Advanced search
Publication Cover
Leukemia & Lymphoma Volume 44, 2003 - Issue 2
Submit an article Journal homepage
82
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Evaluation of Thymic Output by Measurement of T-cell-receptor Gene Rearrangement Excisional Circles (TREC) in Patients who have Received Fludarabine

Victor M. Aquino Department of Pediatrics, the University of Texas Southwestern Medical Center of Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-9063, USA
,
Daniel C. Douek Department of Internal Medicine, the University of Texas Southwestern Medical Center of Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-8852, USA
,
Brian Berryman Department of Internal Medicine, the University of Texas Southwestern Medical Center of Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-8852, USA
,
Matthew Johnson Department of Internal Medicine, the University of Texas Southwestern Medical Center of Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-8852, USA
,
Vinay K. Jain The Baylor-Sammons Cancer Center, Dallas, TX 75390, USA
&
Robert H. Collins Department of Internal Medicine, the University of Texas Southwestern Medical Center of Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-8852, USA
Pages 343-348 | Published online: 01 Jul 2009

  • Borella, L., Green, A.A. and Webster, R.G. (1972) "Immunologic rebound after cessation of long-term chemotherapy in acute leukemia". Blood 40, 42-51.
  • Young, R.C., Corder, M.P., Haynes, H.A. and De Vita, V.T. (1972) "Delayed hypersensitivity in Hodgkin's disease: a study of 103 untreated patients", American Journal of Medicine 52, 63-72.
  • Eltringham, J.R. and Kaplan, H.S. (1973) "Impaired delayed hypersensitivity responses in 154 patients with untreated Hodgkin's disease". National Cancer Institute Monograph 36, 107-115.
  • Young, R.C., Corder, M.P., Berard, C.W., Bostick. F. and De Vita, V.T. (1973) "Immune alterations in Hodgkin's disease". Archives of Internal Medicine 131.
  • Levy, R. and Kaplan. H.S. (1974) "Impaired lymphocyte function in untreated Hodgkin's disease", New England Journal of Medicine 290, 181-186.
  • Bobrove, A. M., Fuks, Z., Strober, S. and Kaplan, H.S. (1975) "Quantitation of T and B lymphocytes and cellular immune function in Hodgkin's disease", Cancer 36, 168-179.
  • Tarpley, J.L., Potvin, C. and Chretien, P.B. (1975) "Prolonged depression of cellular immunity in cured laryngopharyngeal cancer patients treated with radiation therapy", Cancer 35, 638-644.
  • Case, D.C., Hanson, J.A., Corrales, E., Young, C.W., Dupont, B., Pinsky, C. M. and Good, R. A. (1976) "Comparison of multiple in vivo parameters in untreated patients with Hodgkin's disease", Cancer 38, 1807-1815.
  • Fuks, Z., Strober, S., Bobrove, A.M., Saszuki, T., McMichael, A. and Kaplan, H.S. (1976) "Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease". Journal of Clinical Investigation 58, 802-814.
  • Halili, M., Bosworth, J. and Romeny, s. (1976) "The long-term effect of radiotherapy on the immune status of patients cured of a gynecologic malignancy". Cancer 37, 2875-2878.
  • Holm, G., Mellstedt, H., Bjorkholm, M., Johnansson, B., Killander, D., Sundblad, R. and Sodergerg. G. (1976) "Lymphocyte abnormalities in untreated patients with Hodgkin's disease", Cancer (1976), 751-762.
  • Weitzman, S.A., Aisenberg, A.C., Siberg, G. R. and Smith, G. H. (1977) "Impaired humoral immunity in treated Hodgkin's disease", New England Journal of Medicine 297, 245-248.
  • King, G.W., Grozea, P.C., Eyre H.J. and LoBuglio, A.F. (1979) "Neoantigen response in patients successfully treated for lymphoma: a Southwest Oncology Group study", Annals of Internal Medicine 90, 892-895.
  • Douek, D.C., McFarland, R.D., Keiser, P.H., Gage, E.A., Masey, J.M., Haynes, B.F., Polis, M.A., Haase, A. T., Fenberg, M.B., Sullivan, J.L., Jamieson, B.D., Zack, J.A., Picker, L. J. and Koup, R. A. (1988) "Changes in thymic function with age and during the treatment of HIV infection", nature 296, 690-695.
