60
Views
36
CrossRef citations to date
0
Altmetric
Research Article

Review: Initiation of ionizing radiation-induced apoptosis: DNA damage-mediated or does ceramide have a role?

Pages 521-528 | Published online: 03 Jul 2009

  • ALDRIDGE, D. R., ARENDS, M. J. and RADFORD, I. R., 1995, Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response. British Journal of Cancer, 71, 571-577.
  • ALDRIDGE, D. R. and RADFORD, I. R., 1998, Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines. Cancer Research, 58, 2817-2824.
  • ALFER, T., 1977, The role of membrane damage in radiation-induced cell death. Advances in Experimental Medicine and Biology, 84, 139-165.
  • ASHWELL, J. D., SCHWARTZ, R. H., MITCHELL, J. B. and Russo, A., 1986, Effect of gamma radiation on resting B lymphocytes. I. Oxygen-dependent damage to the plasma membrane results in increased permeability and cell enlargement. Journal of Immunology, 136, 3649-3656.
  • BALABAN, N., MONI, J., SHANNON, M., DANG, L., MURPHY, E. and GOLDKORN, T., 1996, The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation. Biochimica et Biophysica Acta, 1314, 147-156.
  • BEHAM, A., MARIN, M. C., FERNANDEZ, A., HERRMANN, J., BRISBAY, S., TARI, A.M., LOPEZ-BERESTEIN, G., LOZANO, G., SARKISS, M. and MCDONNELL, T. J., 1997, Bc1-2 inhibits p53 nuclear import following DNA damage. Oncogene, 15, 2767-2772.
  • BERNHARD, E. J., MAITY, A., MUSCHEL, R. J. and MCKENNA, W. G., 1995, Effects of ionizing radiation on cell cycle progression. A review. Radiation and Environmental Biophysics, 34, 79-83.
  • BRUNO, A. P., LAURENT, G., AVERBECK, D., DEMUR, C., BONNET, J., BETTAIEB, A., LEVADE, T. and JAFFREZOU, J.-P., 1998, Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation. Cell Death and Differentiation, 5, 172-182.
  • CAHILL, D. P., LENGAUER, C., Yu, J., RIGGINS, G. J., WILLSON, J. K. V., MARKOWITZ, S. D., KINZLER, K. W. and VOGELSTEIN, B., 1998, Mutations of mitotic checkpoint genes in human cancers. Nature, 392, 300-303.
  • CHARLTON, D. E., 1986, The range of high LET effects from 125I decays. Radiation Research, 107, 163-171.
  • CHMURA, S. J., NODZENSKI, E., BECKETT, M. A., KUFE, D. W., QUINTANS, J. and WEICHSELBAUM, R. R., 1997, Loss of ceramide production confers resistance to radiation-induced apoptosis. Cancer Research, 57, 1270-1275.
  • COLE, A., MEYN, R. E., CHEN, R., CORRY, P. M. and HITTELMAN, W., 1980, Mechanisms of cell injury. In Radiation Biology in Cancer Research, edited by R. E. Meyn and H. R. Withers (New York: Raven Press), pp. 33-58.
  • CRAMP, W. A., YATVIN, M. B. and HARMS-RINGDAHL, M., 1994, Recent developments in the radiobiology of cellular membranes. Acta Oncobgica, 33, 945-952.
  • DBAIBO, G. S., PUSHKAREVA, M. Y., RACHID, R. A., ALTER, N., SMYTH, M. J., OBEID, L. M. and HANNUN, Y.A., 1998, p53-dependent ceramide response to genotoxic stress. Journal of Clinical Investigation, 102, 329-339.
  • DONALDSON, K. L., GOOLSBY, G. L., KIENER, P. A. and WAHL, A. F., 1994, Activation of p34cdc2 coincident with taxol-induced apoptosis. Cell Growth and Differentiation, 5, 1041-1050.
  • GEORGE, A. M., LUNEC, J. and CRAMP, W. A., 1983, Effect of membrane fatty acid changes on the radiation sensitivity of human lymphoid cells. International Journal of Radiation Biology, 43, 363-378.
  • GRZELINSKA, E., BARTOSZ, G., GWOZDZINSKI, K. and LEYKO, W., 1979, A spin-label study of the effect of gamma radiation on erythrocyte membrane. Influence of lipid peroxidation on membrane structure. International Journal of Radiation Biology, 36, 325-334.
