Short-chain fatty acids, acetate and propionate, directly upregulate osteoblastic differentiation

References

• Alekos NS, Moorer MC, Riddle RC. 2020. Dual effects of lipid metabolism on osteoblast function. Front Endocrinol. 11:578194–578111.
   PubMed Web of Science ®Google Scholar
• Alexander C, Swanson KS, Fahey GC, Garleb KA. 2019. Perspective: physiologic importance of short-chain fatty acids from nondigestible carbohydrate fermentation. Adv Nutr. 10(4):576–589.
   PubMed Web of Science ®Google Scholar
• Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. 2007. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res. 22(3):465–475.
   PubMed Web of Science ®Google Scholar
• Chang PV, Hao L, Offermanns S, Medzhitov R. 2014. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A. 111(6):2247–2252.
   PubMed Web of Science ®Google Scholar
• Cherbut C. 2003. Motor effects of short-chain fatty acids and lactate in the gastrointestinal tract. Proc Nutr Soc. 62(1):95–99.
   PubMed Web of Science ®Google Scholar
• Cummings JH, Pomare EW, Branch WJ, Naylor CP, Macfarlane GT. 1987. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut. 28(10):1221–1227.
   PubMed Web of Science ®Google Scholar
• Cummings JH, Rombeau JK, Sakata T. 1995. Physiological and clinical aspects of short-chain fatty acids. Cambridge (UK): Cambridge University Press. p. 289–305. Chapter 19, Effects of short-chain fatty acids on the proliferation of gut epithelial cells in vivo.
   Google Scholar
• Czekanska EM, Stoddart MJ, Richards RG, Hayes JS. 2012. In search of an osteoblast cell model for in vitro research. Eur Cell Mater. 24:1–17.
   PubMed Web of Science ®Google Scholar
• Darzi J, Frost GS, Robertson MD. 2011. Do SCFA have a role in appetite regulation? Proc Nutr Soc. 70(1):119–128.
   PubMed Web of Science ®Google Scholar
• Denhardt DT, Noda M. 1998. Osteopontin expression and function: role in bone remodeling. J Cell Biochem. 72 (S30-31):92–102.
   PubMedGoogle Scholar
• Dirckx N, Moorer MC, Clemens TL, Riddle RC. 2019. The role of osteoblasts in energy homeostasis. Nat Rev Endocrinol. 15(11):651–665.
   PubMed Web of Science ®Google Scholar
• Fitch MD, Fleming SE. 1999. Metabolism of short-chain fatty acids by rat colonic mucosa in vivo. Am J Physiol. 277(1):G31–G40.
   PubMedGoogle Scholar
• Hino S, Mizushima T, Kaneko K, Kawai E, Kondo T, Genda T, Yamada T, Hase K, Nishimura N, Morita T. 2020. Mucin-derived o-glycans act as endogenous fiber and sustain mucosal immune homeostasis via short-chain fatty acid production in rat cecum. J Nutr. 150(10):2656–2665.
   PubMed Web of Science ®Google Scholar
• Hira T, Ikee A, Kishimoto Y, Kanahori S, Hara H. 2015. Resistant maltodextrin promotes fasting glucagon-like peptide-1 secretion and production together with glucose tolerance in rats. Br J Nutr. 114(1):34–42.
   PubMed Web of Science ®Google Scholar
• Hong D, Chen HX, Yu HQ, Liang Y, Wang C, Lian QQ, Deng HT, Ge RS. 2010. Morphological and proteomic analysis of early stage of osteoblast differentiation in osteoblastic progenitor cells. Exp Cell Res. 316(14):2291–2300.
   PubMed Web of Science ®Google Scholar
• Hou Z, Wang Z, Tao Y, Bai J, Yu B, Shen J, Sun H, Xiao L, Xu Y, Zhou J, et al. 2019. KLF2 regulates osteoblast differentiation by targeting of Runx2. Lab Invest. 99(2):271–280.
   PubMed Web of Science ®Google Scholar
• Icer MA, Gezmen-Karadag M. 2018. The multiple functions and mechanisms of osteopontin. Clin Biochem. 59:17–24.
   PubMed Web of Science ®Google Scholar
• Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC. 1992. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science. 257(5066):88–91.
   PubMed Web of Science ®Google Scholar
• Kanda Y. 2013. Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant. 48(3):452–458.
