Advanced search
Publication Cover
Leukemia & Lymphoma Volume 43, 2002 - Issue 8
Submit an article Journal homepage
101
Views
34
CrossRef citations to date
0
Altmetric
Research Article

Arsenic Trioxide: Acute Promyelocytic Leukemia and Beyond

T. Bachleitner-Hofmann Department of Internal Medicine I, Division of Haematology and Blood Coagulation, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
,
M. Kees Department of Internal Medicine I, Division of Haematology and Blood Coagulation, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
&
H. Gisslinger Department of Internal Medicine I, Division of Haematology and Blood Coagulation, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
Pages 1535-1540 | Published online: 01 Jul 2009

  • Correia, M.A. and Becker, C.E. (1989) "Chelators and heavy metal intoxication". In: Katzung, B.G., ed. Basic and Clinical Pharmacology (Prentice-Hall, London), p 747.
  • Finch, R.G. and Snyder, I.S. (1982) "Antiprotozoal drugs", In: Craig, C.R. and Stitzel, R.K., eds. Modern Pharmacology (Little, Brown, Boston), p 698.
  • Cutler, E.G. and Bradford, E.H. (1878) "Action of iron, cod-liver oil, and arsenic on the globular richness of the blood". American Journal of Medical Sciences 75, 74-84.
  • Forkner, C.E. and Scott, T.F.M. (1931) "Arsenic as a therapeutic agent in chronic myelogenous leukemia". Journal of the American Medical Association 97, 3-5.
  • Kandel, E.V. and LeRoy, G.V. (1937) "Chronic arsenical poisoning during the treatment of chronic myeloid leukemia", Archives of Internal Medicine 60, 846-866.
  • Waxman, S. and Anderson, K.C. (2001) "History of the development of arsenic derivatives in cancer therapy". The Oncologist 6(Suppl. 2), 3-10.
  • Warrell, J.P., de Thé, H., Wang, Z.Y. and Degos, L. (1993) "Acute promyelocytic leukemia". New England Journal of Medicine 329, 177-189.
  • Chen, G.Q., Shi, X.G., Tang, W., Xiong, S.M., Zhu, J., Cai, X., Han, Z.G., Ni, J.H., Shi, G.Y., Jia, P.M., Liu, M.M., He, K.L., Niu, C. Ma, J., Zhang, P., Zhang, T.D., Paul, P., Naoe, T., Kitamura, K., Miller, W., Waxman, S., Wang, Z.Y, de Thé, H., Chen, S.J. and Chen, Z. (1997) "Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): 1. As2O3 exerts, dose-dependent dual effects on APL cells". Blood 89, 3345-3353.
  • Wang, Z.G., Rivi, R., Delva, L., Konig, A., Scheinberg, D.A., Gambacort-Passerini, C., Gabrilove, J.L., Warrell, R.P. and Pandolfi, P.P. (1998) "Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARa independent manner". Blood 92, 1497-1504.
  • Soignet, S.L. (2001) "Clinical experience of arsenic trioxide in relapsed acute promyelocytic leukemia". The Oncologist 6(Suppl. 2), 11-16.
  • Soigriet, S., Fleischauer, A., Polyak T., Heller, G. and Warrell, R.P. (1997) "All-trans retinoic acid significantly increases 5-year survival in patients with acute promyeloeytic leukemia: long-term follow-up of the New York study". Cancer Chemotherapy and Pharmacology 40(Suppl.), S25-S29.
  • Sun, H.D., Ma, L., Hu, X.C. and Zhang, T.D. (1992) "Ai-Lin 1 treated 32 cases of acute promyelocyiic leukemia". Chinese Journal of Integrated Chinese and Western Medicine 12, 170-171.
  • Shen. Z. X., Chen, G.Q., Ni, JH., Li, X.S, Xiong, S.M., Qiu, Q.Y., Zhu, J., Tang, W., Sua, G.L., Yang, K.Q., Chen, Y. Zhou, L., Hang, Z.W., Wang, Y.T., Ma, J., Zhang, P., Zhang, T.D., Chen, S.J., Chen, Z. and Wang, Z.Y. (1997) "Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients". Blood 89, 3354-3360.
  • Niu, C., Yan, H., Yu, T., Sun, H.P., Liu, J.X., Li, X.S., Wu, W., Zhang, F.Q., Chen, Y., Zhou, L., Li, J.M., Zeng, X.Y., Yang, R.R., Yuan, M.M., Ren, M.Y., Gu, F.Y., Cao, Q., Gu, B.W., Su, X.Y., Chen, G.Q., Xiong, S.M., Zhang, T.D., Waxman, S., Wang, Z.Y., Chen, Z., Hu, J., Shen, Z.X. and Chen, S.J. (1999) "Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow up. and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelucytic leukemia patients". Blood 94, 3315-3324.
  • Soignet, S.L., Maslak, P., Wang, Z.G., Jhanwar. S., Calleja, E., Dardashti, L.J., Corso, D., de Balsio, A., Gabrilove, J., Scheinberg, D.A., Pandolfi, P.P. and Warrell, R.P. (1998) "Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide". New England Journal of Medicine 339, 1341-1348.
