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Review Articles

Human exposure to environmental contaminants and congenital anomalies: a critical review

, , , , , , & show all
Pages 59-84 | Received 19 Nov 2015, Accepted 06 Jul 2016, Published online: 11 Aug 2016

References

  • Adewale HB, Jefferson WN, Newbold RR, Patisaul HB. 2009. Neonatal bisphenol-a exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin-releasing hormone neurons. Biol Reprod. 81:690–699.
  • Adibi JJ, Whyatt RM, Williams PL, Calafat AM, Camann D, Herrick R, Nelson H, Bhat HK, Perera FP, Silva MJ, Hauser R. 2008. Characterization of phthalate exposure among pregnant women assessed by repeat air and urine samples. Environ Health Perspect. 116:467–473.
  • Agay-Shay K, Friger M, Linn S, Peled A, Amitai Y, Peretz C. 2013. Air pollution and congenital heart defects. Environ Res. 124:28–34.
  • Agopian AJ, Lupo PJ, Canfield MA, Langlois PH. 2013. Case-control study of maternal residential atrazine exposure and male genital malformations. Am J Med Genet A. 161A:977–982.
  • Anderson WA, Castle L, Scotter MJ, Massey RC, Springall C. 2001. A biomarker approach to measuring human dietary exposure to certain phthalate diesters. Food Addit Contam. 18:1068–1074.
  • Austin AA, Fitzgerald EF, Pantea CI, Gensburg LJ, Kim NK, Stark AD, Hwang SA. 2011. Reproductive outcomes among former Love Canal residents, Niagara Falls, New York. Environ Res. 111:693–701.
  • Barr DB, Silva MJ, Kato K, Reidy JA, Malek NA, Hurtz D, Sadowski M, Needham LL, Calafat AM. 2003. Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers. Environ Health Perspect. 111:1148–1151.
  • Bazulic D, Stampar-Plasaj B, Bujanovic V, Stojanovski N, Nastev B, Rudelic I, Sisul N, Zuzek A. 1984. Organochlorine pesticide residues in the serum of mothers and their newborns from three Yugoslav towns. Bull Environ Contam Toxicol. 32:265–268.
  • Blount BC, Silva MJ, Caudill SP, Needham LL, Pirkle JL, Sampson EJ, Lucier GW, Jackson RJ, Brock JW. 2000. Levels of seven urinary phthalate metabolites in a human reference population. Environ Health Perspect. 108:979–982.
  • Bornehag CG, Carlstedt F, Jonsson BA, Lindh CH, Jensen TK, Bodin A, Jonsson C, Janson S, Swan SH. 2015. Prenatal phthalate exposures and anogenital distance in Swedish boys. Environ Health Perspect. 123:101–107.
  • Boyd DR, Genuis SJ. 2008. The environmental burden of disease in Canada: respiratory disease, cardiovascular disease, cancer, and congenital affliction. Environ Res. 106:240–249.
  • Braun JM, Smith KW, Williams PL, Calafat AM, Berry K, Ehrlich S, Hauser R. 2012. Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancy. Environ Health Perspect. 120:739–745.
  • Brender JD, Zhan FB, Suarez L, Langlois PH, Moody K. 2006. Maternal residential proximity to waste sites and industrial facilities and oral clefts in offspring. J Occup Environ Med. 48:565–572.
  • Cagen SZ, Waechter JM, Jr, Dimond SS, Breslin WJ, Butala JH, Jekat FW, Joiner RL, Shiotsuka RN, Veenstra GE, Harris LR. 1999. Normal reproductive organ development in CF-1 mice following prenatal exposure to bisphenol A. Toxicol Sci. 50:36–44.
  • Calafat AM, Kuklenyik Z, Reidy JA, Caudill SP, Ekong J, Needham LL. 2005. Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population. Environ Health Perspect. 113:391–395.
  • Calafat AM, McKee RH. 2006. Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study. Environ Health Perspect. 114:1783–1789.
  • Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL. 2008. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003–2004. Environ Health Perspect. 116:39–44.
  • Carbone P, Giordano F, Nori F, Mantovani A, Taruscio D, Lauria L, Figa-Talamanca I. 2006. Cryptorchidism and hypospadias in the Sicilian district of Ragusa and the use of pesticides. Reprod Toxicol. 22:8–12.
  • Carbone P, Giordano F, Nori F, Mantovani A, Taruscio D, Lauria L, Figa-Talamanca I. 2007. The possible role of endocrine disrupting chemicals in the aetiology of cryptorchidism and hypospadias: a population-based case-control study in rural Sicily. Int J Androl. 30:3–13.
  • Carmichael SL, Herring AH, Sjodin A, Jones R, Needham L, Ma C, Ding K, Shaw GM. 2010. Hypospadias and halogenated organic pollutant levels in maternal mid-pregnancy serum samples. Chemosphere. 80:641–646.
