Modulation of anxiety circuits by serotonergic systems

References

• Abrams JK, Johnson PL, Hay-Schmidt A, Mikkelsen JD, Shekhar A, Lowry CA. Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs. Neuroscience 2005; 133: 983–997
   PubMed Web of Science ®Google Scholar
• Adamec R, Shallow T, Burton P. Anxiolytic and anxiogenic effects of kindling–role of baseline anxiety and anatomical location of the kindling electrode in response to kindling of the right and left basolateral amygdala. Behav Brain Res 2005; 159: 73–88
   PubMedGoogle Scholar
• Amat J, Baratta MV, Paul E, Bland ST, Watkins LR, Maier SF. Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus. Nat Neurosci 2005; 8: 365–371
   PubMed Web of Science ®Google Scholar
• Amat J, Tamblyn JP, Paul ED, Bland ST, Amat P, Foster AC, Watkins LR, Maier SF. Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala. Neuroscience 2004; 129: 509–519
   PubMed Web of Science ®Google Scholar
• Beekman M, Flachskamm C, Linthorst AC. Effects of exposure to a predator on behaviour and serotonergic neurotransmission in different brain regions of C57bl/6N mice. Eur J Neurosci 2005; 21: 2825–2836
   PubMedGoogle Scholar
• Bell CJ, Nutt DJ. Serotonin and panic. Br J Psychiatry 1998; 172: 465–471
   PubMed Web of Science ®Google Scholar
• Berretta S, Pantazopoulos H, Caldera M, Pantazopoulos P, Pare D. Infralimbic cortex activation increases c-fos expression in intercalated neurons of the amygdala. Neuroscience 2005; 132: 943–953
   PubMed Web of Science ®Google Scholar
• Berridge KC. Motivation concepts in behavioral neuroscience. Physiol Behav 2004; 81: 179–209
   PubMed Web of Science ®Google Scholar
• Berridge KC, Robinson TE. What is the role of dopamine in reward: Hedonic impact, reward learning, or incentive salience?. Brain Res Rev 1998; 28: 309–369
   PubMed Web of Science ®Google Scholar
• Blackmore CG, Varro A, Dimaline R, Bishop L, Gallacher DV, Dockray GJ. Measurement of secretory vesicle pH reveals intravesicular alkalinization by vesicular monoamine transporter type 2 resulting in inhibition of prohormone cleavage. J Physiol 2001; 531: 605–617
   PubMedGoogle Scholar
• Blanchard RJ, Blanchard DC. Attack and defense in rodents as ethoexperimental models for the study of emotion. Prog Neuropsychopharmacol Biol Psychiatry 1989; 13 Suppl: S3–14
   Google Scholar
• Blundell P, Hall G, Killcross S. Preserved sensitivity to outcome value after lesions of the basolateral amygdala. J Neurosci 2003; 23: 7702–7709
   PubMed Web of Science ®Google Scholar
• Campbell BM, Merchant KM. Serotonin 2C receptors within the basolateral amygdala induce acute fear-like responses in an open-field environment. Brain Res 2003; 993: 1–9
   PubMed Web of Science ®Google Scholar
• Campeau S, Davis M. Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. J Neurosci 1995; 15: 2301–2311
   PubMed Web of Science ®Google Scholar
• Chen A, Hough CJ, Li H. Serotonin type II receptor activation facilitates synaptic plasticity via N-methyl-d-aspartate-mediated mechanism in the rat basolateral amygdala. Neuroscience 2003; 119: 53–63
   PubMedGoogle Scholar
• Commons KG, Connolley KR, Valentino RJ. A neurochemically distinct dorsal raphe-limbic circuit with a potential role in affective disorders. Neuropsychopharmacology 2003; 28: 206–215
   PubMed Web of Science ®Google Scholar
• Cunha JM, Masur J. Evaluation of psychotropic drugs with a modified open field test. Pharmacology 1978; 16: 259–267
   PubMedGoogle Scholar
