Phytochemical analysis and evaluation of antibacterial, antifungal, antioxidant and anti-inflammatory potential of Juniperus phoenicea subsp. phoenicea L. essential oil and hydrolate from central Italy

References

• F. Bakkali, S. Averbeck, D. Averbeck and M. Idaomar, Biological effects of essential oils – a review. Food & Chemical Toxicology, 46(2), 446–475 (2008). doi: 10.1016/j.fct.2007.09.106.
   PubMed Web of Science ®Google Scholar
• G. León-Méndez, N. Pájaro-Castro, E. Pájaro-Castro, M. Torrenegra Alarcón and A. Herrera-Barros, Essential oils as a source of bioactive molecules. Revista Colombiana de Ciencias Químico – Farmacéuticas, 48(1), 80–93 (2019). doi: 10.15446/rcciquifa.v48n1.80067.
   Google Scholar
• A. Ch Stratakos and A. Koidis. Methods for extracting essential oils. In:Essential Oils in Food Preservation, Flavor and Safety, Preedy VR. Edit., V. R. Preedy, pp. 31–38, Irish Academic Press, San Diego (2016).
   Google Scholar
• N. Lattaoui and A. Tantaoui-Elaraki, Individual and combined antibacterial activity of the main components of three thyme essential oils. Rivista Italiana EPPOS, 13, 13–19 (1994).
   Google Scholar
• G. Bonnier and R. Douin, La Grande Flore. Belin, Paris (1990).
   Google Scholar
• M. Meloni, D. Perini, R. Filigheddu and G. Binelli, Genetic variation in five Mediterranean populations of juniperus phoenicea as revealed by inter-simple sequence repeat (ISSR) markers. Annals of Botany, 97(2), 299–304 (2006). doi: 10.1093/aob/mcj024.
   PubMed Web of Science ®Google Scholar
• T.G. Tutin, N.A. Burges, A.O. Chater, J.R. Edmondson, V.H. Heywood, D.M. Moore, D.H. Valentine, S.M. Walters and D.A. Webbb. Eds. Flora Europaea, Vol. 1. Cambridge University Press. UK: pp. 46–48. (1964).
   Google Scholar
• J. Bellakhder, La Pharmacop´ee Marocaine traditionnellep. 272. Paris, Ibis Press (1997).
   Google Scholar
• M.M.A. Amer, M.M. Wasif and A.M. Abo-Aytta, Chemical and biological evaluation of juniperus phoenicea as a hypoglycamic agent. Journal of Agricultural Research, 21, 1077–1091 (1994).
   Google Scholar
• V. Stassi, A. Verykokidou, A. Loukis, C. Harvala and S. Philianos, The antimicrobial activity of the essential oils of four juniperus species growing wild in Greece. Flavour and Fragance Journal, 11(1), 71–74 (1996). doi: 10.1002/(SICI)1099-1026(199601)11:1<71:AID-FFJ536>3.0.CO;2-9.
   Google Scholar
• A. Angioni, A. Barra, M.T. Russo, V. Coroneo, S. Dessi and P. Cabras, Chemical composition of the essential oils of juniperus from ripe and unripe berries and leaves and their antimicrobial activity. Journal of Agricultural and Food Chemistry, 51, 3073–3078 (2003). doi: 10.1021/jf026203j.
   PubMed Web of Science ®Google Scholar
• C. Cavaleiro, S. Rezzi, L. Salgueiro, A. Bighelli, J. Casanova and A. Pronça da Cunha, Infraspecific chemical variability of the leaf essential oil of juniperus phoenicea var. turbinata from Portugal. Biochemical Systematics and Ecology, 29(11), 1175–1183 (2001). doi: 10.1016/S0305-1978(01)00041-2.
   Web of Science ®Google Scholar
• S. Rezzi, C. Cavaleiro, A. Bighelli, L. Salgueiro, A. Proença da Cunha and J. Casanova, Intraspecific chemical variability of the leaf essential oil of juniperus phoenicea subsp. turbinata from Corsica. Biochemical Systematics and Ecology, 29, 179–188 (2001). doi: 10.1016/S0305-1978(00)00044-2.