  • HAIMOVITZ-FRIEDMAN, A., KAN, C. C., EHLEITER, D., PERSAUD, R. S., MCLOUGHLIN, M., FUKS, Z. and KOLESNICK, R. N., 1994, Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. Journal of Experimental Medicine, 180, 525-535.
  • HAIMOVITZ-FRIEDMAN, A., KOLESNICK, R. N. and FUKS, Z., 1997, Differential inhibition of radiation-induced apoptosis. Stem Cells, 15 (suppl 2), 43-47.
  • HANNUN, Y. A., 1996, Functions of ceramide in coordinating cellular responses to stress. Science, 274, 1855-1859.
  • HASEGAWA, M., WILSON, G., RUSSELL, L. D. and MEISTRICH, M. L., 1997, Radiation-induced cell death in the mouse testis: relationship to apoptosis. Radiation Research, 147, 457-467.
  • HASEGAWA, M., ZHANG, Y., NIIBE, H., TERRY, N. H. and MEISTRICH, M. L., 1998, Resistance of differentiating spermatogonia to radiation-induced apoptosis and loss in p53-deficient mice. Radiation Research, 149, 263-270.
  • HOCKENBERY, D. M., OLTVAI, Z. N., YIN, X. M., MILLIMAN, C. L. and KORSMEYER, S. J., 1993, Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell, 75, 241-251.
  • HOFER, K. G., HARRIS, C. R. and SMITH, J. M., 1975, Radiotoxicity of intracellular 67Ga, 125I and 3H. Nuclear versus cytoplasmic radiation effects in murine L1210 leukaemia. International Journal of Radiation Biology, 28, 225-241.
  • HOFMANN, K. and DIXIT, V. M., 1998, Ceramide in apoptosis --does it really matter? Trends in Biochemical Sciences, 23, 374-377.
  • JACOBSON, M. D., 1996, Reactive oxygen species and programmed cell death. Trends in Biochemical Sciences, 21, 83-86.
  • KONINGS, A. W. T., 1985, Lipid peroxidation in liposomes. In Liposome Technology, Volume 1, edited by G. Gregoriadis (London and New York: CRC Press), pp. 139-161.
  • KOTELES, G. J., 1979, New aspects of cell membrane radiobiology and their impact on radiation protection. Atomic Energy Review, 17, 3-30.
  • LOWE, S. W., SCHMITT, E. M., SMITH, S. W., OSBORNE, B. A. and JACKS, T., 1993, p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature, 362, 847-849.
  • MCCLAIN, D. E., TRYPUS, C. A. and MAY, L., 1990, Effect of ? radiation on membrane fluidity of MOLT-4 nuclei. Radiation Research, 123, 263-267.
  • MERRITT, A. J., POTTEN, C. S., KEMP, C. J., HICKMAN, J. A., BALMAIN, A., LANE, D. P. and HALL, P. A., 1994, The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Research, 54, 614-617.
  • MICHAEL, J. M., LAVIN, M. F. and WAITERS, D. J., 1997, Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling. Cancer Research, 57, 3600-3605.
  • MOLINARI, M., OKOROKOV, A. L. and MILNER, J., 1996, Interaction with damaged DNA induces selective proteolytic cleavage of p53 to yield 40kDa and 35kDa fragments competent for sequence-specific DNA binding. Oncogene, 13, 2077-2086.
  • OKOROKOV, A. L. and MILNER, J., 1997, Proteolytic cleavage of p53: a model for the activation of p53 in response to DNA damage. Oncology Research, 9, 267-273.
  • PENA, L. A., FUKS, Z. and KOLESNICK, R., 1997, Stress-induced apoptosis and the sphingomyelin pathway. Biochemical Pharmacology, 53, 615-621.
  • POLYAK, K., XIA, Y., ZWEIER, J. L., KINZLER, K. W. and VOGELSTEIN, B., 1997, A model for p53-induced apoptosis. Nature, 389, 300-305.
  • QUINTANS, J., KILKUS, J., MCSHAN, C. L., GOTTSCHALK, A. R. and DAWSON, G., 1994, Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Biochemical and Biophysical Research Communications, 202, 710-714.
  • RADFORD, I. R., 1991, Mouse lymphoma cells that undergo interphase death show markedly increased sensitivity to radiation-induced DNA double-strand breakage as compared with cells that undergo mitotic death. International Journal of Radiation Biology, 59, 1353-1369.
  • RADFORD, I. R., 1994, Radiation response of mouse lymphoid and myeloid cell lines. Part I. Sensitivity to killing by ionizing radiation, rate of loss of viability, and cell type of origin. International Journal of Radiation Biology, 65, 203-215.