• Daugherty WP, Corley KC, Phan TH, Boadle-Biber MC. Further studies on the activation of rat median raphe serotonergic neurons by inescapable sound stress. Brain Res 2001; 923: 103–111
   PubMedGoogle Scholar
• Davis M. Are different parts of the extended amygdala involved in fear versus anxiety?. Biol Psychiatr 1998; 44: 1239–1247
   PubMed Web of Science ®Google Scholar
• Davis M. Neurobiology of fear responses: The role of the amygdala. J Neuropsychiatry Clin Neurosci 1997; 9: 382–402
   PubMed Web of Science ®Google Scholar
• Day HE, Masini CV, Campeau S. The pattern of brain c-fos mRNA induced by a component of fox odor, 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), in rats, suggests both systemic and processive stress characteristics. Brain Res 2004; 1025: 139–151
   PubMed Web of Science ®Google Scholar
• Dayan P, Balleine BW. Reward, motivation, and reinforcement learning. Neuron 2002; 36: 285–298
   PubMed Web of Science ®Google Scholar
• de Jongh R, Groenink L, van der GJ, Olivier B. The light-enhanced startle paradigm as a putative animal model for anxiety: Effects of chlordiazepoxide, flesinoxan and fluvoxamine. Psychopharmacology (Berl) 2002; 159: 176–180
   PubMedGoogle Scholar
• Dong HW, Petrovich GD, Swanson LW. Topography of projections from amygdala to bed nuclei of the stria terminalis. Brain Res Rev 2001; 38: 192–246
   PubMedGoogle Scholar
• Duncan GE, Knapp DJ, Breese GR. Neuroanatomical characterization of Fos induction in rat behavioral models of anxiety. Brain Res 1996; 713: 79–91
   PubMed Web of Science ®Google Scholar
• Dunn AJ, Berridge CW. Physiological and behavioral responses to corticotropin-releasing factor administration: Is CRF a mediator of anxiety or stress responses?. Brain Res Rev 1990; 15: 71–100
   PubMed Web of Science ®Google Scholar
• Etkin A, Klemenhagen KC, Dudman JT, Rogan MT, Hen R, Kandel ER, Hirsch J. Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful faces. Neuron 2004; 44: 1043–1055
   PubMed Web of Science ®Google Scholar
• Fendt M, Endres T, Apfelbach R. Temporary inactivation of the bed nucleus of the stria terminalis but not of the amygdala blocks freezing induced by trimethylthiazoline, a component of fox feces. J Neurosci 2003; 23: 23–28
   PubMedGoogle Scholar
• Ferbinteanu J, Shapiro ML. Prospective and retrospective memory coding in the hippocampus. Neuron 2003; 40: 1227–1239
   PubMed Web of Science ®Google Scholar
• Ferry B, Roozendaal B, McGaugh JL. Basolateral amygdala noradrenergic influences on memory storage are mediated by an interaction between beta- and alpha1-adrenoceptors. J Neurosci 1999; 19: 5119–5123
   PubMedGoogle Scholar
• Fornal CA, Metzler CW, Marrosu F, Ribiero-do-Valle LE, Jacobs BL. A subgroup of dorsal raphe serotonergic neurons in the cat is strongly activated during oral-buccal movements. Brain Res 1996; 716: 123–133
   PubMedGoogle Scholar
• Gardner KL, Thrivikraman KV, Lightman SL, Plotsky PM, Lowry CA. Early life experience alters behavior during social defeat: Focus on serotonergic systems. Neuroscience 2005; 136: 181–191
   PubMed Web of Science ®Google Scholar
• Gewirtz JC, McNish KA, Davis M. Lesions of the bed nucleus of the stria terminalis block sensitization of the acoustic startle reflex produced by repeated stress, but not fear-potentiated startle. Prog Neuropsychopharmacol Biol Psychiatry 1998; 22: 625–648
   PubMedGoogle Scholar
• Gonzalez LE, Andrews N, File SE. 5-HT1A and benzodiazepine receptors in the basolateral amygdala modulate anxiety in the social interaction test, but not in the elevated plus-maze. Brain Res 1996; 732: 145–153
