Advanced search
Publication Cover
International Journal of Radiation Biology Volume 75, 1999 - Issue 12
Submit an article Journal homepage
30
Views
23
CrossRef citations to date
0
Altmetric
Research Article

Underestimation of the small residual damage when measuring DNA double-strand breaks (DSB): is the repair of radiation-induced DSB complete?

N. Foray
,
C. F. Arlett MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, BN1 9RR, UK.
&
E. P. Malaise
Pages 1589-1595 | Published online: 03 Jul 2009

  • AGER, D. D. and DEWEY, W. C., 1990, Calibration of pulsed field gel electrophoresis for measurement of DNA doublestrand breaks. International Journal of Radiation Biology, 58, 242-259.
  • BADIE, C., ILIAKIS, G., FORAY, N., ALSBEIH, G., CEDERVALL, B., CHAVAUDRA, N., PANTELIAS, G., ARLETT, C. F. and MALAISE, E. P., 1995, Induction and rejoining of DNA double-strand breaks and interphase chromosome breaks after exposure to X rays in one normal and two hypersensitive human fibroblast cell lines. Radiation Research, 144, 26-35.
  • BLÖCHER, D., 1990, In CHEF electrophoresis a linear induction of dsb corresponds to a nonlinear fraction of extracted DNA with dose. International Journal of Radiation Biology, 57, 7-12.
  • BRYANT, P. E., 1988, Use of restriction endonucleases to study relationships between DNA double-strand breaks, chromosomal aberrations and other end-points in mammalian cells. International Journal of Radiation Biology, 54, 869-890.
  • CEDERVALL, B. and KÄLLMAN, P., 1994, Randomly distributed DNA double-strand breaks as measured by pulsed field gel electrophoresis: a series of explanatory calculations. Radiation and Environmental Biophysics, 33, 9-21.
  • CEDERVALL, B, KÄLLMAN, P. and DEWEY, W. C., 1995, Repair of DNA double-strand breaks: errors encountered in the determination of half-times in pulsed field gel electrophoresis and neutral filter elution. Radiation Research, 142, 23-28.
  • COOK, V. E. and MORTIMER, R. K., 1991, A quantitative model of DNA fragments by ionizing radiation and possible experimental applications. Radiation Research, 125, 102-106.
  • ERIXON, K., CEDERVALL, B. and LEWENSOHN, R., 1990, Pulsedfield gel electrophoresis for measuring radiation-induced DNA double-strand breaks. Comparison to the method of neutral filter elution. In Ionizing radiation damage to DNA: molecular aspects. UCLA Symposium on Molecular and Cellular Biology, edited by R. Painter and S. Wallace (New York: Wiley), 136, pp. 69-80.
  • FORAY, N., FERTIL, B., ALSBEIH, M. G. A., BADIE, C., CHAVAUDRA, N., ILIAKIS, G. and MALAISE, E. P., 1996a, Dose-rate effect on radiation-induced DNA double-strand breaks in the human fibroblast HF19 cell line. International Journal of Radiation Biology, 69, 241-249.
  • FORAY, N., BADIE, C., ALSBEIH, G., FERTIL, B. and MALAISE, E. P., 1996b, A new model describing the curves for repair of both DNA double-strand breaks and chromosome damage. Radiation Research, 146, 53-60.
  • FORAY, N., ARLETT, C. F. and MALAISE, E. P., 1997a, Radiationinduced DNA double-strand breaks and radiosensitivity of human cells. A closer look. Biochimie, 49, 000-000.
  • FORAY, N., PRIESTLEY, A., ALSBEIH, G., BADIE, C., CAPULAS, E. P., ARLETT, C. F. and MALAISE, E. P., 1997b, Hypersensitivity of Ataxia-Telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks. International Journal of Radiation Biology, 72, 271-285.
  • GARRETT, W. R. and PAYNE, M. G., 1978, Applications of models for cell survival: the fixation time picture. Radiation Research, 73, 201-211.
  • ILIAKIS, G., 1988, Radiation-induced potentially lethal damage: DNA lesions susceptible to fixation. International Journal of Radiation Biology, 53, 541-584.
  • ILIAKIS, G., 1991, The role of DNA double strand breaks in ionizing radiation-induced killing of eukaryotic cells. Bioessays, 13, 641-648.
  • ILIAKIS, G. E., CICILIONI, O. and METZGER, L., 1991, Measurement of DNA double-strand breaks in CHO at various stages of the cell cycle using pulsed field gel electrophoresis: calibration by means of 1251 decay. International Journal of Radiation Biology, 59, 343-357.
  • KILTIE, A. E., ORTON, C. J., RYAN, A. J., ROBERTS, S. A., MARPLES, B., DAVIDSON, S. E., HUNTER, R. D., MARGISON, G. P., WEST, C. M. and HENDRY, J. H., 1997, A correlation between residual DNA double-strand breaks and clonogenic measurements of radiosensitivity in fibroblasts from preradiotherapy cervix cancer patients. International Journal of Radiation Oncology Biology and Physics, 39, 1137-1144.
  • LÖBRICH, M., RYDBERG, B. and COOPER, P. K., 1994, DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. II. Probing individual NotI fragments by hybridization. Radiation Research, 139, 142-151.
  • MACMILLAN, T. J. and STEEL, G. G., 1993, Molecular aspects of radiation biology. In Basic Clinical Radiobiology, edited by G. G. Steel (London: Edward Arnold), pp. 211-224.
  • MORGAN, W. F., CORCORAN, J., HARTMANN, A., KAPLAN, M. I., LIMOLI, C. L. and PONNAIYA, B., 1998, DNA doublestrand breaks, chromosomal rearrangements and genomic instability. Mutation Research, 404, 125-128.
  • RADIVOYEVITCH, T., HOEL, D. G., HAHNFELDT, P. and SACHS, R. K., 1998, Size distributions of misrejoining DNA fragments in irradiated cells. Mathematics Bioscience, 149, 107-136.
  • RUIZ DE ALMODOVAR, J. M., STEEL, G.G., WHITAKER, S. J. and MACMILLAN, T. J., 1994, A comparison of methods for calculating DNA double-strand break induction frequency in mammalian cells by PFGE. International Journal of Radiation Biology, 65, 641-649.
  • RYDBERG, B., LÖBRICH, M. and COOPER, P. K., 1994, DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. I. Pulsed-field gel electrophoresis method. Radiation Research, 139, 133-141.
  • ZHOU, P. K., SPROSTON, A. R., MARPLES, B., WEST, C. M., MARGISON, G. P. and HENDRY, J. H., 1998, The radiosensitivity of human fibroblast cell lines correlates with residual levels of DNA double-strand breaks. Radiotherapy and Oncology, 47, 271-276.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.