Advanced search
Publication Cover
International Journal of Radiation Biology Volume 75, 1999 - Issue 6
Submit an article Journal homepage
17
Views
24
CrossRef citations to date
0
Altmetric
Research Article

Adaptation of human fibroblasts to radiation alters biases in DNA repair at the chromosomal level

E. J. BROOME, D. L. BROWN, R. E. J. MITCHEL Radiation Biology and Health Physics, Atomic Energy of Canada Limited, Chalk River, Ontario, Canada, K0J 1J0.
Pages 681-690 | Published online: 03 Jul 2009

  • AZZAM, E. I., DE TOLEDO, S. M., RAAPHORST, G. P. and MITCHEL, R. E. J., 1992, Radiation-induced radioresistance in a normal human skin fibroblast cell line. In Low Dose Irradiation and Biological Defense Mechanisms, edited by T. Sugahara, L. A. Sagan and T. Aoyoma (Amsterdam: Elsevier Science), pp. 291-294.
  • AZZAM, E. I., DE TOLEDO, S. M., RAAPHORST, G. P. and MITCHEL, R. E. J., 1994a, Adaptive response to ionizing radiation in normal human skin fibroblasts. Enhancement of DNA repair rate and modulation of gene expression. Journal de Chimie Physique et de Physico-Chimie Biologique, 91, 931-936.
  • AZZAM, E. I., DE TOLEDO, S. M., RAAPHORST, G. P. and MITCHEL, R. E. J., 1996, Low-dose ionizing radiation decreases the frequency of neoplastic transformation to a level below the spontaneous rate in C3H 10T1/2 cells. Radiation Research, 146, 369-373.
  • AZZAM, E. I., RAAPHORST, G. P. and MITCHEL, R. E. J., 1994b, Radiation-induced adaptive response for protection against micronucleus formation and neoplastic transformation in C3H 10T1/2 mouse embryo cells. Radiation Research, 138, S28-S31.
  • BARRIOS, L., MIRO, R., CABALUN, M. R., FUSTER, C., GUEDEA, F., SUBIAS, A. and EGOZCUE, J., 1989, Cytogenetic effects of radiotherapy. Breakpoint distribution in induced chromosome aberrations. Cancer Genetics and Cytogenetics, 41, 61-70.
  • BAUCHINGER, M. and GOTZ, G., 1979, Distribution of radiation induced lesions in human chromosomes and dose-effect relation analyzed with G-banding. Radiation and Environmental Biophysics, 16, 355-366.
  • BOEI, J. J. W. A., VERMEULEN, S. and NATARAJAN, A. T., 1996, Detection of chromosomal aberrations by fluorescence in situ hybridization in the first three postirradiation divisions of human lymphocytes. Mutation Research, 349, 127-135.
  • BOREHAM, D. R., TRIVEDI, A. and MITCHEL, R. E. J., 1991, Radiation and stress response in Saccharomyces cerevisiae. In Yeast Molecular Biology and Biotechnology, edited by R. Prasad (New Delhi: Omega Scientific), pp. 294-314.
  • BROOME, E. J., BROWN, D. L. and MITCHEL, R. E. J., 1999, Fluorescence in situ hybridization of micronuclei in binucleate fibroblasts: a protocol for cytoplasm preservation. BioTectmiques (in press).
  • BUCKTON, K. E., 1976, Identification with G and R banding of the position of breakage points induced in human chromosomes by in vitro X-irradiation. International Journal of Radiation Biology, 29, 475-488.
  • BUCKTON, K. E., 1983, Chromosome aberrations in patients treated with X-irradiation for ankylosing spondylitis. In Radiation-Induced Chromosome Damage in Man, edited by T. Ishihara and M. S. Sasaki (New York: Liss), pp. 491-511.
  • COOKE, P., SEABRIGHT, M. and WHEELER, M., 1975, The differential distribution of X-ray induced chromosome lesions in trypsin-banded preparations from human subjects. Humangenetik, 28, 221-231.
  • CREGAN, S. P., BOREHAM, D. R., WALKER, P. R., BROWN, D. L. and MITCHEL, R. E. J., 1994, Modification of radiationinduced apoptosis in radiation- or hyperthermia-adapted human lymphocytes. Biochemistry and Cell Biology, 72, 475-482.
