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Leukemia & Lymphoma Volume 43, 2002 - Issue 10
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Research Article

Acute Myelogenous Leukemia with Internal Tandem Duplication of the Flt3 Gene Appearing or Altering at the Time of Relapse: A Report of Two Cases

Randi Hovland Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital and University of Bergen, Bergen, Norway
,
BjØrn Tore Gjertsen Section for Hematology, Department of Medicine, Haukeland University Hospital and University of Bergen, Bergen, Norway
&
Øystein Bruserud Section for Hematology, Department of Medicine, Haukeland University Hospital and University of Bergen, Bergen, Norway
Pages 2027-2029 | Published online: 03 Aug 2009

  • [Line 17315]Wheatly, K., Burnett, A.K., Goldstone, A.M., Cray. R.G., Hann, I.M., Harrison, C.J., Rees, J.K., Stevens, R.F and Walker. H. (1999) "A simple, robust, validated and highly predictive index for the determination of risk directed therapy in acute mycloid leukemia derived from the MRC AMI. 10 trial". British Journal of Haematology 107, 69-79.
  • [Line 17351]Kottaridis, P.D., Gale, R.E., Frew, M.E., Harrison, G., Langabeer, S.E., Belton, A.A., Walker, H. Wheatley, K., Bowen, D.T., Burnett, A.K., Goldstone, A.H. and Linch. D.C. (2001) "The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML.) adds important prognostic information to cyloyonetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AMI. 10 and 12 trials". Blood 98, 1752-1759.
  • [Line 17390]Whitman, S.P., Archer, K.J., Feng, L., Baldus, C., Becknell, B., Carlson, B.D., Carroll, AJ., Mrozek, K., Vaidiman, J.W., George, S.L., Kolilz, J.E., Larson, R.A., Bloomfield, C.D. and Culigiuri, M.A. (2001) "Absence of the wild type allele predicts poor pronosis in adult de novo acute myeloid leukemia with normal cytogenetics and internal tandem duplication of FLT3: a cancer and leukemia group B study", Canver Research 61, 7233-7239.
  • [Line 17431]Nakano, Y Kiyoi, H., Miyawaki, S. Asou. N., Ohno, R., Saito, H. and Naoe, T. (1999) "Molecular evolution of acute mycloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene". British Journal of Haematology 104, 659-664.
  • [Line 17465]Nakao, M., Yokata, S., Iwai, T., Kaneko, H., Horiike, S., Kashima, K., Sonoda, Y., Fujimoto, T. and Misawa, S. (1996) "Internal tandem duplication of the Ilt3 gene found in acute mycloid leukemia". Leukemia 10, 1911-1918.
  • [Line 17501]Nakao, M., Janssen, J. W., Erz, D., Seria, T. and Bartram, C.R. (2000) "Tandem duplication of the FLT3 gene in acute lymphoblastic leukemia: a marker for the monitoring of minimal residual disease". Leukemia 14, 522-524.

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