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International Journal of Radiation Biology Volume 75, 1999 - Issue 4
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Research Article

Mitochondrial and intracellular free-calcium regulation of radiation-induced apoptosis in human leukemic cells

QING-LI ZHAO Department of Radiation Biophysics and Genetics, Kobe University School of Medicine, Kusunoki-cho 7-5-1, Kobe 650-0017, Japan.
Pages 493-504 | Published online: 03 Jul 2009

  • AKAGI, Y., ITO, K. and SAWADA, S., 1993 Radiation -induced apoptosis and necrosis in Molt-4 cells: A study of dose effect relationships and their modification. International Journal of Radiation Biology, 64, 47-56.
  • ANTONSSON, B., CONTI, F., CIAVATTA, A., MONTESSUIT, S., LEWIS, S., MARTINOU, I., BERNASCONI, L., BERNARD, A., MERMOD, J.-J., MAZZEI, G., MAUNDRELL, K., GAMBALE, F., F., SADOUL, R. AND MARTINOU, J.-C., 1977. Inhibition of Bax-channelforming activity by Bcl-2, Science 277, 270-272.
  • CASCIOLA-ROSEN, L. A., ANHALT, G. J. and ROSEN, A., 1996 DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. Journal of Experimental Medicine, 182, 1625-1634.
  • CLAEKE, A. R., PURDIE, C. A., HARRISON, D. J., MORRIS, R. G., BIRD, C. C., HOOPER, M. L. and WYLLIE, A. H., 1993, Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature, 362, 849-852.
  • COSSARIZA, A., KALASHNIKOVA, G., GRASSILLI, E., CHIAPPELLI, F., SALVIOLI, S., CAPRI, M., BARBIERI, D., TROIANO, F., MONTI, D. and FRANCESCHI, C., 1994. Mitochondrial modifications during rat thynicyte apoptosis: a study at the single cell level. Experimental Cell Research, 214, 323-330.
  • DECAUDIN, D., GELEY, S., HIRSCH, T., CASTEDO, M., MARCHETTI P., MACO, A., KOFLER, R. and KROEMER, G., 1997, Bel2 and Bax-X1 antagonize the intochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Research, 57, 62-67.
  • DOLMETSCH, R. E., LEWIS, R. S., GOODNOW, C. C. and HEALY, J. I., 1997. Differential activation of transcription factors induced by Ca2 response amplitude and duration. Nature 386, 855-858.
  • ENARI, M., SAKAHIRA, H., YOKOYAMA, H., OKAWA, K., WAWATSY, A. and NAGATA S., 1998. A caspase-activated DNase that degraes DNA during apoptosis, and its inhibitor ICAD. Nature, 391, 43-50.
  • FERNANDEZ, A., KEIFER, J., FOSDICK, L., and MCCONEY, D. J., 1995, Oxygen radical production and this depletion are required for Ca6- mediated endogeneous endonuclease activation in apoptotic thymocytes. Journal of Immunology, 155, 5133-5139.
  • FUJIWARA, Y., ICHIHASHI, M., KANO, Y., GOTO, K. and SHIMIZU, K., 1981, A new human photosensitive subject with a defect in the recovery of DNA synthesis after ultracioletlight irradiation. Journal of Investigative Dermatology, 77, 256-273.
  • GRYNKIEWICZ, G., POENIE, M., and TSIEN, R. Y., 1985 A new generation of Ca2 indicator with greatlu improved flourescence properties. Journal of Biological Chemistry, 260, 3440-3450.
  • HEIDEN, M. G. V., CHANDEL, N. S., WILLIAMSON, E. K., SCHUMACKER, P. T. and THOMPSON, C. B 1997, Bel-XL regulates the membrane potential and volume homeostatis of mitochondria. Cell, 91, 627-637.
  • HOPICA, K. L., MCCAREY, Y, Y. L., SYLVESTER, P. F. and HELD, J. D., 1996. Radiation-induced apoptosis in HL60 cells: oxygen effect, relationship between apoptosis and loss of clonogenicity, and dependence of the time to apoplosis on radiation dose. Radiation Research, 145, 315-323.
  • JAYARAMAN, T. and MARKS, A. R., 1997. T cells deficient in inositol 1,4,5-triphosphate receptor are resistant to apoptosis. Molecular and Cellular Biology, 17, 3005-3012.
  • KAMINSKAS, E., and LI, J. C., 1989. DNA frngmentation in permeabilizeed cells and nuclei: the role of (Ca2 Mg2)-dependent endodeoxyribonuclease. Biochemical Journal, 261, 17-21.
