Mercury-induced motor and sensory neurotoxicity: systematic review of workers currently exposed to mercury vapor

References

• Adams CR, Ziegler DK, Lin JT. 1983. Mercury intoxication simulating amyotrophic lateral sclerosis. JAMA. 250:642–643.
   PubMed Web of Science ®Google Scholar
• [ATSDR] Agency for Toxic Substances and Disease Registry. 1999. Toxicological profile for mercury (Update). Washington (DC): Department of Health and Human Services.
   Google Scholar
• Albers JW, Cavender GD, Levine SP, Langolf GD. 1982. Asymptomatic sensorimotor polyneuropathy in workers exposed to elemental mercury. Neurology. 32:1168–1174.
   PubMed Web of Science ®Google Scholar
• American Clinical Neurophysiology Society. 1997. Assessment of Digital EEG, Quantitative EEG, and EEG Brain Mapping (at: https://www.acns.org/pdf/guidelines/QEEG-Statement.pdf) Accessed: 04/17/2015.
   Google Scholar
• [ACGIH] American Conference of Governmental Industrial Hygienists. 1996. Mercury, Elemental and Inorganic Forms. Cincinnati, American Conference of Governmental Industrial Hygienists.
   Google Scholar
• [ACGIH] American Conference of Governmental Industrial Hygienists. 2012. 2012 Threshold Limit Values (TLVs) for Chemical Substances and Physical Agents and Biological Exposure Indices (BEIs). Cincinnati: American Conference of Governmental Industrial Hygienists.
   Google Scholar
• [ACGIH] American Conference of Governmental Industrial Hygienists. 2013. Mercury, Elemental: BEI® 7th Edition Documentation. Cincinnati: American Conference of Governmental Industrial Hygienists.
   Google Scholar
• [ACGIH] American Conference of Governmental Industrial Hygienists. 2014. 2014 Threshold Limit Values (TLVs) for Chemical Substances and Physical Agents and Biological Exposure Indices (BEIs). Cincinnati: American Conference of Governmental Industrial Hygienists.
   Google Scholar
• Anger WK. 2014. Reconsideration of the WHO NCTB strategy and test selection. Neurotoxicology. 45:224–231.
   PubMed Web of Science ®Google Scholar
• Angotzi G, Cassitto MG, Camerino D, Cioni R, Desideri E, Franzinelli A, Gori R, Loi F, Sartorelli E. 1980. Relation between mercury exposure and health conditions in a group of workers employed in a mercury distillation factory in Siena Province. Med Lav. 71:463–480.
   PubMedGoogle Scholar
• Angotzi G, Battistini N, Carboncini F, Cioni R, Desideri E, Paradiso C, Nuti D, Sartorelli E. 1981. Impairment of nervous system in workers exposed to inorganic mercury. Toxicol Eur Res. 3:275–278.
   PubMedGoogle Scholar
• Anon. 1988. State of Vermont, Village of Poultney v. STACO, Inc.. Chase Instruments Corporation, Chase instruments Sales Corporation, Keeper Corporation. Sirkus R, Munzer IW, Robert Munzer (Civ. A. No 86-190). Burlington (VT): United States District Court, District of Vermont.
   Google Scholar
• Ball RD. 2005. Electrodiagnostic evaluation of the peripheral nervous system. In: DeLisa JL, Gans BM, Walsh NE, Bockenek WL, editors. Physical medicine & rehabilitation: principles and practice. 4th ed. Philadelphia (PA): Lippincott Williams & Wilkins.
   Google Scholar
• Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL. 2005. Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect. 113:192–200.
   PubMed Web of Science ®Google Scholar
• Bast-Pettersen R, Ellingsen DG, Efskind J, Jordskogen R, Thomassen Y. 2005. A neurobehavioral study of chloralkali workers after the cessation of exposure to mercury vapor. Neurotoxicology. 26:427–437.
   PubMed Web of Science ®Google Scholar
• Berlin M. 1986. Mercury. In: Friberg L, Nordberg GF, Vouk VB, editors. Handbook on the toxicology of metals. Vol II. 2nd ed. Amsterdam: Elseiver; p. 387–445.
