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Research Article

The Epidemiology of Childhood Leukemia with a Focus on Birth Weight and Diet

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Pages 203-242 | Published online: 10 Oct 2008

REFERENCES

  • Canadian Cancer Statistics 2006, J McLaughlin, D Dryer, H Logan, Y Mao, L Marrett, H Morrison, B Schacter, G Villeneuve, C Waters, R Semenciw. National Cancer Institute of Canada, Toronto 2006
  • SEER Cancer Statistics Review, 1975-2002, L AG Ries, M P Eisner, C L Kosary, B F Hankey, B A Miller, L Clegg, A Mariotto, E J Feuer, B K Edwards. National Cancer Institute, Bethesda, MD 2003
  • Cancer Incidence and Survival Among Children and Adolescents: United States SEER Program 1975–1995, L A Ries, M A Smith, J G Gurney, M Linet, T Tamra, J L Young, G R Bunin. National Cancer Institute, SEER Program, Bethesda, MD 1999
  • Smith M A, Chen T, Simon R. Age-specific incidence of acute lymphoblastic leukemia in U.S. children: In utero initiation model. J Natl Cancer Inst 1997; 89: 1542–1544
  • Greaves M F. Childhood leukaemia. BMJ 2002; 324: 283–287
  • Greaves M, Maia A T, Wiemels J L, Ford A M. Leukemia in twins: lessons in natural history. Blood 2003; 102: 2321–2333
  • International Incidence of Childhood Cancer, Volume II. International Agency for Research on Cancer, LyonFrance 1998
  • Margolin J F, Steuber C P, Poplack D G. Acute lymphoblastic leukemia. Principles and Practice of Pediatric Oncology, 4th Ed, D G Poplack, P A Pizzo. Lippincott Williams & Wilkins, Philadelphia 2002; 489–544
  • Golub T, Arceci R. Acute myelogenous leukemia. Principles and Practice of Pediatric Oncology, 4th Ed., D G Poplack, P A Pizzo. Lippincott Williams & Wilkins, Philadelphia 2002; 545–590
  • Wiemels J L, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith M T, Ma X, Selvin S, Buffler P A, Wiencke J K. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia 2005; 19: 415–419
  • Spector L G, Xie Y, Robison L L, Heerema N A, Hilden J M, Lange B, Felix C A, Davies S M, Slavin J, Potter J D, Blair C K, Reaman G H, Ross J A. Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor hypothesis: A report from the Children's Oncology Group. Cancer Epidemiol Biomarkers Prev 2005; 14: 651–655
  • Buckley J D, Buckley C M, Ruccione K, Sather H N, Waskerwitz M J, Woods W G, Robison L L. Epidemiological characteristics of childhood acute lymphocytic leukemia. Analysis by immunophenotype. The Childrens Cancer Group. Leukemia 1994; 8: 856–864
  • Davies S M, Robison L L, Buckley J D, Radloff G A, Ross J A, Perentesis J P. Glutathione S-transferase polymorphisms in children with myeloid leukemia: a Children's Cancer Group study. Cancer Epidemiol Biomarkers Prev 2000; 9: 563–566
  • Rothman K J, Greenland S. Case-control studies. Modern Epidemiology, 2d Ed, K J Rothman, S Greenland. Lippincott-Raven, Philadelphia 1998; 93–114
  • Mezei G, Kheifets L. Selection bias and its implications for case-control studies: a case study of magnetic field exposure and childhood leukaemia. Int J Epidemiol 2006; 35: 397–406
  • Raaschou-Nielsen O, Reynolds P. Air pollution and childhood cancer: A review of the epidemiological literature. Int J Cancer 2006; 118: 2920–2929
  • Kwan M L, Buffler P A, Abrams B, Kiley V A. Breastfeeding and the risk of childhood leukemia: a meta-analysis. Public Health Rep 2004; 119: 521–535
  • Guise J M, Austin D, Morris C D. Review of case-control studies related to breastfeeding and reduced risk of childhood leukemia. Pediatrics 2005; 116: e724–e731
  • Wartenberg D. Residential EMF exposure and childhood leukemia: meta-analysis and population attributable risk. Bioelectromagnetics 2001; S86–104, Suppl 5
  • Kheifets L, Shimkhada R. Childhood leukemia and EMF: review of the epidemiologic evidence. Bioelectromagnetics 2005; S51–59, Suppl 7
  • McNally R J, Eden T O. An infectious aetiology for childhood acute leukaemia: a review of the evidence. Br J Haematol 2004; 127: 243–263
  • Stiller C A. Epidemiology and genetics of childhood cancer. Oncogene 2004; 23: 6429–6444
  • Dorak M T, Burnett A K, Worwood M. HFE gene mutations in susceptibility to childhood leukemia: HuGE review. Genet Med 2005; 7: 159–168
  • Sinnett D, Labuda D, Krajinovic M. Challenges identifying genetic determinants of pediatric cancers—the childhood leukemia experience. Fam Cancer 2006; 5: 35–47
  • Roman E, Fear N T, Ansell P, Bull D, Draper G, McKinney P, Michaelis J, Passmore S J, von Kries R. Vitamin K and childhood cancer: analysis of individual patient data from six case-control studies. Br J Cancer 2002; 86: 63–69
  • Laurier D, Grosche B, Hall P. Risk of childhood leukaemia in the vicinity of nuclear installations—findings and recent controversies. Acta Oncologica 2002; 41: 14–24
  • Poole C, Greenland S, Luetters C, Kelsey J L, Mezei G. Socioeconomic status and childhood leukaemia: A review. Int J Epidemiol 2006; 35: 370–384
  • Greaves M F, Pegram S M, Chan L C. Collaborative group study of the epidemiology of acute lymphoblastic leukaemia subtypes: Background and first report. Leuk Res 1985; 9: 715–733
  • Greaves M F, Colman S M, Beard M E, Bradstock K, Cabrera M E, Chen P M, Jacobs P, Lam-Po-Tang P R, MacDougall L G, Williams C K, Alexander F E. Geographical distribution of acute lymphoblastic leukaemia subtypes: second report of the collaborative group study. Leukemia 1993; 7: 27–34
  • Gurney J G, Severson R K, Davis S, Robison L L. Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type. Cancer 1995; 75: 2186–2195
  • Heston J F, Kelly J B, Meigs J W, Flannery J T. Forty-Five Years of Cancer Incidence in Connecticut: 1935–1979. National Cancer Institute, Bethesda, MD 1986
