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Research Article

DNA-Reactive Carcinogens: Mode of Action and Human Cancer Hazard

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Pages 673-683 | Published online: 10 Oct 2008

REFERENCES

  • Andersen M. E., Clewell H. J., Gargas M. L., MacNaughton M. G., Reitz R. H., Nolan R. J., McKenna M. J. Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans. Toxicol. Appl. Pharmacol. 1991; 108: 14–27, [PUBMED], [INFOTRIEVE], [CSA]
  • Cardis E., Zeise L., Schwarz M., Molgavkar S. Review of specific examples of QEP. Quantitative Estimation and Prediction of Human Cancer Risks, S. Moolgavkar, D. Krewski, L. Zeise, E. Cardis, H. Moller. IARC Scientific Publication No. 131, International Agency for Research on Cancer, Lyon 1999; 239–304
  • Casanova M., Conolly R. B., Heck H. d'A. DNA–protein cross-links (DPX) and cell proliferation in B6C3F1 mice but not Syrian golden hamsters exposed to dichloromethane: Pharmacokinetics and risk assessment with DPX as dosimeter. Fundam. Appl. Toxicol. 1996; 31: 103–116, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Casanova M., Bell D. A., Heck H. d'A. Dichloromethane metabolism to formaldehyde and reaction of formaldehyde with nucleic acids in hepatocytes of rodents and humans with and without glutathoine S-transferase T1 and M1 genes. Fundam. Appl. Toxicol. 1997; 37: 168–180, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Cole K. E., Jones T. W., Lipsky M. M., Trump B. F., Hsu I. C. In vitro binding of aflatoxin B1 and 2-acetylaminofluorene to rat, mouse and human hepatocyte DNA: The relationship of DNA binding to carcinogenicity. Carcinogenesis 1988; 9: 711–116, [PUBMED], [INFOTRIEVE], [CSA]
  • Croy R. G., Crouch E. A.C. Interaction of aflatoxin and hepatitis B virus as carcinogens in human populations. Mycotoxins, cancer and health, G. A. Bray, D. H. Ryan. Pennington Nutrition series, Louisiana State University Press, Baton Rouge 1991; Vol. 1: 87–100
  • Croy R. G., Wogan G. N. Temporal patterns of covalent DNA adducts in rat liver after single and multiple doses of aflatoxin B1. Cancer Res. 1981; 41: 197–203, [PUBMED], [INFOTRIEVE], [CSA]
  • Croy R. G., Essigmann J. M., Reinhold V. N., Wogan G. N. Identification of the principal aflatoxin B1–DNA adduct formed in vivo in rat liver. Proc. Natl. Acad. Sci. USA 1978; 75: 1745–1749, [PUBMED], [INFOTRIEVE], [CSA]
  • Cupid B. C., Lightfoot T. J., Russell D., Gant S. J., Turner P. C., Dingley K. H., Curtis K. D., Leveson S. H., Turteltaub K. W., Garner R. C. The formation of AFB (1)-macromolecular adducts in rats and humans at dietary levels of exposure. Food Chem. Toxicol. 2004; 42: 559–569, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Dell L. D., Mundt K. A., McDonald M., Tritschler J. P., II, Mundt D. J. Critical review of the epidemiology literature on the potential cancer risks of methylene chloride. Int. Arch Occup Environ Health 1999; 72: 429–442, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Denissenko M. F., Koudriakova T. B., Smith L., O'connor T. R., Riggs A. D., Pfeifer G. P. The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation of persistence or aflatoxin B1adducts. Oncogene 1998; 17: 3007–3014, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Doherty A. T., Ellard S., Parm E. M., Parry J. M. An investigation into the activation and deactivation of chlorinated hydrocarbons to genotoxins in metabolically competent human cells. Mutagenesis 1996; 11: 247–274, [PUBMED], [INFOTRIEVE], [CSA]