   Google Scholar
• Berme N, Oggero E, Pagnacco G. 1999. Power spectrum characteristics of physiologic and pathologic tremor. Acta Bioeng Biomech.1:71–88.
   Google Scholar
• Bidstrup PL, Bonnell JA, Harvey DG, Locket S. 1951. Chronic mercury poisoning in men repairing direct-current meters. Lancet. 2:856–861.
   PubMed Web of Science ®Google Scholar
• Buijink AW, Contarino MF, Koelman JH, Speelman JD, van Rootselaar AF. 2012. How to tackle tremor – systematic review of the literature and diagnostic work-up. Front Neurol. 3:146.
   PubMedGoogle Scholar
• Bunn WB, McGill CM, Barber TE, Cromer JW Jr, Goldwater LJ. 1986. Mercury exposure in chloralkali plants. Am Ind Hyg Assoc J. 47:249–254.
   PubMed Web of Science ®Google Scholar
• Camerino D, Cassitto MG, Desideri E, Angotzi G. 1981. Behavior of some psychological parameters in a population of a Hg extraction plant. Clin Toxicol. 18:1299–1309.
   PubMed Web of Science ®Google Scholar
• Camerino D, Buratti M, Rubino FM, Somaruga C, Belluigi V, Bordiga A, Bordini L, Maraschi R, Molinari M, Colosio C, et al. 2002. Evaluation of the neurotoxic and nephrotoxic effects following long-term exposure to metallic mercury in employed at a chlorine/sodium-hydroxide plant. Med Lav. 93:238–250.
   PubMedGoogle Scholar
• Cavalleri A, Belotti L, Gobba F, Luzzana G, Rosa P, Seghizzi P. 1995. Colour vision loss in workers exposed to elemental mercury vapour. Toxicol Lett. 77:351–356.
   PubMed Web of Science ®Google Scholar
• Cavalleri A, Gobba F. 1998. Reversible color vision loss in occupational exposure to metallic mercury. Environ Res. 77:173–177.
   PubMed Web of Science ®Google Scholar
• CDC. 2014. Alcohol and Public Health (at: http://www.cdc.gov/alcohol/faqs.htm). Atlanta: Centers for Disease Control and Prevention.
   Google Scholar
• Chaffin DB, Dinman BD, Miller JM, Smith RG, Zontine DH. 1973. An Evaluation of the Effects of Chronic Mercury Exposures on EMG and Psychomotor Functions (HSM-099-71-62 Final Report). National Institutes of Health.
   Google Scholar
• Chang YC, Yeh CY, Wang JD. 1995. Subclinical neurotoxicity of mercury vapor revealed by a multimodality evoked potential study of chloralkali workers. Am J Ind Med. 27:271–279.
   PubMed Web of Science ®Google Scholar
• Chapman LJ, Sauter SL, Henning RA, Dodson VN, Reddan WG, Matthews CG. 1990. Differences in frequency of finger tremor in otherwise asymptomatic mercury workers. Br J Ind Med. 47:838–843.
   PubMedGoogle Scholar
• Clarkson TW. 1998. Human toxicology of mercury. J Trace Elem Exp Med. 11:303–317.
   Google Scholar
• Clarkson TW, Magos L, Myers GJ. 2003. The toxicology of mercury-current exposures and clinical manifestations. N Engl J Med. 349:1731–1737.
   PubMed Web of Science ®Google Scholar
• Coggon D, Rose G, Barker DJP. 2003. Epidemiology for the uninitiated (at: http://www.bmj.com/about-bmj/resources-readers/publications/epidemiology-uninitiated). London, British Medical Journal.
   Google Scholar
• Cohen EN, Brown BW, Wu ML, Whitcher CE, Brodsky JB, Gift HC, Greenfield W, Jones TW, Driscoll EJ. 1980. Occupational disease in dentistry and chronic exposure to trace anesthetic gases. J Am Dent Assoc. 101:21–31.
   PubMed Web of Science ®Google Scholar
• Colquitt PJ. 2003. Smoking increases mercury exposure in hospital workers-13 July, 2003. Br Med J. 327:1–4.
   PubMedGoogle Scholar
• Cordeiro Q Jr., de Araujo Medrado FM, Fraguas R. Jr. 2003. Depression, insomnia, and memory loss in a patient with chronic intoxication by inorganic mercury. J Neuropsychiatry Clin Neurosci. 15:457–458.
