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Research Article

Clustering of radiation-produced breaks along chromosomes: modelling the effects on chromosome aberrations

Pages 657-672 | Published online: 03 Jul 2009

  • BAUCHINGER, M. and SCHMID, E., 1998, LET dependence of yield ratios of radiation-induced intra- and interchromosomal aberrations in human lymphocytes. International Journal of Radiation Biology, 74, 17-25.
  • BOEI, J. J. and NATARAJAN, A. T., 1998, Combined use of chromosome painting and telomere detection to analyse radiation-induced chromosomal aberrations in mouse splenocytes. International Journal of Radiation Biology, 73, 125-133.
  • BOEI, J. J., VERMEUIEN, S., FOMINA, J. and NATARAJAN, A. T., 1998, Detection of incomplete exchanges and interstitial fragments in X-irradiated human lymphocytes using a telomeric PNA probe. International Journal of Radiation Biology, 73, 599-603.
  • BROWN, J. M. and KOVACS, M. S., 1993, Visualization of nonreciprocal chromosome exchanges in irradiated human fihroblasts by fluorescence in situ hybridization. Radiation Research, 136, 71-76.
  • CHADWICK, K. H. and LEENHOUTS, H. P., 1981, The Molecular Theory of Radiation Biology (New York: Springer-Verlag), pp. 62-63 and 126-132.
  • CHADWICK, K. H. and LEENHOUTS, H. P., 1998, Radiation induced chromosome aberrations: some biophysical considerations. Mutation Research, 404, 113-117.
  • CHEN, A. M., HAHNFELDT, P. and SACHS, R. K., 1998, Chromosome aberration simulator (CAS). User's manual, source code and executables for UNIX or Windows95/98 available on request or via anonymous Ap at math.-berkeley.edu (directory pub/Preprints/Rainer_Sachs/CAS) or from URL http://math.berkeley.edu/chen/.
  • CHEN, A. M., LUCAS, J. N., BRENNER, D. J., HILL, F. S. and SACHS, R. K., 1996, Proximity effects for chromosome aberrations measured by FISH. International Journal of Radiation Biology, 69,411-420.
  • CHEN, A. M., LUCAS, J. N., HILL, F. S., BRENNER, D. J. and SACHS, R. K., 1995, Chromosomal aberrations produced by ionizing radiation: Monte Carlo simulations and chromosome painting data. Computer Applications in the Biosciences (CABIOS), 11, 389-397.
  • CHEN, A. M., LUCAS, J. N., SIMPSON, P. J., GRIFFIN, C. S, SAVAGE, J. R. K., BRENNER, D. J., HLATKY, L. R. and SACHS, R. K., 1997, Computer simulation of FISH data on chromosome aberrations produced by X-rays or a particles. Radiation Research, 148, S93-S101.
  • CORNFORTH, M. N., 1998, Radiation-induced damage and the formation of chromosomal aberrations. In DMA Damage and Repair, edited byJ. A. Nickoloff and M. F. Hoekstra (Totowa, NJ, Humana Press), pp. 559-585.
  • CORNFORTH, M. N. and BEDFORD, J., 1993, Ionizing radiation damage and its early development in chromosomes. In Advances in Radiation Biology, vol. 17. DNA and Chromatin Damage caused by Radiation, edited by J. T. Lett and W. K. Sinclair (San Diego: Academic Press), pp. 423-496.
  • EDWARDS, A. A., MOISEENKO, V. V. and NIKJOO, H., 1996, On the mechanism of the formation of chromosomal aberrations by ionizing radiation. Radiation and Environmental Biophysics, 35, 25-30.
  • EDWARDS, A. A. and SAVAGE, J. R. K., 1999, Is there a simple answer to the origin of complex exchanges? International Journal of Radiation Biology, 75, 19-22.
  • EVANS, J. W., LIU, X. F., KIRCHGESSNER, C. U. and BROWN, J. M., 1996, Induction and repair of chromosome aberrations in seid cells measured by premature chromosome condensation. Radiation Research, 145, 39-46.
  • GOODHEAD, D. T., THACKER, J. and Cox, R., 1993, Weiss Lecture. Effects of radiations of different qualities on cells: molecular mechanisms of damage and repair. International Journal of Radiation Biology, 63, 543-556.
  • GRIFFIN, C. S, HILL, M. A., PAPWORTH, D. G., TOWNSEND, K. M., SAVAGE, J. R. and GOODHEAD, D. T., 1998, Effectiveness of 0.28 keV carbon K ultrasoft X-rays at producing simple and complex chromosome exchanges in human fibroblasts in vitro detected using FISH. International Journal of Radiation Biology, 73, 591-598.
  • GRIFFIN, C. S., MARSDEN, S. J., STEVENS, D. L., SIMPSON, P. and SAVAGE, J. R., 1995, Frequencies of complex chromosome exchange aberrations induced by 238Pu alphaparticles and detected by fluorescence in situ hybridization using single chromosome-specific probes. International Journal of Radiation Biology, 67, 431-439.