   PubMed Web of Science ®Google Scholar
• R.P. Adams, A.F. Barrero and A. Lara, Comparisons of the leaf essential oils of juniperus phoenicea, J. phoenicea subsp.Eu-mediterranea lebr. & thiv. And J. phoenicea var. turbinata (Guss.) parl.Journal Phoenicea Subsp Eumediterranea Lebr & Thiv and Journal Phoenicea Var Turbinata (Guss) Parl Journal of Essential Oil Research, 8(4), 367–371 (1996). doi: 10.1080/10412905.1996.9700642.
   Google Scholar
• T. Dob, D. Dahamane and C. Chelghoum, Chemical composition of the essential oil of juniperus phoenicea L. from Algeria. Journal of Essential Oil Research, 20(1), 15–20 (2008). doi: 10.1080/10412905.2008.9699410.
   Web of Science ®Google Scholar
• A.E. Edris, Identification and absolute quantification of the major water-soluble aroma components isolated from the hydrosols of some aromatic plants. Journal of Essential Oil-Bearing Plants, 12(2), 155–161 (2009). doi: 10.1080/0972060X.2009.10643705.
   Web of Science ®Google Scholar
• S. D’Amato, A. Serio, C.C. López and A. Paparella, Hydrosols: biological activity and potential as antimicrobials for food applications. Food Control, 86, 126.137 (2018). doi: 10.1016/j.foodcont.2017.10.030.
   Web of Science ®Google Scholar
• B.R. Rajeswara Rao. Hydrosols and water-soluble essential oils: their medicinal and biological properties. In: Book: Recent Progress in Medicinal Plants: Essential Oils I. 1st edn. Edits., J.N. Govil and S. Bhattacharya, Houston, USA: Studium Press LLC, Vol. 36 (2013).
   Google Scholar
• F.L. D’Antuono, G.C. Galletti and P. Bocchini, Variability of essential Oil content and composition of origanum vulgare L. Populations from a North Mediterranean area (Liguria Region, Northern Italy). Annals of Botany, 86(3), 471–478 (2000). doi: 10.1006/anbo.2000.1205.
   Web of Science ®Google Scholar
• S. Rathore, S. Mukhia, S. Kapoor, V. Bahtt, R. Kumar and R. Kumar, Seasonal variability in essential oil composition and biological activity of Rosmarinus officinalis L. accessions in the western Himalaya. Scientific Reports, 12(1), 3305 (2022). doi: 10.1038/s41598-022-07298-x.
   PubMed Web of Science ®Google Scholar
• M. Elyemni, B. Louaste, I. Nechad, T. Elkamli, A. Bouia, M. Taleb, M. Chaouch and N. Eloutassi, Extraction of essential oils of rosmarinus officinalis L. by two different methods: hydrodistillation and microwave assisted hydrodistillation. Scientific World Journal, 3659432, 1–6 (2019). doi: 10.1155/2019/3659432.
   Google Scholar
• E. Ovidi, V. Laghezza Masci, M. Zambelli, A. Tiezzi, S. Vitalini and S. Garzoli, Laurus nobilis, Salvia sclarea and Salvia officinalis Essential Oils and Hydrolates: Evaluation of Liquid and Vapor Phase Chemical Composition and Biological Activities. Plants, 10(4), 707 (2021). doi: 10.3390/plants10040707.
   Google Scholar
• S. Garzoli, V. Laghezza Masci, S. Franceschi, A. Tiezzi, P. Giacomello and E. Ovidi, Headspace/gc–MS analysis and Investigation of Antibacterial, antioxidant and cytotoxic activity of essential oils and hydrolates from rosmarinus officinalis L. and Lavandula angustifolia Miller. Foods, 10(8), 1768 (2021). doi: 10.3390/foods10081768.
