43
Views
9
CrossRef citations to date
0
Altmetric
Research Article

The Cytotoxicity of Arsenic Trioxide to Normal Hematopoietic Progenitors and Leukemic Cells is Dependent on Their Cell-cycle Status

, , , &
Pages 2191-2199 | Published online: 01 Jul 2009

  • Stone, R.M. and Mayer, R.J. (1990) "The unique aspects of acute promyelocytic leukemia", Journal of Clinical Oncology 8, 1913-1921.
  • Grignani, F. De Matleis, S. Nervi, C., Tomassoni, L., Gelmetti, V., Cioce, M., Fanelli, M., Rutbardt, M. Ferrara, F.F. Zamir, I., Selser, C., Grignani, G., Lazar. M.A., Minucci, S. and Pelicci. P.G. (1998) "Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia", Nature 391. 815-818.
  • Lin, R.J., Nagy. L., Inoue, S. Shao. W., Miller, W.H. and Evans. R.M. (1998) "Role of the historic deacetylase complex in acute promyelocytic leukaemia", Nature 391, 811-814.
  • Warrell, R.P., de The. H. Wang, Z.-Y. and Degos, L. (1993) "Acute promyelocytic leukemia", New England Journal of Medicine 329, 177-189.
  • Niu, C. Van, H. Yu, T., Sun, H.P., Liu, J.X. Li, X.S., Wu, W., Zhang, F.Q., Chen, Y. Zhou, L., Li, J.M., Zeng, X.Y., Yang, R.R. Yuan, M.M., Ren, M.Y. Gu, F.Y., Cao. Q., Gu, B.W., Su, X.Y. Chen, G.Q. Xiong, S.M., Thang, T., Waxman, S., Wang, Z.Y. Chen, S.J., et al. (1999) "Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients", Blood 94, 3315-3324.
  • Soignet, S.L., Frankel, S.R., Douer, D., Tallman, M.S. Kanlarjian, H. Calleja. H., Stone, R.M. Kalaycio, M., Scheinberg, D.A. Steinherz, P., Sievers. E.L., Coutre. S. Dahlberg, S. Ellison, R. and Warrell, R.PJ. (2001) "United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia", Journal of Clinical Oncology 19, 3852-3860.
  • Zhang, T.D., Chen, G.Q., Wang, Z.G., Wang, Z.Y, Chen, S.J. and Chen, Z. (2001) "Arsenic trioxide. a therapeutic agent for APL", Oncogene 28, 7146-7153.
  • Cai, X., Shea. Y.L. Zhu, Q. Jia, P.M., Yu, Y, Zhou, L. Huang, Y, Zhang, J.W. Xiong, S.M., Chen, S.J. Wang. Z.Y., Chen, Z. and Chen, G.Q. (2000) "Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondria! Iransmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia", Leukemia 14, 262 -270.
  • Part, J.W., Choi, Y.J. Jang, M.A., Back, S.H. Lim. J.H., Passanti, T. and Kwon, T.K. (2001) "Arsenic trioxide induces G2/M growth arrest and apoptosis after caspase-3 activation and bel-2 phosphorylation in promonocytic U937 cells", Biochemical and Biophysical Research Communications 286, 726-734.
  • Akao, Y, Yamada, H. and Nakagawa, Y. (2000) "Arsenic-induced apoptosis in malignant cells in vitro", Leukemia and Lymphoma 37. 53-63.
  • Akao, Y. Mizoguchi, H. Kojima. S. Naoe.T, Ohishi. N. and Yagi, K. (1998) "Arsenic induces apoptosis in B-cell leukaeniic cell lines in vitro: activation of caspases and down-regulation of Bcl-2 protein", British Journal of Hatmatology 102, 1055-1060.
  • Grad, J.M, Bahlis, N.J., Reis, I. Oshiro, M.M. Dalton, W.S. and Boise, L.H. (2001) "Ascorbic acid enhances arsenic trioxideinduced cytotoxicity in multiple myeloma cells", Blood 98. 805-813.
