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Stress
The International Journal on the Biology of Stress
Volume 6, 2003 - Issue 3
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Research Article

LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress

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Pages 189-197 | Published online: 07 Jul 2009

  • Ballard T.M., Kew J.N.C., Richards J.C., Wolerting T. Pharmacological manipulation of mGlu2 receptors affects cognitive performance in rodent 2002; 43: 275 et al.
  • Benvenga M.J., Overshiner C.D., Monn J.A., Leander J.D. Disinhibitory effects of LY354740, a new mGluR2 agonist, on behaviors suppressed by electric shock, in rats and pigeons 1999; 47: 37-44
  • Bockaert J., Pin J.-P. Molecular tinkering of G protein-coupled receptors: an evolutionary success 1999; 18: 1723-1729
  • Bordi F., Ugolini A. Group I metabotropic glutamate receptors: implications for brain diseases 1999; 59: 55-79
  • Bradley S.R., Marino M.J., Wittmann M., Rouse S.T., Awad H., Levey A.I., Conn P.J. Activation of group II metabotropic glutamate receptors inhibits synaptic excitation of the substantia Nigra pars reticulata 2000; 20: 3085-3094
  • Bruno V., Battaglia G., Copani A., D'Onofrio M., Di Iorio P., De Blasi A., Melchiorri D., Flor P.J., Nicoletti F. Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs 2001; 21: 1013-1033
  • Cartmell J., Schoepp D.D. Regulation of neurotransmitter release by metabotropic glutamate receptors 2000; 75: 889-907
  • Coplan J.D., Mathew S.J., Smith E.L.P., Trost R.C., Scharf B.A., Martinez J., Gorman J.M., Monn J.A., Schoepp D.D., Rosenblum L.A. Effects of LY354740, a novel glutamatergic metabotropic agonist, on non-human primate hypothalamic-pituitary-adrenal axis and noradrenergic function 2001; 6/7: 60-617
  • Cox C.L., Sherman S.M. Glutamate inhibits thalamic reticular neurons 1999; 19: 6694-6699
  • Davis M., Rainnie D., Cassell M. Neurotransmission in the rat amygdala related to fear and anxiety 1994; 17: 208-214
  • Emile L., Mercken L., Apiou F., Pradier L., Bock M.-D., Menager J., Clot J., Doble A., Blanchard J.-C. Molecular cloning, functional expression, pharmacological characterization and chromosomal localization of the human metabotropic glutamate receptor type 3 1996; 35: 523-530
  • Ferris P., Seward E., Dawson G.R. Interactions between LY354740, a group II metabotropic agonist and the GABA A -benzodiazepine receptor complex in the rat elevated plus-maze 2001; 15: 76-82
  • Flor P.J., Lindauer K., Puttner I., Ruegg D., Lukic S., Knopfel T., Kuhn R. Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2 1995; 7: 622-629
  • Forsythe D., Barnes-Davies M. Synaptic transmission: well placed modulators 1997; 7: R362-R365
  • Helton D.R., Tizzano J.P., Monn J.A., Schoepp D.D., Kallman M.J. Anxiolytic and side-effect profile of LY354740: A potent, highly selective, orally active agonist for group II metabotropic glutamate receptors 1998a; 284: 651-660
  • Helton D., Schoepp D.D., Monn J.A., Tizzano J.P., Kallman M.J., Moroni F., Nicoletti F., Pellegrini-Giampietro D.E. A role for metabotropic glutamate receptors in drug withdrawal states 1998b; 305-314Portland Press Ltd
  • Holmes K.H., Keele N.B., Arvanov V.L., Shinnick-Gallagher P. Metabotropic glutamate receptor agonist-induced hyperpolarizations in rat basolateral amygdala neurons: Receptor characterization and ion channels 1996; 76: 3059-3069
  • Johnson J.T., Mattiuz E.L., Chay S.H., Herman J.L., Wheeler W.J., Kassahun K., Swanson P., Phillips D.L. The disposition, metabolism, and pharmacokinetics of a selective metabotropic glutamate receptor agonist in rats and dogs 2002; 1: 27-33
