Interactions between selected over-the-counter drugs and food: clinical relevance and prevention

References

• Abdel-Daim M, Abushouk AI, Reggi R, Yarla NS, Palmery M, Peluso I. 2018. Association of antioxidant nutraceuticals and acetaminophen (paracetamol): friend or foe? J Food Drug Anal. 26(2S):S78–S87.
   PubMed Web of Science ®Google Scholar
• Abdelkawy KS, Donia AM, Turner RB, Elbarbry F. 2016. Effects of lemon and seville orange juices on the pharmacokinetic properties of sildenafil in healthy subjects. Drugs R D. 16(3):271–278.
   PubMedGoogle Scholar
• Achterbergh R, Lammers LA, Kuijsten L, Klümpen HJ, Mathôt RAA, Romijn JA. 2019. Effects of nutritional status on acetaminophen measurement and exposure. Clin Toxicol (Phila). 57(1):42–49.
   PubMed Web of Science ®Google Scholar
• Ahmed M, Kumari S, Manali P, Sonje S, Malik M. 2016. Safety and quality concerns regarding over-the-counter sexual enhancement products sold in the USA market pose a major health risk. J Addict Res Ther. 7(5):299.
   Google Scholar
• Al-Ghazawi MA, Tutunji MS, AbuRuz SM. 2010. The effects of pummelo juice on pharmacokinetics of sildenafil in healthy adult male Jordanian volunteers. Eur J Clin Pharmacol. 66(2):159–163.
   PubMed Web of Science ®Google Scholar
• Amadi CN, Mgbahurike AA. 2018. Selected food/herb–drug interactions: mechanisms and clinical relevance. Am J Ther. 25(4):e423–e433.
   PubMed Web of Science ®Google Scholar
• Angiolillo DJ, Bhatt DL, Lanza F, Deliargyris EN, Prats J, Fan W, Marathi U. 2020. Bioavailability of aspirin in fasted and fed states of a novel pharmaceutical lipid aspirin complex formulation. J Thromb Thrombolysis. 49(3):337–343.
   PubMed Web of Science ®Google Scholar
• de Araújo LML, de Moura Lopes MV, de Arruda RS, Martins RR, Oliveira AG. 2021. Proton pump inhibitor and community pharmacies: usage profile and factors associated with long-term use. PLoS One [Internet]. 16(6):e0252785.
   PubMed Web of Science ®Google Scholar
• Ased S, Wells J, Morrow LE, Malesker MA. 2018. Clinically significant food–drug interactions. Consult Pharm. 33(11):649–657.
   PubMed Web of Science ®Google Scholar
• Avner DL. 2000. Clinical experience with pantoprazole in gastroesophageal reflux disease. Clin Ther. 22(10):1169–1185.
   PubMed Web of Science ®Google Scholar
• Bailey DG, Dresser GK. 2004. Interactions between grapefruit juice and cardiovascular drugs. Am J Cardiovasc Drugs. 4(5):281–297.
   PubMedGoogle Scholar
• Bartra J, Araujo G, Muñoz-Cano R. 2018. Interaction between foods and nonsteroidal anti-inflammatory drugs and exercise in the induction of anaphylaxis. Curr Opin Allergy Clin Immunol. 18(4):310–316.
   PubMed Web of Science ®Google Scholar
• Boardman HF, Delaney BC, Haag S. 2015. Partnership in optimizing management of reflux symptoms: a treatment algorithm for over-the-counter proton-pump inhibitors. Curr Med Res Opin. 31(7):1309–1318.
   PubMed Web of Science ®Google Scholar
• Boullata JI, Hudson LM. 2012. Drug–nutrient interactions: a broad view with implications for practice. J Acad Nutr Diet. 112(4):506–517.
   PubMed Web of Science ®Google Scholar
• Brass EP. 2001. Changing the status of drugs from prescription to over-the-counter availability. N Engl J Med. 345(11):810–816.
   PubMed Web of Science ®Google Scholar
• Chen G-W, Chen T-Y, Yang P-M. 2019. Differential effect of herbal tea extracts on free fatty acids-, ethanol- and acetaminophen-induced hepatotoxicity in FL83B hepatocytes. Drug Chem Toxicol. 45(1):347–352.
