANAGH, T. J. and FAUSTMAN, E. M., 1997, Induction of growth arrest and DNA damage-inducible genes Gadd45 and Gadd153 in primary rodent embryonic cells following exposure to methylmercury. Toxicology and Applied Pharmacology, 147, 31-38.
  • PANTELIAS, G. E. and MALLIE, H. D., 1984. The use of peripheral blood mononuclear cell prematurely condensed chromosomes for biological dosimetry. Radiation Research, 99, 140-150.
  • PARK, J. F., BUSCHBOM, R. L., DAGLE, G. E., JAMES, A. C., WATSON, C. R. and WELLER, R. E., 1997, Biological effects of inhaled 238PuO2 in Beagles. Radiation Research, 148, 365-381.
  • PASTERNAK, G., HOCHHAUS, A., SCHULTHEIS, B. and HEHLMAN, R., 1998, Chronic myelogenous leukemia: molecular and cellular aspects. Journal of Cancer Research Clinical Oncology, 124, 643-660.
  • PELROY, R. A., 1998, Workshop: 'Molecular biology of mutational biomarkers for human exposure to ionizing radiation', 17-18 August 1998, NCI, Rockville, MD.
  • PIATAK, M., LUK, K. C., WILLIAMS, B. and LIFSON, J. D., 1993, Quantitative competitive polymerase chain reaction for accurate quantitation of HIV DNA and RNA species. Biological Techniques, 14, 70-80.
  • PIERCE, D. A., SHIMIZU, Y., PRESTON, D. L., VAETH, M. and MABUCHI, K., 1996, Studies of the mortality of atomic bomb survivors. Report 12, Part I Cancer: 1950-1990. Radiation Research, 146, 1-27.
  • PINKEL, D., LANDEGENT, J. C., COLLINS, J., FUSCO, J., SEGRAVES, R., LUCAS, J. and GRAY, J. W., 1988, Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. Proceedings of the National Academy of Sciences, USA, 85, 9138-9142.
  • PINNACLE, D., STREAM, T. and GRAY, J. W., 1986, Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proceedings of the National Academy of Sciences, 83, 2934-2938.
  • POHL-RÜLING, J., FISCHER, P., HAAS, O., OBE, G., NATARAJAN, A. T., BUCKTON, K. E., BIANCHI, N. O., LARRAMENDY, M., KUCEROVA, M., POLIKOVA, Z., LEONARD, A., FARBY, L., PALITTI, F., SHARMA, T., BINDER, W., MUKERJEE, R. N. and MUKERJEE, U., 1983, Effect of low-dose X-irradiation on the frequencies of chromosomal aberrations in human peripheral lymphocytes in vivo. Mutation Research, 110, 71-82.
  • PONNAIYA, B., CORNFORTH, M. N. and ULLRICH, R. L., 1997, Radiation-induced chromosomal instability in BALB/c and C57 BL/6 mice; the difference is as clear as black and white. Radiation Research, 147, 121-125.
  • PRASAD, A. V., MOHAN, N., CHANDRASEKAR, B. and MELTZ, M., 1995, Induction of transcription of 'immediate early genes' by low-dose ionizing radiation. Radiation Research, 143, 263-272.
  • RAABE, O. G., CULBERTSON, M. R., WHITE, R. G., PARKS, N. J., SPANGLER, W. L. and SAMUELS, S. J., 1997, Lifetime radiation effects in Beagles injected with Ra as young adults. In G. van Kaick, A. Karaoglou and A. M. Kellerer (eds), Health Effects of Internally Deposited Radionuclides: Emphasis on Radium and Thorium (Singapore: World Scientific).
  • RAJU, M. R., EISEN, Y., CARPENTGER, S., JARRET, K. and HARVEY, W. F., 1993, Radiobiology of alpha particles. IV. Cell inactivation by alpha particles of energies 0.4-3.5MeV. Radiation Research, 133, 289-296.
  • RAMSEY, M. J., MOORE II, D. H., BRINER, J. F., LEE, D. A., OLSEN, L. A., SENFT, J. R. and TUCKER, J. D., 1995, The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting. Mutation Research, 338, 95-106.
  • RITHIDECH, K., 1996, Identification of chromosome and gene changes during the development of radiation and benzene-induced murine myeloid leukemia. A report to DOE contract DE-AC02-76CH00016.
  • RITHIDECH, K., BOND, V. P., CRONKITE, E. P. and THOMPSON, M. H., 1993, A specific chromosomal deletion in murine leukemic cells induced by radiation with different qualities. Experimental Hematology, 2, 427-431.