   PubMed Web of Science ®Google Scholar
• Custodio HM, Harari R, Gerhardsson L, Skerfving S, Broberg K. 2005. Genetic influences on the retention of inorganic mercury. Arch Environ Occup Health. 60:17–23.
   PubMed Web of Science ®Google Scholar
• Ehrenberg RL, Vogt RL, Smith AB, Brondum J, Brightwell WS, Hudson PJ, McManus KP, Hannon WH, Phipps FC. 1991. Effects of elemental mercury exposure at a thermometer plant. Am J Ind Med. 19:495–507.
   PubMed Web of Science ®Google Scholar
• El-Sadik YM, Abdel-Aziz ED. 1970. Effects of exposure of workers to mercury at a sodium hydroxide producing plant. Am Ind Hyg Assoc J. 31:705–710.
   PubMed Web of Science ®Google Scholar
• Ellingsen DG, Bast-Pettersen R, Efskind J, Thomassen Y. 2001. Neuropsychological effects of low mercury vapor exposure in chloralkali workers. Neurotoxicology. 22:249–258.
   PubMed Web of Science ®Google Scholar
• Ellingsen DG, Bast-Pettersen R, Efskind J, Gjolstad M, Olsen R, Thomassen Y, Molander P. 2006. Hand tremor related to smoking habits and the consumption of caffeine in male industrial workers. Neurotoxicology. 27:525–533.
   PubMed Web of Science ®Google Scholar
• [EPA] U.S. Environmental Protection Agency. 1984. Mercury health effects update (Health Issue Assessment) (EPA 600/8-84-019F). Research Triangle Park (NC): Environmental Protection Agency.
   Google Scholar
• [EPA] U.S. Environmental Protection Agency. 2012. Integrated risk information system: mercury elemental (CASRN 7439-97-6). Washington (DC): US Environmental Protection Agency.
   Google Scholar
• Fawer RF, DeRibaupierre Y, Gullemin MP, Berode M, Lob M. 1983. Measurement of hand tremor induced by industrial exposure to metallic mercury. Br J Ind Med. 40:204–208.
   PubMedGoogle Scholar
• Feldman RG. 1999a. Mercury. In: Feldman RG, editor. Occupational & environmental neurotoxicology. Philadelphia (PA): Lippincott-Raven; p. 92–114.
   Google Scholar
• Feldman RG. 1999b. Occupational & environmental neurotoxicology. Philadelphia (PA): Lippincott-Raven.
   Google Scholar
• Florentine MJ, Sanfilippo DJ. 1991. Elemental mercury poisoning. Clin Pharm. 10:213–221.
   PubMedGoogle Scholar
• Franssen H, van den Bergh PY. 2006. Nerve conduction studies in polyneuropathy: practical physiology and patterns of abnormality. Acta Neurol Belg. 106:73–81.
   PubMed Web of Science ®Google Scholar
• Friberg L, Vostal J. 1971. Mercury in the environment: an epidemiological and toxicological appraisal. Research Triangle Park (NC): Environmental Protection Agency.
   Google Scholar
• Gambini G. 1978. Correlation between the concentrations of inorganic mercury vapors in the air hydrargyriuria and symptoms of chronic mercurialism in a Cloro-Soda plant, using electrolytic cells with mercury cathodes (Italian). Med Lav. 69(3):379–392.
   Google Scholar
• Gilioli R, Bulgheroni C, Caimi L, Foa V, Filippini C, Boiardi A, Bussone G, Quarti M, Boeri R. 1976. Correlations between subjective complaints and objective neurophysiological findings in workers of a chlor-alkali plant. In: Horvath M, Frantik E, editors. Adverse effects of environmental chemicals and psychotropic drugs. Neurophysiological and behavioural tests (Vol. 2). Amsterdam: Elsevier Scientific Publishing Company; p. 157–164.
   Google Scholar
• Goldstein G, Sanders RD. 2004. Sensory-perceptual and motor function. In: Goldstein G, Beers SR, Hersen M, editors. Comprehensive handbook of psychological assessment: intellectual and neuropsychological assessment (Vol. 1). Hoboken: John Wiley & Sons, p. 309–319.