   PubMed Web of Science ®Google Scholar
• J.L. Rodriguez-Tudela, M.C. Arendrup, F. Barchiesi, J. Bille, E. Chryssanthou, M. Cuenca-Estrella, E. Dannaoui, D.W. Denning, J.P. Donnelly, F. Dromer, W. Fegeler, C. Lass-Flörl, C. Moore, M. Richardson, P. Sandven, A. Velegraki and P. Verweij, et al., EUCAST definitive document EDef 7.1: method for the determination of broth dilution MICs of antifungal agents for fermentative yeasts. Clinical Microbiology and Infection, 14(4), 398–405 (2008). doi: 10.1111/j.1469-0691.2007.01935.x.
   PubMed Web of Science ®Google Scholar
• A. Ait-Ouazzou, S. Lorán, A. Arakrak, A. Laglaoui, C. Rota, A. Herrera, R. Pagán R and P. Conchello, Evaluation of the chemical composition and antimicrobial activity of mentha pulegium, juniperus phoenicea, and cyperus longus essential oils from Morocco. International Food Research Journa, 45(1), 313–319 (2012). doi: 10.1016/j.foodres.2011.09.004.
   Web of Science ®Google Scholar
• N. Achak, A. Romane, A. Abbad, M. Ennajar, M. Romdhane and A. Abderrabba, Essential Oil Composition of Juniperus Phoenicea from Morocco and Tunisia. Journal of Essential Oil Bearing Plants, 11(2), 137–142 (2008). doi: 10.1080/0972060X.2008.10643609.
   Web of Science ®Google Scholar
• E. Derwich, Z. Benziane and A. Boukir, Chemical composition of leaf essential oil of juniperus phoenicea and evaluation of its antibacterial activity. International Journal of Agriculture and Biology, 12, 199–204 (2010).
   Web of Science ®Google Scholar
• M. Ennajar, J. Bouajila, A. Lebrihi, F. Manef Abderraba, A. Raies and A. Romdhane, Chemical composition and antimicrobial and antioxidant activities of essential oils and various extracts of juniperus phoenicea L. (Cupressacees) Journal of Food Science, 74(7), (2009). doi: 10.1111/j.1750-3841.2009.01277.x.
   Google Scholar
• A.C.R. Da Silva, P.M. Lopes, M.M.B. de Azevedo, D.C. Machado Costa, C.S. Alviano and D.S. Alviano, Biological Activities of a-Pinene and β-Pinene Enantiomers. Molecules, 17(6), 6305–6316 (2012). doi: 10.3390/molecules17066305.
   PubMed Web of Science ®Google Scholar
• D.S. Kim, H.-J. Lee, Y.-D. Jeon, Y.-H. Han, J.-Y. Kee, H.-J. Kim, H.-J. Shin, J. Kang, B.S. Lee, S.-H. Kim, S.-J. Kim, S.-H. Park, B.-M. Choi, S.-J. Park, J.-Y. Um and S.-H. Hong, Alpha-pinene exhibits anti-inflammatory activity through the suppression of MAPKs and the NF-κB pathway in mouse peritoneal macrophages. The American Journal of Chinese Medicine, 43(4), 731–742 (2015). doi: 10.1142/S0192415X15500457.
   PubMed Web of Science ®Google Scholar
• C. Khaleel, N. Tabanca and G. Buchbauer, α-Terpineol, a natural monoterpene: A review of its biological properties. Open Chemistry, 16(1), 349–361 (2018). doi: 10.1515/chem-2018-0040.
   Web of Science ®Google Scholar
• Z.-M. Cai, J.-Q. Peng, Y. Chen, L. Tao, Y.-Y. Zhang, L.-Y. Fu, Q.-D. Long and X.-C. Shen, 1,8-cineole: a review of source, biological activities, and application. Journal of Asian Natural Products Research, 23(10), 938–954 (2021). doi: 10.1080/10286020.2020.1839432.