  • Court Brown W M, Doll R. Leukaemia in childhood and young adult life. BMJ 1961; 981–988
  • Bennett J M, Catovsky D, Daniel M T, Flandrin G, Galton D A, Gralnick H R, Sultan C. The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlations. Br J Haematol 1981; 47: 553–561
  • Bennett J M, Catovsky D, Daniel M T, Flandrin G, Galton D A, Gralnick H R, Sultan C. Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group. Ann Intern Med 1985; 103: 620–625
  • Viana M B, Maurer H S, Ferenc C. Subclassification of acute lymphoblastic leukaemia in children: analysis of the reproducibility of morphological criteria and prognostic implications. Br J Haemetol 1980; 44: 383–388
  • Miller D R, Leikin S, Albo V, Sather H, Hammond D. Prognostic importance of morphology (FAB classification) in childhood acute lymphoblastic leukaemia (ALL). Br J Haemetol 1981; 48: 199–206
  • Lilleyman J S, Hann I M, Stevens R F. The clinical significance of blast cell morphology in childhood lymphoblastic leukaemia. Med Pediatr Oncol 1986; 14: 144–147
  • Zipursky A, Peeters M, Poon A. Megakaryoblastic leukemia and Down's syndrome: a review. Pediatr Hematol Oncol 1987; 4: 211–230
  • Rothe G, Schmitz G. Consensus protocol for the flow cytometric immunophenotyping of hematopoietic malignancies. Working Group on Flow Cytometry and Image Analysis. Leukemia 1996; 10: 877–895
  • Pui C H, Behm F G, Crist W M. Clinical and biologic relevance of immunologic marker studies in childhood acute lymphoblastic leukemia. Blood 1993; 82: 343–362
  • Rubnitz J E, Look A T. Molecular genetics of childhood leukemias. J Pediatr Hematol Oncol 1998; 20: 1–11
  • Greaves M F, Wiemels J. Origins of chromosome translocations in childhood leukaemia. Nat Rev Cancer 2003; 3: 639–649
  • Shurtleff S A, Buijs A, Behm F G, Rubnitz J E, Raimondi S C, Hancock M L, Chan G C, Pui C H, Grosveld G, Downing J R. TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 1995; 9: 1985–1989
  • Aldrich M C, Zhang L, Wiemels J L, Ma X, Loh M L, Metayer C, Selvin S, Feusner J, Smith M T, Buffler P A. Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in California. Cancer Epidemiol Biomarkers Prev 2006; 15: 578–581
  • Kempski H, Mensa-Bonsu K A, Kearney L, Jalali G R, Hann I, Khurshid M, Greaves M F. Prenatal chromosomal diversification of leukemia in monozygotic twins. Genes Chromosomes Cancer 2003; 37: 406–411
  • Daley G Q, McLaughlin J, Witte O N, Baltimore D. The CML-specific P210 bcr/abl protein, unlike v-abl, does not transform NIH/3T3 fibroblasts. Science 1987; 237: 532–535
  • Daley G Q, Baltimore D. Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc Natl Acad Sci USA 1988; 85: 9312–9316
  • Castellanos A, Pintado B, Weruaga E, Arevalo R, Lopez A, Orfao A, Sanchez-Garcia I. A BCR-ABL(p190) fusion gene made by homologous recombination causes B-cell acute lymphoblastic leukemias in chimeric mice with independence of the endogenous bcr product. Blood 1997; 90: 2168–2174
  • Crist W M, Carroll A J, Shuster J J, Behm F G, Whitehead M, Vietti T J, Look A T, Mahoney D, Ragab A, Pullen D J, et al. Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study. Blood 1990; 76: 117–122
  • Raimondi S C, Behm F G, Roberson P K, Williams D L, Pui C H, Crist W M, Look A T, Rivera G K. Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19). J Clin Oncol 1990; 8: 1380–1388
  • Lampert F, Harbott J, Ritterbach J, Schellong G, Ritter J, Creutzig U, Riehm H, Reiter A. Karyotypes in acute childhood leukemias may lose prognostic significance with more intensive and specific chemotherapy. Cancer Genet Cytogenet 1991; 54: 277–279
  • Secker-Walker L M, Berger R, Fenaux P, Lai J L, Nelken B, Garson M, Michael P M, Hagemeijer A, Harrison C J, Kaneko Y, et al. Prognostic significance of the balanced t(1;19) and unbalanced der(19)t(1;19) translocations in acute lymphoblastic leukemia. Leukemia 1992; 6: 363–369
  • Uckun F M, Nachman J B, Sather H N, Sensel M G, Kraft P, Steinherz P G, Lange B, Hutchinson R, Reaman G H, Gaynon P S, Heerema N A. Clinical significance of Philadelphia chromosome positive pediatric acute lymphoblastic leukemia in the context of contemporary intensive therapies: a report from the Children's Cancer Group. Cancer 1998; 83: 2030–2039
  • Shima E A, Le Beau M M, McKeithan T W, Minowada J, Showe L C, Mak T W, Minden M D, Rowley J D, Diaz M O. Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia. Proc Natl Acad Sci USA 1986; 83: 3439–3443
  • McKeithan T W, Shima E A, Le Beau M M, Minowada J, Rowley J D, Diaz M O. Molecular cloning of the breakpoint junction of a human chromosomal 8;14 translocation involving the T-cell receptor alpha-chain gene and sequences on the 3′ side of MYC. Proc Natl Acad Sci USA 1986; 83: 6636–6640
  • Begley C G, Aplan P D, Davey M P, Nakahara K, Tchorz K, Kurtzberg J, Hershfield M S, Haynes B F, Cohen D I, Waldmann T A, et al. Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. Proc Natl Acad Sci USA 1989; 86: 2031–2035
  • Chen Q, Cheng J T, Tasi L H, Schneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano M J, Baer R. The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J 1990; 9: 415–424
  • Heerema N A, Nachman J B, Sather H N, Sensel M G, Lee M K, Hutchinson R, Lange B J, Steinherz P G, Bostrom B, Gaynon P S, Uckun F. Hypodiploidy with less than 45 chromosomes confers adverse risk in childhood acute lymphoblastic leukemia: a report from the children's cancer group. Blood 1999; 94: 4036–4045
  • Heerema N A, Sather H N, Sensel M G, Zhang T, Hutchinson R J, Nachman J B, Lange B J, Steinherz P G, Bostrom B C, Reaman G H, Gaynon P S, Uckun F M. Prognostic impact of trisomies of chromosomes 10, 17, and 5 among children with acute lymphoblastic leukemia and high hyperdiploidy (> 50 chromosomes). J Clin Oncol 2000; 18: 1876–1887
