Advanced search
Publication Cover
Critical Reviews in Toxicology Volume 36, 2006 - Issue 10
Submit an article Journal homepage
1,653
Views
386
CrossRef citations to date
0
Altmetric
Research Article

IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans

Alan R. Boobis Section of Experimental Medicine and Toxicology, Division of Medicine, Imperial College London, Hammersmith Campus, London, United Kingdom
,
Samuel M. Cohen Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
,
Vicki Dellarco Office of Pesticide Programs, U.S. Environmental Protection Agency, Washington, DC, USA
,
Douglas McGregor Toxicity Evaluation Consultants, Aberdour, United Kingdom
,
M. E. (Bette) Meek Existing Substances Division, Safe Environments Programme, Health Canada, Ottawa, Ontario, Canada
,
Carolyn Vickers International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland
,
Deborah Willcocks National Industrial Chemicals Notification and Assessment Scheme, Sydney, Australia
&
William Farland Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA
 show all
Pages 781-792 | Published online: 10 Oct 2008

REFERENCES

  • Cohen M., Meek M. E., Klaunig J. E., Patton D. E., Fenner-Crisp P. A. The human relevance of information on carcinogenic modes of action: an overview. Crit. Rev. Toxicol. 2003; 33: 581–589
  • Committee on Carcinogenicity. Guidance on a Strategy for the Risk Assessment of Chemical Carcinogens. Department of Health, London, United Kingdom 2004
  • Cortopassi G. A., Wang E. There is substantial agreement among interspecies estimates of DNA repair activity. Mech. Ageing Dev. 1996; 91: 211–218
  • Hanawalt P. C. Revisiting the rodent repairadox. Environ. Mol. Mutagen. 2001; 38: 89–96
  • Holsapple M. P., Pitot H. C., Cohen S. M., Boobis A. R., Klaunig J. E., Pastoor T., Dellarco V. L., Dragan Y. P. Mode of action in relevance of rodent liver tumors to human cancer risk. Toxicol. Sci. 2006; 89: 51–56
  • IPCS. Scoping meeting to address the human relevance of animal modes of action in assessing cancer risk, Carshalton, United Kingdom, 8–10 November 2000. World Health Organization, International Programme on Chemical Safety, Geneva 2000, http://www.who.int/ipcs/methods/harmonization/areas/cancer/en/index.html
  • IPCS. Report of the first meeting of the Cancer Working Group, Arlington, Virginia, USA, 3–5 March 2004. World Health Organization, International Programme on Chemical Safety, Geneva 2004, http://www.who.int/ipcs/methods/harmonization/areas/cancer/en/index.html
  • IPCS. Record of the Cancer Framework Workshop, Bradford, United Kingdom, 21–23 April 2005. World Health Organization, International Programme on Chemical Safety, Geneva 2005, http://www.who.int/ipcs/methods/harmonization/areas/cancer/en/index.html
  • National Research Council. Risk Assessment in the Federal Government. Managing the Process. National Academy Press, Washington, DC 1983
  • Meek M. E., Bucher J. R., Cohen S. M., Dellarco V., Hill R. N., Lehman-McKeeman L. D., Longfellow D. G., Pastoor T., Seed J., Patton D. E. A framework for human relevance analysis of information on carcinogenic modes of action. Crit. Rev. Toxicol. 2003; 33: 591–653
  • Preston J. R., Williams G. M. DNA-reactive carcinogens: Mode of action and human cancer hazard. Crit. Rev. Toxicol. 2005; 35: 673–683
  • Slikker W., Jr., Andersen M. E., Bogdanffy M. S., Bus J. S., Cohen S. D., Conolly R. B., David R. M., Doerrer N. G., Dorman D. C., Gaylor D. W., Hattis D., Rogers J. M., Setzer R. W., Swenberg J. A., Wallace K. Dose-dependent transitions in mechanisms of toxicity: Case studies. Toxicol. Appl. Pharmacol. 2004; 20: 226–294
  • Sonich-Mullin C., Fielder R., Wiltse J., Baetcke K., Dempsey J., Fenner-Crisp P., Grant D., Hartley M., Knaap A., Kroese D., Mangelsdorf I., Meek E., Rice J., Younes M. IPCS Conceptual framework for evaluating a mode of action for chemical carcinogenesis. Regul. Toxicol. Pharmacol. 2001; 34: 146–152
  • U.S. Environmental Protection Agency. Guidelines for Carcinogen Risk Assessment (Review Draft). Risk Assessment Forum, Washington, DC 1999, NCEA-F-0644
  • U.S. Environmental Protection Agency. Guidelines for Carcinogen Risk Assessment. Risk Assessment Forum, Washington, DC 2005, EPA/639/P-03/001F

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.