  • Carmichael SL, Yang W, Roberts EM, Kegley SE, Wolff C, Guo L, Lammer EJ, English P, Shaw GM. 2013. Hypospadias and residential proximity to pesticide applications. Pediatrics. 132:e1216–e1226.
  • Cech I, Burau KD, Walston J. 2007. Spatial distribution of orofacial cleft defect births in Harris County, Texas, 1990 to 1994, and historical evidence for the presence of low-level radioactivity in tap water. South Med J. 100:560–569.
  • Chen Y, Chen C, Yang B, Xu Q, Wu F, Liu F, Ye X, Meng X, Mougin B, Liu G, et al. 2011. Estrogen receptor-related genes as an important panel of predictors for breast cancer response to neoadjuvant chemotherapy. Cancer Lett. 302:63–68.
  • Chevrier C, Dananche B, Bahuau M, Nelva A, Herman C, Francannet C, Robert-Gnansia E, Cordier S. 2006. Occupational exposure to organic solvent mixtures during pregnancy and the risk of non-syndromic oral clefts. Occup Environ Med. 63:617–623.
  • Chevrier C, Petit C, Philippat C, Mortamais M, Slama R, Rouget F, Calafat AM, Ye X, Silva MJ, Charles MA, Cordier S. 2012. Maternal urinary phthalates and phenols and male genital anomalies. Epidemiology. 23:353–356.
  • Chia SE, Ong CN, Tsakok FM. 1994. Effects of cigarette smoking on human semen quality. Arch Androl. 33:163–168.
  • Clarnette TD, Sugita Y, Hutson JM. 1997. Genital anomalies in human and animal models reveal the mechanisms and hormones governing testicular descent. Br J Urol. 79:99–112.
  • Clementi M, Causin R, Marzocchi C, Mantovani A, Tenconi R. 2007. A study of the impact of agricultural pesticide use on the prevalence of birth defects in northeast Italy. Reprod Toxicol. 24:1–8.
  • Connor KT, Aylward LL. 2006. Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose–response data for enzyme induction indicate an impaired human AhR. J Toxicol Environ Health B Crit Rev. 9:147–171.
  • Cooper K, Marshall L, Vanderlinden L, Urstitti F. Hazardous chemicals/pollutants and associations with chronic disease: a scoping report; 2011.
  • Cresci M, Foffa I, Ait-Ali L, Pulignani S, Kemeny A, Gianicolo EA, Andreassi MG. 2013. Maternal environmental exposure, infant GSTP1 polymorphism, and risk of isolated congenital heart disease. Pediatr Cardiol. 34:281–285.
  • Dimich-Ward H, Hertzman C, Teschke K, Hershler R, Marion S, Ostry A, Kelly S. 1996. Reproductive effects of paternal exposure to chlorophenate wood preservatives in the sawmill industry. Scand J Work Environ Health. 22:267–273.
  • Dodds L, Seviour R. 2001. Congenital anomalies and other birth outcomes among infants born to women living near a hazardous waste site in Sydney, Nova Scotia. Can J Public Health = Rev Canad Sante Publiq. 92:331–334.
  • Dolk H, Vrijheid M. 2003. The impact of environmental pollution on congenital anomalies. Br Med Bull. 68:25–45.
  • Drouillet P, Forhan A, De Lauzon-Guillain B, Thiebaugeorges O, Goua V, Magnin G, Schweitzer M, Kaminski M, Ducimetiere P, Charles MA. 2009a. Maternal fatty acid intake and fetal growth: evidence for an association in overweight women. The 'EDEN mother-child' cohort (study of pre- and early postnatal determinants of the child's development and health). Br J Nutr. 101:583–591.
  • Drouillet P, Kaminski M, De Lauzon-Guillain B, Forhan A, Ducimetiere P, Schweitzer M, Magnin G, Goua V, Thiebaugeorges O, Charles MA. 2009b. Association between maternal seafood consumption before pregnancy and fetal growth: evidence for an association in overweight women. The EDEN mother-child cohort. Paediatr Perinat Epidemiol. 23:76–86.
  • Fein GG, Jacobson JL, Jacobson SW, Schwartz PM, Dowler JK. 1984. Prenatal exposure to polychlorinated biphenyls: effects on birth size and gestational age. J Pediatr. 105:315–320.
  • Felix JF, van Dooren MF, Klaassens M, Hop WC, Torfs CP, Tibboel D. 2008. Environmental factors in the etiology of esophageal atresia and congenital diaphragmatic hernia: results of a case-control study. Birth Defects Res A Clin Mol Teratol. 82:98–105.
  • Ferguson KK, Cantonwine DE, Rivera-Gonzalez LO, Loch-Caruso R, Mukherjee B, Anzalota Del Toro LV, Jimenez-Velez B, Calafat AM, Ye X, Alshawabkeh AN, et al. 2014. Urinary phthalate metabolite associations with biomarkers of inflammation and oxidative stress across pregnancy in Puerto Rico. Environ Sci Technol. 48:7018–7025.