  • Trueworthy R, Shuster J, Look T, Crist W, Borowitz M, Carroll A, Frankel L, Harris M, Wagner H, Haggard M, et al. Ploidy of lymphoblasts is the strongest predictor of treatment outcome in B-progenitor cell acute lymphoblastic leukemia of childhood: a Pediatric Oncology Group study. J Clin Oncol 1992; 10: 606–613
  • Harris M B, Shuster J J, Carroll A, Look A T, Borowitz M J, Crist W M, Nitschke R, Pullen J, Steuber C P, Land V J. Trisomy of leukemic cell chromosomes 4 and 10 identifies children with B-progenitor cell acute lymphoblastic leukemia with a very low risk of treatment failure: a Pediatric Oncology Group study. Blood 1992; 79: 3316–3324
  • Wolman I J. Parallel responses to chemotherapy in identical twin infants with concordant leukemia. J Pediatr 1962; 60: 91–95
  • van Dijk B A, Boomsma D I, de Man A J. Blood group chimerism in human multiple births is not rare. Am J Med Genet 1996; 61: 264–268
  • Greaves M. In utero origins of childhood leukaemia. Early Hum Dev 2005; 81: 123–29
  • Greaves M F, Maia A T, Wiemels J L, Ford A M. Leukemia in twins: lessons in natural history. Blood 2003; 102: 2321–2333
  • Gale K B, Ford A M, Repp R, Borkhardt A, Keller C, Eden O B, Greaves M F. Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots. Proc Natl Acad Sci USA 1997; 94: 13950–1395
  • Wiemels J L, Cazzaniga G, Daniotti M, Addison G M, Masera G, Saha V, Biondi A, Greaves M F. Prenatal origin of acute lymphoblastic leukaemia in children. Lancet 1999; 354: 1499–503
  • Fasching K, Panzer S, Haas O A, Marschalek R, Gadner H, Panzer-Grumayer E R. Presence of clone-specific antigen receptor gene rearrangements at birth indicates an in utero origin of diverse types of early childhood acute lymphoblastic leukemia. Blood 2000; 95: 2722–2724
  • Yagi T, Hibi S, Tabata Y, Kuriyama K, Teramura T, Hashida T, Shimizu Y, Takimoto T, Todo S, Sawada T, Imashuku S. Detection of clonotypic IGH and TCR rearrangements in the neonatal blood spots of infants and children with B-cell precursor acute lymphoblastic leukemia. Blood 2000; 96: 264–268
  • Hjalgrim L L, Madsen H O, Melbye M, Jorgensen P, Christiansen M, Andersen M T, Pallisgaard N, Hokland P, Clausen N, Ryder L P, Schmiegelow K, Hjalgrim H. Presence of clone-specific markers at birth in children with acute lymphoblastic leukaemia. Br J Cancer 2002; 87: 994–999
  • Taub J W, Konrad M A, Ge Y, Naber J M, Scott J S, Matherly L H, Ravindranath Y. High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia. Blood 2002; 99: 2992–2996
  • Wiemels J L, Leonard B C, Wang Y, Segal M R, Hunger S P, Smith M T, Crouse V, Ma X, Buffler P A, Pine S R. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 2002; 99: 15101–15106
  • Wiemels J L, Xiao Z, Buffler P A, Maia A T, Ma X, Dicks B M, Smith M T, Zhang L, Feusner J, Wiencke J, Pritchard-Jones K, Kempski H, Greaves M. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood 2002; 99: 3801–3805
  • Panzer-Grumayer E R, Fasching K, Panzer S, Hettinger K, Schmitt K, Stockler-Ipsiroglu S, Haas O A. Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis. Blood 2002; 100: 347–349
  • McHale C M, Wiemels J L, Zhang L, Ma X, Buffler P A, Guo W, Loh M L, Smith M T. Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California. Genes Chromosomes Cancer 2003; 37: 36–43
  • McHale C M, Wiemels J L, Zhang L, Ma X, Buffler P A, Feusner J, Matthay K, Dahl G, Smith M T. Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16). Blood 2003; 101: 4640–4641
  • Maia A T, Koechling J, Corbett R, Metzler M, Wiemels J L, Greaves M. Protracted postnatal natural histories in childhood leukemia. Genes Chromosomes Cancer 2004; 39: 335–340
  • Maia A T, Tussiwand R, Cazzaniga G, Rebulla P, Colman S, Biondi A, Greaves M. Identification of preleukemic precursors of hyperdiploid acute lymphoblastic leukemia in cord blood. Genes Chromosomes Cancer 2004; 40: 38–43
  • Mori H, Colman S M, Xiao Z, Ford A M, Healy L E, Donaldson C, Hows J M, Navarrete C, Greaves M. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc Natl Acad Sci USA 2002; 99: 8242–8247
  • Schoen R E, Weissfeld J L, Kuller L H, Thaete F L, Evans R W, Hayes R B, Rosen C J. Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps. Gastroenterology 2005; 129: 464–475
  • Murray L, Watson P, Johnston B, Sloan J, Mainie I M, Gavin A. Risk of adenocarcinoma in Barrett's oesophagus: population based study. BMJ 2003; 327: 534–535
  • Ravetto P F, Agarwal R, Chiswick M L, D'Souza S W, Eden O B, Taylor G M. Absence of leukaemic fusion gene transcripts in preterm infants exposed to diagnostic x rays. Arch Dis Child Fetal Neonatal Ed 2003; 88: F237–F244
  • Anderson L M, Diwan B A, Fear N T, Roman E. Critical windows of exposure for children's health: cancer in human epidemiological studies and neoplasms in experimental animal models. Environ Health Perspect 2000; 108: 573–594, Suppl 3
  • Liu L, Krailo M, Reaman G H, Bernstein L. Childhood cancer patients' access to cooperative group cancer programs: a population-based study. Cancer 2003; 97: 1339–1345
  • Ross J A, Severson R K, Pollock B H, Robison L L. Childhood cancer in the United States. A geographical analysis of cases from the Pediatric Cooperative Clinical Trials groups. Cancer 1996; 77: 201–207
  • Heath C W, Jr. Community clusters of childhood leukemia and lymphoma: evidence of infection?. Am J Epidemiol 2005; 162: 817–822
  • Law G R. Invited commentary: Do clusters of leukemia and lymphoma provide evidence for an infectious cause?. Am J Epidemiol 2005; 162: 823–824
