Advanced search
Publication Cover
Leukemia & Lymphoma Volume 44, 2003 - Issue 3
Submit an article Journal homepage
98
Views
8
CrossRef citations to date
0
Altmetric
Research Article

The Dose Related Effect of Steroids on Blast Reduction Rate and Event Free Survival in Children with Acute Lymphoblastic Leukemia

Sevgi Yetgin Faculty of Medicine, Department of Paediatric Haematology, Section of Haematology, Hacettepe University, Ihsan Doğramaci Children's Hospital, Ankara, 06100, Turkey
,
Mualla Çetin Faculty of Medicine, Department of Paediatric Haematology, Section of Haematology, Hacettepe University, Ihsan Doğramaci Children's Hospital, Ankara, 06100, Turkey
&
Aytemiz Gurgey Faculty of Medicine, Department of Paediatric Haematology, Section of Haematology, Hacettepe University, Ihsan Doğramaci Children's Hospital, Ankara, 06100, Turkey
Pages 489-495 | Published online: 01 Jul 2009

  • Jacquillat, C., Weil, M., Gemon, M.F., Auclerc, G., Loisel, I.P., Delobel, J., Flandrin, G., Schaison, G., Izrael, V, Bussel, A., Dresch, C., Weisgerber, C., Rain, D., Tanzer, J., Najean, Y., Seligmann, M., Boiron, M. and Bernard, I. (1973) "Combination therapy in 130 patients with acute lymphoblastic leukemia (protocol 06 LA 99-Paris)", Cancer Research 33, 3278-3284.
  • Miller, D.R., Coccia, P.F., Bleyer, W.A., Lukens, J.N., Siegel, S.E., Sather, H.N. and Hammond, G.D. (1989) "Early response to induction therapy as a predictor of disease-free survival and late recurrence of childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group", Journal of Clinical Oncology 7, 1807-1815.
  • Gaynon, P.S., Bleyer, W.A., Steinherz, P.G., Finklestein, J.Z., Liftman, P., Miller, D.R., Reaman, G., Sather, H. and Hammond, G.D. (1990) "Day 7 marrow response and outcome for children with acute lymphoblastic leukemia and unfavorable presenting features", Medical and Pediatric Oncology 18, 273-279.
  • Riehm, H., Gadner, H., Henze, G., Kornhuber, B., Lampen, F., Niethammer, D., Reiter, A. and Schellong, G. (1990) "Results and significance of six randomized trials in four consecutive ALL-BFM studies", Hematology Blut Transfusion 33, 439-450.
  • Hutchinson, R., Bertolone, S., Cooper, H., Roskos, K., Welis, L., Heerema, N., Tamnous, R., Neerhout, R., Sather, H., Sailer, S., Hummell, D., Trigg, M. and Hammond, G. (1994) "Early marrow response predicts outcome for patients with low-risk ALL: result of CCG-1881", Proceedings of American Society for Clinical Oncology 13, 319, Abstract 1051.
  • Steinhetz, P.C., Gaynon, P.S., Breneman, J.C., Cherlow, I.M., Grossman, N.J., Kersey, I.H., Johnstone, H.S., Sather, H.N., Trigg, M.E., Chappell, R., Hammond, D. and Bleyer, W.A. (1996) "Cytoreduction and prognosis in acute lymphoblastic leukemia: the importance of early marrow response: report from the Childrens Cancer Group", Journal of Clinical Oncology 14, 389-398.
  • Nachman, I., Sather, H.N., Gaynon, P.S., Lukens, J.N., Wolff, L. and Trigg, M.E. (1997) "Augmented Berlin-Frankfurt-Munster therapy abrogates the adverse prognostic significance of slow early response to induction chemotherapy for children and adolescents with acute lymphoblastic leukemia and unfavorable presenting features: a report from the Children's Cancer Group", Journal of Clinical Oncology IS, 2222-2230.