  • DOMINGUEZ, I., BOEI, J. J. W. A., BALAJEE, A. S. and NATARAIAN, A. T., 1996, Analysis of radiation-induced chromosome aberrations in Chinese hamster cells by FISH using chromosome-specific DNA libraries. International Journal of Radiation Biology, 70, 199-208.
  • DOMINGUEZ, I., PANNEERSELVAM, N., ESCALZA, P., NATARAIAN, A. T. and CORTES, F., 1993, Adaptive response to radiation damage in human lymphocytes conditioned with hydrogen peroxide as measured by the cytokinesisblock micronucleus technique. Mutation Research, 301, 135-141.
  • DRAPKIN, R., SANCAR, A. and REINBERG, D., 1994, Where transcription meets repair. Cell, 77, 9-12.
  • DUBOS, C., VIEGAS-PEQUIGNOT, E. and DUTRILLAUX, B., 1978, Localization of /-rays induced chromatid breaks using a three consecutive staining technique. Mutation Research, 49, 127-131.
  • DUTRILLAUX, B., COUTURIER, J., VIEGAS-PEQUIGNOT, E. and SCHAISON, G., 1977, Localization of chromatid breaks in Fanconi's Anemia, using three consecutive stains. Human Genetics, 37, 65-71.
  • DUTRILLAUX, B., VIEGAS-PEQUIGNOT, E., AURIAS, A., PROD'HOMME, M., SPORTES, M. and PRIEUR, M., 1981, Tentative estimate of the risk of chromosomal disease due to radiation-induced translocations in man. Mutation Research, 82, 191-200.
  • DUTRILLAUX, B, VIEGAS-PEQUIGNOT, E., MOUTHUY, M., ANTOINE, J.-L., PROD'HOMME, M. and SPORTES, M., 1983, Risk of chromosomal disease due to radiation. Tentative estimate from the study of radiation-induced translocations in human fibroblasts. Mutation Research, 119, 343-350.
  • FENECH, M., 1993, The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations. Mutation Research, 285, 35-44.
  • FENECH, M. and MORELY, A. A., 1985, Measurement of micronuclei in lymphocytes. Mutation Research, 147, 29-36.
  • FIMOGNARI, C., SAUER-NEHLS, S., BRASELMANN, H. and NUSSE, M., 1997, Analysis of radiation-induced micronuclei by FISH using a combination of painting and centromeric DNA probes. MutagenesL, 12, 91-95.
  • FINNON, P., LLOYD, D. C. and EDWARDS, A. A., 1995, Fluorescence in situ hybridization detection of chromosomal aberrations in human lymphocytes: applicability to biological dosimetry. International Journal of Radiation Biology, 68, 429-435.
  • GRANATH, F., GRIGOREVA, M. and NATARAJAN, A. T., 1996, DNA content proportionality and persistence of radiationinduced chromosomal aberrations studied by FISH. Mutation Research, 366, 145-152.
  • IKUSHIMA, T., 1987, Chromosomal responses to ionizing radiation reminiscent of an adaptive response in cultured Chinese hamster cells. Mutation Research, 180, 215-221.
  • IKUSHIMA, T., 1989, Radio-adaptive response: characterization of a cytogenetic repair induced by low-level ionizing radiation in cultured Chinese hamster cells. Mutation Research, 227, 241-246.
  • IKUSHIMA, T., ARITOMI, H. and M ORISTA, J., 1996, Radioadaptive response: Efficient repair of radiation-induced DNA damage in adapted cells. Mutation Research, 358, 193-198.
  • JALAL, S. M., LAW, M. E. and DEWALD, G. W., 1996, Atlas of Whole Chromosome Paint Probes. Normal Patterns and Utility for Abnormal Cases (Rochester: The Mayo Foundation for Medical Education and Research).
  • KANO, Y. and LITTLE, J. B., 1986, Site-specific chromosomal rearrangements induced in human diploid cells by x-irradiation. Cytogenetics and Cell Genetics, 41, 22-29.
  • KIM, J. H., LEE, K. J., CHO, C. K., Yoo, S. Y., KIM, T. H., Ji, Y. H. and KIM, S. H., 1995, Adaptive response induced by low dose ionizing radiation in human cervical carcinoma cells. Archwes of Pharmaceutical Research (Seoul), 18, 410-414.