  • Grufferman S. Methodologic approaches to studying environmental factors in childhood cancer. Environ Health Perspec. 1998; 106: 881–886, Suppl 3
  • Reynolds P, Smith D F, Satariano E, Nelson D O, Goldman L R, Neutra R R. The four county study of childhood cancer: clusters in context. Stat Med 1996; 15: 683–697
  • Alexander F. Clustering of childhood acute leukaemia: The EUROCLUS Project. Radiat Environ Biophys 1998; 37: 71–74
  • Alexander F E, Boyle P, Carli P M, Coebergh J W, Draper G J, Ekbom A, Levi F, McKinney P A, McWhirter W, Magnani C, Michaelis J, Olsen J H, Peris-Bonet R, Petridou E, Pukkala E, Vatten L. Spatial temporal patterns in childhood leukaemia: further evidence for an infectious origin. EUROCLUS project. Br J Cancer 1998; 77: 812–817
  • Alexander F E, Boyle P, Carli P M, Coebergh J W, Draper G J, Ekbom A, Levi F, McKinney P A, McWhirter W, Michaelis J, Peris-Bonet R, Petridou E, Pompe-Kirn V, Plisko I, Pukkala E, Rahu M, Storm H, Terracini B, Vatten L, Wray N. Spatial clustering of childhood leukaemia: summary results from the EUROCLUS project. Br J Cancer 1998; 77: 818–824
  • Steinmaus C, Lu M, Todd R L, Smith A H. Probability estimates for the unique childhood leukemia cluster in Fallon, Nevada, and risks near other U.S. military aviation facilities. Environ Health Perspect 2004; 112: 766–771
  • Rothman K J, Greenland S. Cohort studies. Modern Epidemiology, 2nd Ed, K J Rothman, S Greenland. Lippincott-Raven, Philadelphia 1998; 79–91
  • Westergaard T, Andersen P K, Pedersen J B, Olsen J H, Frisch M, Sorensen H T, Wohlfahrt J, Melbye M. Birth characteristics, sibling patterns, and acute leukemia risk in childhood: a population-based cohort study. J Natl Cancer Inst 1997; 89: 939–947
  • Murray L, McCarron P, Bailie K, Middleton R, Davey Smith G, Dempsey S, McCarthy A, Gavin A. Association of early life factors and acute lymphoblastic leukaemia in childhood: historical cohort study. Br J Cancer 2002; 86: 356–361
  • Paltiel O, Harlap S, Deutsch L, Knaanie A, Massalha S, Tiram E, Barchana M, Friedlander Y. Birth weight and other risk factors for acute leukemia in the Jerusalem Perinatal Study cohort. Cancer Epidemiol Biomarkers Prev 2004; 13: 1057–1064
  • Mucci L A, Granath F, Cnattingius S. Maternal smoking and childhood leukemia and lymphoma risk among 1,440,542 Swedish children. Cancer Epidemiol Biomarkers Prev 2004; 13: 1528–1533
  • Wacholder S, McLaughlin J K, Silverman D T, Mandel J S. Selection of controls in case-control studies. I. Principles. Am J Epidemiol 1992; 135: 1019–1028
  • Wacholder S, Silverman D T, McLaughlin J K, Mandel J S. Selection of controls in case-control studies. II. Types of controls. Am J Epidemiol 1992; 135: 1029–1041
  • Wacholder S, Silverman D T, McLaughlin J K, Mandel J S. Selection of controls in case-control studies. III. Design options. Am J Epidemiol 1992; 135: 1042–1050
  • Neglia J P, Linet M S, Shu X O, Severson R K, Potter J D, Mertens A C, Wen W, Kersey J H, Robison L L. Patterns of infection and day care utilization and risk of childhood acute lymphoblastic leukaemia. Br J Cancer 2000; 82: 234–240
  • Ross J A, Olshan A F. Pediatric cancer in the United States: the Children's Oncology Group Epidemiology Research Program. Cancer Epidemiol Biomarkers Prev 2004; 13: 1552–1554
  • Ma X, Buffler P A, Selvin S, Matthay K K, Wiencke J K, Wiemels J L, Reynolds P. Daycare attendance and risk of childhood acute lymphoblastic leukaemia. Br J Cancer 2002; 86: 1419–1424
  • Infante-Rivard C. Diagnostic x rays, DNA repair genes and childhood acute lymphoblastic leukemia. Health Phys 2003; 85: 60–64
  • Ma X, Metayer C, Does M B, Buffler P A. Maternal pregnancy loss, birth characteristics, and childhood leukemia (United States). Cancer Causes Control 2005; 16: 1075–1083
  • Robison L L, Daigle A. Control selection using random digit dialing for cases of childhood cancer. Am J Epidemiol 1984; 120: 164–166
  • Ross J A, Spector L G, Olshan A F, Bunin G R. Invited commentary: birth certificates—a best control scenario?. Am J Epidemiol 2004; 159: 922–924, discussion 925
  • Ma X, Buffler P A, Layefsky M, Does M B, Reynolds P. Control selection strategies in case-control studies of childhood diseases. Am J Epidemiol 2004; 159: 915–921
  • Gilboa S M, Mendola P, Olshan A F, Savitz D A, Herring A H, Loomis D, Langlois P H, Keating K. Characteristics that predict locating and interviewing mothers identified by a state birth defects registry and vital records. Birth Defects Res A Clin Mol Teratol 2006; 76: 60–65
  • Spector L G, Unpublished observations
  • Bunin G R, Gyllstrom M E, Brown J E, Kahn E B, Kushi L H. Recall of diet during a past pregnancy. Am J Epidemiol 2001; 154: 1136–1142
  • Schuz J, Spector L G, Ross J A. Bias in studies of parental self-reported occupational exposure and childhood cancer. Am J Epidemiol 2003; 158: 710–716
  • Ruccione K S, Waskerwitz M, Buckley J, Perin G, Hammond G D. What caused my child's cancer? Parents' responses to an epidemiology study of childhood cancer. J Pediatr Oncol Nurs 1994; 11: 71–84
  • Trivers K F, Mertens A C, Ross J A, Steinbuch M, Olshan A F, Robison L L. Parental marijuana use and risk of childhood acute myeloid leukaemia: a report from the Children's Cancer Group (United States and Canada). Paediatr Perinat Epidemiol 2006; 20: 110–118
  • Spector L, Groves F, DeStefano F, Liff J, Klein M, Mullooly J, Black S, Shinefield H, Ward J, Marcy M. Medically recorded allergies and the risk of childhood acute lymphoblastic leukaemia. Eur J Cancer 2004; 40: 579–584
  • Reynolds P, Von Behren J, Elkin E P. Birth characteristics and leukemia in young children. Am J Epidemiol 2002; 155: 603–613