   Google Scholar
• Gonzalez-Fernandez E, Mena J, Diaz-Gonzalez M, Martinez-Gil de Arana JM. 1984. A long-term survey of environmental, blood and urine mercury levels and clinical findings in workers manufacturing mercury relays. Ind Health. 22:97–106.
   PubMedGoogle Scholar
• Gonzalez-Usigli HA, Espay A. 2013. Tremor: a Merck Manual of Patient Symptoms Podcast (http://www.merckmanuals.com/professional/neurologic_disorders/movement_and_cerebellar_disorders/tremor.html). Whitehouse Station (NJ): Merk & Company, Inc.
   Google Scholar
• Goodrich JM, Wang Y, Gillespie B, Werner R, Franzblau A, Basu N. 2011. Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals. Toxicol Appl Pharmacol. 257:301–308.
   PubMed Web of Science ®Google Scholar
• Greenberg MI, Hamilton RJ, Phillips SD, McCluskey GJ. 2003. Clinical toxicology: mercury pathophysiology. In: Greenberg MI, Hamilton RJ, Phillips SD, McCluskey GJ, editors. Occupational, industrial, and environmental toxicology. 2nd ed. St. Louis (MO): Mosby; p. 91–95.
   Google Scholar
• Gundacker C, Gencik M, Hengstschlager M. 2010. The relevance of the individual genetic background for the toxicokinetics of two significant neurodevelopmental toxicants: mercury and lead. Mutat Res. 705:130–140.
   PubMed Web of Science ®Google Scholar
• Gunther W, Sietman B, Seeber A. 1996. Repeated neurobehavioral investigations in workers exposed to mercury in a chloralkali plant. Neurotoxicology. 17:605–614.
   PubMed Web of Science ®Google Scholar
• Hudson PJ, Vogt RL, Brondum J, Witherell L, Myers G, Paschal DC. 1987. Elemental mercury exposure among children of thermometer plant workers. Pediatrics. 79:935–938.
   PubMed Web of Science ®Google Scholar
• Hursh JB, Greenwood MR, Clarkson TW, Allen J, Demuth S. 1980. The effect of ethanol on the fate of mercury vapor inhaled by man. J Pharmacol Exp Ther. 214:520–527.
   PubMed Web of Science ®Google Scholar
• [IPCS] International Programme on Chemical Safety. 2003. Concise international chemical assessment document 50: elemental mercury and inorganic mercury compounds: human health aspects. Geneva: World Health Organization.
   Google Scholar
• Iwata T, Sakamoto M, Feng X, Yoshida M, Liu XJ, Dakeishi M, Li P, Qiu G, Jiang H, Nakamura M, Murata K. 2007. Effects of mercury vapor exposure on neuromotor function in Chinese miners and smelters. Int Arch Occup Environ Health. 80:381–387.
   PubMed Web of Science ®Google Scholar
• Johnson BL, Baker EL. 1987. Prevention of neurotoxic illness in working populations. New York, Wiley.
   Google Scholar
• Khayat A, Dencker L. 1984. Organ and cellular distribution of inhaled metallic mercury in the rat and Marmoset monkey (Callithrix jacchus): influence of ethyl alcohol pretreatment. Acta Pharmacol Toxicol (Copenh). 55:145–152.
   PubMedGoogle Scholar
• Kissin B. 1977. Medical management of the alcoholic patient. In: Kissin B, Begleiter H, editors. The biology of alcoholism: treatment and rehabilitation of the chronic alcoholic. Vol. 5, 5th ed. Boston: Springer; p. 53–103.
   Google Scholar
• Langolf GD, Chaffin DB, Henderson R, Whittle HP. 1978. Evaluation of workers exposed to elemental mercury using quantitative tests of tremor and neuromuscular functions. Am Ind Hyg Assoc J. 39:976–984.
   PubMed Web of Science ®Google Scholar
• Langolf GD, Smith PJ, Henderson R, Whittle H. 1981. Measurements of neurological functions in the evaluations of exposure to neurotoxic agents. Ann Occup Hyg. 24:293–296.
