Advanced search
Publication Cover
Leukemia & Lymphoma Volume 44, 2003 - Issue 4
Submit an article Journal homepage
126
Views
16
CrossRef citations to date
0
Altmetric
Research Article

Immunosuppressive Treatments for Myelodysplastic Syndromes

Takashi Shimamoto First Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
&
Kazuma Ohyashiki First Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
Pages 593-604 | Published online: 01 Jul 2009

  • Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A.G., Gralnick, H.R. and Sultan, C. (1982) "Proposals for the classification of the myelodysplastic syndromes". British Journal of Haematology 51, 189-199.
  • Mufti, G.J., Stevens, J.R., Oscier, D.G., Hamblin, T.J. and Machin, D. (1985) "Myelodysplastic syndromes: a scoring system with prognostic ignificance". British Journal of Haematology 59, 425-433.
  • Foucar, K., Langdon, R.M.I.I., Armitage, J.O., Olson, D.B. and Carroll, Jr, T.J. (1985) "Myelodysplastic syndromes. A clinical and pathologic analysis of 109 cases". Cancer 56, 553-561.
  • Kouides, P.A. and Bennett, J.M. (1996) "Morphology and classification of the myelodysplastic syndromes and their pathologic variants". Seminars in Hematology 33, 95-110.
  • Tuzuner, N., Cox, C., Rowe, J.M., Watrous, D. and Bennett, J.M. (1995) "Hypocellular myelodysplastic syndromes (MDS): new proposals". British Journal of Haematotogy 91, 612-617.
  • Hamblin, T.J. (1996) "Immunological abnormalities in myelodysplastic syndromes". Seminars in Hematology 33, 150-162.
  • Culligan, D.J., Cachia, P., Whittaker, C.J., Jacobs, A. and Pauda, R.A. (1992) "Clonal lymphocytes are detectable in only some cases of MDS". British Journal of Haematology 81, 346-352.
  • Hellstrom-Lindberg, E., Willman, C., Barrett, A.J. and Saunthararajah, Y. (2000) "Achievements in understanding and treatment of myelodysplastic syndromes". Hematology 2000. American Society of Hematology Educational Program Book, 110-132.
  • Matsutani, R., Yosida, T., Tsuruta, Y., Shimaraoto, T., Ohyashiki, J.H., Suzuki, R. and Ohyashiki, K. (2002). Leukemia Research, In press.
  • Dhodapkar, M.V., Li, C.Y., Lust, J.A., Tefferi, A. and Phyliky, R.L. (1994) "Clinical spectrum of clonal proliferations of T-large granular lymphocytes: a T-cell clonopathy of undetermined significance?". Blood 84, 1620-1627.
  • Young, N.S. and Maciejewski, J. (1997) "The pathopysiology of acquired aplastic anemia". New England Journal of Medicine 336, 1365-1372.
  • Barrett, A.J., Saunthararajah, Y. and Molldrem, J. (2000) "Myelodysplastic syndrome and aplastic anemia; distinct entities or diseases linked by a common pathopysiology?". Seminars in Hematology 37, 15-29.
  • Smith, M.A. and Smith, J.G. (1991) "The occurrence subtype and significance of haemopoietic inhibitory T cells (HIT cells) in myelodysplasia: an in vitro study". Leukemia Research 5, 597-601.
  • Molldrem, J.J., Jiang, Y.Z., Stetler-Stevenson, M.A., Mavroudis, D., Hansel, N. and Barrett, A.J. (1998) "Haematological response of patients with myclodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor V beta profiles". British Journal of Haematology 102, 1314-1322.
  • Sugawara, T. Endo, K., Shishido, T., Sato, A., Kameoka, J., Fukuhara, O., Yoshinaga, K. and Miura, A. (1992) "T-cell mediated inhibition of erythropoiesis in myelodysplastic syndromes". American Journal of Hematology 41, 304-305.
  • Harris, N.L., Jaffe, E.S., Diebold, J., Flandrin, G., Muller-Hermelink, H.K., Vardiman, J., Lister, T.A. and Bloomfield, C.D. (1999) "World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997". Journal of Clinical Oncology 17, 3835-3849.
  • Bennett, J.M. (2000) "World Organization Classification of the acute leukemias and myelodysplastic syndrome". International Journal of Hematology 72, 131-133.