  • Fernandez MF, Olmos B, Granada A, Lopez-Espinosa MJ, Molina-Molina JM, Fernandez JM, Cruz M, Olea-Serrano F, Olea N. 2007. Human exposure to endocrine-disrupting chemicals and prenatal risk factors for cryptorchidism and hypospadias: a nested case-control study. Environ Health Perspect. 115:8–14.
  • Foster W, Chan S, Platt L, Hughes C. 2000. Detection of endocrine disrupting chemicals in samples of second trimester human amniotic fluid. J Clin Endocrinol Metab. 85:2954–2957.
  • Foster WG, Chan S, Platt L, Hughes CL Jr. 2002. Detection of phytoestrogens in samples of second trimester human amniotic fluid. Toxicol Lett. 129:199–205.
  • Foster WG, Gregorovich S, Morrison KM, Atkinson SA, Kubwabo C, Stewart B, Teo K. (2011). Human maternal and umbilical cord blood concentrations of polybrominated diphenyl ethers. Environ Res. 84:1301–1309.
  • Foster WG, Holloway AC, Hughes CL. Jr. 2005. Dioxin-like activity and maternal thyroid hormone levels in second trimester maternal serum. Am J Obstet Gynecol. 193:1900–1907.
  • Garlantezec R, Chevrier C, Coiffec I, Celebi C, Cordier S. 2012. Combined effect of prenatal solvent exposure and GSTT1 or GSTM1 polymorphisms in the risk of birth defects. Birth Defects Res A Clin Mol Teratol. 94:481–485.
  • Garlantezec R, Monfort C, Rouget F, Cordier S. 2009. Maternal occupational exposure to solvents and congenital malformations: a prospective study in the general population. Occup Environ Med. 66:456–463.
  • Gaspari L, Paris F, Jandel C, Kalfa N, Orsini M, Daures JP, Sultan C. 2011. Prenatal environmental risk factors for genital malformations in a population of 1442 French male newborns: a nested case-control study. Hum Reprod. 26:3155–3162.
  • Gaspari L, Sampaio DR, Paris F, Audran F, Orsini M, Neto JB, Sultan C. 2012. High prevalence of micropenis in 2710 male newborns from an intensive-use pesticide area of Northeastern Brazil. Int J Androl. 35:253–264.
  • Gianicolo EA, Bruni A, Rosati E, Sabina S, Guarino R, Padolecchia G, Leo C, Vigotti MA, Andreassi MG, Latini G. 2012. Congenital anomalies among live births in a polluted area. A ten-year retrospective study. BMC Pregnancy Childbirth. 12:165.
  • Gianicolo EA, Mangia C, Cervino M, Bruni A, Andreassi MG, Latini G. 2014. Congenital anomalies among live births in a high environmental risk area – a case-control study in Brindisi (southern Italy). Environ Res. 128:9–14.
  • Gilboa SM, Mendola P, Olshan AF, Langlois PH, Savitz DA, Loomis D, Herring AH, Fixler DE. 2005. Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997–2000. Am J Epidemiol. 162:238–252.
  • Gilbreath S, Kass PH. 2006a. Adverse birth outcomes associated with open dumpsites in Alaska Native Villages. Am J Epidemiol. 164:518–528.
  • Gilbreath S, Kass PH. 2006b. Fetal and neonatal deaths and congenital anomalies associated with open dumpsites in Alaska Native villages. Int J Circumpolar Health. 65:133–147.
  • Giordano F, Abballe A, De FE, di DA, Ferro F, Grammatico P, Ingelido AM, Marra V, Marrocco G, Vallasciani S, Figa-Talamanca I. 2010. Maternal exposures to endocrine disrupting chemicals and hypospadias in offspring. Birth Defects Res A Clin Mol Teratol. 88:241–250.
  • Hansen CA, Barnett AG, Jalaludin BB, Morgan GG. 2009. Ambient air pollution and birth defects in Brisbane, Australia. PLoS One. 4:e5408.
  • Heeren GA, Tyler J, Mandeya A. 2003. Agricultural chemical exposures and birth defects in the Eastern Cape Province, South Africa: a case-control study. Environ Health. 2:11.
  • Hindin R, Brugge D, Panikkar B. 2005. Teratogenicity of depleted uranium aerosols: a review from an epidemiological perspective. Environ Health. 4:17.
  • Huang PC, Kuo PL, Chou YY, Lin SJ, Lee CC. 2009. Association between prenatal exposure to phthalates and the health of newborns. Environ Int. 35:14–20.
  • Hughes IA, Lim HN, Martin H, Mongan NP, Dovey L, Ahmed SF, Hawkins JR. 2001. Developmental aspects of androgen action. Mol Cell Endocrinol. 185:33–41.