  • Weslervelt, P. Brown, R.A., Adkins. D.R., Khoury, H., Curtin, P. Huid, D. Luger, S.M., Ma, M.K. Ley. T.J. and DiPersio. J.F. (2001) "Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide", Blood, 98.
  • Orrnerod, M.G., Payne, A.W. and Watson. J.V. (1987) "Improved program for the analysis of DNA histograms", Cytometry 8, 637-641.
  • Gothot, A. Pyatt, R., McMahcl, J., Rice, S. and Srour, E.F. (1997) "Functional heterogeneity of human CD34+ cells isolated in subcompartmenls of G0/G1 phase of the cell cycle", Blood 90, 4384-4393.
  • Chaudhary, P.M. and Roninson, I.B. (1991) "Expression and activity of P-glycoprotein a multidmg efflux pump, in human hematopoietic stem cells", Cell 66, 85-94.
  • Fardel, O. Payen, L., Counois, A., Drenou, B., Fauchet, R. and Raull, B. (1998) "Differential expression and activity of P"-glycoprotein and multidrug-resistance associated protein in CD34-positive KG1a leukemic cells". International Journal of Oncology 12, 315-319.
  • Su, G.M., Davey, M.W. Davey, R.A. and Kidman, A.D. (1994) "Development of extended inullidrug resistance in HL60 promyelocytic leukemia cells", British Journal of Haematology 88, 566-574.
  • Sordet, O., Rebe, C., Leroy. I., Brucy,J.-M. Oarrido.C. Miguet,C., Lizard, G., Plenchette, S. Corcos, I., and Solary, E. (2001) "Mitochondria-targeting drugs arsenic trioxidc and lonidamine bypass the resistance of TPA-differeniiated kukernie cells to apoptosis", Blood 97, 3931 -3940.
  • Zhu, X.-H., Shen, Y.-L., Jing. Y.-K., Cai, X., Jia, P.-M., Huang, Y, Tang, W. Shj, G.-Y. Sun, Y.-P., Dai. J., Wang, Z.-Y. Chen, S.-J., Zhang, T-D., Waxman, S. Chen, Z and Chen, G.-Q. (1999) "Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations", Journal of the National Cancer Institute 91, 772-778.
  • Roboz, G.J., Dias, S. Lam, G. Lane, W.J., Soignet, S.L. Warrell. R.P. and Rafii. S. (2000) "Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis", Blood 96, 1525-1530.
  • lshitsuka, K., Hanada, S., Uozumi. K. Utsunomiya, A. and Arima, T. (2000) "Arsenic trioxide and the growth of human T-cell leukemia virus type I infected T-cetl lines", Leukemia and Lymphoma 37, 649-655.
  • Lehmann, S. Bcngtzen, S., Paul, A., Chrislen-sson, B. and Paul, C. (2001) "Effects of arsenic trioxide (As2O3) on leukemic cells from patients with non-M3 acute myelogenous leukemia: studies of cytoioxcity, apoptosis and the pattern of resistance", European Journal of Haematology 66, 357-364.
  • Scharenberg, C.W., Harkey, M.A. and Torok-Storb. B. (2002) "The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is perferentially expressed by immature human hematopoietic progenitors", Blood 99, 507- 512.
  • Zhou, S., Schuetz, J.D., Bunting, K.D., Colapictro, A.-M. Sampath, J. Morris. J.J., Lagutina, I. Grosveld, C.C., Osawa M Nakauchi, H. and Sorrenlino, B.P. (2001) "The ABC transporter Bcrpl/ABCG2 is expressed in a wide variety of stem cells and is molecular determinant of the side population phenotype" Nature Medicine 7, 1028-1034.
  • Berardi, A.C. Wang. A. Levine, J.D. Lopez, P. and Scadden, D.T. (1995) "Functional isolation and characterization of human hematopoietic stem cells", Science 267, 104-104.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.