  • Rautonen, J., Hovi, L. and Siimes, M.A. (1988) "Slow disappearance of peripheral blast cells: an independent risk factor indicating poor prognosis in children with acute lymphoblastic leukemia", Blood 71, 989-991.
  • Gajjar, A., Ribeiro, R., Hancock, M.L., Rivera, G.K., Mahmoud, H., Sandlund, J.T., Crist, W.M. and Pui, C.H. (1995) "Persistence of circulating blasts after 1 week of multiagent chemotherapy confers a poor prognosis in childhood acute lymphoblastic leukemia", Blood 86, 1292-1295.
  • Schrappe, M., Reiter, A. and Riehm, H. (1996) "Cytoreduction and prognosis in childhood acute lymphoblastic leukemia", Journal of Clinical Oncology 14, 2403-2406.
  • Griffin, T.C., Sinister, I.J., Buchanan, G.R., Murphy, S.B., Camilla, B.M. and Amylon, M.D. (2000) "Slow disappearance of peripheral blood blasts is an adverse prognostic factor in childhood T cell acute lymphoblastic leukemia: a Pediatric Oncology Group study", Leukemia 14, 792-795.
  • Dordelmann, M, Reiter, A., Borkhardt, A., Ludwig, W.D., Gotz, N., Viehmann, S., Gadner, H., Riehm, H. and Schrappe, M. (1999) "Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia", Blood 94,1209-1217.
  • Yetgin, S., Gurgey, A., Tuncer, A.M., Cetin, M., Özbek, N., Sayli, T., Guler, E., Kara, A., Olcay, L., Dura, F., Glimruk, E., Atahan, L. and Tunçbilek, E. (1998) "A comparison of the effect of high-dose methylprednisolone with conventional-dose prednisolone in acutelymphoblastic leukemia patients with randomization", Leukemia Research 22, 485-493.
  • Yetgin, S., Tuncer, M.A., Çetin, M., Gümrük, E., Yenicesu, I., Tunç, B., Oner, A.F., Toksoy, H., Koç, A., Asian, D., Özyürek, E., Olcay, L., Atahan, L., Tunçbilek, E. and Gürgey, A. (2002) "Benefit of high-dose methylprednisolone in comparison of conventional dose prednisolone during remission induction therapy in childhood acute lymphoblastic leukemia for long-period follow-up", Leukemia 16, In press.
  • Rivera, G.K., Raimondi, S.C., Hancock, M.L., Behm, E.G., Pui, C.H., Abromowitch, M., Mirro, Jr, J., Ochs, J.S., Look, A.T., Williams, D.L., Murphy, S.B., Dahl, G.V., Kalwinsky, D.K., Evans, W.E., Run, L.E., Simone, I.V. and Grist, W.M. (1991) "Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy", Lancet 337, 61 -66.
  • Reiter, A., Schrappe, M., Ludwig, W.D., Hiddemann, W., Sauter, S., Henze, G., Zimmermann, M., Lampert, F., Havers, W., Niethammer, D., et al. (1994) "Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86", Blood 84, 3122-3133.
  • Schwartz, C.L., Thompson, E.B., Gelber, R.D., Young, M.L., Chilton, D., Cohen, H.J. and Sallan, S.E. (2001) "Improved response with higher corticosteroid dose in children with acute lymphoblastic leukemia", Journal of Clinical Oncology 19, 1040-1046.
  • Arico, M., Basso, G., Mandelli, E, Rizzari, C., Colella, R., Barisone, E., Zanesco, L., Rondelli, R., Pession, A. and Masera, G. (1995) "Good steroid response in vivo predicts a favorable outcome in children with T-cell acute lymphoblastic leukemia", Cancer 75, 1684-1693.
  • Felice, M.S., Zubizarreta, P.A., Alfaro, E.M. and Sackmann-Muriel, E (2001) 11ChUdIiOOd acute lymphoblastic leukemia: prognostic value of initial peripheral blood blast count in good responders to prednisone", Journal of Pediatric Hematology and Oncology 23, 411-415.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.