  • KNEHR, S., ZITZELSBERGER, H., BRASELMANN, H. and BAUCHINGER, M., 1994, Analysis for DNA-proportional distribution of radiation-induced chromosome aberrations in various triple combinations of human chromosomes using fluorescence in situ hybridization. International Journal of Radiation Biology, 65, 683-690.
  • KNEHR, S., ZITZELSBERGER, H., BRASELMANN, H., NAHRSTEDT, U. and BAUCHINGER, M., 1996, Chromosome analysis by fluorescence in situ hybridization: further indications for a non-DNA-proportional involvement of single chromosomes in radiation-induced structural aberrations. International Journal of Radiation Biology, 70, 385-392.
  • KOVACS, M.S., EVANS, J. W., JOHNSTONE, I. M. and BROWN, J. M., 1994, Radiation-induced damage, repair and exchange formation in different chromosomes of human fibroblasts determined by fluorescence in situ hybridization. Radiation Research, 137, 34-43.
  • LE, X. C., XING, J. Z., LEE, J., LEADON, S. A. and WEINFELD, M., 1998, Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage. Science, 280, 1066-1069.
  • LEE, C. L. Y. and KAMRA, O. P., 1981, The pattern of radiationinduced transmissible aberrations in a human cell culture. Human Genetics, 57, 380-384.
  • LUCAS, J. N., AWA, A., STRAUME, T., POGGENSEE, M., KODAMA, Y,NAKANO, M., OHTAKI, K., WEIER, H.-U., PINKEL, D., GRAY, J. and LITTLEFIELD, G., 1992, Rapid translocation frequency analysis in humans decades after exposure to ionizing radiation. International Journal of Radiation Biology, 62, 53-63.
  • MITCHEL, R. E. J., AZZAM, E. I. and DE TOLEDO, S. M., 1997, Adaptation to ionizing radiation in mammalian cells. In Sfress-Inducible Processes in Higher Eukaryotic Cells, edited by T. M. Koval (New York: Plenum Press), pp. 221-243.
  • MITCHEL, R. E. J. and MORRISON, D. P., 1982, Heat-shock induction of ionizing radiation resistance in Saccharomyces cereaisiae. Transient changes in growth cycle distribution and recombinational ability. Radiation Research, 92, 182-187.
  • MITCHEL, R. E. J. and MORRISON, D. P., 1984, An oxygen effect for gamma-radiation induction of radiation resistance in yeast. Radiation Research, 100, 205-210.
  • MITCHEL, R. E. J. and MORRISON, D. P., 1987, Inducible DNArepair systems in yeast: Competition for lesions. Mutation Research, 183, 149-159.
  • MORTON, N. E., 1991, Parameters of the human genome. Proceedings of the National Academy of Sciences, USA, 88, 7474-7476.
  • MULLENDERS, L. H. F., VRIELING, H., VENEMA, J. and VANZEELAND, A. A., 1991, Hierarchies of DNA repair in mammalian cells: biological consequences. Mutation Research, 250, 223-228.
  • NATARAIAN, A. T., DARROUDI, F., VERMEULEN, S. and WIEGANT, J., 1992a, Frequency of X-ray and neutron induced chromosome translocations in human peripheral blood lymphocytes as detected by in situ hybridization using chromosome specific DNA libraries. In Low Dose Irradiation and Biological Defense Mechanisms, edited by T. Sugahara, L. A. Sagan and T. Aoyama (Amsterdam: Elsevier Science), pp. 343-346.
  • NATARAJAN, A. T., VYAS, R. C., DARROUDI, F. and VERMEULEN, S., 1992b, Frequencies of X-ray induced chromosome translocations in human peripheral lymphocytes as detected by in situ hybridization using chromosome specific DNA libraries. International Journal of Radiation Biology, 61, 199-203.
  • OLIVIERI, G., BODYCOTE, J. and WOLFF, S., 1984, Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. Science, 223, 594-597.
  • REDPATH, J. L. and ANTONIONO, R. J., 1998, Induction of an adaptive response against spontaneous neoplastic transformation in vitro by low-dose gamma radiation. Radiation Research, 149, 517-520.
  • RIGAUD, O. and MOUSTACCHI, E., 1996, Radioadaptation for gene mutation and the possible molecular mechanisms of the adaptive response. Mutation Research, 358, 127-134.