  • RITHIDECH, K., BOND, V. P., CRONKITE, E. P., THOMPSON, M. H. and BULLIS, J. E., 1991, Characterization of radiationinduced murine myelogenous leukemia. Environmental and Molecular Mutagens, 17(suppl. 19), 61.
  • RODENHUIS, S., SLEBOS, R. J. and BOOT, A. J., 1990, Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Cancer Research, 48, 5738-5741.
  • ROWLEY, J. D., 1980, The Philadelphia chromosome translocation. A paradigm for understanding leukemia, Cancer, 65, 2178-2184.
  • RUSSELL, N. S., GRUMMELS, A., HART, A. A. M., SMOLDERS, I. J. H., BORGER, J., BARTELINK, H. and BEGG, A. C., 1998, Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer. International Journal of Radiation Biology, 73, 661-670.
  • SACCO, M. G., ZACCA, L., BAGNASCO, L., CHIESA, G., PAROLINI, C., BROMLEY, P., CATO, E. M., RONCUCCI, R., CLERICI, L. A. and VEZZONI, P., 1997, A transgenic mouse model for the detection of cellular stress induced by toxic inorganic compounds. Nature Biotechnology, 14, 1329-1397.
  • SAENKO, A. S., ZAMULAEVA, I. A., SMIRNOVA, S. G., ORLOVA, N. V., SELIVANOVA, E. I., SAENKO, V. A., MATVEEVA, N. P., KAPLAN, M. A., NUGIS, V. Y., NADEZHINA, N. M. and TSYB, A. F., 1998, Determination of somatic mutant frequencies at glycophorin A and T-cell receptor loci for biodosimetry of prolonged irradiation. International Journal of Radiation Biology, 73, 613-618.
  • SANDBERG, A. A., CLAUDE, T.-C. and GEMMILL, R. M., 1988, Chromosomes in solid tumors and beyond. Cancer Research, 48, 1049-1059.
  • SANFORD, K. K., PARSHAD, R., GANTT, R., TARONE, R. E., JONES, G. M. and PRICE, F. M., 1989, Factors affecting and significance of Gs chromatid radiosensitivity in predisposition to cancer. International Journal of Radiation Biology, 55, 963-981.
  • SANKARANARAYANAN, K. and CHAKKRABORTH, R., 1995, Cancer predisposition, radiosensitivity and the risk of radiationinduced cancers. I. Background. Radiation Research, 143, 121-143.
  • SASAKI, M. S., 1983, Use of lymphocyte chromosome aberrations in biological dosimetry: possibilities and limitations. In T. Ishihara and M. S. Sasaki (eds), Radiation-induced Chromosome Damage in Man (New York: Alan R. Liss), pp. 585-604.
  • SAVAGE, J. R. K. and PAPWORTH, D. G., 1996, Comment on the ratio of chromosome-type dicentric interchanges to centric rings for track-clustered compared with random breaks. Radiation Research, 146, 236-240.
  • SAVAGE, J. R. K. and SIMPSON, P. J., 1994a, On the scoring of FISH-'painted' chromosome exchange aberrations. Mutation Research, 307, 345-353.
  • SAVAGE, J. R. K. and SIMPSON, P. J., 1994b, FISH 'painting' patterns resulting from complex exchanges. Mutation Research, 312, 51-60.
  • SAVITSKY, K., SFEZ, S., TAGIE, D. A., ZIV, Y., SARTIEL, A., SHILOH, Y. and ROTMAN, G., 1995, The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Human Molecular Genetics, 4, 2025-2032.
  • SCHRÖCK, E., DUMANOIR, S., VELDMAN, T., SCHOELL, B., WIENBERG, J., FERGUSON-SMITH, M. A., NING, Y., LEDBETTER, D.H., BAR-AM, I., SOENKSEN, D., GARINI, Y. and REID, T., 1996, Multicolor spectral karyotyping of human chromosomes. Science, 273, 494-497.
  • SCOTT, D., BARBER, J. B. P., SPREADBOROUGH, A. R., BURRILL, W. and ROBERTS, S. A., 1999, Increased chromosomal radiosensitivity in breast cancer patients: a comparison of two assays. International Journal of Radiation Biology, 75, 1-10.
  • SCOTT, D., SPREADBOROUGH, A. R., JONES, L. A., ROBERTS, S. A. and MOORE, C. J., 1996, Chromosomal radiosensitivity in G2-phase lymphocytes as an indicator of cancer predisposition. Radiation Research, 145, 3-16.