   PubMed Web of Science ®Google Scholar
• Langworth S, Almqvist O, Soderman E, Wikstrom BO. 1992. Effects of occupational exposure to mercury vapour on the central nervous system. Br J Ind Med. 49:545–555.
   PubMedGoogle Scholar
• Lauwerys RR, Hoet P. 2001. Industrial chemical exposure: guidelines for biological monitoring (3rd ed.). Boca Raton: CRC Press.
   Google Scholar
• Levine SP, Cavender GD, Langolf GD, Albers JW. 1982. Elemental mercury exposure: peripheral neurotoxicity. Br J Ind Med. 39:136–139.
   PubMedGoogle Scholar
• Li P, Feng X, Qui G, Li Z, Fu X, Sakamoto M, Liu X, Wang D. 2008. Mercury exposures and symptoms in smelting workers and artisanal mercury mines in Wuchuan, Guizhou, China. Environ Res. 107:108–114.
   PubMed Web of Science ®Google Scholar
• Liang YX, Sun RK, Sun Y, Chen ZQ, Li LH. 1993. Psychological effects of low exposure to mercury vapor: application of a computer-administered neurobehavioral evaluation system. Environ Res. 60:320–327.
   PubMed Web of Science ®Google Scholar
• Lippold OCJ, Williams EJ, Wilson CG. 1980. Finger tremor and cigarette smoking. Br J Clin Pharmacol. 10:83–86.
   PubMed Web of Science ®Google Scholar
• Locket S, Nazroo IA. 1952. Eye changes following exposure to metallic mercury. Lancet. 259:528–532.
   Google Scholar
• Louis ED, Yousefzadeh E, Barnes LF, Yu Q, Pullman SL, Wendt KJ. 2000. Validation of a portable instrument for assessing tremor severity in epidemiologic field studies. Mov Disord. 15:95–102.
   PubMed Web of Science ®Google Scholar
• Louis ED, Pullman SL. 2001. Comparison of clinical vs. electrophysiological methods of diagnosing of essential tremor. Mov Disord. 16:668–673.
   PubMed Web of Science ®Google Scholar
• Louis ED. 2007. Kinetic tremor: differences between smokers and non-smokers. Neurotoxicology. 28:569–575.
   PubMed Web of Science ®Google Scholar
• Lucchini R, Placidi D, Toffoletto F, Alessio L. 1996. Neurotoxicity in operating room personnel working with gaseous and nongaseous anesthesia. Int Arch Occup Environ Health. 68:188–192.
   PubMed Web of Science ®Google Scholar
• McCullough J, Dick R. 1999. Mercury Waste Solutions, Inc., Union Grove, Wisconsin (HETA 98-0320-2751). Cincinnati (OH): National Institute for Occupational Safety and Health, Centers for Disease Control.
   Google Scholar
• McCullough JE, Dick R, Rutchik J. 2001. Chronic mercury exposure examined with a computer-based tremor system. J Occup Environ Med. 43:295–300.
   PubMed Web of Science ®Google Scholar
• McGill CM, Ladd AC, Jacobs MB, Goldwater LJ. 1964. Mercury exposure in a chlorine plant. J Occup Med. 6:335–337.
   PubMedGoogle Scholar
• Meyer-Baron M, Schaeper M, Seeber A. 2002. A meta-analysis for neurobehavioural results due to occupational mercury exposure. Arch Toxicol. 76:127–136.
   PubMed Web of Science ®Google Scholar
• Meyer-Baron M, Schaeper M, van Thriel C, Seeber A. 2004. Neurobehavioural test results and exposure to inorganic mercury: in search of dose-response relations. Arch Toxicol. 78:207–211.
   PubMed Web of Science ®Google Scholar
• Miller JM, Chaffin DB, Smith RG. 1975. Subclinical psychomotor and neuromuscular changes in workers exposed to inorganic mercury. Am Ind Hyg Assoc J. 36:725–733.
   PubMed Web of Science ®Google Scholar
• Monforte R, Estruch R, Valls-Sole J, Nicolas J, Villalta J, Urbano-Marquez A. 1995. Autonomic and peripheral neuropathies in patients with chronic alcoholism. A dose-related toxic effect of alcohol. Arch Neurol. 52:45–51.