   PubMedGoogle Scholar
• Gonzalez LE, Quinonez B, Rangel A, Pino S, Hernandez L. Tonic and phasic alteration in amygdala 5-HT, glutamate and GABA transmission after prefrontal cortex damage in rats. Brain Res 2004; 1005: 154–163
   PubMed Web of Science ®Google Scholar
• Goosens KA, Maren S. Pretraining NMDA receptor blockade in the basolateral complex, but not the central nucleus, of the amygdala prevents savings of conditional fear. Behav Neurosci 2003; 117: 738–750
   PubMedGoogle Scholar
• Graeff FG. Brain defense systems and anxiety. Handbook of Anxiety, M Roth, GD Burrows, R Noyes. Elsevier, Amsterdam 1990; 3: 307–354
   Google Scholar
• Graeff FG. On serotonin and experimental anxiety. Psychopharmacology (Berl) 2002; 163: 467–476
   PubMedGoogle Scholar
• Graeff FG, Guimaraes FS, De Andrade TG, Deakin JF. Role of 5-HT in stress, anxiety, and depression. Pharmacol Biochem Behav 1996; 54: 129–141
   PubMed Web of Science ®Google Scholar
• Graeff FG, Netto CF, Zangrossi H, Jr. The elevated T-maze as an experimental model of anxiety. Neurosci Biobehav Rev 1998; 23: 237–246
   PubMedGoogle Scholar
• Graeff FG, Viana MB, Mora PO. Dual role of 5-HT in defense and anxiety. Neurosci Biobehav Rev 1997; 21: 791–799
   PubMedGoogle Scholar
• Gray JA. A theory of anxiety: The role of the limbic system. Encephale 1983; 9: 161B–166B
   Google Scholar
• Gray JA. The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system. Clarendon Press, Oxford 1982
   Google Scholar
• Gray JA, McNaughton N. The neuropsychology of anxiety: Reprise. Perspectives on Anxiety, Panic, and Fear, RA Dienstbier, DA Hope. University of Nebraska Press, Lincoln, Nebraska 1987; 61–134
   Google Scholar
• Gray JA, McNaughton N. The Neuropsychology of Anxiety, Second Edition. Oxford Medical Publications, Oxford 2000; 1–424
   Google Scholar
• Gray TS, Bingaman EW. The amygdala: Corticotropin-releasing factor, steroids, and stress. Crit Rev Neurobiol 1996; 10: 155–168
   PubMed Web of Science ®Google Scholar
• Griebel G. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research. Pharmacol Ther 1995; 65: 319–395
   PubMed Web of Science ®Google Scholar
• Hajos M, Richards CD, Szekely AD, Sharp T. An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat. Neuroscience 1998; 87: 95–108
   PubMed Web of Science ®Google Scholar
• Hall FS, Huang S, Fong GW, Sundstrom JM, Pert A. Differential basis of strain and rearing effects on open-field behavior in Fawn Hooded and Wistar rats. Physiol Behav 2000; 71: 525–532
   PubMedGoogle Scholar
• Hammack SE, Schmid MJ, LoPresti ML, Der-Avakian A, Pellymounter MA, Foster AC, Watkins LR, Maier SF. Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress. J Neurosci 2003; 23: 1019–1025
   PubMed Web of Science ®Google Scholar
• Handley SL. 5-Hydroxytryptamine pathways in anxiety and its treatment. Pharmacol Ther 1995; 66: 103–148
   PubMed Web of Science ®Google Scholar
• Heilig M, Koob GF, Ekman R, Britton KT. Corticotropin-releasing factor and neuropeptide Y: Role in emotional integration. Trends Neurosci 1994; 17: 80–85
   PubMed Web of Science ®Google Scholar
• Heimer L. A new anatomical framework for neuropsychiatric disorders and drug abuse. Am J Psychiatry 2003; 160: 1726–1739
   PubMed Web of Science ®Google Scholar
• Herry C, Bach D, Scheffler K, Seifritz E, Luthi A. The amygdala as a detector of unpredictability in mice and humans. 2005 Abstract Viewer/Itinerary Planner. Washington, DC 2005, Online. 416.1. 2005