  • Lei U, Wohlfahrt J, Hjalgrim H, Hjalgrim L L, Simonsen H, Melbye M. Neonatal level of thyroid-stimulating hormone and acute childhood leukemia. Int J Cancer 2000; 88: 486–488
  • Lander E S, Schork N J. Genetic dissection of complex traits. Science 1994; 265: 2037–2048
  • Rothman N, Wacholder S, Caporaso N E, Garcia-Closas M, Buetow K, Fraumeni J F, Jr. The use of common genetic polymorphisms to enhance the epidemiologic study of environmental carcinogens. Biochim Biophys Acta 2001; 1471: C1–C10
  • Caporaso N E. Why have we failed to find the low penetrance genetic constituents of common cancers?. Cancer Epidemiol Biomarkers Prev 2002; 11: 1544–1549
  • O'Sullivan J J, Pearce M S, Parker L. Parental recall of birth weight: how accurate is it?. Arch Dis Child 2000; 82: 202–203
  • Buka S L, Goldstein J M, Seidman L J, Tsuang M T. Maternal recall of pregnancy history: accuracy and bias in schizophrenia research. Schizophr Bull 2000; 26: 335–350
  • Buka S L, Goldstein J M, Spartos E, Tsuang M T. The retrospective measurement of prenatal and perinatal events: accuracy of maternal recall. Schizophr Res 2004; 71: 417–426
  • Hjalgrim L L, Westergaard T, Rostgaard K, Schmiegelow K, Melbye M, Hjalgrim H, Engels E A. Birth weight as a risk factor for childhood leukemia: a meta-analysis of 18 epidemiologic studies. Am J Epidemiol 2003; 158: 724–735
  • MacMahon B, Newill V A. Birth characteristics of children dying of malignant neoplasms. J Natl Cancer Inst 1962; 28: 231–244
  • Fasal E, Jackson E W, Klauber M R. Birth characteristics and leukemia in childhood. J Natl Cancer Inst 1971; 47: 501–509
  • Daling J R, Starzyk P, Olshan A F, Weiss N S. Birth weight and the incidence of childhood cancer. J Natl Cancer Inst 1984; 72: 1039–1041
  • Shaw G, Lavey R, Jackson R, Austin D. Association of childhood leukemia with maternal age, birth order, and paternal occupation. A case-control study. Am J Epidemiol 1984; 119: 788–795
  • Robison L L, Codd M, Gunderson P, Neglia J P, Smithson W A, King F L. Birth weight as a risk factor for childhood acute lymphoblastic leukemia. Pediatr Hematol Oncol 1987; 4: 63–72
  • Shu X O, Gao Y T, Brinton L A, Linet M S, Tu J T, Zheng W, Fraumeni J F, Jr. A population-based case-control study of childhood leukemia in Shanghai. Cancer 1988; 62: 635–644
  • Shu X O, Jin F, Linet M S, Zheng W, Clemens J, Mills J, Gao Y T. Diagnostic X-ray and ultrasound exposure and risk of childhood cancer. Br J Cancer 1994; 70: 531–536
  • Savitz D A, Ananth C V. Birth characteristics of childhood cancer cases, controls, and their siblings. Pediatr Hematol Oncol 1994; 11: 587–599
  • Cnattingius S, Zack M M, Ekbom A, Gunnarskog J, Kreuger A, Linet M, Adami H O. Prenatal and neonatal risk factors for childhood lymphatic leukemia. J Natl Cancer Inst 1995; 87: 908–914
  • Roman E, Ansell P, Bull D. Leukaemia and non-Hodgkin's lymphoma in children and young adults: are prenatal and neonatal factors important determinants of disease?. Br J Cancer 1997; 76: 406–415
  • Petridou E, Trichopoulos D, Kalapothaki V, Pourtsidis A, Kogevinas M, Kalmanti M, Koliouskas D, Kosmidis H, Panagiotou J P, Piperopoulou F, Tzortzatou F. The risk profile of childhood leukaemia in Greece: a nationwide case-control study. Br J Cancer 1997; 76: 1241–1247
  • Schuz J, Kaatsch P, Kaletsch U, Meinert R, Michaelis J. Association of childhood cancer with factors related to pregnancy and birth. Int J Epidemiol 1999; 28: 631–639
  • McKinney P A, Juszczak E, Findlay E, Smith K, Thomson C S. Pre-and perinatal risk factors for childhood leukaemia and other malignancies: a Scottish case control study. Br J Cancer 1999; 80: 1844–1851
  • Suminoe A, Matsuzaki A, Kinukawa N, Inamitsu T, Tajiri T, Suita S, Hara T. Rapid somatic growth after birth in children with neuroblastoma: a survey of 1718 patients with childhood cancer in Kyushu-Okinawa district. J Pediatr 1999; 134: 178–184
  • Shu X O, Linet M S, Steinbuch M, Wen W Q, Buckley J D, Neglia J P, Potter J D, Reaman G H, Robison L L. Breast-feeding and risk of childhood acute leukemia. J Natl Cancer Inst 1999; 91: 1765–1772
  • Ou S X, Han D, Severson R K, Chen Z, Neglia J P, Reaman G H, Buckley J D, Robison L L. Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States). Cancer Causes Control 2002; 13: 15–25
  • Hjalgrim L L, Rostgaard K, Hjalgrim H, Westergaard T, Thomassen H, Forestier E, Gustafsson G, Kristinsson J, Melbye M, Schmiegelow K. Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland. J Natl Cancer Inst 2004; 96: 1549–1556
  • Ananth C V, Wen S W. Trends in fetal growth among singleton gestations in the United States and Canada, 1985 through 1998. Semin Perinatol 2002; 26: 260–267
  • Ross J A. High birth weight and cancer: evidence and implications. Cancer Epidemiol Biomarkers Prev 2006; 15: 1–2
  • Boulet S L, Alexander G R, Salihu H M, Pass M. Macrosomic births in the United States: determinants, outcomes, and proposed grades of risk. Am J Obstet Gynecol 2003; 188: 1372–1378
  • Stotland N E, Hopkins L M, Caughey A B. Gestational weight gain, macrosomia, and risk of cesarean birth in nondiabetic nulliparas. Obstet Gynecol 2004; 104: 671–677
  • Surkan P J, Hsieh C C, Johansson A L, Dickman P W, Cnattingius S. Reasons for increasing trends in large for gestational age births. Obstet Gynecol 2004; 104: 720–726
  • Ricart W, Lopez J, Mozas J, Pericot A, Sancho M A, Gonzalez N, Balsells M, Luna R, Cortazar A, Navarro P, Ramirez O, Flandez B, Pallardo L F, Hernandez-Mijas A, Ampudia J, Fernandez-Real J M, Corcoy R. Body mass index has a greater impact on pregnancy outcomes than gestational hyperglycaemia. Diabetologia 2005; 48: 1736–1742