   PubMed Web of Science ®Google Scholar
• Chen M, Zhou S, Fabriaga E, Zhang P, Zhou Q. 2018. Food–drug interactions precipitated by fruit juices other than grapefruit juice: An update review. J Food Drug Anal. 26(2S):S61–S71.
   PubMedGoogle Scholar
• Cheng Y, Lin B-J, Guo J-H, Huang B-L, Fang L-P, Que W-C, Liu M-B, Chen X-F, Qiu H-Q. 2019. The effect of food on the pharmacokinetic properties and bioequivalence of two formulations of levocetirizine dihydrochloride in healthy Chinese volunteers. Drug Des Devel Ther. 13:3625–3634.
   PubMed Web of Science ®Google Scholar
• Cusinato DAC, Martinez EZ, Cintra MTC, Filgueira GCO, Berretta AA, Lanchote VL, Coelho EB. 2019. Evaluation of potential herbal-drug interactions of a standardized propolis extract (EPP-AF®) using an in vivo cocktail approach. J Ethnopharmacol. 245:112174.
   PubMed Web of Science ®Google Scholar
• D’Alessandro C, Benedetti A, Di Paolo A, Giannese D, Cupisti A. 2022. Interactions between food and drugs, and nutritional status in renal patients: a narrative review. Nutrients. 14(1):212.
   PubMed Web of Science ®Google Scholar
• Dasgupta A, Reyes MA, Risin SA, Actor JK. 2008. Interaction of white and pink grapefruit juice with acetaminophen (paracetamol) in vivo in mice. J Med Food. 11(4):795–798.
   PubMed Web of Science ®Google Scholar
• Davies NM, Anderson KE. 1997. Clinical pharmacokinetics of naproxen. Clin Pharmacokinet. 32(4):268–293.
   PubMed Web of Science ®Google Scholar
• Deng J, Zhu X, Chen Z, Fan CH, Kwan HS, Wong CH, Shek KY, Zuo Z, Lam TN. 2017. A review of food–drug interactions on oral drug absorption. Drugs. 77(17):1833–1855.
   PubMed Web of Science ®Google Scholar
• Dhabali AAH, Awang R, Zyoud SH. 2012. Clinically important drug-drug interactions in primary care. J Clin Pharm Ther. 37(4):426–430.
   PubMed Web of Science ®Google Scholar
• DuBuske L. 2007. Desloratadine for chronic idiopathic urticaria. Am J Clin Dermatol. 8(5):271–283.
   PubMed Web of Science ®Google Scholar
• DuBuske LM. 2005. Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders. Expert Opin Pharmacother. 6(14):2511–2523.
   PubMed Web of Science ®Google Scholar
• El-Shobaki FA, Srour MG. 1989. The influence of ascorbic acid and lactose on the interaction of iron with each of cobalt and zinc during intestinal absorption. Z Ernahrungswiss. 28(4):310–315.
   PubMedGoogle Scholar
• Fabiana M, Anil P, Simrit R, Tausif M, Leonard M, Jaime I, Gustavo M, Gilberto N. 2011. Comparative bioavailability study with two pantoprazole delayed-released tablet formulations administered with and without food in healthy subjects. Arzneimittelforschung. 58(03):141–148.
   Google Scholar
• Forbes JA, Sandberg RA, Bood-Björklund L. 1998. The effect of food on bromfenac, naproxen sodium, and acetaminophen in postoperative pain after orthopedic surgery. Pharmacotherapy. 18(3):492–503.
   PubMed Web of Science ®Google Scholar
• Gaitán D, Flores S, Saavedra P, Miranda C, Olivares M, Arredondo M, López de Romaña D, Lönnerdal B, Pizarro F. 2011. Calcium does not inhibit the absorption of 5 milligrams of nonheme or heme iron at doses less than 800 milligrams in nonpregnant women. J Nutr. 141(9):1652–1656.