  • Greenberg, P., Cox, C. LeBeau, M.M., Fenaux, P., Sanz, G., Sanz, M., Vallespi, T., Hamblin, T., Oscier, D., Ohyashiki, K., Toyama, K., Aul, C., Mufti, G. and Bennett, J. (1997) "International scoring system for evaluating prognosis in myelodysplastic syndromes". Blood 89, 2079-2088
  • Verbeek, W. and Ganser, A. (2001) "Evolving treatment options of myelodysplastic syndromes". Annals of Hematology 80, 499-509.
  • Young, N.S. and Barrett, A.J. (1995) "The treatment of severe acquired aplastic anemia". Blood 85, 3367-3377.
  • Williamson, P.J., Oscier, D.G., Bell, A.J. and Hamblin, T.J. (1991) "Red cell aplasia in myelodysplastic syndrome". Journal of Clinical Pathology 44, 431-432
  • Molldrem, J.J., Caples, M., Mavroudis, D., Plante, M., Young, N.S. and Barrett, A.J. (1997) "Antithymocyte globulin for patients with myelodysplastic syndrome". British Journal of Haematology 99, 699-705.
  • Biesma, D.H., van den Tweel, J.G. and Verdonck, L.F. (1997) "Immunosuppressive therapy for hypoplastic myelodysplastic syndrome". Cancer 79, 1548-1551.
  • Jonasova, A., Neuwirtova, R., Cermak, J., Vozobulova, V., Mocikova, K., Siskova, M. and Hochova, I. (1998) "Cyclosporin A therapy in hypoplastic MDS patients and certain refractory anaemias wothout hypoplastic bone marrow". British Journal of Haematology 100, 304-309.
  • Asano, Y. Maeda, M., Uchida, N., Yokoyama, T., Osaki, K., Shimoda, K., Gondo, H., Okamura, T., Okamura, S. and Niho, Y. (2001) "Immunosuppressive therapy for patients with refractory anemia". Annals of Hematology 80, 634-638.
  • Shimamoto, T., Iguchi, I., Ando, K., Katagiri, T., Tauchi, T., Ito. Y., Yaguchi, M., Miyazawa, K., Kimura, Y., Masuda, M., Mizoguchi, H. and Ohyashiki, K. (2001) "Successful treatment with cyclosporin A for myelodysplastic syndrome with erythroid hypoplasia associated with T-cell receptor gene rearrangements". British Journal of Haematology 114, 358-361.
  • Hamblin, T.J. (1996) "Immunological abnormialites in myelodysplastic syndromes". Seminars in Hematology 33, 150-162.
  • van Kamp, H., Fibbe, W.E., Jansen, R.P.M., van der Keur, M., de Graaff, E., Willemze, R. and Landegent, J.E. (1992) "Clonal involvement of granulocytes and monocytes, but not of T and B lymphocytes and natural killer cells in patients with myelodysplasia: analysis by X-linked restriction fragment length polymorphisms and polymerase chain reaction of the phosphoglycerate kinase gene". Blood 80, 1774-1780.
  • Kroef, M.J., Fibbe, W.E., Mout, R., Jansen, R.P., Haak, H.L., Weseels, J.W., van Kamp, H., Willemze, R. and Landegent, J.E. (1993) "Myeloid but not lymphoid cells carry the 5q deletion: polymerase chain reaction analysis of loss of heterozygosity using mini-repeat sequences on highly purified cell fractions". Blood 81, 1849-1854.
  • White, N.J., Nacheve, E., Asimakopoulos, F.A., Bloxham, D., Paul, B. and Green, A.R. (1994) "Deletion of chromosome 20q in myelodysplasia can occur in a multipotent precursor of both myeloid cells and B cells". Blood 83, 2809-2816.
  • Abrahamson, G., Boultwood, J., Madden, J., Kelly, S., Oscier, D.G., Rack, K., Buckle, V.J. and Wainscoat, J.S. (1991) "Clonality of cell populations in refractory anaemia using combined approach of gene loss and X-linked restriction fragment length polymorphismmethylation analyses". British Journal of Haematology 79, 550-555.
