Advanced search
Publication Cover
International Journal of Radiation Biology Volume 75, 1999 - Issue 6
Submit an article Journal homepage
39
Views
53
CrossRef citations to date
0
Altmetric
Research Article

Protection against UV-induced systemic immunosuppression in mice by a single topical application of the antioxidant vitamins C and E

D. P. T. STEENVOORDEN, G. M. J. BEIJERSBERGEN VAN HENEGOUWEN Department of Medicinal Photochemistry, Leiden/Amsterdam Center for Drug Research, University of Leiden, PO Box 9502,2300 RA Leiden, The Netherlands.
Pages 747-755 | Published online: 03 Jul 2009

  • BEIIERSBERGEN VAN HENEGOUWEN, G. M. J., JUNGINGER, H.E. and DE VRIES, H., 1995, Hydrolysis of RRR-o-tocopherol acetate (vitamin E acetate) in the skin and its UVprotecting activity (an in vino study in the rat). Journal of Photochemistry and Photobiology. B, Biology, 29, 45-51.
  • BLACK, H. S., LENGER, W., MCCANN, V. and THORNBY, J. I., 1983, Relation of UV dose to antioxidant modification to photocarcinogenesis. Journal of the American College of Toxicology, 2, 201-207.
  • CHEN, F., Lu, Y., DEMERS, L. M., ROIANASAKUL, Y., SHI, X., VALLYATHAN, V. and CASTRANOVA, V., 1998, Role of hydroxyl radical in silica-induced NF-kappa B activation in macrophages. Annals of Clinical and Laboratory Science, 28, 1-13.
  • CHEN, W., BARTHELMAN, M., MARTINEZ, J., ALBERTS, D. and GENSLER, H. L., 1997, Inhibition of cyclobutane pyrimidine dimer formation in epidermal p53 gene of UV-irradiated mice by o-tocopherol. Nutrition and Cancer, 29,205-211.
  • CLEMENT-LACROIX, P., MICHEL, L., MOYSAN, A., MORLIERE, P. and DUBERTRET, L., 1996, UVA-induced immune suppression in human skin: protective effect of vitamin E in human epidermal cells in vitro. British Journal of Dermatology, 134, 77-84.
  • DARR, D., COMBS, S., DUNSTON, S., MANNING, T. and PINNELL, S., 1992, Topical vitamin C protects porcine skin fromultraviolet radiation-induced damage. British Journal of Dermatology, 127, 247-253.
  • DE FABO, E. C. and NOONAN, F. P., 1983, Mechanism of immune suppression by ultraviolet irradiation in vino. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology. Journal of Experimental Mediant, 157, 84-98.
  • DERIOS, G., CHAN, J. T., BLACK, H. S., RUDOLPH, A. H. and KNOX, J. M., 1978, Systemic protection by antioxidants against UVL-induced erythema. Journal of Investigative Dermatology, 70, 123-125.
  • FUCHS, J., HUFLEJT, M. E., ROTHFUSS, L. M., WILSON, D. S., CARCAMO, G. and PACKER, L., 1989, Impairment of enzymic and nonenzymic antioxidants in skin by UVB radiation. Journal of Investigative Dermatology, 93, 769-773.
  • GENSLER, H. L. and MAGDALENO, M., 1991, Topical vitamin E inhibition of immunosuppression and tumorigenesis induced by ultraviolet irradiation. Nutrition and Cancer, 15, 97-106.
  • HEMELAAR, P. J. and BEIIERSBERGEN VAN HENEGOUWEN, G. M. J., 1996, The protective effect of JV-acetylcysteine on UVB-induced immunosuppression by inhibition of the action of cis-urocanic acid. Photochemistry and Photobiology, 63, 322-327.
  • HORIO, T. and OKAMOTO, H., 1987, Oxygen intermediates are involved in ultraviolet radiation induced damage of Langerhans cells. Journal of Investigative Dermatology, 88, 699-702.