  • Livak, F. and Schatz, D. (1996) "T-cell receptor a locus V(D)J recombination by-products are abundant in thymocytes and mature T cells", Molecular and Cellular Biology 16, 609-618.
  • Weinberg, K., Blazar, B.R., Wagner, J.E., Collins, R.H., Agura, E., Hill. B.J., Smogorzewska. M., Koup. R.A., Betts, M.R. and Douek, D.C. (2001) "Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation", Blood 97, 1458-1466.
  • Douek, D.C., Vescio, R.A., Betts, M.R., Brenchley, J.M., Hill, B.J., Zhang, L., Brenson. J.R., Collins, R.H. and Koup. R.A. (2000) "Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution", lancet 355, 1875-1881.
  • Wijermans, P.W., Gerrits, W.B. and Haak, H. L. (1993) "Severe immunodeficiency in patients treated with fludarabine monophosphate", European Journal of Haematology 50, 292-296.
  • Atkinson, K. (1990) "Reconstitution of the haematopoietic and immune systems after marrow transplantation", Bone Marrow Transplantation 5. 209-226.
  • Lenarsky. C. (1993) "Mechanisms in immune recovery after bone marrow transplantation: management of posttransplant immune deficiency", American Journal of Pediatric Heamatology Oncology 15. 49-55.
  • Parkman, R. and Weinberg, K. (1997) "Immunological reconstitution following bone marrow transplantation", Immunology Reviews 157, 73-78.
  • Hitzig, W.H., Pluss, H.J., Joller, P., Pilgrim, U., Tacier-Eugster, H. and Jakob. M. (1976) "Studies on the immune status of children with acute lymphocytic leukaemia. II. In remission with and without cytostatic treatment", Clinical and Experimental Immunology 26, 414-418.
  • Mustafa, M.M., Buchanan, G.R., Winick. N.J., McCracken, G.H., Tkaczewski, L, Lipscomb, M., Ansari, Q. and Agopian, M.S. (1998) "Immune recovery in children with malignancy after cessation of chemotherapy". Journal of Pediatric Hematology/Oncology 20, 451-457.
  • Smith, S., Schiffman, G., Karayalcin, G. and Bonagura, V. (1995) "Immunodeficiency in long-term survivors of acute lymphoblastic leukemia treated with Berlin-Frankfort-Munster therapy", Journal of Pediatrics 127, 68-75.
  • Fisher, R.L. De Vita, V.T., Bostick, F., Vanhaelen, C., Howser, D.M. Hubbard, S.M. and Young, R.C. (1980) "Persistent immunologic abnormalities in long-term survivors of Hodgkin's disease", Annals of Internal Medicine 92, 595-599.
  • Mackall, C.L., Fleisher, T.A., Brown, M.A., Andrich, M.P., Chen, C.C., Feuerstein, I.M., Horowitz, M.E., Magrath, I.T., Shad, A.T. and Steinberg, S.M. (1995) "Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy". New England Journal of Medicine 332, 143-149.
  • De Ruysscher, D., Waer, M., Vandeputte, M., Aerts, R., Vantongelen, K. and van der Schueren, E. (1992) "Changes of lymphocyte subsets after local irradiation therapy for early stage breast cancer and seminoma testis: long-term increase of activated (HLA-DR+) T cells and decrease of "naive" (CD4-CD45R) T lymphocytes", European Journal of Cancer 28, 1729-1734.
  • Rotstein, S., Blomgren, H., Petrini, B., Wasserman, J. and Baral, E. (1985) "Long-term effects on the immune system following local radiation therapy for breast cancer: I, Cellular composition of the peripheral lymphocyte population", International Journal of Radiation Oncology, Biology, Physics 11, 921-925.
  • Rotstein, S., Blomgren. H., Baral, E., Lax, I., Israelsson. A., Nilsson, B., Petrini. B. and Wasserman. J. (1987) "Incidence of infectious symptoms after radiation therapy for breast cancer: long-term effects", Acta Oncology 26, 197-201.
  • Adkins, J.C., Peter, D.H. and Markham. A. (1997) "Fludarabine. An update of its pharmacology and use in the treatment of haematological malignancies", Drugs 53, 1005-1037.
  • Grever, M., Leiby, J., Kraut, E., Metz, E., Neidhart. J., Balcerzak. S. and Malspeis, L. (1990) "A comprehensive phase I and II clinical investigation of fludarabine phosphate", Seminars in Oncology 17, 39-48.