  • Hughes IA. 2001. Minireview: sex differentiation. Endocrinology. 142:3281–3287.
  • Hutson JM. 1985. A biphasic model for the hormonal control of testicular descent. Lancet. 2:419–421.
  • Hwang BF, Jaakkola JJ, Guo HR. 2008. Water disinfection by-products and the risk of specific birth defects: a population-based cross-sectional study in Taiwan. Environ Health. 7:23.
  • Hwang BF, Jaakkola JJ. 2008. Ozone and other air pollutants and the risk of oral clefts. Environ Health Perspect. 116:1411–1415.
  • Hwang BF, Magnus P, Jaakkola JJ. 2002. Risk of specific birth defects in relation to chlorination and the amount of natural organic matter in the water supply. Am J Epidemiol. 156:374–382.
  • Iszatt N, Nieuwenhuijsen MJ, Nelson P, Elliott P, Toledano MB. 2011. Water consumption and use, trihalomethane exposure, and the risk of hypospadias. Pediatrics. 127:e389–e397.
  • Jorgensen KT, Jensen MS, Toft GV, Larsen AD, Bonde JP, Hougaard KS. 2014. Risk of cryptorchidism among sons of horticultural workers and farmers in Denmark. Scand J Work Environ Health. 40:323–330.
  • Jorgensen KT, Jensen MS, Toft GV, Larsen AD, Bonde JP, Hougaard KS. 2013. Risk of cryptorchidism and hypospadias among boys of maternal hairdressers – a Danish population-based cohort study. Scand J Work Environ Health. 39:302–309.
  • Kassotis CD, Tillitt DE, Davis JW, Hormann AM, Nagel SC. 2014. Estrogen and androgen receptor activities of hydraulic fracturing chemicals and surface and ground water in a drilling-dense region. Endocrinology. 155:897–907.
  • Kato K, Silva MJ, Reidy JA, Hurtz D, III, Malek NA, Needham LL, Nakazawa H, Barr DB, Calafat AM. 2004. Mono(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate as biomarkers for human exposure assessment to di-(2-ethylhexyl) phthalate. Environ Health Perspect. 112:327–330.
  • Kay VR, Bloom MS, Foster WG. 2014. Reproductive and developmental effects of phthalate diesters in males. Crit Rev Toxicol. 44:467–498.
  • Kay VR, Chambers C, Foster WG. 2013. Reproductive and developmental effects of phthalate diesters in females. Crit Rev Toxicol. 43:200–219.
  • Koch HM, Calafat AM. 2009. Human body burdens of chemicals used in plastic manufacture. Philos Trans R Soc Lond B Biol Sci. 364:2063–2078.
  • Koya PK, Chougaonkar MP, Predeep P, Jojo PJ, Cheriyan VD, Mayya YS, Seshadri M. 2012. Effect of low and chronic radiation exposure: a case-control study of mental retardation and cleft lip/palate in the monazite-bearing coastal areas of southern Kerala. Radiat Res. 177:109–116.
  • Krysiak-Baltyn K, Toppari J, Skakkebaek NE, Jensen TS, Virtanen HE, Schramm KW, Shen H, Vartiainen T, Kiviranta H, Taboureau O, et al. 2012. Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures. Int J Androl. 35:294–302.
  • Kuehl KS, Loffredo CA. 2003. Population-based study of l-transposition of the great arteries: possible associations with environmental factors. Birth Defects Res A Clin Mol Teratol. 67:162–167.
  • Kuscu OO, Caglar E, Aslan S, Durmusoglu E, Karademir A, Sandalli N. 2009. The prevalence of molar incisor hypomineralization (MIH) in a group of children in a highly polluted urban region and a windfarm-green energy island. Int J Paediatr Dent. 19:176–185.
  • Lawson CC, Schnorr TM, Whelan EA, Deddens JA, Dankovic DA, Piacitelli LA, Sweeney MH, Connally LB. 2004. Paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and birth outcomes of offspring: birth weight, preterm delivery, and birth defects. Environ Health Perspect. 112:1403–1408.
  • Li Z, Zhang L, Ye R, Liu J, Pei L, Zheng X, Ren A. 2013. Partner cigarette smoking and risk of neural tube defects among infants of non-smoking women in northern China. Tob Control. 22:401–405.
  • Li Z, Zhang L, Ye R, Pei L, Liu J, Zheng X, Ren A. 2011a. Indoor air pollution from coal combustion and the risk of neural tube defects in a rural population in Shanxi Province, China. Am J Epidemiol. 174:451–458.
  • Li ZW, Zhang L, Ye RW, Liu JM, Pei LJ, Zheng XY, Ren AG. 2011b. Maternal periconceptional consumption of pickled vegetables and risk of neural tube defects in offspring. Chin Med J (Engl). 124:1629–1633.