  • KHAN, A. A., SOLOSKI, M. K., SHAKP, A. H., SCHILLING, G., SABTINI, D. M., LI, S.-H., Ross, A. and SNYDER, S. H., 1996. Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-triphosphate receptor. Science, 273, 503-507.
  • KIMURA, C., ZHAO, Q.-L., KONDO, T., AMASTU, M. and FUJIWARA, Y., 1998, mechanism of UV-induced aptosis in human leukemia cells: roles of Ca2 /Mg2-dependent endocuelease, caspase-3 and stress-activated protein kinases. Experimental Cell Research, 239, 411-422.
  • KLUCK, R. M., BOSSEY-WETZEL, E., GREEN, D. R. and NEWMEYER, D. D., 1997, The release of cytochrome c from mitochondria a primary site for Bel-2 regulation of apoptosis. Science, 274, 1132-1136.
  • LI, P., NIJHAWAN, D., BUDIHARDJO, L., SRINIVASULA, S. M., AHMAD, M., ALNEMRI, E. S. and WANG, X., 1997, Cytochrome c and dATP-dependent formation of Apaf1/ caspase-9 complex initiates an apoptotic protease cascade. Cell, 91, 479-489.
  • LIU, X., KIM, C. N., YANG, J., JEMMERSON, R. WANG, X. 1996. Introduction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell, 86. 147-157.
  • LOWE, S. W., SCHMITT, E. M., SMITH, S. W., OSBORNE, B. A. and JACKS, T., 1993, p53 is required for radiation-induced apoptosis in mouse thuymocytes. Nature, 362,847-849.
  • NCCONKEY, D. J., 1989, Glucosorticoids activate a suicide process in thymocytes through clevation of cytosolic Ca2 concentration. Archives of Biochemistry and Biophysics, 269, 365-370.
  • MCCONEY, D. J., HARTZELL, P., AMADOR-PEREZ, ORRENIUS. S. and JONDAL, M., 1989, Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex. Journal of Immunology, 143, 1801-1806.
  • MINN, A. J., VALEZ, P., SCHENDEL, S. L., LIANG, H., MUCHMORE, S. W., FESIK, S. W., FILL, M. and THOMPSON, C. B., 1997, Bel-x1 forms an ion channel in synthetic lipid membrances. Nature, 387, 353-367.
  • MIYASHITA, T., KRAJEWSKI, S., KRAJEWSKA, M., WANG, H. G., LIN, H.-K., KIEBERMAN, D., HOFFMAN, B. and REED, J. C., 1994, Tumor suppressor p53 is a regular of bel-2 and bax gene expression in citro and in vivo. Oncogen, 9, 1799-1805.
  • MIYASHITA, T. and REED, J. C., 1995, Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80, 293-299.
  • NICHOLSON, D. W., ALL, A., THORNBERRY, N. A., VAILLANCOURT, J. P., DING, C. K., GALLANT, M., GAREAU, Y., GAREIFFIN P. R., LEBELLE, M., LAZEBNIK, Y. A., MOUNDAY, N. A., RAJU, S. M., SMULSON, M. E., YAMIN, T.-T., YU, V. L. and MILLER, D. K., 1995, Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature, 376, 37-43.
  • OLTVAI, Z. N., MILLIMAN, V. L. and KORSMEYER, S. J., 1993, Bel-2 heterodimerizes in vivo with a conserved homolog, Nax, that accelerates progremmed cell death. Cell, 74, 609-619.
  • REED, J. C., 1997, Double identity for proteins of the Bel-2 family. Nature, 387, 773-776.
  • SALVESEN, G. S. and DIGIT, V. M., 1997, Casoases: intracellular signaling by protecolysis. Cell, 91, 443-446.
  • SEDLACK, T. W., OLTVAI, J. L., YANF, E., WANG, K, BOISE, L. H., THOMPSON, C. B. and KORSMEYER, S. J., 1995, Multiple Bel-2 family members demonstrate selective dimerization with Bax. Proceedings of the National Academy of Sciences. USA, 92, 7834-7838.
  • SELLINS, K. S. and COHEN, J. J., 1987, Gene induction by ?-irradiation leads to DNA fragmentation in lymphocytes. Journal of Immunology, 139, 3199-3206.