   PubMed Web of Science ®Google Scholar
• M. Ivanov, A. Kannan, D.S. Stojkovi´c, J. Glamoˇclija, R.C. Calhelha, I.C.F.R. Ferreira, D. Sanglard and M. Sokovi´c, Camphor and eucalyptol—anticandidal spectrum, antivirulence effect, efflux pumps interference and cytotoxicity. International Journal of Molecular Sciences, 22(2), 483 (2021). doi: 10.3390/ijms22020483.
   PubMed Web of Science ®Google Scholar
• U.R. Juergens, U. Dethlefsen, G. Steinkamp, A. Gillissen, R. Repges and H. Vetter, Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial. Respiratory Medicine, 97(3), 250–256 (2003). doi: 10.1053/rmed.2003.1432.
   PubMed Web of Science ®Google Scholar
• U.R. Juergens, Anti-inflammatory properties of the monoterpene 1.8-cineole: Current evidence for Co-medication in inflammatory airway diseases. Drug Research, 64(12), 638–646 (2014). doi: 10.1055/s-0034-1372609.
   PubMedGoogle Scholar
• S. Held, P. Schieberle and V. Somoza, Characterization of α-terpineol as an anti-inflammatory component of Orange Juice by in vitro studies using oral buccal cells. Journal of Agricultural and Food Chemistry, 55(20), 8040–8046 (2007). doi: 10.1021/jf071691m.
   PubMed Web of Science ®Google Scholar
• S.E. Silva-Filho, F.M. de Souza Silva-Comar, L. Wiirzler, R. Do Pinho, R. Grespan, C.A. Bersani-Amado and R.K.N. Cuman, Effect of camphor on the behavior of leukocytes in vitro and in vivo in acute inflammatory response. Tropical Journal of Pharmaceutical Research, 13(12), 2031 (2014). doi: 10.4314/tjpr.v13i12.13.
   Web of Science ®Google Scholar
• D. Nowicka and E. Grywalska, Staphylococcus aureus and Host Immunity in Recurrent Furunculosis. Dermatology, 235(4), 295–305 (2019). doi: 10.1159/000499184.
   PubMed Web of Science ®Google Scholar
• S. Soglia, V. Maione, M. Bugatti, W. Vermi, P. Calzavara-Pinton and M. Venturini, Adalimumab for interleukin-1β-mediated chronic non-scarring scalp folliculitis: case report and literature review. The Journal of Dermatology, 49(1), 157–160. (2022). doi: 10.1111/1346-8138.16106.
   PubMed Web of Science ®Google Scholar
• I. Kurokawa, Perifolliculitis capitis abscedens et suffodiens with hidradenitis suppurativa and nodulocystic acne treated with adalimumab. The Journal of Dermatology, 48(8), 374–375 (2021). doi: 10.1111/1346-8138.15945.
   Web of Science ®Google Scholar
• K. Nakai and D. Tsuruta, What are reactive oxygen species, free radicals, and oxidative stress in skin diseases? International Journal of Molecular Sciences, 22(19), 10799 (2021). doi: 10.3390/ijms221910799.
   PubMed Web of Science ®Google Scholar
• I. Mironczuk-Chodakowska, A.M. Witkowska and M.E. Zujko, Endogenous non-enzymatic antioxidants in the human body. Advances in Medical Sciences, 63(1), 68–78 (2018). doi: 10.1016/j.advms.2017.05.005.
   PubMed Web of Science ®Google Scholar
• A. Merecz-Sadowska, P. Sitarek, K. Zajdel, E. Kucharska, T. Kowalczyk and R. Zajdel, The modulatory influence of plant-derived compounds on human keratinocyte function. International Journal of Molecular Sciences, 22(22), 12488 (2021). doi: 10.3390/ijms222212488.
   PubMed Web of Science ®Google Scholar
• H.M.A. Cavanagh and J.M. Wilkinson, Lavender essential oil: a review. Australian Infection Control, 10(1), 35–37 (2005). doi: 10.1071/HI05035.
   Google Scholar
• The Complete IFRA Standards up to and including the 50th amendment. The international fragrance association. Jenuary 2022. https://ifrafragrance.org/safe-use/standards-documentation (24 September 2023).
   Google Scholar