  • RADFORD, I. R. and ALDRIDGE, D. R., 1999, Importance of DNA damage in the induction of apoptosis by ionising radiation: effect of the seid mutation and DNA ploidy on the radiosensitivity of murine lymphoid cell lines. International Journal of Radiation Biology, 75, 521-528.
  • RADFORD, I. R. and MURPHY, T. K., 1994, Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage. International Journal of Radiation Biology, 65, 229-239.
  • RAJU, M. R., EISEN, Y., CARPENTER, S., JARRETT, K. and HARVEY, W. F., 1993, Radiobiology of alpha particles. IV. Cell inactivation by alpha particles of energies 0.4-3.5MeV. Radiation Research, 133, 289-296.
  • RAMAKRISHNAN, N., KALINICH, J. F. and MCCLAIN, D. E., 1998, Radiation-induced apoptosis in lymphoid cells: induction, prevention, and molecular mechanisms. In Radioprotectors: Chemical, Biological, and Clinical Perspectives, edited by E. A. Bump and K. Malaker (Boca Raton, FL: CRC Press), pp. 253-273.
  • RAO, D. V., NARRA, V. R., HOWELL, R. W. and SASTRY, K. S., 1990, Biological consequence of nuclear versus cytoplasmic decays of 125I: cysteamine as a radioprotector against Auger cascades in moo. Radiation Research, 124, 188-193.
  • REED, M., WOELKER, B, WANG, P., WANG, Y., ANDERSON, M. E. and TEGTMEYER, P., 1995, The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation. Proceedings of the National Academy of Sciences, USA, 92, 9455-9459.
  • SANTANA, P., PENA, L. A., HAIMOVITZ-FRIEDMAN, A., MARTIN, S., GREEN, D., MCLOUGHLIN, M., CORDON-CARDO, C., SCHUCHMAN, E. H., FUKS, Z. and KOLESNICK, R., 1996, Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell, 86, 189-199.
  • SMITH, E. R. and MERRILL, A. H. J., 1995, Differential roles of de novo sphingolipid biosynthesis and turnover in the 'burst' of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture. Journal of Biological Chemistry, 270, 18749-18758.
  • STRASSER, A., HARRIS, A. W., JACKS, T. and GORY, S., 1994, DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell, 79, 329-339.
  • VERHEIJ, M., BOSE, R., LIN, X. H., YAO, B, JARVIS, W. D., GRANT, S., BIRRER, M. J., SZABO, E., ZON, L. I., KYRIAKIS, J. M., HAIMOVITZFRIEDMAN, A., FUKS, Z. and KOLESNICK, R. N., 1996, Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature, 380, 75-79.
  • VOEHRINGER, D. W., MCCONKEY, D. J., MCDONNELL, T. J., BRISBAY, S. and MEYN, R. E., 1998, Bcl-2 expression causes redistribution of glutathione to the nucleus. Proceedings of the National Academy of Sciences, USA, 95, 2956-2960.
  • WARTERS, R. L., 1992, Radiation-induced apoptosis in a murine T-cell hybridoma. Cancer Research, 52, 883-890.
  • WARTERS, R. L., HOFER, K. G., HARRIS, C. R. and SMITH, J. M., 1978, Radionuclide toxicity in cultured mammalian cells: elucidation of the primary site of radiation damage. Current Topics in Radiation Research Quarterly, 12, 389-407.
  • WATTS, J. D., GU, M., PATTERSON, S. D., AEBERSOLD, R. and POLVERINO, A. J., 1999, On the complexities of ceramide changes in cells undergoing apoptosis: lack of evidence for a second messenger function in apoptotic induction. Cell Death and Differentiation, 6, 105-114.
  • WATTS, J. D., GU, M., POLVERINO, A. J., PATTERSON, S. D. and AEBERSOLD, R., 1997, Fas-induced apoptosis of T cells occurs independently of ceramide generation. Proceedings of the National Academy of Sciences, USA, 94, 7292-7296.
  • ZHOU, H. L., SUMMERS, S. K., BIRNBAUM, M. J. and PITTMAN, R. N., 1998, Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. Journal of Biological Chemistry, 273, 16568-16575.
  • ZUNDEL, W. and GIACCIA, A., 1998, Inhibition of the antiapoptotic PI(S)K/Akt/Bad pathway by stress. Genes and Development, 12, 1941-1946.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.