  • Loffredo CA, Silbergeld EK, Ferencz C, Zhang J. 2001. Association of transposition of the great arteries in infants with maternal exposures to herbicides and rodenticides. Am J Epidemiol. 153:529–536.
  • Longnecker MP, Gladen BC, Cupul-Uicab LA, Romano-Riquer SP, Weber JP, Chapin RE, Hernandez-Avila M. 2007. In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México. Am J Epidemiol. 165:1015–1022.
  • Longnecker MP, Kelbanoff MA, Zhou H, Brock JW. 2001. Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-for-gestational-age babies at birth. Lancet. 358:110–114.
  • Luben TJ, Nuckols JR, Mosley BS, Hobbs C, Reif JS. 2008. Maternal exposure to water disinfection by-products during gestation and risk of hypospadias. Occup Environ Med. 65:420–429.
  • Ma J, Qiu X, Ren A, Jin L, Zhu T. 2012. Using placenta to evaluate the polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) exposure of fetus in a region with high prevalence of neural tube defects. Ecotoxicol Environ Saf. 86:141–146.
  • Mageroy N, Mollerlokken OJ, Riise T, Koefoed V, Moen BE. 2006. A higher risk of congenital anomalies in the offspring of personnel who served aboard a Norwegian missile torpedo boat. Occup Environ Med. 63:92–97.
  • Main KM, Mortensen GK, Kaleva MM, Boisen KA, Damgaard IN, Chellakooty M, Schmidt IM, Suomi AM, Virtanen HE, Petersen DV, et al. 2006. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environ Health Perspect. 114:270–276.
  • Mangones T, Visintainer P, Brumberg HL. 2013. Congenital anomalies, prematurity, and low birth weight rates in relation to nuclear power plant proximity. J Perinat Med. 41:429–435.
  • Manzetti S, van der Spoel ER, van der Spoel D. 2014. Chemical properties, environmental fate, and degradation of seven classes of pollutants. Chem Res Toxicol. 27:713–737.
  • Marshall EG, Harris G, Wartenberg D. 2010. Oral cleft defects and maternal exposure to ambient air pollutants in New Jersey. Birth Defects Res A Clin Mol Teratol. 88:205–215.
  • Mattix KD, Winchester PD, Scherer LR. 2007. Incidence of abdominal wall defects is related to surface water atrazine and nitrate levels. J Pediatr Surg. 42:947–949.
  • McKenzie LM, Guo R, Witter RZ, Savitz DA, Newman LS, Adgate JL. 2014. Birth outcomes and maternal residential proximity to natural gas development in rural Colorado. Environ Health Perspect. 122:412–417.
  • Miao M, Yuan W, He Y, Zhou Z, Wang J, Gao E, Li G, Li DK. 2011. In utero exposure to bisphenol-A and anogenital distance of male offspring. Birth Defects Res A Clin Mol Teratol. 91:867–872.
  • Monroy R, Morrison K, Teo K, Atkinson S, Kubwabo C, Stewart B, Foster WG. 2008. Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples. Environ. Res 108:56–62.
  • Morales-Suarez-Varela MM, Toft GV, Jensen MS, Ramlau-Hansen C, Kaerlev L, Thulstrup AM, Llopis-Gonzalez A, Olsen J, Bonde JP. 2011. Parental occupational exposure to endocrine disrupting chemicals and male genital malformations: a study in the Danish National Birth Cohort study. Environ Health. 10:3.
  • Nassar N, Abeywardana P, Barker A, Bower C. 2010. Parental occupational exposure to potential endocrine disrupting chemicals and risk of hypospadias in infants. Occup Environ Med. 67:585–589.
  • Naufal Z, Zhiwen L, Zhu L, Zhou GD, McDonald T, He LY, Mitchell L, Ren A, Zhu H, Finnell R, Donnelly KC. 2010. Biomarkers of exposure to combustion by-products in a human population in Shanxi, China. J Expo Sci Environ Epidemiol. 20:310–319.
  • Niazi AK, Niazi SK. 2011. Endocrine effects of Fukushima: radiation-induced endocrinopathy. Indian J Endocrinol Metab. 15:91–95.
  • Nieuwenhuijsen MJ, Dadvand P, Grellier J, Martinez D, Vrijheid M. 2013. Environmental risk factors of pregnancy outcomes: a summary of recent meta-analyses of epidemiological studies. Environ Health. 12:6.
  • Nieuwenhuijsen MJ, Toledano MB, Bennett J, Best N, Hambly P, de HC, Wellesley D, Boyd PA, Abramsky L, Dattani N, et al. 2008. Chlorination disinfection by-products and risk of congenital anomalies in England and Wales. Environ Health Perspect. 116:216–222.
  • Ong CN, Chia SE, Foo SC, Ong HY, Tsakok M, Liouw P. 1993. Concentrations of heavy metals in maternal and umbilical cord blood. BioMetals. 6:61–66.