  • Keating, M.J., Kantarjian, H., O'Brien. S., Koller, C., Talpza, M., Schachner, J., Childs. C.C., Freireich, E.J. and McCredie, K.B. (1991) "Fludarabine: a new agent with marked cytoreductive activity in untreated chronic lymphocytic leukemia", Journal of Clinical Oncology 9, 44-49.
  • Cervantes, F., Salgado, C., Montserrat, E. and Rozman, C. (1990) "Fludarabine for promyelocytic leukemia and risk of interstitial pneumonitis [letter]", Lancet 336, 1130.
  • Puccio, C.A., Mittelman, A., Lichtman, S.M., Silver, R.T., Budman, D.R., Ahmed, T., Feldman, E.J., Colemen, M., Arnold, P.M. and Arlin, Z.A. (1991) "A loading dose/continuous infusion schedule of fludarabine phosphate in chronic lymphocytic leukemia", Journal of Clinical Oncology 9. 1562-1569.
  • Kantarjian, H., Childs, C.C., O'Brien, S., Huh, Y., Beran, M., Schachner, J., Koller, C. and Keating, M.J. (1991) "Efficacy of fludarabine, a new adenine nucleoside analogue, in patients with prolymphocytic leukemia and the prolymphocytoid variant of chronic lymphocytic leukemia", American Journal of medicine 90, 223-228.
  • Hochster, H., Kim. K., Green. M.D., Mann, R. B., Neiman, R.S., Oken. M.M., Cassileth, P. A., Stott, P., Ritch, P. and O'Connell, M.J. (1992) "Activity of fludarabine in previously treated non-Hodgkin's low-grade lymphoma: results of an Easter Cooperative Oncology Group study", Journal of Clinical Oncology 10, 28-32.
  • Schilling, P.J. and Vadhan-Raj, S. (1990) "Concurrent cytomegalo-virus and pneumocystis pneumonia after Fludarabine therapy for chronic lymphocytic leukemia", New England Journal of Medicine 323, 833-834.
  • Sanders, C., Perez, E.A. and Lawrence, H.H. (1992) "Opportunistic infections in patients with chronic leukemia following treatment with fludarabine (letter)", American Journal of Hematology 39, 314-315.
  • Bastion, Y., Coiffier, B., Tigaud, J.D., Espinouse. D. and Bryon, P.A. (1991) "Pneumocystis pneumonia in a patient treated with Fludarabine for chronic lymphocytic leukemia", European Journal of Cancer 27, 671.
  • Soares, M.V., Borthwick, N.J., Maini, M.K., Janossy, G. Salmon, M. and Akbar, A. N. (1998) "IL-7-dependent extrathymic expansion of CD45RA+T cells enables preservation of a nïve repertoire", Journal of Immunology 161, 5909-5911.
  • Young, J.L. Ramage, J.M. Gaston, J.S. and Beverley, P.C. (1997) "In vitro responses of human CD45RObrightRA- and CD45RO-RAbright T cell subsets and their relationship to memory and naïve T cells", European Journal of Immunology 27, 2383-2390.
  • Tough, D.F. and Sprent, J. (1994) "Turnover of nE-and memoryphenotype T cells". Journal of Experimental Medicine 179, 1127-1135.
  • McClane, A. and Michie, C. (1995) "In vivo estimates of division and death rates of human T lymphocytes", Proceedings of the National Academy of Sciences of the United States of America 92, 3707-3711.
  • Picker, L.J., Treer, J., Ferguson-Darnell. B., Collins, P., Buck. D. and Terstappen, L. (1933) "Control of lymphocyte recirculation in man", Journal of Immunology 27, 1105-1121.
  • Bolotion. E., Smogorzewska, M., Smith, S., Widmer, M. and Weinberg, K. (1996) "Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7", Blood 88, 1887-1894.
  • Hofmeister, R., Khaled, A.R., Benbernou, N., Rahnavolgyi, E., Muegge, K. and Durum, S.K. (1999). "Interleukin-7: physiological roles and mechanism of action". Cytokine and Growth Factor Reviews 10, 41-60.
  • Uribe, I. and Weinberg, K. (1998) "X-linked SCD and other diseases of cytokines and receptors", Seminars in Hematology 35, 299-309.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.