  • KOIZUMI, H., SHIMIZU, T., NISHINO, H. and OHKAWARA, A., 1998, Cif-urocanic acid attenuates histamine receptormediated activation of adenylate cyclase and increase in intracellular Ca2+ Archives of Dermatological Research, 290, 264-269.
  • KRIPKE, M. L., Cox, P. A., ALAS, L. G. and YAROSH, D. B., 1992, Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice. Proceedings of the National Academy of Sciences, USA, 89, 7516-7520.
  • LENARDO, M. J. and BALTIMORE, D., 1989, NF-kB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell, 58, 227-229.
  • LEUNG, H.-W., VANG, M. J. and MAVIS, R. D., 1981, The cooperative interaction between vitamin E and vitamin C in suppression of peroxidation of membrane phospholipids. Biochimica Biophysica Acta, 664, 266-272.
  • LIU, S. L., DEGLI-EPOSTI, S., YAO, T., DIEHL, A. M. and ZERN, M. A., 1995, Vitamin E therapy of acute CCH-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding. Hepatology, 22, 1474-1481.
  • McCAY, P. B., 1985, Vitamin E: interactions with free radicals and ascorbate. Annual Reviews in Nutrition, 5, 323-340.
  • MEYDANI, S. N., MEYDANI, M., VERDON, C. P., SHAPIRO, A. A., BLUMBERG, J. B. and HAYED, K. C., 1986, Vitamin E supplementation suppresses prostaglandin E2 synthesis and enhances the immune response of aged mice. Mechanisms of Ageing and Development, 34, 191-201.
  • MILLER, C. C., HALE, P. and PENTLAND, A. P., 1994, Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVBinduced epidermal growth factor receptor activation. Journal of Biological Chemistry, 269, 3529-3533.
  • MILLER, S. C., TAYLOR, A., WATANABE, K., MOK, K. and TORTI, F. M., 1997, Regulation of NFxB and HIV-I LTR activity in mouse L cells by ultraviolet radiation: LTR trans-activation in a nonirradiated genome in heterokaryons. Experimental CeU Research, 230, 9-21.
  • MUELLER, J. M., RUPEC, R. A. and BAEUERLE, P. A., 1997, Study of gene regulation by NFkB and AP-I in response to reactive oxygen intermediates. Methods: a companion to Methods in Enzymology, 11, 301-312.
  • NAKAMURA, T., PINNELL, S. R., DARR, D., KURIMOTO, I., ITAMI, S., YOSHIKAWA, K. and STREILEIN, J. W., 1997, Vitamin C abrigates the deleterious effects of UVB radiation on cutaneous immunity by a mechanism that does not depend on TNF-á Journal of Investigative Dermatology, 109, 20-24.
  • NIJMEIJER, B. A., STEENVOORDEN, D. P. T., BEIJERSBERGEN VAN HENEGOUWEN, G. M. J., ROZA, L. and VINK, A. A., 1998, The mechanism of N-acetylcysteine photoprotection is not related to dipyrimidine photoproducts. Journal of Photochemistry and Photobiology. B, Biology, 44, 225-230.
  • NIKI, E., NOGUCHI, N., TSCHUCHIHASHI, H. and GOTOH, N., 1995, Interaction among vitamin C, vitamin E, and ß-carotene. American Journal of Clinical Nutrition, 62, 1322S-1326S.
  • NOONAN, F. P. and DE FABO, E. C., 1990, Ultraviolet-B dose-response curves for local and systemic immunosuppression are identical. Photochemistry and Photobiology, 52, 801-810.
  • NOONAN, F. P. and DE FABO, E. C., 1992, Immunosuppression by ultraviolet B radiation: initiation by urocanic acid. Immunology Today, 13, 250-254.