   Google Scholar
• Higgins GA, Bradbury AJ, Jones BJ, Oakley NR. Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphe nucleus of the rat. Neuropharmacology 1988; 27: 993–1001
   PubMedGoogle Scholar
• Higgins GA, Jones BJ, Oakley NR. Effect of 5-HT1A receptor agonists in two models of anxiety after dorsal raphe injection. Psychopharmacology (Berl) 1992; 106: 261–267
   PubMedGoogle Scholar
• Holstege G. The basic, somatic, and emotional components of the motor system in mammals. The Rat Nervous System, G Paxinos. Academic Press, San Diego 1995; 137–154
   Google Scholar
• Imai H, Steindler da, Kitai ST. The organization of divergent axonal projections from the midbrain raphe nuclei in the rat. J Comp Neurol 1986; 243: 363–380
   PubMed Web of Science ®Google Scholar
• Insel TR, Volkow ND, Landis SC, Li TK, Battey JF, Sieving P. Limits to growth: Why neuroscience needs large-scale science. Nat Neurosci 2004; 7: 426–427
   PubMedGoogle Scholar
• Insel TR, Volkow ND, Li TK, Battey JF, Jr, Landis SC. Neuroscience networks: Data-sharing in an information age. PLoS Biol 2003; 1: E17
   Google Scholar
• Iversen SD. 5-HT and anxiety. Neuropharmacology 1984; 23: 1553–1560
   PubMed Web of Science ®Google Scholar
• Jackson ME, Moghaddam B. Stimulus-specific plasticity of prefrontal cortex dopamine neurotransmission. J Neurochem 2004; 88: 1327–1334
   PubMedGoogle Scholar
• Jeffery KJ. Remembrance of futures past. Trends Cogn Sci 2004; 8: 197–199
   PubMedGoogle Scholar
• Kahn RS, van Praag HM, Wetzler S, Asnis GM, Barr G. Serotonin and anxiety revisited. Biol Psychiatry 1988; 23: 189–208
   PubMed Web of Science ®Google Scholar
• Kalivas PW, Nakamura M. Neural systems for behavioral activation and reward. Curr Opin Neurobiol 1999; 9: 223–227
   PubMed Web of Science ®Google Scholar
• Kelley AE. Memory and addiction: Shared neural circuitry and molecular mechanisms. Neuron 2004; 44: 161–179
   PubMed Web of Science ®Google Scholar
• Killcross S, Robbins TW, Everitt BJ. Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala. Nature 1997; 388: 377–380
   PubMed Web of Science ®Google Scholar
• Köhler C, Chan-Palay V, Haglund L, Steinbusch H. Immunohistochemical localization of serotonin nerve terminals in the lateral entorhinal cortex of the rat: Demonstration of two separate patterns of innervation from the midbrain raphe. Anat Embryol (Berl) 1980; 160: 121–129
   PubMedGoogle Scholar
• Köhler C, Chan-Palay V, Steinbusch H. The distribution and origin of serotonin-containing fibers in the septal area: A combined immunohistochemical and fluorescent retrograde tracing study in the rat. J Comp Neurol 1982; 209: 91–111
   PubMed Web of Science ®Google Scholar
• Köhler C, Steinbusch H. Identification of serotonin and non-serotonin-containing neurons of the mid-brain raphe projecting to the entorhinal area and the hippocampal formation A combined immunohistochemical and fluorescent retrograde tracing study in the rat brain. Neuroscience 1982; 7: 951–975
   PubMedGoogle Scholar
• Kovacs KJ. c-Fos as a transcription factor: A stressful (re)view from a functional map. Neurochem Int 1998; 33: 287–297
   PubMed Web of Science ®Google Scholar
• Lacroix L, Spinelli S, Heidbreder CA, Feldon J. Differential role of the medial and lateral prefrontal cortices in fear and anxiety. Behav Neurosci 2000; 114: 1119–1130
   PubMed Web of Science ®Google Scholar