   PubMed Web of Science ®Google Scholar
• Galanello R, Piga A, Cappellini MD, Forni GL, Zappu A, Origa R, Dutreix C, Belleli R, Ford JM, Rivière G-J, et al. 2008. Effect of food, type of food, and time of food intake on deferasirox bioavailability: recommendations for an optimal deferasirox administration regimen. J Clin Pharmacol. 48(4):428–435.
   PubMed Web of Science ®Google Scholar
• Garba M, Yakasai IA, Bakare MT, Munir HY. 2003. Effect of tamarindus indica. l on the bioavailability of ibuprofen in healthy human volunteers. Eur J Drug Metab Pharmacokinet. 28(3):179–184.
   PubMed Web of Science ®Google Scholar
• Gelotte CK. 2018. An open-label, randomized, four-treatment crossover study evaluating the effects of salt form, acetaminophen, and food on the pharmacokinetics of phenylephrine. Regul Toxicol Pharmacol. 95:333–338.
   PubMed Web of Science ®Google Scholar
• Gezmen-Karadağ M, Çelik E, Kadayifçi FZ, Yeşildemir Ö, Öztürk YE, Ağagündüz D. 2018. Role of food-drug interactions in neurological and psychological diseases. Acta Neurobiol Exp (Wars). 78(3):187–197.
   PubMed Web of Science ®Google Scholar
• González MA, Estes KS. 1998. Pharmacokinetic overview of oral second-generation H1 antihistamines. Int J Clin Pharmacol Ther. 36(5):292–300.
   PubMed Web of Science ®Google Scholar
• Hatlebakk JG, Katz PO, Camacho-Lobato L, Castell DO. 2000. Proton pump inhibitors: better acid suppression when taken before a meal than without a meal. Aliment Pharmacol Ther. 14(10):1267–1272.
   PubMed Web of Science ®Google Scholar
• Hilmer SN, MacPherson R. 2015. Effects of food on pharmacokinetics of immediate release oral formulations of simple analgesics: potential implications for drug use, safety and efficacy. Br J Clin Pharmacol. 80(6):1243–1244.
   PubMed Web of Science ®Google Scholar
• Hwang SS, Gorsline J, Louie J, Dye D, Guinta D, Hamel L. 1995. In vitro and in vivo evaluation of a once-daily controlled-release pseudoephedrine product. J Clin Pharmacol. 35(3):259–267.
   PubMed Web of Science ®Google Scholar
• Jáuregui-Garrido B, Jáuregui-Lobera I. 2012. Interactions between antihypertensive drugs and food. Nutr Hosp. 27(6):1866–1875.
   PubMed Web of Science ®Google Scholar
• Jetter A, Kinzig-Schippers M, Walchner-Bonjean M, Hering U, Bulitta J, Schreiner P, Sörgel F, Fuhr U. 2002. Effects of grapefruit juice on the pharmacokinetics of sildenafil. Clin Pharmacol Ther. 71(1):21–29.
   PubMed Web of Science ®Google Scholar
• Johnson DA, Katz PO, Armstrong D, Cohen H, Delaney BC, Howden CW, Katelaris P, Tutuian RI, Castell DO. 2017. The safety of appropriate use of over-the-counter proton pump inhibitors: an evidence-based review and delphi consensus. Drugs. 77(5):547–561.
   PubMed Web of Science ®Google Scholar
• Johnson DA, Roach AC, Carlsson AS, Karlsson AAS, Behr DE. 2003. Stability of esomeprazole capsule contents after in vitro suspension in common soft foods and beverages. Pharmacotherapy. 23(6):731–734.
   PubMed Web of Science ®Google Scholar
• Kamp F, Jandel D, Hoenicke I, Pietrzk K, Gross R, Trugo NMF, Donangelo CM. 2003. Bioavailability of iron, zinc, folate, and vitamin c in the iris multi-micronutrient supplement: effect of combination with a milk-based cornstarch porridge. Food Nutr Bull. 24(3_suppl_1):S20–S26.
   PubMedGoogle Scholar
• Kapil R, Nolting A, Roy P, Fiske W, Benedek I, Abramowitz W. 2004. Pharmacokinetic properties of combination oxycodone plus racemic ibuprofen: Two randomized, open-label, crossover studies in healthy adult volunteers. Clin Ther. 26(12):2015–2025.