  • Olivecrona H, Hilding A, Ekstrom C, Barle H, Nyberg B, Moller C, Delhanty P J, Baxter R C, Angelin B, Ekstrom T J, Tally M. Acute and short-term effects of growth hormone on insulin-like growth factors and their binding proteins: serum levels and hepatic messenger ribonucleic acid responses in humans. J Clin Endocrinol Metab 1999; 84: 553–560
  • Watson A J, Watson P H, Arcellana-Panlilio M, Warnes D, Walker S K, Schultz G A, Armstrong D T, Seamark R F. A growth factor phenotype map for ovine preimplantation development. Biol Reprod 1994; 50: 725–733
  • Fowden A L, Li J, Forhead A J. Glucocorticoids and the preparation for life after birth: are there long-term consequences of the life insurance?. Proc Nutr Soc 1998; 57: 113–122
  • Hill D J, Petrik J, Arany E. Growth factors and the regulation of fetal growth. Diabetes Care 1998; 21: B60–B69, Suppl 2
  • Fowden A L. The insulin-like growth factors and feto-placental growth. Placenta 2003; 24: 803–812
  • Skalkidou A, Petridou E, Papathoma E, Salvanos H, Kedikoglou S, Chrousos G, Trichopoulos D. Determinants and consequences of major insulin-like growth factor components among full-term healthy neonates. Cancer Epidemiol Biomarkers Prev 2003; 12: 860–865
  • Blatt J. IGF1 and leukemia. Pediatr Hematol Oncol 2000; 17: 199–201
  • Grimberg A, Cohen P. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol 2000; 183: 1–9
  • Yang S W, Kim S Y. The relationship of the levels of leptin, insulin-like growth factor-I and insulin in cord blood with birth size, ponderal index, and gender difference. J Pediatr Endocrinol Metab 2000; 13: 289–296
  • Skalkidou A, Petridou E, Papathom E, Salvanos H, Chrousos G, Trichopoulos D. Birth size and neonatal levels of major components of the IGF system: implications for later risk of cancer. J Pediatr Endocrinol Metab 2002; 15: 1479–1486
  • Vatten L J, Nilsen S T, Odegard R A, Romundstad P R, Austgulen R. Insulin-like growth factor I and leptin in umbilical cord plasma and infant birth size at term. Pediatrics 2002; 109: 1131–1135
  • Ohnishi Y, Yamashiro C, Yanagihara T, Hata T. Hepatocyte growth factor concentration in the early second-trimester amniotic fluid does not predict fetal growth at birth. Hum Reprod 1999; 14: 2625–2628
  • Verhaeghe J, Coopmans W, van Herck E, van Schoubroeck D, Deprest J A, Witters I. IGF-I, IGF-II, IGF binding protein 1, and C-peptide in second trimester amniotic fluid are dependent on gestational age but do not predict weight at birth. Pediatr Res 1999; 46: 101–108
  • Tisi D K, Liu X J, Wykes L J, Skinner C D, Koski K G. Insulin-like growth factor II and binding proteins 1 and 3 from second trimester human amniotic fluid are associated with infant birth weight. J Nutr 2005; 135: 1667–1672
  • Wilpshaar J, Joekes E C, Lim F T, Van Leeuwen G A, Van den Boogaard P J, Kanhai H H, Willemze R, Falkenburg J H. Magnetic resonance imaging of fetal bone marrow for quantitative definition of the human fetal stem cell compartment. Blood 2002; 100: 451–457
  • Baik I, Devito W J, Ballen K, Becker P S, Okulicz W, Liu Q, Delpapa E, Lagiou P, Sturgeon S, Trichopoulos D, Quesenberry P J, Hsieh C C. Association of fetal hormone levels with stem cell potential: evidence for early life roots of human cancer. Cancer Res 2005; 65: 358–363
  • Grimberg A. Mechanisms by which IGF-I may promote cancer. Cancer Biol Ther 2003; 2: 630–635
  • Ross J A, Perentesis J P, Robison L L, Davies S M. Big babies and infant leukemia: a role for insulin-like growth factor-1?. Cancer Causes Control 1996; 7: 553–539
  • Ogilvy-Stuart A L, Gleeson H. Cancer risk following growth hormone use in childhood: implications for current practice. Drug Saf 2004; 27: 369–382
  • Resnicoff M, Abraham D, Yutanawiboonchai W, Rotman H L, Kajstura J, Rubin R, Zoltick P, Baserga R. The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Res 1995; 55: 2463–2469
  • Prisco M, Hongo A, Rizzo M G, Sacchi A, Baserga R. The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal. Mol Cell Biol 1997; 17: 1084–1092
  • D'Ambrosio C, Valentinis B, Prisco M, Reiss K, Rubini M, Baserga R. Protective effect of the insulin-like growth factor I receptor on apoptosis induced by okadaic acid. Cancer Res 1997; 57: 3264–3271
  • Grimberg A. P53 and IGFBP-3: apoptosis and cancer protection. Mol Genet Metab 2000; 70: 85–98
  • Nieto-Diaz A, Villar J, Matorras-Weinig R, Valenzuela-Ruiz P. Intrauterine growth retardation at term: association between anthropometric and endocrine parameters. Acta Obstet Gynecol Scand 1996; 75: 127–131
  • Anselmo J, Cao D, Karrison T, Weiss R E, Refetoff S. Fetal loss associated with excess thyroid hormone exposure. JAMA 2004; 292: 691–695
  • Ross J A, Potter J D, Robison L L. Infant leukemia, topoisomerase II inhibitors, and the MLL gene. J Natl Cancer Inst 1994; 86: 1678–1680
  • Schutt B S, Weber K, Elmlinger M W, Ranke M B. Measuring IGF-I, IGFBP-2 and IGFBP-3 from dried blood spots on filter paper is not only practical but also reliable. Growth Horm IGF Res 2003; 13: 75–80
  • Vaessen N, Janssen J A, Heutink P, Hofman A, Lamberts S W, Oostra B A, Pols H A, van Duijn C M. Association between genetic variation in the gene for insulin-like growth factor-I and low birth weight. Lancet 2002; 359: 1036–1037
  • Frayling T M, Hattersley A T, McCarthy A, Holly J, Mitchell S M, Gloyn A L, Owen K, Davies D, Smith G D, Ben-Shlomo Y. A putative functional polymorphism in the IGF-I gene: association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in U.K. populations. Diabetes 2002; 51: 2313–2316
  • Johnston L B, Dahlgren J, Leger J, Gelander L, Savage M O, Czernichow P, Wikland K A, Clark A J. Association between insulin-like growth factor I (IGF-I) polymorphisms, circulating IGF-I, and pre-and postnatal growth in two European small for gestational age populations. J Clin Endocrinol Metab 2003; 88: 4805–4810