  • Knuutila, S., Teerenhovi, L., Larramendy, M.L. Elonen, E., Franssila, K.O., Nylund, S.J., Timonen, T., Heinonen, K., Mahlamaki, E. and Winqvist, R. (1994) "Cell lineage involvement of reccurent chromosomal abnormalities in hematologic neoplasms". Genes and Chromosomes in Cancer 10, 95-102.
  • Kibbelaar, R.E., van Kamp, H., Dreef, E.J., de Groot-Swings, G., Kluin-Nelemans, J.C., Beverstock, G.C., Fibbe, W.E. and Kluin, P.M. (1992) "Combined immunophenotyping and DNA in situ hybridization to study lineage involvement in patients with myelodysplastic syndromes". Blood 79, 1823-1828.
  • Tefferi, A., Thibodeau, S.N. and Solberg, Jr., L.A. (1990) "Clonal studies in the myelodysplastic syndromes using X-linked restriction fragment length polymorphisms". Blood 75, 1770-1773.
  • Janssen, J.W., Buschle, M., Layton, M., Drexler, H.G., Lyons, J., van den Berghe, H., Heimpel, H., Kubanek, B., Kleihauer, E. and Mufti, G.J. (1989) "Clonal studies in the myelodysplastic syndromes: evidence of multipotent stem cell origin". Blood 73, 248-254.
  • Ramakrishna, R., Chaudhuri, K., Sturgess, A. and Manoharan, A. (1992) "Haemtological manifestations of primary Sjogren's syndrome: a clinicopathological study". Quarterly Journal of Medicine 83, 547-554.
  • Hebbar, M., Brouillard, M., Wattel, E., Decoulx, M., Hatron, P.Y., Devulder, B. and Fenaux, P. (1995) "Association of myelodysplastic syndrome and relapsing polychondritis: further evidence". Leukemia 9, 731-733.
  • Ng, H.S., Ng, H.W., Sinniah, R. and Feng, P.H. (1981) "A case of systemic lupus erythematosus with sideroblastic anaemia terminating in erythroleukaemia". Annals of the Rheumatic diseases 40, 422-426.
  • Green, A.R., Shuttleworth, D., Bowen, D.T. and Bentley, D.P. (1990) "Cutaneous vasculitis in patients with myelodysplasia". British Journal of Haematology 74, 364-365.
  • Marullo, S., Dallot, A., Cavelier-Balloy, B., Valensi, F. and Clauvel, J.P. (1989) "Subcutaneous eosinophilic necrosis associated with refractory anemia with an excess of myeloblasts". Journal of the American Academy of Dermatology 20, 320-323.
  • Pagliuca, A., Higgins, E., Samson, D., Humphries, S. and Mufti, G.J. (1990) "Prodromal cutaneous vasculitis in myelodysplastic syndromes". British Journal of Haematology 75, 444-446.
  • Castro, M., Conn, D.L., Su, W.P. and Garton, J.P. (1991) "Rheumatic manifestations in myelodysplastic syndromes". Journal of Rheumatology 18, 721-727.
  • Billström, R., Johansson, H., Johansson, B. and Mitelman, F. (1995) "Immune-mediated complications in patients with myelodysplastic syndromes--clinical and cytogenetic features". European Journal of Haematology 55, 42-48.
  • Enright, H., Jacob, H.S., Vercelloti, G., Howe, R., Belzer, M. and Miller, W. (1995) "Paraneoplastic autoimmune phenomena in patients with myelodysplastic syndromes: response to immunosupressive therapy". British Journal of Haematology 91, 403-408.
  • Enright, H. and Miller, W. (1996) "Autoimmune phenomena in patients with myelodysplastic syndromes". Leukemia and Lymphoma 24, 483-489.
  • Okamoto, T., Okada, M., Mori, A., Saheki, K., Takatsuka, H., Wada, H, Tamura, A., Fujimori, Y., Takemoto, Y., Kanamaru, A. and Kakishita, E. (1997) "Correlation between immunological abnormalities and prognosis in myelodysplastic syndrome patients". International Journal of Hematology 66, 345-351.
  • Mufti, G.J., Figes, A., Hamblin, T.J., Oscier, D.G. and Copplestone, J.A. (1986) "Immunological abnormlities in myelodysplastic syndromes. I. Serum immunoglobulins and autoantibodies", British Journal of Haematology 63, 143-147.