  • HLATKY, L. R., SACHS, R. K. and HAHNFELDT, P., 1992, The ratio of centric rings to dicentrics in irradiated human lymphocytes. Radiation Research, 129, 304-308.
  • HOLLEY, W. R. and CHATTERJEE, A., 1996, Clusters of DNA induced by ionizing radiation: formation of short DNA fragments. I. Theoretical modeling. Radiation Research, 145, 188-199.
  • JOHNSTON, P. J., MACPHAIL, S. H., STAMATO, T. D., KIRCHGESSNER, C. U. and OLIVE, P. L., 1998, Higher-order chromatin structure-dependent repair of DNA double-strand breaks: involvement of the V(D)J recombination double-strand break repair pathway. Radiation Research, 149, 455-460.
  • JOHNSTON, P. J., OLIVE, P. L. and BRYANT, P. E., 1997, Higherorder chromatin structure-dependent repair of DNA doublestrand breaks: modeling the elution of DNA from nudeoids. Radiation Research, 148, 561-567.
  • KNEHR, S., ZITZELSBERGER, H., BRASELMANN, H., NAHRSTEDT, U. and BAUCHINGER, M., 1996, Chromosome analysis by fluorescence in situ hybridization: further indications for a non-DNA-proportional involvement of single chromosomes in radiation-induced structural aberrations. International Journal of Radiation Biology, 70, 385-392.
  • KNEHR, S, ZITZELSBERGER, H., NAHRSTEDT, U. and BAUCHINGER, M., 1998, FISH-based analysis of radiation-induced chromosomal aberrations using different nomenclature systems. International Journal of Radiation Biology, 73, 135-141.
  • KODAMA, Y., NAKANO, M., OHTAKI, K., AWA, A. A., NAKAMURA, N. and DELONGCHAMP, R., 1997, Estimation of minimal size of translocated chromosome segments detectable by fluorescence in situ hybridization. International Journal of Radiation Biology, 71, 35-39.
  • KRAXENBERGER, A., 1996, Verbesserungen der Methoden zur Pulsfeld-Gelektrophorese and Anwendung der Technik auf die Analyse von DNA-Schaeden durch dicht ionisierende Strahlung, Thesis. (Technische Universitaet Muenchen, Munich, Germany), pp. 74-91.
  • LEA, D. E., 1946, Actions of Radiations on Hang Cells (London: Cambridge University Press).
  • LIEBER, M. R., GRAWUNDER, U., Wu, X. and YANEVA, M., 1997, Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks. Current Option m Genetics ami Development, 7, 99-104.
  • LINDHOLM, C., LUOMAHAARA, S., KOIVISTOINEN, A., ILUS, T., EDWARDS, A. A. and SALOMAA, S., 1998, Comparison of dose-response curves for chromosomal aberrations established by chromosome painting and conventional analysis. International Journal of Radiation Biology, 74, 27-34.
  • LOBRICH, M., COOPER, P. K. and RYDBERG, B., 1996, Non-random distribution of DNA double-strand breaks induced by particle irradiation. International Journal of Radiation Biology, 70, 493-503.
  • LUCAS, J. N., AWA, A., STRAUME, T., POGGENSEE, M., KODAMA, Y., NAKANO, M., OHTAKI, K., WEIER, H. U., PINKEL, D., GRAY, J. and LITTLEFIELD, G., 1992, Rapid translocation frequency analysis in humans decades after exposure to ionizing radiation. International Journal of Radialion Biology, 62, 53-63.
  • LUCAS, J. N., CHEN, A. M. and SACHS, R. K., 1996, Theoretical predictions on equality of radiation-produced dicentrics and translocations detected by chromosome painting. International Journal of Radiation Biology, 69, 145-153.
  • LUCAS, J. N. and SACHS, R. K., 1993, Using 3-colour chromosome painting to decide between chromosome aberration models. Proceedings of the National Academy of Sciences, USA, 90, 1484-1487.
  • MOISEENKO, V. V., EDWARDS, A. A. and NIKJOO, N., 1996, Modelling the kinetics of chromosome exchange formation in human cells exposed to ionising radiation. Radiation and Environmental Biophysics, 35, 31-35.
  • NEWMAN, H. C., PRI, K. M., FOLKARD, M. and MICHAEL, B. D., 1997, DNA double-strand break distributions in X-ray and alpha-particle irradiated V97 cells: evidence for non-random breakage. International Journal of Radiation Biology, 71, 347-363.
  • OTTOLENGHI, A., MERZAGORA, M. and PARETZKE, H. G., 1997, DNA complex lesions induced by protons and alphaparticles: track structure characteristics determining linear energy transfer and particle type dependence. Radiation and Environmental Biophysics, 36, 97-103.