   PubMedGoogle Scholar
• Moore LE, Boffetta P, Karami S, Brennan P, Stewart PS, Hung R, Zaridze D, Matveev V, Janout V, Kollarova H, et al. 2010. Occupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variants. Cancer Res. 70:6527–6536.
   PubMed Web of Science ®Google Scholar
• [NIOSH] National Institute for Occupational Safety and Health. 2015. NIOSH Alerts: Controlling Exposures to Nitrous Oxide during Anesthetic Administration (DHHS (NIOSH) Publication No. 94-100)(http://www.cdc.gov/niosh/docs/94-100/). Atlanta: Centers for Disease Control and Prevention.
   Google Scholar
• [NINDS] National Institute of Neurological Disorders and Stroke. 2012. Tremor (NIH Publication No. 12-4734). Bethesda: National Institute of Neurological Disorders and Stroke, National Institute of Health.
   Google Scholar
• [NINDS] National Institute of Neurological Disorders and Stroke. 2016. Tremor Fact Sheet (http://www.ninds.nih.gov/disorders/tremor/detail_tremor.htm). Bethesda: NIH Neurological Institute.
   Google Scholar
• National Institute on Alcohol Abuse and Alcoholism. 2016. Drinking Levels Defined (http://www.niaaa.nih.gov/alcohol-health/overview-alcohol-consumption/moderate-binge-drinking). Bethesda: National Institutes of Health.
   Google Scholar
• National Research Council. 1992. Environmental neurotoxicology. Washington (DC): The National Academies Press.
   Google Scholar
• Nerudova J, Cabelkova Z, Frantik E, Lukas E, Urban P, Blaha K, Pelclova D, Lebedova J, Cikrt M. 2000. Mobilization of mercury by DMPS in occupationally exposed workers and in model experiments on rats: evaluation of body burden. Int J Occup Med Environ Health. 13:131–146.
   PubMedGoogle Scholar
• Nuwer M. 1997. Assessment of digital EEG, quantitative EEG, and EEG brain mapping: report of the American Academy of Neurology and the American Clinical Neurophysiology Society. Neurology. 49:277–292.
   PubMed Web of Science ®Google Scholar
• Ogata M, Wang DH, Ogino K. 2016. Mammalian acatalasemia: the perspectives of bioinformatics and genetic toxicology. Acta Med Okayama. 62:345–361.
   Google Scholar
• OSHA. 1978. Occupational exposure to lead. Fed Reg. 43:52952–53007.
   Google Scholar
• OSHA. 1992. Occupational exposure to cadmium. Final rule. Fed Reg. 57:42102–42463.
   Google Scholar
• Piikivi L, Hanninen H, Martelin T, Mantere P. 1984. Psychological performance and long-term exposure to mercury vapors. Scand J Work Environ Health. 10:35–41.
   PubMed Web of Science ®Google Scholar
• Piikivi L, Hanninen H. 1989. Subjective symptoms and psychological performance of chlorine-alkali workers. Scand J Work Environ Health. 15:69–74.
   PubMed Web of Science ®Google Scholar
• Piikivi L, Tolonen U. 1989. EEG findings in chlor-alkali workers subjected to low long term exposure to mercury vapour. Br J Ind Med. 46:370–375.
   PubMedGoogle Scholar
• Pranjic N, Sinanovic O, Jakubovic R. 2003. Chronic psychological effects of exposure to mercury vapour among chlorine-alkali plant workers. Med Lav. 94:531–541.
   PubMedGoogle Scholar
• Rajaniemi R. 1986. Clinical evaluation of occupational toxicity of methylmethacrylate monomer to dental technicians. J Soc Occup Med. 36:56–59.
   PubMedGoogle Scholar
• Reeves AG, Swenson RS. 2008a. Evaluation of the ataxic patient. In: Reeves AG, Swenson RS, editors. Disorders of the nervous system. A primer. Hanover: Dartmouth Medical School.
   Google Scholar
• Reeves AG, Swenson RS. 2008b. Motor system examination. In: Reeves AG, Swenson RS, editors. Disorders of the nervous system. A primer. Hanover: Dartmouth Medical School.