  • Pui C H, Ribeiro R C, Hancock M L, Rivera G K, Evans W E, Raimondi S C, Head D R, Behm F G, Mahmoud M H, Sandlund J T, et al. Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. N Engl J Med 1991; 325: 1682–1687
  • Kumar L. Epipodophyllotoxins and secondary leukaemia. Lancet 1993; 342: 819–820
  • Gewirtz D A. Does bulk damage to DNA explain the cytostatic and cytotoxic effects of topoisomerase II inhibitors?. Biochem Pharmacol 1991; 42: 2253–2258
  • Zandvliet D W, Hanby A M, Austin C A, Marsh K L, Clark I B, Wright N A, Poulsom R. Analysis of foetal expression sites of human type II DNA topoisomerase alpha and beta mRNAs by in situ hybridisation. Biochim Biophys Acta 1996; 1307: 239–247
  • Long B H. Mechanisms of action of teniposide (VM-26) and comparison with etoposide (VP-16). Semin Oncol 1992; 19: 3–19
  • Ross J A, Potter J D, Robison L L. Infant leukemia, topoisomerase II inhibitors, and the MLL gene. J Natl Cancer Inst 1994; 86: 1678–1680
  • Ross J A, Potter J D, Reaman G H, Pendergrass T W, Robison L L. Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group. Cancer Causes Control 1996; 7: 581–590
  • Ross J A, Kasum C M. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 2002; 22: 19–34
  • Strissel P L, Strick R. Multiple effects of bioflavonoids on gene regulation, cell proliferation and apoptosis: natural compounds move into the lime light of cancer research. Leuk Res 2005; 29: 859–861
  • Adlercreutz H, Markkanen H, Watanabe S. Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 1993; 342: 1209–1210
  • Xu X, Wang H J, Murphy P A, Cook L, Hendrich S. Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J Nutr 1994; 124: 825–832
  • Hollman P C, de Vries J H, van Leeuwen S D, Mengelers M J, Katan M B. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am J Clin Nutr 1995; 62: 1276–1282
  • Xu X, Harris K S, Wang H J, Murphy P A, Hendrich S. Bioavailability of soybean isoflavones depends upon gut microflora in women. J Nutr 1995; 125: 2307–2315
  • Hollman P C, van Trijp J M, Buysman M N, van der Gaag M S, Mengelers M J, de Vries J H, Katan M B. Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Lett 1997; 418: 152–156
  • Setchell K D, Zimmer-Nechemias L, Cai J, Heubi J E. Exposure of infants to phyto-oestrogens from soy-based infant formula. Lancet 1997; 350: 23–27
  • de Vries J H, Hollman P C, Meyboom S, Buysman M N, Zock P L, van Staveren W A, Katan M B. Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake. Am J Clin Nutr 1998; 68: 60–65
  • Hollman P C, Katan M B. Dietary flavonoids: intake, health effects and bioavailability. Food Chem Toxicol 1999; 37: 937–942
  • Felgines C, Texier O, Morand C, Manach C, Scalbert A, Regerat F, Remesy C. Bioavailability of the flavanone naringenin and its glycosides in rats. Am J Physiol Gastrointest Liver Physiol 2000; 279: G1148–G1154
  • Moon J H, Nakata R, Oshima S, Inakuma T, Terao J. Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women. Am J Physiol Regul Integr Comp Physiol 2000; 279: R461–R467
  • Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr 2000; 130: 2073S–2085S
  • de Vries J H, Hollman P C, van Amersfoort I, Olthof M R, Katan M B. Red wine is a poor source of bioavailable flavonols in men. J Nutr 2001; 131: 745–748
  • Schroder-van d er, Elst J P, van der Heide D, Rokos H, Morreale de Escobar G, Kohrle J. Synthetic flavonoids cross the placenta in the rat and are found in fetal brain. Am J Physiol 1998; 274: E253–E256
  • Strick R, Strissel P L, Borgers S, Smith S L, Rowley J D. Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia. Proc Natl Acad Sci USA 2000; 97: 4790–4795
  • Michael McClain R, Wolz E, Davidovich A, Bausch J. Genetic toxicity studies with genistein. Food Chem Toxicol 2006; 44: 42–55
  • Moneypenny C G, Shao J, Song Y, Gallagher E P. MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells. Carcinogenesis 2006; 27: 874–881
  • Ross J A, Potter J D, Reaman G H, Pendergrass T W, Robison L L. Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group. Cancer Causes Control 1996; 7: 581–590
  • De Long M J, Prochaska H J, Talalay P. Induction of NAD(P)H:quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectors: a model system for the study of anticarcinogens. Proc Natl Acad Sci USA 1986; 83: 787–791
  • Uda Y, Price K R, Williamson G, Rhodes M J. Induction of the anticarcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids. Cancer Lett 1997; 120: 213–216
  • Wiemels J L, Pagnamenta A, Taylor G M, Eden O B, Alexander F E, Greaves M F. A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators. Cancer Research. 1999; 59: 4095–4099
  • Smith M T, Wang Y, Skibola C F, Slater D J, Lo Nigro L, Nowell P C, Lange B J, Felix C A. Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children. Blood 2002; 100: 4590–4593
  • Kracht T, Schrappe M, Strehl S, Reiter A, Elsner H A, Trka J, Cario G, Viehmann S, Harbott J, Borkhardt A, Metzler M, Langer T, Repp R, Marschalek R, Welte K, Haas O A, Stanulla M. NQO1 C609T polymorphism in distinct entities of pediatric hematologic neoplasms. Haematologica 2004; 89: 1492–1497
  • Lanciotti M, Dufour C, Corral L, DiMichele P, Pigullo S, De Rossi G, Basso G, Leszl A, Luciani M, Lo Nigro L, Micalizzi C, Valsecchi M G, Biondi A, Haupt R. Genetic polymorphism of NAD(P)H:quinone oxidoreductase is associated with an increased risk of infant acute lymphoblastic leukemia without MLL gene rearrangements. Leukemia 2005; 19: 214–216
  • Duthie S J. Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull 1999; 55: 578–92