  • Eaton D. L., Bammler T. K., Kelly E. J. Interindividual differences in response to chemoprotection against aflatoxin-induced hepatocarcinogenesis: Implications for human biotransformation enzyme polymorphisms. Biol. React. Intermed. VI. Adn. Exp. Med. Biol. 2001; 500: 559–576, [CSA]
  • European Center for Ecotoxicology and Toxicology of Chemicals. The assessment of carcinogenic hazard for human beings exposed to methylene chloride. Technical Report No. 26, ECETOC, Brussels 1987
  • Gargas M. L., Clewell H. J., Andersen M. E. Metabolism of inhaled dichloromethane in vivo: Differentiation of kinetic constants for two independent pathways. Toxicol. Appl. Pharmacol. 1986; 82: 211–223, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Graves R. J., Coutts C., Green T. Methylene chloride induced DNA damage: An interspecies comparison. Carcinogenesis 1995; 16: 1919–1926, [PUBMED], [INFOTRIEVE], [CSA]
  • Groopman J. D., Jiaqi Z., Donahue P. R., Pikul A., Lisheng Z., Chen J. -S., Wogan G. N. Molecular dosimetry of urinary aflatoxin–DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China. Cancer Res. 1992; 52: 45–52, [PUBMED], [INFOTRIEVE], [CSA]
  • Groopman J. D., Wild C. P., Hasler J., Junshi C., Wogan G. N., Kensler T. W. Molecular epidemiology of aflatoxin exposures: Validation of aflatoxin–N7-guanine levels in urine as a biomarker in experimental rat models and humans. Environ. Health Perspect. 1993; 99: 107–113, [PUBMED], [INFOTRIEVE], [CSA]
  • Guengerich F. P., Johnson W. W., Ueng Y. -F., Yamasaki H., Shimada T. Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer. Environ. Health Perspect. 1996; 104(3)557–562, [PUBMED], [INFOTRIEVE], [CSA]
  • IARC. Some naturally occurring substances: Food items and constituents, heterocyclic aromatic amines and mycotoxins. Aflatoxins: B1, B2, G1, G2, M1,. IARC Monogr. Eval. Carcinogen. Risks Hum. 1993; 56: 245–395, Lyon: International Agency for Research on Cancer[CSA]
  • IARC. Dichloromethane. IARC Monographs. International Agency for Research on Cancer, Lyon 1999a; Vol. 71: 251–315
  • IARC. Consensus report. The use of short- and medium-term tests for carcinogens and data on genetic effects in carcinogenic hazard evaluation, J. B. McGregor, J. M. Rice, S. Venitt. IARC Scientific Publications No. 1467, International Agency for Research on Cancer, Lyon 1999b; 1–18
  • IARC. Some traditional herbal medicines, Some mycotoxins, napthalene and styrene. Aflatoxins. IARC Monogr. Evalu. Carcinogen. Risks Hum. 2002; 82: 171–274, [CSA]
  • International Programme on Chemical Safety. Environmental Health Criteria: Methylene chloride. World Health Organization, Geneva 1996
  • Kim S. K., Kim Y. C. Effect of a single administration of benzene, toluene or m-xylene on carboxyhemoglobin elevation and metabolism of dichloromethane in rats. J. Appl. Toxicol. 1996; 16: 437–444, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Mainwaring G. W., Williams S. M., Foster J. R, Tugwood J., Green T. The distribution of theta class glutathione S-transferases in the liver and lung of mouse, rat and human. Biochem. J. 1996; 318: 297–303, [PUBMED], [INFOTRIEVE], [CSA]
  • Mainwaring G. W., Foster J. R., Green T. Nuclear and cellular immunolocalization of theta class glutathione S-transferase GSTT1-1 in the liver and lung of the mouse. Biochem. J. 1998; 325: 431–432, [CSA]
  • Massey T. W., Stewart R. K., Daniels J. M., Liu L. Biochemical and molecular aspects of mammalian susceptibility to aflatoxin B1 carcinogenicity. Proc. Exp. Soc. Biol. Med. 1995; 208: 213–227, [CSA]
