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Leukemia & Lymphoma Volume 44, 2003 - Issue 1
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Research Article

Cytogenetics, FISH and RT-PCR Analysis of Acute Promyelocytic Leukemia: Structure of the Fusion Point in a Case Lacking Classic t(15;17) Translocation

Kazuhiro Fujita Blood Center, Showa University, Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan
,
Remi Oba Division of Hematology, Showa University Fujigaoka Hospital, Yokohama 227-8501, Japan
,
Hiroshi Harada Division of Hematology, Showa University Fujigaoka Hospital, Yokohama 227-8501, Japan
,
Hiraku Mori Division of Hematology, Showa University Fujigaoka Hospital, Yokohama 227-8501, Japan
,
Haruo Niikura Division of Hematology, Showa University Fujigaoka Hospital, Yokohama 227-8501, Japan
,
Keiichi Isoyama Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama 227-8501, Japan
&
Mitsuhiro Omine Division of Hematology, Showa University Fujigaoka Hospital, Yokohama 227-8501, Japan
 show all
Pages 111-115 | Published online: 01 Jul 2009

  • Second MIC Cooperative Study Group(1988) "Morphologic, immunologic, and cytogenetic (MIC) working classification of the acute myeloid leukemias", Cancer Genetics and Cytogenetics 30, 1-15.
  • Mitelman, F. (1991) Catalog of Chromosome Aberrations in Cancer, 4th Ed. (Wiley-Liss, New York).
  • de Thé, H., chornienne, C., Lanotte, M., Degos, L. and Dejean, A. (1990) "The t(15;17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor a gene to a novel transcribed locus", Nature 347, 558-561.
  • Kakizuka, A., Miller, Jr., W.H., Umesono, K., Warrell, Jr., R.P., Frankel, S.R., Murty, V.V.V.S., Domitrovsky, E. and Evans, R.M. (1991) "Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARa with a novel putative transcription factor PML", Cell 66, 663-674.
  • Lo Coco, F., Diverio, D., D'Adamo, F., Avvisati, G., Alimena, G., Nanni, M., Alcalay, M., Pandolfi, P.P. and Pelicci, P.G. (1992) "PML-RARa rearrangement in acute promyelocytic leukemias apparently lacking the t(15;17) translocation", European Journal of Haematology 48, 173-176.
  • Hiorns, L.R., Min, T., Swansbury, G.J., Zelent, A., Dyer, M.J.S. and Catovsky, D. (1994) "Interstitial insertion of retinoic acid receptor-a gene in acute promyelocytic leukemia with normal chromosome 15 and 17" Blood 83, 2946-2951.
  • Lafage-Pochitaloff, M., Alcalay, M., Brunel, V., Longo, L., Sainty, D., Simmonetti, J., Birg, F. and Pelicci, P.G. (1995) "Acute promylocytic leukemia cases with nonreciprocal PML/RARa or RARa/PML fusion gene", Blood 85, 1169-1174.
  • Grimwade, D., Biondi, A., Mozziconacci, M.J., Hagemeijer, A., Berger, R., Neat, M., Howe, K., Dastugue, N., Jansen, J., Radford-Weiss, I., Lo Coco, F., Lessard, M., Hernandez, J.M., Delabesse, E., Head, D., Liso, V., Sainty, D., Frandrin, G., Solomon, E., Birg, F. and Lafage-Pochitaloff, M. (2000) "Characterization of acute promylocytic leukemia cases lacking the classic t(15;17): results of the European Working Party", Blood 96, 1297-1308.
  • Biondi, A., Rambaldi, A., Pandolfi, P.P., Rossi, V., Giudici, G., Alcalay, M., Coco, F.L., Diverio, D., Pogliani, E.M., Lanzi, E.M., Mandelli, L.F., Masera, G., Barbui, T. and Pelicci, P.G. (1992) "Molecular monitoring of the myl/retinoic acid receptor-a fusion gene in aute promyelocytic leukemia by polymerase chain reaction", Blood 80, 492-497.
  • Pandolfi, P.P., Alcalay, M., Fagioli, M., Zangrilli, D., Mencarelli, A., Diverio, D., Biondi, A., Lo Coco, F., Rambaldi, A., Grignani, F., Rochette-Egly, C., Gaube, M-P., Chambon, P. and Pelicci, P.G. (1992) "Genomic variability and alternative splicing generate multiple PML-RARa transcripts that encode aberrant PML protein and PML-RARa isoforms in acute promyelocytic leukemia", European Molecular Biology Organization Journal 11, 1397-1407.
  • The Leukemia Study Group of the Ministry of Health and Welfare (Khoseisho)Fukutani, H., Naoe, T., Ohno, R., Yoshida, H., Miyawaki, S., Shimazaki, C., Miyake, T., Nakayama, Y., Kobayashi, H. and Goto, S. (1995) "Isoforms of PML-retinoic acid receptor alpha fused transcript affect neither clinical features of acute promyelocytic leukemia nor prognosis after treatment with all-trans retinoic acid", Leukemia 9, 478-1482.
  • Gallagher, R.E., William, C.L., Slack, J.L., Anderson, J.W., Li, Y.P., Viswanatha, D., Bloomfield, C.D., Appelbaum, F.R., Schiffer, C.A., Tallman, M.S. and Wiernik, P.H. (1997) "Association of PML-RAR alpha fusion mRNA type with pretreatment hematologic characteristics but not treatment outcome in acute promyelocytic leukemia: an intergroup molecular study", Blood 90, 1656-1663.
  • Bennet, J.M. (2000) "World Health Organization Classification of the acute leukemias and myelodysplastic syndrome", International Journal of Hematology 72, 131-133.
  • Mitelman, F. (1995) ISCN: An International System for Human Cytogenetic Nomanclature (Karger, Basel).
  • Inazawa, J., Nishigaki, H., Takahira, H., Nishimura, J., Horiike, S., Taniwaki, M., Misawa, S. and Abe, T. (1989) "Rejoining between 9q+ and Philadelphia chromosome results in normal-looking chromosome 9 and 22 in Phl-negative chronic myelocytic leukemia", Human Genetics 83, 115-118.

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