  • SELVAKUMARAN, M., LIN, H.-K., MIYASITA, T., WANG H. G., KRAJEWSKI, S., REED, J. C., HOFFMAN, B. and LIEBERMANN, D., 1994, Immediate early up-regulation of bax expression by p53 but not TGF ß1: a paradigm for distinct apoptotic pathways. Oncogene, 9, 1791-1798.
  • SHIOKAWA, D., OHYAMA, H., YAMADA, T., TAKAHASI, K. and TANUMA, S., 1994. Identification of an endonuclease responsible for apoptosis in rat thymocytes. European Journal of Biochemistry, 226, 23-30.
  • STORY, M.D., STEPHENS, L. C., THOMPSOVIC, S. P. and MEYN, R. E., 1992, A role of calcium in regulating apoptosis in rat thymocytes irradiated in vitro. International Journal of Radiation Biology, 61, 243-251.
  • SUSIN, S. A., ZAMZAMI, N., CASTEDO, M., HIRSCH, T., MARCHETTI, P., MACHO, A., DAYGAS, E., GEUSKENS, M. and KROEMER, G., 1996, Bel-2 inhibits the mitochondrial release of a apoptogenic protease. Journal of Experimental Medicine, 184, 1331-1341.
  • SZEKELEY, J. G., LOBREAU, A. U., ENSPINNER, M. and RAAPHORST, G. P., 1985, The use of flow cytometry to measure X-ray survival in cultured T lymphocytes. International Journal of Radiation Biology, 47, 681-688.
  • TAKAHASHI, A., ALNEMRI, E. S., LAZEBNIK, Y. A., FERNANDESALNEMRI, T., LITWACK, G., MOIR, R. D., GOLDMAN, R. D., POIRIER, G. G., KAUFMANN, S. H. and EARNSHAW, W. C., 1996. Cleavage of lamin A by Mch2a but not CPP32: multiple interleukin 1ß-converting enzymerelated proteases with distinct substrate recognition properties are active in apoptosis. Proceedings of the National Academy of Sciences. USA, 93, 8395-8400.
  • TANUMA, S. and SHIOKAWA, D., 1994 Multiple forms of nuclear deoxyribionuclease in rat thymocytes. Biotechnical and Biophysica; Research Communications, 203, 789-797.
  • VANDENBERGHE, P. A. and CEUPPENS, J. L., 1990, Flow cytometric measurement of cytoplasmatic free calcium in human peripheral blood T lymphocytes with fluo-3, a new flourescent calcium indicator. Journal of Immunological Methods, 127, 197-205.
  • WOLTER, K. G., HSU, T.-T., SMITH, C. L., NECHUSHTAN, A., XI, X.-G. and YOULE, R. J., 1997, Movement of Bax from the cytosol to mitochondria during apoptosis. Journal of Cell Biology, 139, 1281-1292.
  • WYLLIE, A. H., KERR, J. F. R. and CURRIE, A. R., 1980, Cell death: the significance of apoptosis. International Review of Cytology, 68, 251-306.
  • XIANG, J., CHAO, D. T. and KORSMEYER, S. J., 1996, Bax-induced cell deaty may not require interleukin 1ß-converting enzyme-like proteases. Procedings of National Academy of Sciences. USA., 93, 14559-14563.
  • YANG, J., LIU, Z., BHALLA, K., KIM, C. N., IBRADO, A. M., CAI, J., PENG, T.-L., JONES, D. P. and WANG, X., 1997, Prevention of apoptosis by bel-2; release of cytochrome c from mitochondria blocked. Science, 275, 1129-1132.
  • ZAMZAMI, N., MARCHETTI, P., CASTEDO, M., ZANIN, C., VAYASSIERE, J.-L., PETIT, P. X. and KROEMER, G., 1995, Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphicyte death in vivo. Journal of Experimental Medicine, 181, 1661-1672.
  • ZAMZAMI, N., SUSIN, S. A., MARCHETTI, P., HIRSCH, T., GOMEZMONTERREY, L., CASTEDO, M. and KROEMER, G., 1996, Mitochondrial control of nuclear apoptosis. Journal of Experimental Medicine, 183, 1533-1544.
  • ZHAN, Q., FAN, S., BAE, L., GUILLOUF, C., LIEBERMANN, D. A., O'CONNOR, P. M. and FORNANCE, J. A. JR., 1994, Introduction of ax by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene, 9, 3743-3751.
  • ZOU, H., HENZEL, W. J., LIU, X., LUTSCHG, A. and WANG, X., 1997. Apaf-1, a human protein homologous to C. elegance CED-1, participates in cytochrome c-dependent activation of caspase-3. Cell, 90, 405-413.

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