   PubMed Web of Science ®Google Scholar
• Koh A, De Vadder F, Kovatcheva-Datchary P, Backhed F. 2016. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell. 165(6):1332–1345.
   PubMed Web of Science ®Google Scholar
• Komori T. 2006. Regulation of osteoblast differentiation by transcription factors. J Cell Biochem. 99(5):1233–1239.
   PubMed Web of Science ®Google Scholar
• Li M, van Esch BCAM, Wagenaar GTM, Garssen J, Folkerts G, Henricks PAJ. 2018. Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells. Eur J Pharmacol. 831:52–59.
   PubMed Web of Science ®Google Scholar
• Lucas S, Omata Y, Hofmann J, Böttcher M, Iljazovic A, Sarter K, Albrecht O, Schulz O, Krishnacoumar B, Krönke G, et al. 2018. Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nat Commun. 9(1):55, 1–11.
   PubMedGoogle Scholar
• Matsubara T, Kida K, Yamaguchi A, Hata K, Ichida F, Meguro H, Aburatani H, Nishimura R, Yoneda T. 2008. BMP2 regulates osterix through Msx2 and Runx2 during osteoblast differentiation. J Biol Chem. 283(43):29119–29125.
   PubMed Web of Science ®Google Scholar
• Morita T, Kasaoka S, Ohhashi A, Ikai A, Numasaki Y, Kiriyama S. 1998. Resistant proteins alter cecal short-chain fatty acid profiles in rats fed high amylose cornstarch. J Nutr. 128(7):1156–1164.
   PubMed Web of Science ®Google Scholar
• Morozumi A. 2011. High concentration of sodium butyrate suppresses osteoblastic differentiation and mineralized nodule formation in ROS17/2.8 cells. J Oral Sci. 53(4):509–516.
   PubMedGoogle Scholar
• Nishide Y, Tousen Y, Tadaishi M, Inada M, Miyaura C, Kruger MC, Ishimi Y. 2015. Combined effects of soy isoflavones and β-carotene on osteoblast differentiation. Int J Environ Res Public Health. 12(11):13750–13761.
   PubMed Web of Science ®Google Scholar
• Ochiai H, Okada S, Saito A, Hoshi K, Yamashita H, Takato T, Azuma T. 2012. Inhibition of insulin-like growth factor-1 (IGF-1) expression by prolonged transforming growth factor-β1 (TGF-β1) administration suppresses osteoblast differentiation. J Biol Chem. 287(27):22654–22661.
   PubMed Web of Science ®Google Scholar
• Quarles LD, Yohay DA, Lever LW, Caton R, Wenstrup RJ. 1992. Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development. J Bone Miner Res. 7(6):683–692.
   PubMed Web of Science ®Google Scholar
• Raggatt LJ, Partridge NC. 2010. Cellular and molecular mechanisms of bone remodeling. J Biol Chem. 285(33):25103–25108.
   PubMed Web of Science ®Google Scholar
• Rahman MM, Kukita A, Kukita T, Shobuike T, Nakamura T, Kohashi O. 2003. Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. Blood. 101(9):3451–3459.
   PubMed Web of Science ®Google Scholar
• Schroeder TM, Westendorf JJ. 2005. Histone deacetylase inhibitors promote osteoblast maturation. J Bone Miner Res. 20(12):2254–2263.
   PubMed Web of Science ®Google Scholar
• Si J, Wang C, Zhang D, Wang B, Zhou Y. 2020. Osteopontin in bone metabolism and bone diseases. Med Sci Monit. 26:e919159.
   PubMed Web of Science ®Google Scholar
• Sudo H, Kodama H, Amagai Y, Yamamoto S, Kasai S. 1983. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol. 96(1):191–198.
   PubMed Web of Science ®Google Scholar
• Tappenden KA, Albin DM, Bartholome AL, Mangian HF. 2003. Glucagon-like peptide-2 and short-chain fatty acids: a new twist to an old story. J Nutr. 133(11):3717–3720.
   PubMed Web of Science ®Google Scholar
• Tyagi AM, Yu M, Darby TM, Vaccaro C, Li JY, Owens JA, Hsu E, Adams J, Weitzmann MN, Jones RM, et al. 2018. The microbial metabolite butyrate stimulates bone formation via T regulatory cell-mediated regulation of WNT10B expression. Immunity. 49(6):1116–1131.
   PubMed Web of Science ®Google Scholar