   Google Scholar
• Reh CM, Deitchman SD, Moss CE. 1991. NIOSH Health Hazard Evaluation Report: HETA: 87-402-2145, LCP Chemicals and Plastics, Inc., Brunswick, Georgia. Cincinnati: National Institute for Occupational Safety and Health, Centers for Disease Control.
   Google Scholar
• Rentos PG, Seligman EJ. 1968. Relationship between environmental exposure to mercury and clinical observation. Arch Environ Health. 16:794–800.
   PubMed Web of Science ®Google Scholar
• Roels H, Lauwerys R, Buchet JP, Bernard A, Barthels A, Oversteyns M, Gaussin J. 1982. Comparison of renal function and psychomotor performance in workers exposed to elemental mercury. Int Arch Occup Environ Health. 50:77–93.
   PubMed Web of Science ®Google Scholar
• Roels H, Gennart JP, Lauwerys R, Buchet JP, Malchaire J, Bernard A. 1985. Surveillance of workers exposed to mercury vapour: validation of a previously proposed biological threshold limit value for mercury concentration in urine. Am J Ind Med. 7:45–71.
   PubMed Web of Science ®Google Scholar
• Roels H, Abdeladim S, Braun M, Malchaire J, Lauwerys R. 1989. Detection of hand tremor in workers exposed to mercury vapor: a comparative study of three methods. Environ Res. 49:152–165.
   PubMed Web of Science ®Google Scholar
• Rohlman DS, Gimenes LS, Eckerman DA, Kang SK, Farahat FM, Anger WK. 2003. Development of the behavioral assessment and research system (BARS) to detect and characterize neurotoxicity in humans. Neurotoxicology. 24:523–531.
   PubMed Web of Science ®Google Scholar
• Schuckmann F. 1979. Study of preclinical changes in workers exposed to inorganic mercury in chloralkali plants. Int Arch Occup Environ Health. 44:193–200.
   PubMed Web of Science ®Google Scholar
• Schulte PA, Whittaker C, Curran CP. 2015. Considerations for using genetic and epigenetic information in occupational health risk assessment and standard setting. J Occup Environ Hyg. 12(1):S69–S81.
   Google Scholar
• Seppalainen AM, Rajaniemi R. 1984. Local neurotoxicity of methyl methacrylate among dental technicians. Am J Ind Med. 5:471–477.
   PubMed Web of Science ®Google Scholar
• Smith RG, Vorwald AJ, Patil LS, Mooney TF. 1970. Effects of exposure to mercury in the manufacture of chlorine. Am Ind Hyg Assoc J. 31:687–700.
   PubMed Web of Science ®Google Scholar
• Soleo L, Urbano ML, Petrera V, Ambrosi L. 1990. Effects of low exposure to inorganic mercury on psychological performance. Br J Ind Med. 47:105–109.
   PubMedGoogle Scholar
• Spencer PS, Schaumburg HH, Ludolph AC. 2000. Experimental and clinical neurotoxicology. New York: Oxford University Press.
   Google Scholar
• Stern Y. 2010a. Gait disorders. In: Rowland LP, Pedley TA, editors. Merritt’s neurology. 12th ed. Philadelphia (PA): Lippincott Williams & Wilkins.
   Google Scholar
• Stern Y. 2010b. Neuropsychological evaluation. In: Rowland LP, Pedley TA, editors. Merritt’s nNeurology. 12th ed. Philadelphia (PA): Lippincott Williams & Wilkins.
   Google Scholar
• Sternberg EJ, Alcalay RN, Levy OA, Louis ED. 2013. Postural and intention tremors: a detailed clinical study of essential tremor vs. Parkinson’s disease. Front Neurol. 4:1–8.
   PubMed Web of Science ®Google Scholar
• Suwa N, Takahata N. 1969. Clinical studies of chronic inorganic mercury poisoning [in Japanese]. Rec Adv Res Nerv System. 13:89–92.
   Google Scholar
• Tang N, Li YM. 2006. Neurotoxic effects in workers of the clinical thermometer manufacture plant. Int J Occup Med Environ Health. 19:198–202.
   PubMedGoogle Scholar
• Triebig G, Schaller KH. 1982. Neurotoxic effects in mercury-exposed workers. Neurobehav Toxicol Teratol. 4:717–720.
