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International Journal of Radiation Biology Volume 75, 1999 - Issue 6
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Research Article

Ionizing radiation alters hepatic cholesterol metabolism and plasma lipoproteins in Syrian hamster

C. FEURGARD, N. BOEHLER, J. FEREZOU, C. SEROUGNE, J. AIGUEPERSE, P. GOURMELON, C. LUTTON, D. MATHE Institut de Protection et de Surete Nucleaire, Departement de Protection de la sante de l’Homme et de Dosimetrie, Section Autonome de Radiobiologie Appliquee a la Medecine, IPSN,BP n 6, F-92265 Fontenay-Aux-Roses Cedex, France.
Pages 757-766 | Published online: 03 Jul 2009

  • AUERBACH, B. J. and PARKS, J. S., 1989, Lipoprotein abnormalities associated with lipopolysaccharide-induced lecithin:cholesterol acyltransferase and lipase deficiency. Journal of Biological Chemistry, 264, 10264-10270.
  • BECCIOLINI, A., BALZI, M. and POTTEN, C. S., 1995, Radiation effects on proliferation and differentiation in the rat small intestine. In C. S. Potten and J. M. Hendry (eds), Radiation and Gut (Amsterdam: Elsevier), pp. 85-143.
  • BERROUD, A., LE ROY, A. and VOISIN, P., 1996, Membrane oxidative damage induced by ionizing radiation detected by fluorescence polarization. Radiation and Environmental Biophysics, 33, 455-471.
  • BONNEFONT-ROUSSELOT, D., GARDES-ALBERT, M., DELATTRE, J. and FERRADINI, C., 1993, Oxidation of low-density lipoproteins by OH' and OH/O2 free radicals produced by gamma radiolysis. Radiation Research, 134, 271-282.
  • CHEETHAM, P. M. S. J., 1979, Removal of Triton X100 from aqueous solution using amberlite XAD-2. Analytical Biochemistry, 92, 447-452.
  • DIETSCHY, J. M., TURLEY, S. D. and SPADY, D. K., 1993, Role of liver in the maintenance of cholesterol and low-densitylipoprotein homeostasis in different animal species, including humans. Journal of Lipid Research, 34, 1637-1659.
  • DOUSSET, N., FELISTE, R., CARTON, M. and DOUSTE-BLAZY, L., 1984, Irradiation-induced free cholesterol accumulation in very low-density lipoproteins. Role of lipoprotein lipase deficiency. Biochimica et Biophysica Ada, 794, 444-453.
  • ESTERBAUER, H., TRIEGL, G., PUHL, H. and ROTHENER, M., 1989, Continuous monitoring of in vitro oxidation of human low-density lipoprotein. Free Radical Research Communications, 6, 67-75.
  • FEINGOLD, K. R. and GRUNFELD, C., 1987, Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo. Journal of Clinical Investigation, 80, 184-190.
  • FEINGOLD, K. R., FUNK, J. L., MOSER, A. H., SHIGENAGA, J. K., RAPP,J. H. and GRUNFELD, C., 1995a, Role for circulating lipoproteins in protection from endotoxin toxicity. Infection and Immunity, 63, 2041-2046.
  • FEINGOLD,K. R.,HARDARDOTHR, I.,MEMON,R.,KRUL, E. J.T., MOSER, A. H., TAYLOR,J. M. and GRUNFELD, C., 1993, Effect of endotoxin on cholesterol biosynthesis and distribution in serum lipoproteins in Syrian hamsters. Journal of Upid Research, 34, 2147-2158.
  • FEINGOLD, K. R., POLLOCK, A. S., MOSER, A. H., SHIGENAGA, J. K. and GRUNFELD, C., 1995b, Discordance regulation of proteins of cholesterol metabolism during the acute phase response. Journal of Lipid Research, 36, 1474-1482.
  • FEINGOLD, K. R., SOUED, M., SERIO, M. K., MOSER, A. H., DINARELLO, C. A. and GRUNFELD, C., 1989, Multiple cytokines stimulate hepatic lipid synthesis in vivo. Endocrinology, 125, 267-274.
  • FEINGOLD, K. R., SPADY, D. K., POLLOCK, A. S., MOSER, A. H. and GRUNFELD, C., 1996, Endotoxin, TNF and IL-I decrease cholesterol 706-hydroxylase mRNA levels and activity. Journal of Upid Research, 37, 223-228.
  • FELISTE, R., DOUSSET, N., CARTON, M. and DOUSTE-BLAZY, L., 1981, Changes in plasma apolipoproteins following wholebody irradiation in rabbit. Radiation Research, 87, 602-612.