• LaLumiere RT, Buen TV, McGaugh JL. Post-training intra-basolateral amygdala infusions of norepinephrine enhance consolidation of memory for contextual fear conditioning. J Neurosci 2003; 23: 6754–6758
   PubMed Web of Science ®Google Scholar
• Ledford CC, Fuchs RA, See RE. Potentiated reinstatement of cocaine-seeking behavior following D-amphetamine infusion into the basolateral amygdala. Neuropsychopharmacology 2003; 28: 1721–1729
   PubMedGoogle Scholar
• LeDoux JE, Cicchetti P, Xagoraris A, Romanski LM. The lateral amygdaloid nucleus: Sensory interface of the amygdala in fear conditioning. J Neurosci 1990; 10: 1062–1069
   PubMed Web of Science ®Google Scholar
• Lee Y, Schulkin J, Davis M. Effect of corticosterone on the enhancement of the acoustic startle reflex by corticotropin releasing factor (CRF). Brain Res 1994; 666: 93–98
   PubMed Web of Science ®Google Scholar
• Levita L, Hammack SE, Mania I, Li XY, Davis M, Rainnie DG. 5-hydroxytryptamine1A-like receptor activation in the bed nucleus of the stria terminalis: Electrophysiological and behavioral studies. Neuroscience 2004; 128: 583–596
   PubMedGoogle Scholar
• Li YQ, Kaneko T, Mizuno N. Collateral projections of nucleus raphe dorsalis neurones to the caudate-putamen and region around the nucleus raphe magnus and nucleus reticularis gigantocellularis pars alpha in the rat. Neurosci Lett 2001; 299: 33–36
   PubMedGoogle Scholar
• Lista A, Blier P, de Montigny C. Benzodiazepine receptors modulate 5-hydroxytryptamine neurotransmission in the rat hippocampus: In vivo electrophysiological evidence. J Pharmacol Exp Ther 1990; 254: 318–323
   PubMedGoogle Scholar
• Lowry CA. Functional subsets of serotonergic neurones: Implications for control of the hypothalamic-pituitary-adrenal axis. J Neuroendocrinol 2002; 14: 911–923
   PubMed Web of Science ®Google Scholar
• Macedo CE, Martinez RC, de Souza Silva MA, Brandao ML. Increases in extracellular levels of 5-HT and dopamine in the basolateral, but not in the central, nucleus of amygdala induced by aversive stimulation of the inferior colliculus. Eur J Neurosci 2005; 21: 1131–1138
   PubMedGoogle Scholar
• Maier SF, Busch CR, Maswood S, Grahn RE, Watkins LR. The dorsal raphe nucleus is a site of action mediating the behavioral effects of the benzodiazepine receptor inverse agonist DMCM. Behav Neurosci 1995; 109: 759–766
   PubMedGoogle Scholar
• Maier SF, Watkins LF. Stressor controllability, anxiety, and serotonin. Cognitive Therapy Res 1998; 22: 595–613
   Web of Science ®Google Scholar
• Maier SF, Watkins LR. Stressor controllability and learned helplessness: The roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci Biobehav Rev 2005; 29: 829–841
   PubMed Web of Science ®Google Scholar
• Mayford M, Bach ME, Huang YY, Wang L, Hawkins RD, Kandel ER. Control of memory formation through regulated expression of a CaMKII transgene. Science 1996; 274: 1678–1683
   PubMed Web of Science ®Google Scholar
• McGaugh JL. Memory consolidation and the amygdala: A systems perspective. Trends Neurosci 2002; 25: 456
   PubMed Web of Science ®Google Scholar
• Meil WM, See RE. Lesions of the basolateral amygdala abolish the ability of drug associated cues to reinstate responding during withdrawal from self-administered cocaine. Behav Brain Res 1997; 87: 139–148
   PubMed Web of Science ®Google Scholar
• Millan MJ. The neurobiology and control of anxious states. Prog Neurobiol 2003; 70: 83–244
   PubMed Web of Science ®Google Scholar
• Miserendino MJ, Sananes CB, Melia KR, Davis M. Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala. Nature 1990; 345: 716–718