  • Economopoulos, T., Economonidou, J., Giannopoulos, G., Terzoglou, C., Papageorgiou, E., Dervenoulas, J., Arseni, P., Hadjioannou, J. and Rartis, S. (1985) "Immune abnormalities in myelodysplastic syndromes". Journal of Clinical Pathology 38, 908-911.
  • Baumann, M.A., Milson, T.J., Patrick, C.W., Libnoch, J.A. and Keller, R.H. (1986) "Immunoregulatory abnormalities in myelodysplastic disorders". American Journal of Hematology 22, 17-26.
  • Merchav, S., Nagler, A., Silvian, J., Carter, A., Tatarsky, I. and Spira, G. (1987) "Immunogloblin synthesis in myelodysplastic syndromes: normal B-cell and immunoregulatory T-cell functions". Clinical Immunology and Immunopathology 42, 195-201.
  • Colombat, P.H., Renoux, M., Lamagnere, J.P. and Renoux, G. (1988) "Immunologic indices in myelodysplastic syndromes". Cancer 61, 1075-1081.
  • Symeonidis, A., Kourakli, A., Katevas, P., Perraki, M., Tiniakou, M., Matsouka, P., Georgoulias, V. and Zoumbos, N. (1991) "Immune function parameters at diagnosis in patients with myelodysplastic syndromes: correlation with the FAB classification and prognosis". European Journal of Haematology 47, 277-281.
  • Miescher, P.A., Farve, H. and Beris, P. (1991) "Autoimmune myelodysplasias". Seminars in Hematology 28, 322-330.
  • Felzmann, T., Gisslinger, H. and Ludwig, H. (1994) "Immunological findings in patients with myelndysplastic syndrome". Leukemia and Lymphoma 15, 201-208.
  • Bagby, G.C. (1980) "Mechanisms of glucocorticoid activity in patients with the preleukemic syndrome (hemopoietic dysplasia)". Leukemia Research 4, 571-580.
  • Motoji, T., Teramura, M., Takahashi, M., Oshimi, K., Okada, M., Kusakabe, K. and Mizoguchi, H. (1990) "Successful treatment of refractory anemia with high-dose methylprednisolone". American Journal of Hematology 33, 8-12.
  • Tichelli, A., Gratwohl, A., Wuersch, A., Nissen, C. and Speck, B. (1988) "Antilymphocyte globulin for myelodysplastic syndrome". British Journal of Haematology 68, 139-140.
  • Cheson, B.D., Bennett, J.M., Kantarjian, H., Pinto, A., Schiffer, C.A., Nimer, S.D., Lowenberg, B., Beran, M., de Witte, T.M., Stone, R.M., Mittelman, M., Sanz, G.F., Wijermans, P.W., Gore, S. and Greenberg, P.L. (2000) "Report of an international working group to standardize response criteria for myelodysplastic syndromes". Blood 96, 3671-3674.
  • Nakao, S., Takamatsu, H., Chuhjo, T., Ueda, M., Shiobara, S., Matsuda, T., Kaneshige, T. and Mizoguchi, H. (1994) "Identification of a specific HLA class II haplotype strongly associated with susceptibility to cyclosporin-dependent aplastic anemia". Blood 84, 4257-4261.
  • Craig, A., Geary, C.G., Love, E.M and Liu-Yin, J. (1988) "Red cell hypoplasia, thrombocytosis, and leukocytosis: myelodysplastic and proliferative syndrome". Journal of Clinical Pathology 42, 1168-1170.
  • Cook, M.K. (1989) "Red cell hypoplasia associated with myeloproliferative and myelodysplastic syndrome". Journal of Clinical Pathology 42, 890-891.
  • Williamson, P.J., Oscier, D.G., Bell, A.J. and Hamblin, T.J. (1991) "Red cell aplasia in myelodysplastic syndrome". Journal of Clinical Pathology 44, 431-432.
  • Garcia-Suarez, J., Pascual, T., Munoz, M.A., Herrero, B. and Pardo, A. (1998) "Myelodysplastic syndrome with erythroid hypoplasia/aplasia: a case report and review of the literature". American Journal of Hematology 58, 319-325.