   PubMed Web of Science ®Google Scholar
• Kolawole JA, Maduenyi A. 2004. Effect of zobo drink (Hibiscus sabdariffa water extract) on the pharmacokinetics of acetaminophen in human volunteers. Eur J Drug Metab Pharmacokinet. 29(1):25–29.
   PubMed Web of Science ®Google Scholar
• Kondal A, Garg SK. 2003. Influence of an acidic beverage (coca-cola) on the pharmacokinetics of phenytoin in healthy rabbits. Methods Find Exp Clin Pharmacol. 25(10):823–825.
   PubMedGoogle Scholar
• Magallanes L, Lorier M, Ibarra M, Guevara N, Vázquez M, Fagiolino P. 2016. Sex and food influence on intestinal absorption of ketoprofen gastroresistant formulation. Clin Pharmacol Drug Dev. 5(3):196–200.
   PubMed Web of Science ®Google Scholar
• Marzo A, Dal Bo L, Wool C, Cerutti R. 1998. Bioavailability, food effect and tolerability of S-naproxen betainate sodium salt monohydrate in steady state. Arzneimittelforschung. 48(9):935–940.
   PubMed Web of Science ®Google Scholar
• Moore RA, Derry S, Wiffen PJ, Straube S. 2015. Effects of food on pharmacokinetics of immediate release oral formulations of aspirin, dipyrone, paracetamol and NSAIDs – a systematic review. Br J Clin Pharmacol. 80(3):381–388.
   PubMed Web of Science ®Google Scholar
• Mutebi A, Warholak TL, Hines LE, Plummer R, Malone DC. 2013. Assessing patients’ information needs regarding drug–drug interactions. J Am Pharm Assoc. 53(1):39–45.
   Google Scholar
• Nomeir AA, Mojaverian P, Kosoglou T, Affrime MB, Nezamis J, Rodwanski E, Lin CC, Cayen MN. 1996. Influence of food on the oral bioavailability of loratadine and pseudoephedrine from extended-release tablets in healthy volunteers. J Clin Pharmacol. 36(10):923–930.
   PubMed Web of Science ®Google Scholar
• Norman P, Dihlmann A, Rabasseda X. 2001. Desloratadine: a preclinical and clinical overview. Drugs Today (Barc). 37(4):215–227.
   PubMed Web of Science ®Google Scholar
• Pargal A, Kelkar MG, Nayak PJ. 1996. The effect of food on the bioavailability of ibuprofen and flurbiprofen from sustained release formulations. Biopharm Drug Dispos. 17(6):511–519.
   PubMed Web of Science ®Google Scholar
• Paśko P, Rodacki T, Domagała-Rodacka R, Palimonka K, Marcinkowska M, Owczarek D. 2017. Second generation H1 - antihistamines interaction with food and alcohol—a systematic review. Biomed Pharmacother. 93:27–39.
   PubMed Web of Science ®Google Scholar
• Pawaskar MD, Balkrishnan R. 2007. Switching from prescription to over-the counter medications: a consumer and managed care perspective. Manag Care Interface. 20(1):42–47.
   PubMedGoogle Scholar
• Perales S, Barberá R, Lagarda MJ, Farré R. 2006. Fortification of milk with calcium: effect on calcium bioavailability and interactions with iron and zinc. J Agric Food Chem. 54(13):4901–4906.
   PubMed Web of Science ®Google Scholar
• Péter S, Navis G, de Borst MH, von Schacky C, van Orten-Luiten ACB, Zhernakova A, Witkamp RF, Janse A, Weber P, Bakker SJL, et al. 2017. Public health relevance of drug–nutrition interactions. Eur J Nutr. 56(Suppl 2):23–36.
   PubMedGoogle Scholar
• Qinna NA, Ismail OA, Alhussainy TM, Idkaidek NM, Arafat TA. 2016. Evidence of reduced oral bioavailability of paracetamol in rats following multiple ingestion of grapefruit juice. Eur J Drug Metab Pharmacokinet. 41(2):187–195.