  • Ormond G, Nieuwenhuijsen MJ, Nelson P, Toledano MB, Iszatt N, Geneletti S, Elliott P. 2009. Endocrine disruptors in the workplace, hair spray, folate supplementation, and risk of hypospadias: case-control study. Environ Health Perspect. 117:303–307.
  • Padula AM, Tager IB, Carmichael SL, Hammond SK, Lurmann F, Shaw GM. 2013a. The association of ambient air pollution and traffic exposures with selected congenital anomalies in the San Joaquin Valley of California. Am J Epidemiol. 177:1074–1085.
  • Padula AM, Tager IB, Carmichael SL, Hammond SK, Yang W, Lurmann F, Shaw GM. 2013b. Ambient air pollution and traffic exposures and congenital heart defects in the San Joaquin Valley of California. Paediatr Perinat Epidemiol. 27:329–339.
  • Padula AM, Tager IB, Carmichael SL, Hammond SK, Yang W, Lurmann FW, Shaw GM. 2013c. Traffic-related air pollution and selected birth defects in the San Joaquin Valley of California. Birth Defects Res A Clin Mol Teratol. 97:730–735.
  • Papadopoulou E, Vafeiadi M, Agramunt S, Mathianaki K, Karakosta P, Spanaki A, Besselink H, Kiviranta H, Rantakokko P, Katerina S, et al. 2013. Maternal diet, prenatal exposure to dioxins and other persistent organic pollutants and anogenital distance in children. Sci Total Environ. 461–462:222–229.
  • Pereira MG, Murk AJ, Van den Berg H, Walker LA, Shore RF. 2014. How much do PCB toxic equivalents account for PHAH toxicity in predatory birds? Environ Pollut. 193:240–246.
  • Pryor JL, Hughes C, Foster W, Hales BF, Robaire B. 2000. Critical windows of exposure for children's health: the reproductive system in animals and humans. Environ Health Perspect. 108:491–503.
  • Queisser-Luft A, Wiesel A, Stolz G, Mergenthaler A, Kaiser M, Schlaefer K, Wahrendorf J, Blettner M, Spix C. 2011. Birth defects in the vicinity of nuclear power plants in Germany. Radiat Environ Biophys. 50:313–323.
  • Ramakrishnan A, Lupo PJ, Agopian AJ, Linder SH, Stock TH, Langlois PH, Craft E. 2013. Evaluating the effects of maternal exposure to benzene, toluene, ethyl benzene, and xylene on oral clefts among offspring in Texas: 1999–2008. Birth Defects Res A Clin Mol Teratol. 97:532–537.
  • Ren A, Qiu X, Jin L, Ma J, Li Z, Zhang L, Zhu H, Finnell RH, Zhu T. 2011. Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects. Proc Natl Acad Sci USA. 108:12770–12775.
  • Rignell-Hydbom A, Lindh CH, Dillner J, Jonsson BA, Rylander L. 2012. A nested case-control study of intrauterine exposure to persistent organochlorine pollutants and the risk of hypospadias. PLoS ONE. 7:e44767.
  • Ritz B, Yu F, Chapa G, Fruin S. 2000. Effect of air pollution on preterm birth among children born in Southern California between 1989 and 1993. Epidemiology. 11:502–511.
  • Ritz B, Yu F, Fruin S, Chapa G, Shaw GM, Harris JA. 2002. Ambient air pollution and risk of birth defects in Southern California. Am J Epidemiol. 155:17–25.
  • Rodriguez HA, Santambrosio N, Santamaria CG, Munoz-de-Toro M, Luque EH. 2010. Neonatal exposure to bisphenol A reduces the pool of primordial follicles in the rat ovary. Reprod Toxicol. 30:550–557.
  • Rull RP, Ritz B, Shaw GM. 2006. Neural tube defects and maternal residential proximity to agricultural pesticide applications. Am J Epidemiol. 163:743–753.
  • Salazar-Martinez E, Romano-Riquer P, Yanez-Marquez E, Longnecker MP, Hernandez-Avila M. 2004. Anogenital distance in human male and female newborns: a descriptive, cross-sectional study. Environ Health. 3:8.
  • Saxena M, Seth T, PL M. 1980. Organo chlorine pesticides in human placenta and accompanying fluid. Int J Environ Anal Chem. 7:248–251.
  • Saxena MC, Siddiqui MK, Seth TD, Krishna Murti CR, Bhargava AK, Kutty D. 1981. Organochlorine pesticides in specimens from women undergoing spontaneous abortion, premature of full-term delivery. J Anal Toxicol. 5:6–9.
  • Schnorr TM, Lawson CC, Whelan EA, Dankovic DA, Deddens JA, Piacitelli LA, Reefhuis J, Sweeney MH, Connally LB, Fingerhut MA. 2001. Spontaneous abortion, sex ratio, and paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ Health Perspect. 109:1127–1132.