  • McQueen C. A., Way B. M., Williams G. M. Genotoxicity of carcinogens in human hepatocytes; application in hazard assessment. Toxicol. Appl. Pharmacol. 1988; 96: 360–366, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Meek M. E., Bucher J. R., Cohen S. M., Dellarco V., Hill R. N., Lehman-McKeeman L. D., Longfellow D. G., Pastoor T., Seed J., Patton D. E. A framework for human relevance analysis of information on carcinogenic modes of action. Crit. Rev. Toxicol. 2003; 33: 591–654, [PUBMED], [INFOTRIEVE], [CSA]
  • Meltzer P. S., Kallioniemi A., Trent J. M. Chromosome aberrations in human solid tumors. The genetic basis of human cancer, 2nd eds., B. Vogelstein, K. W. Kinzler. McGraw-Hill, New York 2002; 93–113
  • Mori H., Kawai K., Ohbayashi F., Kuniyasu T., Yamazaki M., Hamasaki T., Williams G. M. Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes. Cancer Res. 1984; 44: 2918–2923, [PUBMED], [INFOTRIEVE], [CSA]
  • Moss E. J., Neal G. E. The metabolism of aflatoxin B1 by human liver. Biochem. Pharmacol. 1985; 34: 3193–3197, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • National Toxicology Program. Technical report on the toxicology and carcinogenesis studies of dichloromethane in F344/N rats and B6C3F1 mice (inhalation studies). NIH publication 86-2562, NTP-TR 306, U.S. Department of Health and Human Services, Research Triangle Park, NC 1986
  • Nitschke K. D., Eisenbrandt D. L., Lomax L. G., Rao K. S. Methylene chloride: Two-generation inhalation reproductive study in rats. Fundam. Appl. Toxicol. 1988; 11: 60–67, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Peers F., Bosch X., Kaldo J., Linsell A., Pluijem M. Aflatoxin exposure, hepatitis B virus infection and liver cancer in Swaziland. Int. J. Cancer 1987; 39: 545–553, [PUBMED], [INFOTRIEVE], [CSA]
  • Peers F. G., Gilman G. A., Linsell C. A. Dietary aflatoxins and human liver cancer: A study in Swaziland. Int. J. Cancer 1976; 17: 167–176, [PUBMED], [INFOTRIEVE], [CSA]
  • Pitot H. C., III, Dragan Y. P. Chemical carcinogenesis. Cassarett and Doull's Toxicology: The Basic Science of Poisons, 6th ed., C. D. Klaassen. McGraw-Hil, New York 2001; 241–319
  • Puisieux A., Lim S., Groopman J., Ozturk M. Selective targeting of p53 mutational hotspots in human cancers by etiologically defined carcinogens. Cancer Res. 1991; 51: 6185–6189, [PUBMED], [INFOTRIEVE], [CSA]
  • Qian G. -S., Ross R. K., Yu M. C., Yuan J. -M., Gao Y. -T., Henderson B. E., Wogan G. N., Groopman J. D. A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiol. Biomarkers Prev. 1994; 3: 3–10, [PUBMED], [INFOTRIEVE], [CSA]
  • Ramsdell H. S., Eaton D. L. Species susceptibility to aflatoxin B1 carcinogenesis: Comparative kinetics of microsomal biotransformation. Cancer Res. 1990; 50: 615–620, [PUBMED], [INFOTRIEVE], [CSA]
  • Raney K. D., Coles B., Ketterer B., Harris T. M., Guengerich F. P. Glutathione conjugation of aflatoxin B1 expo and endo epoxides by rat and human glutathione S-transferases. Chem. Res. Toxicol. 1992; 5: 470–478, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Reitz R. H., Mendrola A. L., Guengerich F. P. In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically based pharmacokinetic models. Toxicol. Appl. Pharmacol. 1989; 97: 230–246, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Shank R. C., Bhamarapravati N., Gordon J. E., Wogan G. N. Dietary aflatoxins and human liver cancer. IV. Incidence of primary liver cancer in two municipal populations of Thailand. Food Cosmet. Toxicol. 