  • PANG, D., VIDIC, B., RODGERS, J., BERMAN, B. L. and DRITSCHILO, A., 1997, Atomic force microscope imaging of DNA and DNA repair proteins: applications in radiobiological research. Radiation Oncology Investigations, 5, 163-169.
  • RADIVOYEVITCH, T., 1997, Mathematical models of misrejoining DNA double-strand breaks and DNA fragment size distributions, PhD Thesis. Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC, USA.
  • RADIVOYEVITCH, T., HOEL, D. G., HAHNFELDT, P. H., RYDBERG, B. and SACHS, R. K., 1998, Recent data obtained by pubedfield gel electrophoresis suggest two types of double-strand breaks. Radiation Research, 149, 52-58.
  • REVELL, S. H., 1974, The breakage-and-rejoining theory and the exchange theory for chromosomal aberrations induced by ionizing radiation: a short history. Advances in Radiation Biology, 4, 367-416.
  • RYDBERG, B., 1996, Clusters of DNA damage induced by ionizing radiation: formation of short DNA fragments. II. Experimental detection. Radiation Research, 145, 200-209.
  • SABATIER, L., AL ACHKAR, W., HOFFSCHIR, F., LUCCIONI, C. and DUIRILLAUX, B., 1987, Qualitative study of chromosomal lesions induced by neutrons and neon ions in human lymphocytes at GO phase. Mutation Research, 178, 91-97.
  • SACHS, R. K., BRENNER, D. J., CHEN, A. M., HAHNFELDT, P. and HLATKY, L. R., 1997b, Intra-arm and inter-arm chromosome interchanges: tools for probing chromatin geometry and dynamics, Radialion Research, 148, 330-339.
  • SACHS, R. K., BRENNER, D. J., HAHNFELDT, RJ. and HLATKY, L. R., 1998, A formalism for analyzing large-scale clustering of radiation-induced breaks along chromosomes. International Journal of Radiation Biology, 74, 185-206.
  • SACHS, R. K., CHEN, A. M. and BRENNER, D. J., 1997a, Review: proximity effects in the production of chromosome aberrations by ionizing radiation. International Journal of Radiation Biology, 71, 1-19.
  • SACHS, R. K., CHEN, P.-L., HAHNFELDT, P. L. and HLATKY, L. R., 1992, DNA damage caused by ionizing radiation. Mathematical Biasciences, 112, 271-303.
  • SAH, L., 1967, Abstract Algebra (New York: Academic Press), pp. 80-88.
  • SAVAGE, J. R., 1976, Classification and relationships of induced chromosomal structural changes. Journal of Medical Genetics, 1976, 103-122.
  • SAVAGE, J. R., 1996, Insight into sites. Mutation Research, 366, 81-95.
  • SAVAGE, J. R., 1998, A brief survey of aberration origin theories. Mutation Research, 404, 139-147.
  • SAVAGE, J. R. K. and PAPWORTH, D. G., 1982, Frequency and distribution studies of asymmetrical versus symmetrical chromosome aberrations. Mutation Research, 95, 7-18.
  • SAVAGE, J. R. K. and SIMPSON, P., 1994, FISH 'painting' patterns resulting from complex exchanges. Mutation Research, 312, 51-60.
  • SAVAGE, J. R. and TUCKER, J. D., 1996, Nomenclature systems for FISH-painted chromosome aberrations. Mutation Research, 366, 153-161.
  • SIMPSON, P. J., PAPWORTH, D. G. and SAVAGE, J. R. K., 1999, X-ray induced simple, pseudosimple, and complex exchanges involving two distinctly painted chromosomes. International Journal of Radiation Biology, 75, 11-180.
  • SIMPSON, P. J. and SAVAGE, J. R., 1995, Estimating the true frequency of X-ray-induced complex chromosome exchanges using fluorescence in situ hybridization. International Journal of Radiation Biology, 67, 37-45.
  • SIMPSON, P. J. and SAVAGE, J. R. K., 1996, Dose-response curves for simple and complex chromosome aberrations induced by X-rays and detected using fluorescence in situ hybridization. International Journal of Radiation Biology, 69, 429-436.
  • TUCKER, J. D, MORGAN, W. F, AWA, A. A., BAUCHINGER, M., BLAKELY, D., CORNFORTH, M. N., LITTLEFIELD, L. G., NATARAJAN, A. T. and SHASSERRE, C., 1995, PAINT: a proposed nomenclature for structural aberrations detected by whole chromosome painting. Mutation Research, 347, 21-24.
  • WU, H., DURANTE, M., SACHS, R. K. and YANG, T. C., 1997, A random walk model for interphase chromosomes and the relationship between centric rings, acentric rings and excess acentric fragments induced by low-LET radiation. International Journal of Radiation Biology, 71, 487-496.
  • WU, H., GEORGE, K. and YANG, T. C., 1998, Estimate of true incomplete exchanges using fluorescence in situ hybridization with telomere probes. International Journal of Radiation Biology, 73, 521-527.

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