  • Schreinemachers DM. 2003. Birth malformations and other adverse perinatal outcomes in four U.S. wheat-producing states. Environ Health Perspect. 111:1259–1264.
  • Sharpe RM. 2006. Pathways of endocrine disruption during male sexual differentiation and masculinization. Best Pract Res Clin Endocrinol Metab. 20:91–110.
  • Shekharyadav C, Bajpai M, Kumar V, Ahmed RS, Gupta P, Banerjee BD. 2011. Polymorphism in CYP1A1, GSTMI, GSTT1 genes and organochlorine pesticides in the etiology of hypospadias. Hum Exp Toxicol. 30:1464–1474.
  • Siddiqui MK, Saxena MC, Bhargava AK, Murti CR, Kutty D. 1981a. Chlorinated hydrocarbon pesticides in blood of newborn babies in India. Pestic Monit J. 15:77–79.
  • Siddiqui MK, Saxena MC, Bhargava AK, Seth TD, Murti CR, Kutty D. 1981b. Agrochemicals in the maternal blood, milk, and cord blood: a source of toxicants for prenates and neonates. Environ Res. 24:24–32.
  • Silva MJ, Barr DB, Reidy JA, Malek NA, Hodge CC, Caudill SP, Brock JW, Needham LL, Calafat AM. 2004. Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999–2000. Environ Health Perspect. 112:331–338.
  • Skakkebaek NE, Rajpert-De E, Main KM. 2001. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod. 16:972–978.
  • Snijder CA, Vlot IJ, Burdorf A, Obermann-Borst SA, Helbing WA, Wildhagen MF, Steegers EA, Steegers-Theunissen RP. 2012. Congenital heart defects and parental occupational exposure to chemicals. Hum Reprod. 27:1510–1517.
  • Stingone JA, Luben TJ, Daniels JL, Fuentes M, Richardson DB, Aylsworth AS, Herring AH, Anderka M, Botto L, Correa A, et al. 2014. Maternal exposure to criteria air pollutants and congenital heart defects in offspring: results from the national birth defects prevention study. Environ Health Perspect. 122:863–872.
  • Suzuki G, Tue NM, van der Linden S, Brouwer A, van der Burg B, van Velzen M, Lamoree M, Someya M, Takahashi S, Isobe T, et al. 2011. Identification of major dioxin-like compounds and androgen receptor antagonist in acid-treated tissue extracts of high trophic-level animals. Environ Sci Technol. 45:10203–10211.
  • Suzuki Y, Yoshinaga J, Mizumoto Y, Serizawa S, Shiraishi H. 2012. Foetal exposure to phthalate esters and anogenital distance in male newborns. Int J Androl. 35:236–244.
  • Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, Mao CS, Redmon JB, Ternand CL, Sullivan S, Teague JL. 2005. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect. 113:1056–1061.
  • Swan SH, Sathyanarayana S, Barrett ES, Janssen S, Liu F, Nguyen RH, Redmon JB, Team TS. 2015. First trimester phthalate exposure and anogenital distance in newborns. Hum Reprod. 30:963–972.
  • Swan SH. 2008. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ Res. 108:177–184.
  • Thomas P, Dong J. 2006. Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption. J Steroid Biochem Mol Biol. 102:175–179.
  • Tinwell H, Haseman J, Lefevre PA, Wallis N, Ashby J. 2002. Normal sexual development of two strains of rat exposed in utero to low doses of bisphenol A. Toxicol Sci. 68:339–348.
  • Torres-Sanchez L, Zepeda M, Cebrian ME, Belkind-Gerson J, Garcia-Hernandez RM, Belkind-Valdovinos U, Lopez-Carrillo L. 2008. Dichlorodiphenyldichloroethylene exposure during the first trimester of pregnancy alters the anal position in male infants. Ann N Y Acad Sci. 1140:155–162.
  • Tue NM, Suzuki G, Takahashi S, Kannan K, Takigami H, Tanabe S. 2013. Dioxin-related compounds in house dust from New York State: occurrence, in vitro toxic evaluation and implications for indoor exposure. Environ Pollut. 181:75–80.
  • Tyl RW, Myers CB, Marr MC, Sloan CS, Castillo NP, Veselica MM, Seely JC, Dimond SS, Van Miller JP, Shiotsuka RN Jr., et al. 2008. Two-generation reproductive toxicity study of dietary bisphenol A in CD-1 (Swiss) mice. Toxicol Sci. 104:362–384.
  • Vafeiadi M, Agramunt S, Papadopoulou E, Besselink H, Mathianaki K, Karakosta P, Spanaki A, Koutis A, Chatzi L, Vrijheid M, Kogevinas M. 2013. In utero exposure to dioxins and dioxin-like compounds and anogenital distance in newborns and infants. Environ Health Perspect. 121:125–130.