1972; 10: 171–179, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Smela M. E., Currier S. S., Bailey E. A., Essigmann J. The chemistry and biology of aflatoxin B1: From mutational spectrometry to carcinogenesis. Carcinogenesis 2001; 22: 535–545, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Stoler D. L., Chen N., Basik M., Kahlenberg M. S., Rodriguez-Bigas M. A., Petrelli N. J., Anderson G. R. The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc. Natl. Acad. Sci.USA. 1999; 96: 15121–15126, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Taskinen H., Lindbohm M. -L., Hemminki K. Spontaneous abortions among women working in the pharmaceutical industry. Br. J. Ind. Med. 1986; 43: 199–205, [PUBMED], [INFOTRIEVE], [CSA]
  • Thorgeirsson U. P., Dalgard D. W., Reeves J., Adamson R. H. Tumor incidence in a chemical carcinogenesis study of nonhuman primates. Regul. Toxicol. Pharmacol. 1994; 19: 130–151, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Trueman R. W., Ashby J. Lack of UDS activity in the livers of mice and rats exposed to dichloromethane. Environ. Mol. Mutagen. 1987; 10: 189–195, [PUBMED], [INFOTRIEVE], [CSA]
  • U.S. Environmental Protection Agency. Guidelines for carcinogen risk assessment and supplemental guidelines for assessing susceptibility from early life exposure to carginogens. Risk Assessment Forum. U.S. Environmental Protection Agency. www.epa.gov/cancerguidelines, Washington, 2005DC 2005
  • Van Rensburg S. J., Cook-Mozaffari P., van Schalkwyk D. J., van der Watt J. J., Vincent T. J., Purchase I. F. Hepatocellular carcinoma and dietary aflatoxin in Mozambique and Transkei. Br. J. Cancer 1985; 51: 713–726, [PUBMED], [INFOTRIEVE], [CSA]
  • Wang L. -Y., Hatch M., Chen C. -J., Levin B., You S. -L., Lu S. -N., Wu M. -H., Wu W. -P., Wang L. -W., Wang Q., Huang G. -T., Yang P. -M., Lee H. -S., Santella R. M. Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan. Int. J. Cancer 1996; 67: 620–625, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Wild C. P., Hasegawa R., Barraud L., Chutimataewin S., Chapot B., Ito N., Montesano R. Aflatoxin–albumin adducts: A basis for comparative carcinogenesis between animals and humans. Cancer Epidemiol. Biomarkers Prev. 1996; 5: 179–189, [PUBMED], [INFOTRIEVE], [CSA]
  • Williams G. M. DNA reactive and epigenetic carcinogens. Exp. Toxicol. Pathol. 1992; 44: 457–463, [PUBMED], [INFOTRIEVE], [CSA]
  • Williams G. M., Iatropoulos M. J. Inhibition of the hepatocarcinogenicity of aflatoxin B1 in rats by low levels of phenolic antioxidants butylated hydroxyanisole and butylated hydroxytoluene. Cancer Lette. 1996; 104: 49–53, [CSA], [CROSSREF]
  • Williams G. M., Reiss B., Weisburger J. H. A comparison of the animal and human carcinogenicity of several environmental, occupational and therapeutic chemicals. Mechanisms and Toxicity of Chemical Carcinogens and Mutagens. Advances in Environmental Toxicology, G. Flamm, R. Lorentzen. Princeton Scientific, Princeton NJ 1985; vol. IX: 207–248
  • Wogan G. N. Aflatoxin carcinogenesis. Methods Cancer Res. 1973; 7: 309–344, [CSA]
  • Wogan G. N., Edwards G. S., Newberne P. M. Structure-activity relationships in toxicity and carcinogenicity of aflatoxins and analogs. Cancer Res. 1971; 31: 1936–1942, [PUBMED], [INFOTRIEVE], [CSA]
  • Yeh F. -S., Yu M. C., Mo C. -C., Luo S., Tong M. J., Henderson B. E. Hepatitis B virus, aflatoxin and hepatocellular carcinoma in Southern Guangxi, China. Cancer Res. 1989; 49: 2506–2509, [PUBMED], [INFOTRIEVE], [CSA]

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