  • FEURGARD, C., BAYLE, D., SEROUGNE, C., MAZUR, A., LUTTON, C., AIGUEPERSE, J., GOURMELON, P. and MATHE, D., 1998, Effects of ionizing radiation (neutrons/gamma rays) on plasma lipids and lipoproteins in rats. Radiation Research, 150, 43-51.
  • GAVISH, D., OSHRY, Y. and EISENBERG, S., 1987, In moo conversion of human HDL3 to HDL2 and apoe-rich HDLl in the rat: Effects of lipid transfer protein. Journal of Lipid Research, 28, 257-267.
  • GIBBONS, G. F. and BURNHAM, F. J., 1991, Effect of nutritional state on the utilization of fatty acids for hepatic triacylglycerol synthesis and secretion as very lowniensity lipoprotein. Biochemical Journal, 275, 87-92.
  • GONNERMAN, W. A., LIM, M., SIPE, J. D., HAYES, K. C. and CATHCART, E. S., 1996, The acute phase response in Syrian hamsters elevates apolipoprotein serum amyloid A (apoSAA) and disrupts lipoprotein metabolism. International Journal of Experimental and Clinical Investigation, 4, 261-269.
  • GOULD, R. G., BELL, V. L. and LILLY, E. H., 1966, Stimulation of cholesterol biosynthesis from acetate in rat liver and adrenals by whole-body X-irradiation. American Journal of Physiology, 196, 1231-1237.
  • GOUNI, L, OKA, K., ETIENNE, J. and CHAN, L., 1993, Endotoxininduced hypertriglyceridemia is mediated by suppression of lipoprotein lipase at a post-transcriptional level. Journal of Upid Research, 34, 139-146.
  • GRUNFELD, C., GULLI, R., MOSER, A. H., GAVIN, L. A. and FEINGOLD, K. R., 1989, Effect of tumor necrosis factoradministration in vivo on lipoprotein lipase activity in various tissues of the rat. Journal of Lipid Research, 30, 579-585.
  • HUFFMAN, J. S. and BENDITT, E. P., 1983, Plasma clearance kinetics of the amyloid-related high-density apoprotein, serum amyloid protein (apo SAA), in the mouse. Evidence for rapid apo SAA clearance. Journal of Clinical Investigation, 71, 926-934.
  • KISILEVSKY, R. and SUBRAHMANYAN, L., 1992, Serum amyloid A changes high-density lipoprotein's cellular affinity. A clue to serum amyloid A's principal function. Laboratory Investigations, 66, 778-785.
  • KONINGS, A. W. T., 1987, Role of membrane lipid composition in radiation induced death of mammalian cells. In Waiden and Hughes (eds), Prostaglandin and lipid metabolism in radiation injury (New York: Plenum), pp. 29-43.
  • KOVANEN, P. T., BROWN, M. S. and GOLDSTEIN, J. L., 1979, Increased binding of low-density lipoprotein to liver membranes from rats treated with 17 os-ethinyl estradiol. Journal of Biological Chemistry, 254, 11367-11373.
  • KRAEMER, F. B., LAANE, C., PARK, B. and SZTALRYD, C., 1994, Low density lipoprotein receptors in rat adipocytes: regulation with fasting. American Journal of Physiology, 266, 26-32.
  • LOWRY, O. H., ROSEBROUGH, N. J., FARR, A. L. and RANDALL, L. J., 1951, Protein measurement with the Polin phenol reagent. Journal of Biological Chemistry, 193, 265-275.
  • LY, H., FRANCONE, O. L., FIELDING, C. J., SHIGENAGA, J. K., MOSER, A. H., GRUNFELD, C. and FEINGOLD, K. R., 1995, Endotoxin and TNF lead to reduced plasma LCAT activity and decreased hepatic LCAT mRNA levels in Syrian hamsters. Journal of Lipid Research, 36, 1254-1263.
  • MAGIC, Z., MATIC-IVANOVIC, S., SAVIC.J. and POZNANOVIC, G., 1995, Ionizing radiation-induced expression of the genes associated with the acute response to injury in the rat. Radiation Research, 143, 187-193.
  • MALLE, E., STEINMETZ, A. and RAYNES, J. G., 1993, Serum amyloid A (SAA): an acute phase protein and apolipoprotein. Atherosclerosis, 102, 131-146.
  • MATHE, D., SEROUGNE, C., FÉRÉZOU, J. and LECUYER, B., 1991, Lipolytic activities in rats fed a sucrose-rich diet supplemented with either cysteine or cholesterol: relationships with lipoprotein profiles. Annals of Nutrition and Metabolism, 35, 165-173.