  • Vandenbergh JG, Huggett C. 1995. The anogenital distance index, a predictor of the intrauterine position effects on reproduction in female house mice. Lab Anim Sci. 45:567–573.
  • Vinceti M, Malagoli C, Fabbi S, Teggi S, Rodolfi R, Garavelli L, Astolfi G, Rivieri F. 2009. Risk of congenital anomalies around a municipal solid waste incinerator: a GIS-based case-control study. Int J Health Geogr. 8:8.
  • Vinceti M, Malagoli C, Teggi S, Fabbi S, Goldoni C, De GG, Ferrari P, Astolfi G, Rivieri F, Bergomi M. 2008. Adverse pregnancy outcomes in a population exposed to the emissions of a municipal waste incinerator. Sci Total Environ. 407:116–121.
  • Vrijheid M, Armstrong B, Dolk H, van TM, Botting B. 2003. Risk of hypospadias in relation to maternal occupational exposure to potential endocrine disrupting chemicals. Occup Environ Med. 60:543–550.
  • Wagner-Mahler K, Kurzenne JY, Delattre I, Berard E, Mas JC, Bornebush L, Tommasi C, Boda-Buccino M, Ducot B, Boulle C, et al. 2011. Prospective study on the prevalence and associated risk factors of cryptorchidism in 6246 newborn boys from Nice area, France. Int J Androl. 34:e499–e510.
  • Waller SA, Paul K, Peterson SE, Hitti JE. 2010. Agricultural-related chemical exposures, season of conception, and risk of gastroschisis in Washington State. Am J Obstet Gynecol. 202:241–246.
  • Wang C, Xie L, Zhou K, Zhan Y, Li Y, Li H, Qiao L, Wang F, Hua Y. 2013. Increased risk for congenital heart defects in children carrying the ABCB1 Gene C3435T polymorphism and maternal periconceptional toxicants exposure. PLoS One. 8:e68807.
  • Warner J, Osuch JR, Karmaus W, Landgraf JR, Taffe B, O'Keefe M, Mikucki D, Haan P. 2012. Common classification schemes for PCB congeners and the gene expression of CYP17, CYP19, ESR1 and ESR2. Sci Total Environ. 414:81–89.
  • Welshons WV, Nagel SC, Thayer KA, Judy BM, vom Saal FS. 1999. Low-dose bioactivity of xenoestrogens in animals: fetal exposure to low doses of methoxychlor and other xenoestrogens increases adult prostate size in mice. Toxicol Ind Health. 15:12–25.
  • Weselak M, Arbuckle TE, Wigle DT, Walker MC, Krewski D. 2008. Pre- and post-conception pesticide exposure and the risk of birth defects in an Ontario farm population. Reprod Toxicol. 25:472–480.
  • Whitworth KW, Symanski E, Coker AL. 2008. Childhood lymphohematopoietic cancer incidence and hazardous air pollutants in southeast Texas, 1995–2004. Environ Health Perspect. 116:1576–1580.
  • WHO. Global assessment of the state-of-the-science of endocrine disruptors; 2002. Available from: http://www.who.int/ipcs/publications/new_issues/endocrine_disruptors/en/.
  • Wigle DT, Arbuckle TE, Turner MC, Berube A, Yang Q, Liu S, Krewski D. 2008. Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J Toxicol Environ Health B Crit Rev. 11:373–517.
  • Williams F, Lawson A, Llyod O. 1992. Low sex ratios of births in areas at risk from air pollution from incinerators, as shown by geographical analysis and 3-dimensional mapping. Int J Epidemiol. 21:311–319.
  • Winchester PD, Huskins J, Ying J. 2009. Agrichemicals in surface water and birth defects in the United States. Acta Paediatr. 98:664–669.
  • Wittassek M, Angerer J. 2008. Phthalates: metabolism and exposure. Int J Androl. 31:131–138.
  • Wittassek M, Koch HM, Angerer J, Bruning T. 2011. Assessing exposure to phthalates – the human biomonitoring approach. Mol Nutr Food Res. 55:7–31.
  • Yang W, Carmichael SL, Roberts EM, Kegley SE, Padula AM, English PB, Shaw GM. 2014. Residential agricultural pesticide exposures and risk of neural tube defects and orofacial clefts among offspring in the San Joaquin Valley of California. Am J Epidemiol. 179:740–748.
  • Yang W, Zeng L, Cheng Y, Chen Z, Wang X, Li X, Yan H. 2012. The effects of periconceptional risk factor exposure and micronutrient supplementation on birth defects in Shaanxi Province in Western China. PLoS One. 7:e53429.
  • Zhang QG, Zhang J, Yu P, Shen H. 2009. Environmental and genetic factors associated with congenital microtia: a case-control study in Jiangsu, China, 2004 to 2007. Plast Reconstr Surg. 124:1157–1164.

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