   PubMed Web of Science ®Google Scholar
• Morgan JI, Curran T. Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and jun. Annu Rev Neurosci 1991; 14: 421–451
   PubMed Web of Science ®Google Scholar
• Morgane PJ, Galler JR, Mokler DJ. A review of systems and networks of the limbic forebrain/limbic midbrain. Prog Neurobiol 2005; 75: 143–160
   PubMedGoogle Scholar
• Nutt DJ. Neurobiological mechanisms in generalized anxiety disorder. J Clin Psychiatry 2001; 62(Suppl 11)22–27
   PubMed Web of Science ®Google Scholar
• Nutt DJ. Overview of diagnosis and drug treatments of anxiety disorders. CNS Spectr 2005; 10: 49–56
   PubMed Web of Science ®Google Scholar
• Nutt DJ, Bell CJ, Malizia AL. Brain mechanisms of social anxiety disorder. J Clin Psychiatry 1998; 59(Suppl 17)4–11
   PubMed Web of Science ®Google Scholar
• Nutt DJ, Forshall S, Bell C, Rich A, Sandford J, Nash J, Argyropoulos S. Mechanisms of action of selective serotonin reuptake inhibitors in the treatment of psychiatric disorders. Eur Neuropsychopharmacol 1999; 9(Suppl 3)S81–S86
   Google Scholar
• Nutt DJ, Glue P, Lawson C. The neurochemistry of anxiety: An update. Prog Neuropsychopharmacol Biol Psychiatry 1990; 14: 737–752
   PubMedGoogle Scholar
• Orozco-Cabal L, Pollandt S, Liu J, Vergara L, Shinnick-Gallagher P, Gallagher JP. A novel rat medial prefrontal cortical slice preparation to investigate synaptic transmission from amygdala to layer V prelimbic pyramidal neurons. J Neurosci Methods 2005, Sep 7; [Epub ahead of print]
   PubMedGoogle Scholar
• Ottersen OP. Afferent connections of the amygdaloid complex of the rat with some observations in the cat. III. Afferents from the lower brain stem. J Comp Neurol 1981; 202: 335–356
   PubMed Web of Science ®Google Scholar
• Pesold C, Treit D. The central and basolateral amygdala differentially mediate the anxiolytic effects of benzodiazepines. Brain Res 1995; 671: 213–221
   PubMedGoogle Scholar
• Petrov T, Krukoff TL, Jhamandas JH. The hypothalamic paraventricular and lateral parabrachial nuclei receive collaterals from raphe nucleus neurons: A combined double retrograde and immunocytochemical study. J Comp Neurol 1992; 318: 18–26
   PubMedGoogle Scholar
• Petrov T, Krukoff TL, Jhamandas JH. Chemically defined collateral projections from the pons to the central nucleus of the amygdala and hypothalamic paraventricular nucleus in the rat. Cell Tissue Res 1994; 277: 289–295
   PubMed Web of Science ®Google Scholar
• Peyron C, Petit J-M, Rampon C, Jouvet M, Luppi P-H. Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods. Neuroscience 1998; 82: 443–468
   PubMed Web of Science ®Google Scholar
• Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nat Neurosci 2005; 8: 828–834
   PubMed Web of Science ®Google Scholar
• Rainnie DG. Serotonergic modulation of neurotransmission in the rat basolateral amygdala. J Neurophysiol 1999; 82: 69–85
   PubMedGoogle Scholar
• Rainnie DG, Bergeron R, Sajdyk TJ, Patil M, Gehlert DR, Shekhar A. Corticotrophin releasing factor-induced synaptic plasticity in the amygdala translates stress into emotional disorders. J Neurosci 2004; 24: 3471–3479
   PubMed Web of Science ®Google Scholar
• Rasmussen K, Heym J, Jacobs BL. Activity of serotonin-containing neurons in nucleus centralis superior of freely moving cats. Exp Neurol 1984; 83: 302–317
   PubMed Web of Science ®Google Scholar