  • SHIMAHARA, H., KATO, T., HIRAI, Y. and AKAYAMA, M., 1995, Spectrum of in vivo HPRT mutations in T lymphocytes from atomic bomb survivors. I. Sequence alterations in cDNA. Caranogenesis, 16, 583-591.
  • SIMPSON, P. J. and SAVAGE, J. R. K., 1995a, Detecting 'hidden' exchange events within X-ray induced aberrations using multi-colour chromosome paints. Chromosome Research, 3, 69-72.
  • SIMPSON, P. J. and SAVAGE, J. R. K., 1995b, Estimating the true frequency of X-ray induced complex chromosome exchanges using florescence in situ hybridization. International Journal of Radiation Biology, 67, 37-45.
  • SLOZINA, N., NERONOVA, E., KHARCHENKO, T. and NIKIFOROV, A., 1997, Increased level of chromosomal aberrations in lymphocytes of Chernobyl liquidators 6-10 years after the accident. Mutation Research, 379, 121-125.
  • SMIDA, J. ZITZELSBERGER, H., KELLERER, A. M., LEHMANN, L., MINKUS, G., NEGELE, T., SPELSBERG, F., HIEBER, L., DEMIDCHIK, E. P., LENGFELDER, E. and BAUCHINGER, M., 1997, p53 mutations in childhood thyroid tumors from Belarus and in thyroid tumours without radiation history. International Journal of Cancer, 73, 802-807.
  • SOINI, Y., VAHAKANGAS, K., NUORVA, K., KAMEL, D., LANE, D. P. and PAAKKO, P., 1992, p53 immunohistochemistry in malignant fibrous histiocytomas and other mesenchymal tumours. Journal of Pathology, 168, 29-33.
  • SPEICHER, M. R., BALLARD, S. G. and WARD, D. C., 1996, Karyotyping human chromosomes by combinatorial multi-fluor FISH. Nature, Genetics, 12, 368-375.
  • STANNARD, J. N., 1988, Radioactivity and Health: A. History. DOE/R1/01/1830-T59, DE88013791, UC-408 (Office of Scientific Information).
  • STRAUME, T. and BENDER, M. A., 1997, Issues in cytogenetic biological dosimetry: emphasis on radiation environments in space. Radiation Research, 148, S60-70.
  • STRAUME, T., LONGLOIS, R. G., LUCAS, J., JENSEN, R. H., BIGBEE, W. L., RAMÃLHO, A. T. and BRANDAOMELLO, C. E., 1991, Novel biodosimetry methods applied to victims of the Goiânia accident. Health Physics, 60, 71-76.
  • TAMPLIN, A. R. and COCHRAN, T. B., 1974, Radiation standards for hot particles. A report on the inadequacy of existing radiation protection standards related to internal exposures of man to insoluble particles of plutonium and other alpha-emitting hot particles. In Natural Resources Defense Council Report (Washington, DC).
  • TAUB, R., MOULDING, C., BETTEY, J., MURPHY, W., VASICEK, T., LENOIR, G. M. and LEDER, P., 1984, Activation and somatic mutation of the translocated c-myc gene in Burkitt Lymphoma cells. Cell, 36, 339-384.
  • TAYLOR, A. M. R., 1998, What has the cloning of the ATM gene told us about ataxia-telangiectasia? International Journal of Radiation Biology, 73, 365-371.
  • TAYLOR, J. A., WATSON, M. A., DEVEREUS, T. R., MICHELS, R. Y., SACCOMANNO, G. and ANDERSON, M., 1994, p53 mutation hotspot in radon-associated lung cancer. Lancet, 343, 86-87.
  • TEMPEST, P. R., REEVES, B. R., SPURR, N. K., RANCE, A. J., LUHAN, A. M. and BROOKES, P., 1986, Activation of the met oncogene in the human MNG-HOS cell line involves a chromosomal rearrangement. Cardnogenesis, 7, 2051-2057.
  • TKACHUK, D. C., WESTBROOK, C. A., ANDREEFF, M., DONLON, T. A., CLEARKY, M. L., SURYANARAYAN, K., HOMGE, M., REDNER, A., GRAY, J. and PINKEL, D., 1990, Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization. Science, 250, 559-561.
  • TUCKER, J. D., LEE, D. A., RAMSEY, M. J., BRINER, J., OLSEN, L. and MOORE, D. H., II, 1994, On the frequency of chromosome exchanges in a control population measured by chromosome painting. Mutation Research, 313, 193-202.
  • TUCKER, J. D., MORGAN, W. F., AWA, A. A., BAUCHINGER, M., BLAKEY, D., CORNFORTH, M. N., LITTLEFIELD, L. G., NATARAJAN, A. T. and SHASSERRE, C., 1995, A proposed system for scoring structural aberrations detected by chromosome painting. Cytogmetics and Cell Genetics, 68, 211-221.