   PubMedGoogle Scholar
• Urban P, Lukas E, Benicky L, Moscovicova E. 1996. Neurological and electrophysiological examination on workers exposed to mercury vapors. Neurotoxicology. 17:191–196.
   PubMed Web of Science ®Google Scholar
• Urban P, Lukas E, Nerudova J, Cabelkova Z, Cikrt M. 1999. Neurological and electrophysiological examinations on three groups of workers with different levels of exposure to mercury vapors. Eur J Neurol. 6:571–577.
   PubMed Web of Science ®Google Scholar
• Urban P, Gobba F, Nerudova J, Lukas E, Cabelkova Z, Cikrt M. 2003. Color discrimination impairment in workers exposed to mercury vapor. Neurotoxicology. 24:711–716.
   PubMed Web of Science ®Google Scholar
• Verberk MM, Salle HJA, Kemper CH. 1986. Tremor in workers with low exposure to metallic mercury. Am Ind Hyg Assoc J. 47:559–562.
   PubMed Web of Science ®Google Scholar
• Verkkala E, Rajaniemi R, Savolainen H. 1983. Local neurotoxicity of methylmethacrylate monomer. Toxicol Lett. 18:111–114.
   PubMed Web of Science ®Google Scholar
• Vroom FQ, Greer M. 1972. Mercury vapour intoxication. Brain. 95:305–318.
   PubMed Web of Science ®Google Scholar
• Walker HK. 1990. The cerebellum. In: Walker HK, Hall WD, Hurst JW, editors. Clinical methods: the history, physical, and laboratory examinations. 3rd ed. Boston: Butterworths; p. 356–359.
   Google Scholar
• Wang Y, Goodrich JM, Gillespie B, Werner R, Basu N, Franzblau A. 2012. An investigation of modifying effects of metallothionein single-nucleotide polymorphisms on the association between mercury exposure and biomarker levels. Environ Health Perspect. 120:530–534.
   PubMed Web of Science ®Google Scholar
• Wastensson G, Lamoureux D, Sallsten G, Beuter A, Barregard L. 2006. Quantitative tremor assessment in workers with currrent low exposure to mercury vapor. Neurotoxicol Teratol. 28:681–693.
   PubMed Web of Science ®Google Scholar
• Wastensson G, Lamoureux D, Sallsten G, Beuter A, Barregard L. 2008. Quantitative assessment of neuromotor function in workers with current low exposure to mercury vapor. Neurotoxicology. 29:596–604.
   PubMed Web of Science ®Google Scholar
• Wastensson G. 2010. Quantitative methods for evaluation of tremor and neuromotor function (at: https://gupea.ub.gu.se/handle/2077/23133). Goteborg, Sweden: University of Gothenburg.
   Google Scholar
• West I, Lim J. 1968. Mercury poisoning among workers in California’s mercury mills. A preliminary report. J Occup Med. 10:697–701.
   PubMedGoogle Scholar
• White RF, Feldman RG, Moss MB, Proctor SP. 1993. Magnetic resonance imaging (MRI), neurobehavioral testing, and toxic encephalopathy: two cases. Environ Res. 61:117–123.
   PubMed Web of Science ®Google Scholar
• Wood RW, Weiss AB, Weiss B. 1973. Hand tremor induced by industrial exposure to inorganic mercury. Arch Environ Health. 26:249–252.
   PubMed Web of Science ®Google Scholar
• [WHO] World Health Organization. 1991. Environmental health criteria 118: inorganic mercury. Geneva: World Health Organization.
   Google Scholar
• Zampollo A, Baruffini A, Cirla AM, Pisati G, Zedda S. 1987. Subclinical inorganic mercury neuropathy: neurophysiological investigation 17 occupationally exposed subjects. Ital J Neuro Sci. 8:249–254.
   PubMedGoogle Scholar
• Zedda S, Cirla AM, Ratti R, Sala C, Zampollo A. 1980. Rischio da mercurio nella fabbricazione di lampade fluorescenti studio clinico e ambientale. G Ital Med Lav. 2:187–192.
   Google Scholar
• Zirschky J, Witherell L. 1987. Cleanup of mercury contamination of thermometer workers’ homes. Am Ind Hyg Assoc J. 48:81–84.
   PubMedGoogle Scholar