  • NOONAN, F. P., DE FABO, E. C. and MORRISON, H., 1988, Cuurocanic acid, a product formed by ultraviolet B irradiation of the skin, initiates an antigen presenting defect in splenic dendritic cells in vitro. Journal of Investigative Dermatology, 90, 92-99.
  • NORVAL, M., GIBBS, N. K. and GILMOUR.J., 1995, The role of urocanic acid in UV-induced immunosuppression: recent advances (1992-1994). Photochemistry and Photobiology, 62, 209-217.
  • NORVAL, M., GILMOUR, J. W. and SIMPSON, T. J., 1990, The effect of histamine receptor antagonists on immunosuppression induced by the cis-isomer of urocanic acid. Photodermatology, Photommunology and Photomediane, 7, 243-248.
  • PESTERIS, P., CLARK, B. D., GATTI, S., FAGGIONI, R., MANTOVANI, M., MENGOZZI, M., ORENCOLE, S. F., SIRONI, M. and GHEZZI, P., 1992, P., N-acetylcysteine and glutathione as inhibitors of tumor necrosis factor production. Cell Immunology, 140, 390-399.
  • REEVE, V. E., GREENOAK, G. E., CANFIELD, P. J., BOEHMWILCOX, C. and GALLAGHER, C. H., 1989, Topical urocanic acid enhances UV-induced tumour yield and malignancy in the hairless mouse. Photochemistry and Photobiology, 49, 459-464.
  • SCHRECK, R., RIEBER, P. and BAEUERLE, P. A., 1991, Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kB transcription factor and HIV-I. European Molecular Biology Organisation Journal, 10, 2247-2258.
  • SCHUEP, W. and KECK, E., 1990, Measurement of ascorbic acid and erythorbic acid in processed meat by HPLC. Zweitschrift ßa Lebensrnittel-Untersuchung und -Forschung, 191, 290-292.
  • SHINDO, Y., WITT, E., HAN, D. and PACKER, L., 1994, Dose-response effects of acute ultraviolet irradiation on antioxidants and molecular markers of oxidation in murine epidermis. Journal of Investigative Dermatology, 104, 470-475.
  • STEENVOORDEN, D. P. T. and BEIJERSBERGENVANHENEGOUWEN, G. M. J., 1997, The use of endogenous antioxidants toimprove photoprotection. Journal of Photochemistry and Photobiology. B, Biology, 41, 1-10.
  • STCENVOORDEN, D. P. T. and BEIIER SBERGEN VAN HENEGOUWEN, G. M. J., 1998a, Glutathione synthesis is not involved in protection by N-acetylcysteine against UVB-induced systemic immunosuppression in mice. Photochemistry and Photobiology, 68, 97-100.
  • STCENVOORDEN, D. P. T. and BEIIER SBERGEN VAN HENEGOUWEN, G. M. J., 1998b, Glutathione-ethylester protects against ultraviolet B-induced local and systemic suppression of contact hypersensitivity in mice. Radiation Research, 150, 292-297.
  • ULLMAN, K. S., NORTHROP, J. P., VERWEII, C. L. and CRABTREE, G. R., 1990, Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. Annual Reviews in Immunology, 8, 421-452.
  • VALERIE, K., LASTER, W. S., CHENG, L., KIRKHAM, J. C., REAVEY, P. and KUEMMERLE, N. C., 1996, Signal transduction and HIV transcriptional activation after exposure to ultraviolet light and other DNA-damaging agents. Photochemistry and Photobiology, 64, 280-285.
  • VILE, G. F., TANEW-LLIITSCHEW, A. and TYRRELL, R. M., 1995, Activation of NF-xB in human skin fibroblasts by the oxidative stress generated by UVA radiation. Photochemistry and Photobiology, 62, 463-468.
  • YUEN, K. S. and HALIIDAY, G. M., 1997, o-Tocopherol, an inhibitor of epidermal lipid peroxidation, prevents ultraviolet radiation from suppressing the skin immune system. Photochemistry and Photobiology, 65, 587-592.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.