  • TURNER, D. R., GRIST, S. A., JANATIPOUR, M. and MORLEY, A. A., 1988, Mutations in human lymphocytes commonly involve gene duplication and resemble those seen in cancer cells. Proceedings of the National Academy of Sciences, USA, 85, 3189-3192.
  • ULLRICH, R. L. and STORER, J. B., 1979, Influence of gamma irradiation on the development of neoplastic disease in mice. III. Dose-rate effects. Radiation Research, 80, 325-342.
  • VAHAKANGAS, K. H., SAMET, J. H., METCALF, R. A., WELSH, J. A., BENNETT, W. P., LANE, D. P. and HARRIS, C. C., 1992, Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners. Lancet, 339, 576-580.
  • VAN KAICK, G., WESCH, H., LÖHRS, H., LIEBERMANN, D. and KAUL, A., 1995, Epidemiological results and dosimetric calculations - an update of the German Thorotrast study. In G. van Kaick, A. Karaoglou and A. M. Kellerer (eds), Health Effects of Internally Deposited Radionulcides, Emphasis on Radium and Thorium (Singapore: World Scientific), pp. 171-177.
  • VOGELSTEIN, B., FEARON, E. R., HAMILTON, S. R., KERN, S. E., PREISINGER, A. C., LEPPERT, M., NAKAMURA, Y., WHITE, R., SMITS, A. M. M. and BOS, J. L., 1988, Genetic alterations during colorectal-tumor development. New England Journal of Medicine, 319, 525-532.
  • WARD, J. F., 1994, The complexity of DNA damage: relevance to biological consequences. International Journal of Radiation Biology, 66, 427-432.
  • WEST, C. M., DAVIDSON, S. E., ELAAN, S. A., SWINDELL, R., ROBERTS, S. A., ORTON, C. J., COYLE, C. A., VALENTINE, H., WILKS, D. P., HUNTER, R., D. and HENDRY, J. H., 1998, The intrinsic radiosensitivity of normal and tumour cells. International Journal of Radiation Biology, 73, 409-413.
  • WHELAN, G., BUCK, J. W., STRENGE, D. L., DROPPO, JR, J. G., HOOPES, B. L. and AIKEN, R. J., 1992, Overview of the multimedia environmental pollutant assessment system (MEPAS) In Hazardous Waste and Hazardous Materials, vol. 9 (Mary Ann Liebert), pp. 191-208.
  • WHITEHOUSE, C. A., TAWN, E. J. and RIDDELL, A. E., 1998, Chromosome aberrations in radiation workers with internal deposits of plutonium. Radiation Research, 150, 459-468.
  • WISHKERMAN, V. Y., OUASTEL, M. R., DOUVDEVANI, A. and GOLDSMITH, J. R., 1997, Somatic mutations at the glycophorin A (GPA) locus measured in red cells of Chernobyl liquidators who immigrated to Israel. Environmental Health Perspectives, 105 (suppl. 6), 1451-1454.
  • WOLFF, S., 1996, Aspects of the adaptive response to very low doses of radiation and other agents. Mutation Research, 358, 135-142.
  • WOLFF, S., 1998, The adaptive response in radiobiology: evolving insights and implications. Environmental Health Perspectives, 106, 277-283.
  • WOLFF, S., AFZAL, V., WIENCKE, J. K., OLIVIERI, G. and MICHAELI, A., 1988, Human lymphocytes exposed to low doses of ionizing radiations become refractory to high doses of radiation as well as to chemical mutagens that induce double-strand breaks in DNA. International Journal of Radiation Biology, 53, 39-48.
  • WOOSTER, R., HEUHAUSEN, S. L., MANGION, J., QUIRK, Y., FORD, D., COLLINS, N., NGUYEN, K., SEAL, S., TRAN, T., AVERILL, D., FIELDS, P., MARSHALL, G., NAROD, S., LENOIR, G. M., LYNCH, H., FEUNTEUN, J., DEVILEE, P., CORNELISSE, C. J., MENKO, F. H., DALY, P. A., ORMISTON, W., MCMANUS, R., PYE, C., LEWIS, C. M., CANNON-ALBRIGHT, L. A., PETO, J., PONDER, B. A. J., SKOLNICK, M. H., EASTON, D. F., GOLDGAR, D. E. and STRATTON, M. R., 1994, Localization of a breast cancer susceptibility gene, BRCA2, to Chromosome 13q 12-13. Science, 265, 2088-2090.

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