  • MERAIHI, Z., LUTZ, O., SCHEFTEL, J. M., FREY, A., FEREZOU, J. and BACH, A. C., 1991, Decreased lipolytic activity in tissues during infectious and inflammatory stress. Nutrition, 7, 93-97.
  • PHIIIPPOT, J. R., VERMA, S. P. and LIN, P. S., 1986, Uptake of irradiated human low-density lipoprotein by culture Chinese hamster V79 cells. Biochemical and Biophysical Research Communications, 138, 938-944.
  • PHILUP, B. W. and SHAPIRO, D. J., 1979, Improved method for the assay and activation of 3-hydroxy-3-methyl glutaryl CoA reductase. Journal of Lipid Research, 20, 588-593.
  • RAYSSIGUIER, Y., GUEUX, E., BUSSIERE, L. and MAZUR, A., 1993, Copper deficiency increases the susceptibility of lipoproteins and tissues to peroxidation in rats. Journal of Nutrition, 123, 1343-1348.
  • RIZVI, R. Y., JOHRI, S. K. and ALI, R., 1984, Changes in cholesterol and phospholipids levels of albino rats follow-ing whole-body gamma-irradiation with sublethal doses. Journal of Radiation Research, 25, 85-90.
  • RUDLING, M., 1992, Hepatic mRNA levels for the LDL receptor and HMG-CoA reductase show coordinate regulation in vioo. Journal of Lipid Research, 33, 493-501.
  • SEDLAKOVA, A., BORIKOVA, K. and AHLERS, I., 1986, Changes in lipoprotein lipase activity in the adipose tissue and heart of non-lethally X-irradiated rats. Physiologia Bohemoslovaca, 35, 400-405.
  • SHELLEY, R. N., 1966, The effect of ionising radiations on cholesterol levels of adrenals, liver and plasma. Radiation Research, 29, 608-613.
  • SOUIDI, M., PARQUET, M. and LUTTON, C., 1998, Improved assay of hepatic microsomal cholesterol 7o-hydroxylase activity by use of hydroxyl-/ß-cyclodextrin and an NADPH regenerating system. Clinica et Chimica Acta, 269, 201-217.
  • SPADY, D. K., CUTHBERT, J. A., WILLARD, M. N. and MEIDELL, R. S., 1995, Adenovirus-mediated transfer of a gene encoding cholesterol 7-06-hydroxylase into hamsters increases hepatic enzyme activity and reduces plasma total and low-density lipoprotein cholesterol. Journal of Clinical Investigation, 96, 700-709.
  • SPADY, D. K., WOOLLETT, L. A. and DIETSCHY, J. M., 1993, Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids. Annual Review of Nutrition, 13, 355-381.
  • STEEL, L. K., HUGHES, H. N. and WALDEN, JR, T. L., 1988, Quantitative, functional and biochemical alterations in the peritoneal cells of mice exposed to whole-body gamma-irradiation. I. Changes in cellular protein, adherence properties and enzymatic activities associated with platelet-activating factor formation and inactivation and arachidonate metabolism. International Journal of Radiation Biology, 53, 943-964.
  • STEIN, Y., DABACH, Y., HOLLANDER, G. and STEIN, O., 1990, Cholesteryl ester transfer activity in hamster plasma: increase by fat and cholesterol rich diets. Biochimica et Biophysica Acta, 1042, 138-141.
  • STEINBERG, D., PARTHASARATHY, S., CAREW, T. E., KHOO,J. C. and WITZTUM, J. L., 1989, Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. New England Journal of Medicine, 320, 915-924.
  • STEINMETZ, A., HOCKE, G., SAILE, R., PUCHOIS, P. and FRUCHART, J. C., 1989, Influence of serum amyloid A on cholesterol esterification in human plasma. Biochimica et Biophysica Acta, 1006, 173-178.
  • STOUDEMIRE, J. B., RENAUD, G., SHAMES, D. M. and HAVEL, R. J., 1984, Impaired receptor mediated catabolism of low-density lipoproteins in fasted rabbits. Journal ofLipid Research, 25, 33-39.
  • WITZTUM, J. L. and STEINBERG, D., 1991, Role of oxidized lowdensity lipoprotein in atherogenesis. Journal of Clinical Investigation, 88, 1785-1792.
  • YOUSRI, R. M., ROUSHDY, H. and GAVISH, M. A. M., 1991, Changes in some blood lipid fractions in whole-body irradiated rats as influenced by some radioprotectors. Isopenpraxis, 27, 117-123.
  • YUKAWA, O., NAGATSUKA, S. and NAKASAWA, T., 1983, Reconstitution studies on the involvement of radiationinduced lipid peroxidation in damage to membranes enzymes. International Journal of Radiation Biology, 43, 391-398.

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