  • Jun, M., Guoqiang, X. and Guang, Y. (2000) "Clinical observations of As2O3 safety in the treatment of pediatric patients with acute promyelocytic leukemia (APL)". Blood 96(Suppl. 1), 722a.
  • Zhu, J., Koken, H.M., Quignon, F., Chelbi-Alix, M.K., Degos, L., Wang, Z.V., Chen, Z. and de Thé. H. (1997) "Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia", Proceedings of the National Academy of Sciences 94, 3978-3983.
  • Shao, W., Fanclli, M., Ferrara, F.F., Riccioni, R., Rosenauer, A., Davison, K., Lamph, W.W., Waxman, S., Pelicci, P.G., Coco, F.L., Avvisati, G., Testa, U., Peschle, C., Gambacorti-Passerini C. Nervi, C. and Miller, W.H. (1998) "Arsenic trioxide as an inducer of apoptosis and loss of PML/RARa protein in acute promyelocytic leukemia cells". Journal of the National Cancer Institute 90, 124-133.
  • Li, Y.M. and Broome, J.D. (1999) "Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells". Cancer Research 59, 776-780.
  • Roboz, G.J. Dias, S., Lam, G., Lane, W.J., Soignet, S.L., Warrell, Jr., R.P. and Rafti, S. (2000) "Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileuketnic effect via inhibition of angiogcnesis". Blood 96, 1525-1530.
  • Chen, G.Q., Zhu. J., Shi, X.G., Ni, J.H., Zhong, H.J., Si, G.Y., Jin, X.L., Tang, W., Li, X.S., Xong, S.M., Shen, Z.X., Sun, G.L., Ma, J., Zhang, P., Zhang, T.D., Gazin, C., Naoe, T., Chen, S.J., Wang, Z.Y. and Chen, Z. (1996) "In vitra studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RARa/PML proteins". Blood 88, 1052-1061.
  • Akao, Y., Mizoguchi, H., Kojima, S., Naoe, T., Ohishi, N. and Yagi, K. (1998) "Arsenic induces apoptosis in B-cell leukaemic cell lines in vitra: activation of caspases and down-regulation of Bcl-2 protein". British Journal of Haematology 102, 1055-1060.
  • Zhang, W., Ohnishi, K., Shigeno, K., Fujisama, S., Nailo, K., Nakamura, S., Takeshita, K., Takeshila, A. and Ohno, R. (1998) "The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms", Leukemia 12, 1383-1391.
  • Jing, Y., Dai, J., Chalmers-Redman, R.M.E., Tatton, W.G. and Waxman, S. (1999) "Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway". Blood 94, 2102-2111.
  • Perkins, C., Kim, C.N., Fang, G. and Bhalla, K.N. (2000) "Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or BCL-xL" Blood 95, 1014-1022.
  • Bachleitner-Hofmann, T., Gisslinger, B., Grumbeck, F. and Gisslinger. H. (2001) "Arsenic trioxide and ascorbic acid: synergy with potential implications for the treatment of acute myeloid leukaemia?". British Journal of Haematology 112, 783-786.
  • Zheng, J., Deng, Y.P., Lin, C., Fu, M., Xiao, P.G. and Wu, M. (1999) "Arsenic trioxidc induces apoptosis of HPV16 DNA-immortalized human cervical epithelial cells and selectively inhibits viral gene expression". International Journal of Cancer 82, 286-292.
  • Ishitsuka, K., Hanada. S., Suzuki, S., Utsunomiya, A., Chyuman, Y., Takeuchi, S., Takeshita, T., Shimotakahara, S., Uozumi, K., Makino, T. and Arima, T. (1998) "Arsenic trioxide inhibits growth of human T-cell leukaemia virus type I infected T-cell lines more effectively than relinoic acids", British Journal of Haematology 103, 721-728.
  • Rousselot, P., Labaume, S., Marollcacu, J.P., Larghero, J., Noguera, M.H., Brouet, J.C. and Fermand, J.P. (1999) "Arsenic trioxide and melarsoprol induce apuptosis in plasma cell lines and in plasma cells from myeloma patients". Cancer Research 59, 1041-1048.
  • Wang, T.S., Kuo, C.F., Jan, K.Y. and Huang, H. (2001) "Arsenic induces apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species". Journal of Cellular Physiology 169, 256-268.
  • Huang, X.J., Wieroik, P.H., Klein, R.S. and Gallagher, R.E. (1999) "Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases", Medical Oncology 16, 58-64.
  • Dai, J., Weinberg, R.S., Waxman, S. and Jing, Y. (1999) "Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the gluiathione redox system". Blood 93, 268-277.
  • Grad, J.M., Bahlis, N.J., Reis, I., Oshiro, M.M., Dalton, W.S. and Boise, L.H. (2001) "Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells". Blood 98, 805-813.
  • Murgo, A.J. (2001) "Clinical trials of arsenic trioxide in hematologic and solid tumors: overview of the national cancer institute cooperative research and development studies". The Oncologist 6(Suppl. 2), 22-28.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.