   PubMed Web of Science ®Google Scholar
• Rainsford KD, Bjarnason I. 2012. NSAIDs: take with food or after fasting? J Pharm Pharmacol. 64(4):465–469.
   PubMed Web of Science ®Google Scholar
• Rostami-Hodjegan A, Shiran MR, Ayesh R, Grattan TJ, Burnett I, Darby-Dowman A, Tucker GT. 2002. A new rapidly absorbed paracetamol tablet containing sodium bicarbonate. i. a four-way crossover study to compare the concentration–time profile of paracetamol from the new paracetamol/sodium bicarbonate tablet and a conventional paracetamol tablet in fed and fasted volunteers. Drug Dev Ind Pharm. 28(5):523–531.
   PubMed Web of Science ®Google Scholar
• Salminen WF, Yang X, Shi Q, Greenhaw J, Davis K, Ali AA. 2012. Green tea extract can potentiate acetaminophen-induced hepatotoxicity in mice. Food Chem Toxicol. 50(5):1439–1446.
   PubMed Web of Science ®Google Scholar
• Sandström B. 2001. Micronutrient interactions: effects on absorption and bioavailability. Br J Nutr. 85 Suppl 2(Suppl 2):S181–S5.
   PubMedGoogle Scholar
• Savarino V, Marabotto E, Zentilin P, Furnari M, Bodini G, De Maria C, Pellegatta G, Coppo C, Savarino E. 2018. Proton pump inhibitors: use and misuse in the clinical setting. Expert Rev Clin Pharmacol. 11(11):1123–1134.
   PubMed Web of Science ®Google Scholar
• Scallion R, Moore KA. 2009. Effects of food intake on the pharmacokinetics of diclofenac potassium soft gelatin capsules: a single-dose, randomized, two-way crossover study. Clin Ther. 31(10):2233–2241.
   PubMed Web of Science ®Google Scholar
• Schmidt LE, Dalhoff K. 2002. Food–drug interactions. Drugs. 62(10):1481–1502.
   PubMed Web of Science ®Google Scholar
• Seden K, Dickinson L, Khoo S, Back D. 2010. Grapefruit-drug interactions. Drugs. 70(18):2373–2407.
   PubMed Web of Science ®Google Scholar
• Seki H, Akiyoshi T, Imaoka A, Ohtani H. 2019. Inhibitory kinetics of fruit components on CYP2C19 activity. Drug Metab Pharmacokinet. 34(3):181–186.
   PubMed Web of Science ®Google Scholar
• Shaker MA, Akhtar N, Minhas MU, Khan KU, Zangi MI-D, Munir A. 2020. Effect of an Al/Mg hydroxide antacid and food on the pharmacokinetics of dexibuprofen. Drug Res (Stuttg). 70(4):158–164.
   PubMed Web of Science ®Google Scholar
• Sheikh AB, Javed N, Ijaz Z, Barlas V, Shekhar R, Rukov B. 2021. Iron deficiency anemia in males: a dosing dilemma? J Community Hosp Intern Med Perspect. 11(1):46–52.
   PubMed Web of Science ®Google Scholar
• Shi S, Zhang Y, Xiong X, Huang K, Chen X, Peng M. 2012. The influence of flavonoids on the binding of pantoprazole to bovine serum albumin by spectroscopic methods: With the viewpoint of food/drug interference. Food Chem. 135(3):1083–1090.
   PubMed Web of Science ®Google Scholar
• Singh D, Asad M. 2010. Effect of soybean administration on the pharmacokinetics of carbamazepine and omeprazole in rats. Fundam Clin Pharmacol. 24(3):351–355.
   PubMed Web of Science ®Google Scholar
• Skrypnik K, Bogdański P, Schmidt M, Suliburska J. 2019. The effect of multispecies probiotic supplementation on iron status in rats. Biol Trace Elem Res. 192(2):234–243.
   PubMed Web of Science ®Google Scholar
• Smith S, Collaku A, Heaslip L, Yue Y, Starkey Y-Y, Clarke G, Kronfeld N. 2012. A new rapidly absorbed paediatric paracetamol suspension. A six-way crossover pharmacokinetic study comparingthe rate and extent of paracetamol absorption from a new paracetamol suspension with two marketed paediatric formulations. Drug Dev Ind Pharm. 38(3):372–379.