  • Kilbride J., Huang L.Q., Rowan M.J., Anwyl R. Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists, LY354740 and DCG-IV 1998; 356: 149-157
  • Klodzinska A., Chojnacka-Wojcik E., Palucha A., Branski P., Popik P., Pilc A. Potential anti-anxiety, anti-addictive effects of LY354740, a selective group II glutamate metabotropic receptor agonist in animal models 1999; 38: 1831-1839
  • Krystal, J.H., Abi-Saab, W., Perry, E., D-Souza, D., Liu, N., Gueorguieva, R., McDougall, L., Belger, A., Levine, L. and Breier, A. (2003). "Attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor (mGluR) agonist, LY354740, in healthy human subjects". Manuscript Submitted
  • Levine L., Gaydos B., Sheenan D., Goddard A., Feighner J., Potter W.Z., Schoepp D.D. The mGlu2/3 receptor agonist, LY354740, reduces panic anxiety induced by CO 2 2002; 43: 2942
  • Makoff A., Volpe F., Lelchuk R., Harrington K., Emson P. Molecular characterization and localization of human metabotropic glutamate receptor type 3 1996; 40: 55-63
  • Marek G.J., Wright R.A., Schoepp D.D., Monn J.A., Aghajanian G.K. Physiological antagonism between 5-hydroxytryptamine2A and group II metabotropic glutamate receptors in prefrontal cortex 2000; 292: 76-87
  • Mathis C., Ungerer A. The retention deficit induced by (RS)-a-methyl-4-carboxyphenylglycine in a lever-press learning task is blocked by selective agonists of either group I or group II metabotropic glutamate receptors 1999; 129: 147-155
  • Moghaddam B., Adams B. Reversal of phencyclidine effects by a Group II Metabotropic Glutamate Receptor Agonist in rats 1998; 281: 1349-1352
  • Monn J.A., Valli M.J., Massey S.M., Wright R.A., Salhoff C.R., Johnson B.G., Howe T., Alt C.A., Rhodes G.A., Robey R.L., Griffey K.R., Tizzano J.P., Kallman M.J., Helton D.R., Schoepp D.D. Design, synthesis and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: A potent, selective, systemically active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties 1997; 40: 528-537
  • Monn J.A., Valli M.J., Massey S.M., Hansen M.M., Kress T.J., Wepsiec J.P., Harkness A.R., Grutsch J.L., Wright R.A., Johnson B.G., Andis S.L., Kingston A., Tomlinson R., Lewis R., Griffey K.R., Tizzano J.P., Schoepp D.D. Synthesis, pharmacological characterization and molecular modeling of heterobicyclic amino acids related to LY354740: Identification of two new potent, selective and systemically active agonists for group II metabotropic glutamate receptors 1999; 42: 1027-1040
  • Moore N.A., Rees G., Monn J.A. Effects of the group II metabotropic glutamate receptor agonist, LY354740 on schedule-controlled behaviour in rats 1999; 10: 319-325
  • Neugebauer V., Zinebi F., Russell R., Gallagher J.P., Shinnick-Gallagher P. Cocaine and kindling alter the sensitivity of group II and III metabotropic glutamate receptors in the central amygdala 2000; 759-770
  • Parsons C.G., Danysz W., Quack G. Glutamate in CNS disorders as a target for drug development: an update 1998; 11: 523-569
  • Petralia R.S., Wang Y.-X., Niedzielski A.S., Wenthold R.J. The metabotropic glutamate receptors, mGluR2 and mGlur3, show unique postsynaptic, presynaptic and glial localizations 1996; 71: 949-976
  • Phillips T., Rees S., Augood S., Waldvogel H., Faull R., Svendsen C., Emson P. Localization of metabotropic glutamate receptor type 2 in the human brain 2000; 95: 1139-1156
  • Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: structure and functions 1995; 34: 1-26
  • Pin J.-P., Acher F. The metabotropic glutamate receptors: structure, activation mechanism and pharmacology 2002; 1: 297-317
  • Pratt J.A. The neuroanatomical basis of anxiety 1992; 55: 149-181
  • Rasmussen K., Herman B.H. Morphine withdrawal as a state of glutamate hyperactivity 2003; 329-339Humana Press Inc.