  • SACHS, R. K., AWA, A., KODAMA, Y., NAKANO, M., OHTAKI, K. and LUCAS, J. N., 1993, Ratios of radiation-produced chromosome aberrations as indicators of large-scale DNA geometry during interphase. Radiation Research, 133, 345-350.
  • SAN ROMAN, C. and BOBROW, M., 1973, The sites of radiation induced-breakage in human lymphocyte chromosomes, determined by quinacrine fluorescence. Mutation Research, 18, 325-331.
  • SHADiEY1J. D., 1994, Chromosomal adaptive response in human lymphocytes. Radiation Research, 138, S9-S12.
  • SHADLEY, J. D. and WIENCKE, J. K., 1989, Induction of the adaptive response by X-rays is dependent on radiation intensity. International Journal of Radiation Biology, 56, 107-118.
  • SLAVOTINEK, A., SAUER-NEHLS, S., BRASELMANN, H., TAYLOR, G. M. and NÜSSE, M., 1996, Chromosome painting of radiation-induced micronuclei. International Journal of Radiation Biology, 70, 393-401.
  • SLIJEPCEVIC, P. and NATARAJAN, A. T., 1994a, Distribution of radiation-induced Gl exchange and terminal deletion breakpoints in Chinese hamster chromosomes as detected by G banding. International Journal of Radiation Biology, 66, 747-755.
  • SLIJEPCEVIC, P. and NATARAJAN, A. T., 1994b, Distribution of X-ray induced G2 chromatid damage among Chinese hamster chromosomes: influence of chromatid configuration. Mutation Research, 323, 113-119.
  • SURRALLES, J., DARROUDI, F. and NATARAJAN, A. T., 1997b, Low level of DNA repair in human chromosome 1 heterochromatin. Genes, Chromosomes and Cancer, 20, 173-184.
  • SURRALLES, J., SEBASTCAN, S. and NATARAJAN, A. T., 1997a, Chromosomes with high gene density are preferentially repaired in human cells. Mutagenesis, 12, 437-442.
  • TANAKA, K., KAMADA, N., OHKITA, T. and KURAMOTO, A., 1983, Nonrandom distribution of chromosome breaks in lymphocytes of atomic bomb survivors. Journal of Radiation Research, 24, 291-304.
  • TAWN, E. J., 1988, The non-random occurrence of exchanges involving chromosomes 7 and 14 in human lymphocytes: a prospective study of control individuals. Mutation Research, 199, 215-220.
  • TELENIUS, H., CARTER, N. P., BEBB, C. E., NORDENSKJOLD, M., PONDER, B. A. and TUNNACLIFFE, A., 1992, Degenerate oligonucleotide-primed PCR: general amplification of target DNA by a single degenerate primer. Genomics, 13, 718-725.
  • VIJAYALAXMI, LEAL, B. Z., DEAHL, T. S. and MELTZ, M. L., 1995, Variability in adaptive response to low dose radiation in human blood lymphocytes: consistent results from chromosome aberrations and micronuclei. Mutation Research, 348, 45-50.
  • VRAL, A., THIERENS, H. and DE RIDDER, L., 1997, In vitro micronucleus-centromere assay to detect radiationdamage induced by low doses in human lymphocytes. International Journal of Radiation Biology, 71, 61-68.
  • WALKER, L-A., BOREHAM, D. R., UNRAU, P. and DUNCAN, A. M. V., 1996, Chromosome content and ultrastructure of radiation-induced micronuclei. Mutagenesis, 11, 419-424.
  • WOJCIK, A. and STREFFER, C., 1994, Adaptive response to ionizing radiation in mammalian cells: a review. Biologisches Zentralblatt, 113, 417-434.
  • WOJEWODZKA, M., KRUSZEWSKI, M. and SZUMIEL, L, 1996, AntiCD 38 prevents the development of the adaptive response induced by X-rays in human lymphocytes. Mutagenesis, 11, 593-596.
  • WOJEWODZKA, M., KRUSZEWSKI, M. and SZUMIEL, L, 1997, Effect of signal transduction inhibition in adapted lymphocytes: micronuclei frequency and DNA repair. International Journal of Radiation Biology, 71, 245-252.
  • WUTTKE, K., STREFFER, C. and MÜLLER, W.-U., 1997, Detection of chromosome 2 and chromosome 7 within X-ray- or colchicine-induced micronuclei by fluorescence in situ hybridization. Mutagenesis, 12, 55-59.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.