   PubMed Web of Science ®Google Scholar
• Sostek MB, Chen Y, Andersson T. 2007. Effect of timing of dosing in relation to food intake on the pharmacokinetics of esomeprazole. Br J Clin Pharmacol. 64(3):386–390.
   PubMed Web of Science ®Google Scholar
• Strand DS, Kim D, Peura DA. 2017. 25 years of proton pump inhibitors: a comprehensive review. Gut Liver. 11(1):27–37.
   PubMed Web of Science ®Google Scholar
• Tarabar S, Kelsh D, Vince B, Leyva R, Song D, Matschke K, Kellstein DE, Meeves S, Cruz-Rivera M. 2020. Phase I pharmacokinetic study of fixed-dose combinations of ibuprofen and acetaminophen in healthy adult and adolescent populations. Drugs R D. 20(1):23–37.
   PubMed Web of Science ®Google Scholar
• Teucher B, Olivares M, Cori H. 2004. Enhancers of iron absorption: ascorbic acid and other organic acids. Int J Vitam Nutr Res. 74(6):403–419.
   PubMed Web of Science ®Google Scholar
• Uesawa Y, Tsuji N. 2018. Bananas decrease acetaminophen potency in in vitro assays. PLoS One. 13(10):e0205612.
   PubMed Web of Science ®Google Scholar
• Unger M. 2013. Pharmacokinetic drug interactions involving Ginkgo biloba. Drug Metab Rev. 45(3):353–385.
   PubMed Web of Science ®Google Scholar
• Ushijima K, Tsuruoka S, Tsuda H, Hasegawa G, Obi Y, Kaneda T, Takahashi M, Maekawa T, Sasaki T, Koshimizu T, et al. 2009. Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmacol. 68(2):194–200.
   PubMed Web of Science ®Google Scholar
• Veerman GDM, Hussaarts KGAM, Jansman FGA, Koolen SWL, van Leeuwen RWF, Mathijssen RHJ. 2020. Clinical implications of food–drug interactions with small-molecule kinase inhibitors. Lancet Oncol. 21(5):e265–e279.
   PubMed Web of Science ®Google Scholar
• Wang T, Zhang K, Li T, He L, Xie H, Jiang X, Wang L. 2015. Prevalence of desloratadine slow-metabolizer phenotype and food-dependent pharmacokinetics of desloratadine in healthy chinese volunteers. Clin Drug Investig. 35(12):807–813.
   PubMed Web of Science ®Google Scholar
• Weiser T, Schepers C, Mück T, Lange R. 2019. Pharmacokinetic properties of ibuprofen (IBU) from the fixed‐dose combination IBU/caffeine (400/100 mg; FDC) in comparison with 400 mg IBU as acid or lysinate under fasted and fed conditions—data from 2 single‐center, single‐dose, randomized crossover studies in healthy volunteers. Clin Pharmacol Drug Dev. 8(6):742–753.
   PubMed Web of Science ®Google Scholar
• Werba JP, Misaka S, Giroli MG, Shimomura K, Amato M, Simonelli N, Vigo L, Tremoli E. 2018. Update of green tea interactions with cardiovascular drugs and putative mechanisms. J Food Drug Anal. 26(2S):S72–S77.
   PubMedGoogle Scholar
• Yamasaki I, Uotsu N, Yamaguchi K, Takayanagi R, Yamada Y. 2011. Effects of kale ingestion on pharmacokinetics of acetaminophen in rats. Biomed Res. 32(6):357–362.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Gerk PM. 2018. Effects of generally recognized as safe (GRAS) and dietary compounds on phenylephrine metabolism in LS180 human intestinal cells. Biopharm Drug Dispos. 39(9):443–447.
   PubMed Web of Science ®Google Scholar
• Zinner N. 2007. ORIGINAL RESEARCH—ED PHARMACOTHERAPY: do food and dose timing affect the efficacy of sildenafil? A randomized placebo‐controlled study. J Sex Med. 4(1):137–144.
   PubMed Web of Science ®Google Scholar