  • Robbe D., Alonso G., Chaumont S., Bockaert J., Manzoni O.J. Role of p/q-Ca 2+ 2002; 22: 4346-4356
  • Salt T.E. Metabotropic glutamate (mGlu) receptors and nociceptive processing 2002; 54: 129-139
  • Schoepp D.D., Johnson B.G., Wright R.A., Salhoff C.R., Mayne N.G., Wu S., Cockerham S.L., Burnett J.P., Belagaje R., Bleakman D., Monn J.A. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors 1997; 36: 1-11
  • Schoepp D.D., Johnson B.G., Wright R.A., Salhoff C.R., Monn J.A. Potent, stereoselective, and brain region selective modulation of second messengers in the rat brain by (+)LY354740, a novel group II metabotropic glutamate receptor agonist 1998; 358: 175-180
  • Schoepp D.D., Jane D.E., Monn J.A. Pharmacological agents acting at subtypes of metabotropic glutamate receptors 1999a; 38: 1431-1476
  • Schoepp D.D., Monn J.A., Marek G.J., Aghajanian G., Moghaddam B. LY354740: A systemically active mGlu2/3 receptor agonist 1999b; 5: 1-12
  • Schoepp D.D. Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system 2001; 299: 12-20
  • Schoepp D.D., Cartmell J., Johnson B.G., Salhoff C.R., Wright R.A., Tizzano J.P., Monn J.A., Turski L., Schoepp D.D., Cavalheiro E.A. Metabotropic glutamate receptors: a novel approach to treat psychiatric disorders 2001; 45: 207-216Biomedical and Health Research
  • Schoepp D.D., Conn P.J. Editorial: Metabotropic Glutamate Receptors 2002; 73: 285-2862
  • Schoepp D.D., Marek G.J. Preclinical pharmacology of mGlu2/3 receptor agonists: Novel agents for schizophrenia? 2002; 1: 215-225
  • Shekhar A. Effects of chronic treatment with imipramine and clonazepam in an animal model of panic disorder 1994; 36: 748-758
  • Shekhar A., Keim S.R. LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate induced panic responses in panic prone rats 2000; 39: 1139-1146
  • Shekhar A., McCann U.D., Meaney M.J., Blanchard D.C., Davis M., Frey D.A., Liberzon I., Overall K.L., Shear M.K., Tecott L.H., Winsky L. Summary of a national institute of mental health workshop: developing animal models of anxiety disorders 2001; 157: 327-339
  • Spooren W.P., Schoeffter P., Gasparini F., Kuhn R., Gentsch C. Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608) 2002; 435: 161-170
  • Swanson C., Schoepp D.D., Perry K. The group II metabotropic glutamate receptor agonist, LY354740 blocks, immobilization-induced increases in catecholamine release in the rat medial prefrontal cortex 2003; 391:
  • Tamaru Y., Nomura S., Mizuno N., Shigemoto R. Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and post-synaptic sites 2001; 106: 481-503
  • Tatarczynska E., Klodzinska A., Kroczka B., Chojnacka-Wojcik E., Pilc A. The antianxiety-like effects of antagonists of group I and agonists of group II and III metabotropic glutamate receptors after intrahippocampal administration 2001; 158: 94-99
  • Tankosic T. Metabotropic glutamate receptor modulation: A new wave in neuropharmacology? 2002; April: 52-53
  • Tizzano J.P., Griffey K.I., Schoepp D.D. The anxiolytic action of mGlu2/3 receptor agonist LY354740 in fear potentiated startle model in rats is independent of GABAergic modulation and mechanistically distinct from diazepam 2002; 73: 367-3742
  • Walker D.L., Davis M. The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction 2002; 71: 379-392
  • Watkins J.C. l -Glutamate as a central neurotransmitter: looking back 2000; 28: 297-3104
  • Wright R.A., Monn J.A., Schoepp D.D. Pharmacology of [3H]-LY354740 binding to recombinant mGlu2 and mGlu3 receptors and rat brain 2001; 27: #705.3
  • Yokoi M., Kobayashi K., Manabe T., Takahashi T., Sakaguchi I., Katsuura G., Shigemoto R., Ohishi H., Nomura S., Nakamura K., Nakoa K., Katsuki M., Nakanishi S. Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2 1996; 273: 645-650

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