  • Thompson J R, Gerald P F, Willoughby M L, Armstrong B K. Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study. Lancet 2001; 358: 1935–1940
  • Jensen C D, Block G, Buffler P, Ma X, Selvin S, Month S. Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States). Cancer Causes Control 2004; 15: 559–570
  • Wiemels J L, Smith R N, Taylor G M, Eden O B, Alexander F E, Greaves M F. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci USA 2001; 98: 4004–4009
  • Franco R F, Simoes B P, Tone L G, Gabellini S M, Zago M A, Falcao R P. The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol 2001; 115: 616–618
  • Krajinovic M, Lamothe S, Labuda D, Lemieux-Blanchard E, Theoret Y, Moghrabi A, Sinnett D. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 2004; 103: 252–257
  • French A E, Grant R, Weitzman S, Ray J G, Vermeulen M J, Sung L, Greenberg M, Koren G. Folic acid food fortification is associated with a decline in neuroblastoma. Clin Pharmacol Ther 2003; 74: 288–294
  • Kwan M L, Block G, Selvin S, Month S, Buffler P A. Food consumption by children and the risk of childhood acute leukemia. Am J Epidemiol 2004; 160: 1098–1107
  • Petridou E, Ntouvelis E, Dessypris N, Terzidis A, Trichopoulos D. Maternal diet and acute lymphoblastic leukemia in young children. Cancer Epidemiol Biomarkers Prev 2005; 14: 1935–1939
  • Gurney J G, Smith M A, Olshan A F, Hecht S S, Kasum C M. Clues to the etiology of childhood brain cancer: N-nitroso compounds, polyomaviruses, and other factors of interest. Cancer Invest 2001; 19: 630–640
  • Sarasua S, Savitz D A. Cured and broiled meat consumption in relation to childhood cancer: Denver, Colorado (United States). Cancer Causes Control 1994; 5: 141–148
  • Peters J M, Preston-Martin S, London S J, Bowman J D, Buckley J D, Thomas D C. Processed meats and risk of childhood leukemia (California, USA). Cancer Causes Control 1994; 5: 195–202
  • Wen W, Shu X O, Potter J D, Severson R K, Buckley J D, Reaman G H, Robison L L. Parental medication use and risk of childhood acute lymphoblastic leukemia. Cancer 2002; 95: 1786–1794
  • Ross J A, Blair C K, Olshan A F, Robison L L, Smith F O, Heerema N A, Roesler M. Periconceptional vitamin use and leukemia risk in children with Down syndrome: a Children's Oncology Group study. Cancer 2005; 104: 405–410
  • Omenn G S, Goodman G E, Thornquist M D, Balmes J, Cullen M R, Glass A, Keogh J P, Meyskens F L, Jr., Valanis B, Williams J H, Jr., Barnhart S, Cherniack M G, Brodkin C A, Hammar S. Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J Natl Cancer Inst 1996; 88: 1550–1559
  • Chen D, Daniel K G, Chen M S, Kuhn D J, Landis-Piwowar K R, Dou Q P. Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. Biochem Pharmacol 2005; 69: 1421–1432
  • Matsui J, Kiyokawa N, Takenouchi H, Taguchi T, Suzuki K, Shiozawa Y, Saito M, Tang W R, Katagiri Y U, Okita H, Fujimoto J. Dietary bioflavonoids induce apoptosis in human leukemia cells. Leuk Res 2005; 29: 573–581
  • Chow L M, Chui C H, Tang J C, Lau F Y, Yau M Y, Cheng G Y, Wong R S, Lai P B, Leung T W, Teo I T, Cheung F, Guo D, Chan A S. Anti-angiogenic potential of Gleditsia sinensis fruit extract. Int J Mol Med 2003; 12: 269–273
  • Chen M S, Chen D, Dou Q P. Inhibition of proteasome activity by various fruits and vegetables is associated with cancer cell death. In Vivo 2004; 18: 73–80
  • Graham S. Epidemiology of retinoids and cancer. J Natl Cancer Inst 1984; 73: 1423–1428
  • Wolterbeek A P, Roggeband R, van Moorsel C J, Baan R A, Koeman J H, Feron V J, Rutten A A. Vitamin A and beta-carotene influence the level of benzo[a]pyrene-induced DNA adducts and DNA-repair activities in hamster tracheal epithelium in organ culture. Cancer Lett 1995; 91: 205–214
  • Fillion L, Collins A, Southon S. Beta-carotene enhances the recovery of lymphocytes from oxidative DNA damage. Acta Biochim Pol 1998; 45: 183–190
  • Torbergsen A C, Collins A R. Recovery of human lymphocytes from oxidative DNA damage; the apparent enhancement of DNA repair by carotenoids is probably simply an antioxidant effect. Eur J Nutr 2000; 39: 80–85
  • Astley S B, Elliott R M, Archer D B, Southon S. Increased cellular carotenoid levels reduce the persistence of DNA single-strand breaks after oxidative challenge. Nutr Cancer 2002; 43: 202–213
  • Padayatty S J, Katz A, Wang Y, Eck P, Kwon O, Lee J H, Chen S, Corpe C, Dutta A, Dutta S K, Levine M. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr 2003; 22: 18–35
  • Tatman D, Mo H. Volatile isoprenoid constituents of fruits, vegetables and herbs cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukemia cells. Cancer Lett 2002; 175: 129–139
  • Jansson B. Dietary, total body, and intracellular potassium-to-sodium ratios and their influence on cancer. Cancer Detect Prev 1990; 14: 563–565
  • Jansson B. Potassium, sodium, and cancer: a review. J Environ Pathol Toxicol Oncol 1996; 15: 65–73
  • Thompson B, Demark-Wahnefried W, Taylor G, McClelland J W, Stables G, Havas S, Feng Z, Topor M, Heimendinger J, Reynolds K D, Cohen N. Baseline fruit and vegetable intake among adults in seven 5 a day study centers located in diverse geographic areas. J Am Diet Assoc 1999; 99: 1241–1248
  • Li R, Serdula M, Bland S, Mokdad A, Bowman B, Nelson D. Trends in fruit and vegetable consumption among adults in 16 US states: Behavioral Risk Factor Surveillance System, 1990–1996. Am J Public Health 2000; 90: 777–781
  • Riboli E, Norat T. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 2003; 78: 559S–569S
  • Kristal A R, Peters U, Potter J D. Is it time to abandon the food frequency questionnaire?. Cancer Epidemiol Biomarkers Prev 2005; 14: 2826–2828

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