• Roesler R, Schroder N, Vianna MR, Quevedo J, Bromberg E, Kapczinski F, Ferreira MB. Differential involvement of hippocampal and amygdalar NMDA receptors in contextual and aversive aspects of inhibitory avoidance memory in rats. Brain Res 2003; 975: 207–213
   PubMedGoogle Scholar
• Rogan MT, Staubli UV, LeDoux JE. Fear conditioning induces associative long-term potentiation in the amygdala. Nature 1997; 390: 604–607
   PubMed Web of Science ®Google Scholar
• Roozendaal B, Brunson KL, Holloway BL, McGaugh JL, Baram TZ. Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation. Proc Natl Acad Sci U S A 2002; 99: 13908–13913
   PubMed Web of Science ®Google Scholar
• Roozendaal B, de Quervain DJ, Ferry B, Setlow B, McGaugh JL. Basolateral amygdala-nucleus accumbens interactions in mediating glucocorticoid enhancement of memory consolidation. J Neurosci 2001; 21: 2518–2525
   PubMedGoogle Scholar
• Roozendaal B, Nguyen BT, Power AE, McGaugh JL. Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activation. Proc Natl Acad Sci USA 1999; 96: 11642–11647
   PubMed Web of Science ®Google Scholar
• Rushworth MF, Walton ME, Kennerley SW, Bannerman DM. Action sets and decisions in the medial frontal cortex. Trends Cogn Sci 2004; 8: 410–417
   PubMed Web of Science ®Google Scholar
• Sajdyk TJ, Schober DA, Gehlert DR, Shekhar A. Role of corticotropin-releasing factor and urocortin within the basolateral amygdala of rats in anxiety and panic responses. Behav Brain Res 1999; 100: 207–215
   PubMed Web of Science ®Google Scholar
• Sajdyk TJ, Shekhar A. Sodium lactate elicits anxiety in rats after repeated GABA receptor blockade in the basolateral amygdala. Eur J Pharmacol 2000; 394: 265–273
   PubMedGoogle Scholar
• Sajdyk TJ, Shekhar A, Gehlert DR. Interactions between NPY and CRF in the amygdala to regulate emotionality. Neuropeptides 2004; 38: 225–234
   PubMed Web of Science ®Google Scholar
• Sakai K, Crochet S. Differentiation of presumed serotonergic dorsal raphe neurons in relation to behavior and wake-sleep states. Neuroscience 2001; 104: 1141–1155
   PubMed Web of Science ®Google Scholar
• Sanders SK, Shekhar A. Regulation of anxiety by GABAA receptors in the rat amygdala. Pharmacol Biochem Behav 1995; 52: 701–706
   PubMed Web of Science ®Google Scholar
• Schafe GE, Atkins CM, Swank MW, Bauer EP, Sweatt JD, LeDoux JE. Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning. J Neurosci 2000; 20: 8177–8187
   PubMed Web of Science ®Google Scholar
• Schreiber R, De VJ. Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat. Eur J Pharmacol 1993; 249: 341–351
   PubMedGoogle Scholar
• Shumyatsky GP, Tsvetkov E, Malleret G, Vronskaya S, Hatton M, Hampton L, Battey JF, Dulac C, Kandel ER, Bolshakov VY. Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 2002; 111: 905–918
   PubMedGoogle Scholar
• Singewald N, Salchner P, Sharp T. Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs. Biol Psychiatry 2003; 53: 275–283
   PubMed Web of Science ®Google Scholar
• Singewald N, Sharp T. Neuroanatomical targets of anxiogenic drugs in the hindbrain as revealed by Fos immunocytochemistry. Neuroscience 2000; 98: 759–770
   PubMedGoogle Scholar
• Sommer W, Moller C, Wiklund L, Thorsell A, Rimondini R, Nissbrandt H, Heilig M. Local 5,7-dihydroxytryptamine lesions of rat amygdala: Release of punished drinking, unaffected plus-maze behavior and ethanol consumption. Neuropsychopharmacology 2001; 24: 430–440
   PubMedGoogle Scholar
• Staub DR, Spiga F, Lowry CA. Urocortin 2 increases c-Fos expression in topographically organized subpopulations of serotonergic neurons in the rat dorsal raphe nucleus. Brain Res 2005; 1044: 176–189
   PubMed Web of Science ®Google Scholar
• Stein C, Davidowa H, Albrecht D. 5-HT(1A) receptor-mediated inhibition and 5-HT(2) as well as 5-HT(3) receptor-mediated excitation in different subdivisions of the rat amygdala. Synapse 2000; 38: 328–337
   PubMedGoogle Scholar
• Steinbusch HW, Nieuwenhuys R, Verhofstad AA, van der KD. The nucleus raphe dorsalis of the rat and its projection upon the caudatoputamen. A combined cytoarchitectonic, immunohistochemical and retrograde transport study. J Physiol (Paris) 1981; 77: 157–174
   PubMedGoogle Scholar
• Stutzmann GE, McEwen BS, LeDoux JE. Serotonin modulation of sensory inputs to the lateral amygdala: Dependency on corticosterone. J Neurosci 1998; 18: 9529–9538
   PubMed Web of Science ®Google Scholar
• Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, Orban PC, Bock R, Klein R, Schutz G. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 1999; 23: 99–103
   PubMed Web of Science ®Google Scholar
• Valle FP. Effects of strain, sex, and illumination on open-field behavior of rats. Am J Psychol 1970; 83: 103–111
   PubMed Web of Science ®Google Scholar
• Van Bockstaele EJ, Biswas A, Pickel VM. Topography of serotonin neurons in the dorsal raphe nucleus that send axon collaterals to the rat prefrontal cortex and nucleus accumbens. Brain Res 1993; 624: 188–198
   PubMed Web of Science ®Google Scholar
• van der Kooy D, Hattori T. Dorsal raphe cells with collateral projections to the caudate-putamen and substantia nigra: A fluorescent retrograde double labeling study in the rat. Brain Res 1980; 186: 1–7
   PubMed Web of Science ®Google Scholar
• Vinogradova OS. Hippocampus as comparator: Role of the two input and two output systems of the hippocampus in selection and registration of information. Hippocampus 2001; 11: 578–598
   PubMed Web of Science ®Google Scholar
• Walker DL, Davis M. Anxiogenic effects of high illumination levels assessed with the acoustic startle response in rats. Biol Psychiatry 1997; 42: 461–471
   PubMedGoogle Scholar
• Walker DL, Davis M. Light-enhanced startle: Further pharmacological and behavioral characterization. Psychopharmacology (Berl) 2002; 159: 304–310
   PubMedGoogle Scholar
• Walker DL, Toufexis DJ, Davis M. Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety. Eur J Pharmacol 2003; 463: 199–216
   PubMed Web of Science ®Google Scholar
• Wang RY, Aghajanian GK. Inhibition of neurons in the amygdala by dorsal raphe stimulation: Mediation through a direct serotonergic pathway. Brain Res 1977; 120: 85–102
   PubMedGoogle Scholar
• Wise CD, Berger BD, Stein L. Benzodiazepines: Anxiety-reducing activity by reduction of serotonin turnover in the brain. Science 1972; 177: 180–183
   PubMedGoogle Scholar
• Zangrossi H, Jr, Viana MB, Graeff FG. Anxiolytic effect of intra-amygdala injection of midazolam and 8-hydroxy-2-(di-n-propylamino)tetralin in the elevated T-maze. Eur J Pharmacol 1999; 369: 267–270
   PubMedGoogle Scholar
• Zangrossi H, Jr, Viana MB, Zanoveli J, Bueno C, Nogueira RL, Graeff FG. Serotonergic regulation of inhibitory avoidance and one-way escape in the rat elevated T-maze. Neurosci Biobehav Rev 2001; 25: 637–645
   PubMedGoogle Scholar
• Zhuang X, Gross C, Santarelli L, Compan V, Trillat AC, Hen R. Altered emotional states in knockout mice lacking 5-HT1A or 5-HT1B receptors. Neuropsychopharmacology 1999; 21: 52S–60S
   PubMed Web of Science ®Google Scholar