  • Park, S., Merlat, A., Guesnu, M., Picard, F., Viguie, F., Vassilieff, D. and Dreyfus, F. (2000) "Pure red cell aplasia associated with myelodysplastic syndromes". Leukemia 14, 1709-1710.
  • Grigg, A.P. and O'Flaherty, E. (2001) "Cyclosporin A for the treatment of pure red cell aplasia associated with myelodysplasia". Leukemia and Lymhoma 42, 1339-1342.
  • Charles, R.J., Sabo, K.M., Kidd, P.G. and Abkowitz, J.L. (1996) "The pathophysiology of pure red cell aplasia: implications for therapy". Blood 87, 4831-4838.
  • Mamiya, S., Itoh, T. and Miura, A.B. (1997) "Acquired pure red cell aplasia in Japan". European Journal of Haematology 59, 199-205.
  • Shimamoto, T. and Ohyashiki, K. (2002) "Myelodysplastic syndrome with erythroid hypoplasia is a new clinical entity responsive to cyclosporin A therapy". Leukemia and Lymphoma 43, 1895-1896.
  • Zhu, X., Imamura, M., Hashino, S., Tanaka, J., Kobayashi, S., Tao, H.-R., Asaka, M., Kasai, M., Matsudaira, T. and Asano, S. (1995) "Enhancing and suppressive effects of immunosuppressants cyclosporin A. FK506, and KM2210 on the colony formation of murine bone marrow cells". Annals of Hematology 71, 301-306.
  • MacCarthy, K.P., Sloane, J.P., Kabarowski, J.H.S., Matutes, E. and Wiedemann, L.M. (1991) "The rapid detection of clonal T-cell proliferations in patients with lymphoid disorders". American Journal of Pathology 138, 821-828.
  • Wainscoat, J.S., Fey, M.F., Pilkington, S., Summers, C. and Oscier, D.G. (1988) "Absence of immunoglobulin and T-cell receptor gene rearrangements in myelodysplastic syndromes and acute nonlymphocytic leukemias". American Journal of Hematology 28, 95-97.
  • Preudhomme, C., Vachee, A., Morschauser, F., Henic, N., Cosson, A. and Fenaux, P. (1994) "Immunoglobulin and T-cell receptor delta gene rearrangements are rarely found in myelodysplastic syndromes in chronic phase". Leukemia Research 18, 365-371.
  • Kwong, Y.L. and Wong, K.F. (1998) "Association of pure red cell aplasia with T-large granular lymphocyte leukaemia', Journal of Clinical Pathology 51, 672-675.
  • Masuda, M., Arai, Y., Okamura, T. and Mizoguchi, H. (1997) "Pure red cell aplasia with thymoma: evidence of T-cell clonal disorder". American Journal of Hematology 54, 324-328.
  • Schmetzer, H.M., Poleck, B., Duell, T., Gerhartz, H.H. and Mittermuller, J. (2000) "Cytogenetic and Southern blot analysis to demonstrate clonaliiy and to estimate prognosis in patients with myelodysplastic syndromes". Annual Hematology 79, 20-29.
  • Epperson, D.E., Nakamura, R., Saumhararajah, Y., Melenhorst, J. and Barrett, A.J. (2001) "Oligoclonal T cell expansion in myelodysplastic syndrome: evidence for an autoimmune process". Leukemia Research 25, 1075-1083.
  • Kook, H., Zeng, W., Guibin, C., Kirby, M., Young, N.S. and Maciejewski, J.P. (2001) "Increased cytotoxic T cells with effector phenotype in aplastic anemia and myelodysplasia". Experimental Hematology 29, 1270-1277.
  • Saunthararajah, Y., Molldrem, J.L., Rivera, M., Williams, A., Stetler-Stevenson, M., Sorbara, L., Young, N.S. and Barrett, J.A. (2001) "Coincident myelodysplastic syndrome and T-cell large granular lymphocytic disease: clinical and pathophysiological features". British Journal of Haematology 112, 195-200.
  • Hashimoto, M., Kinoshita, T., Yamasaki, M., Tanaka, H., Imanishi, T., Ihara, H., Ichikawa, Y. and Fukunishi, T. (1994) "Gene frequencies and haplotypic associations within the HLA region in 916 unrelated Japanese individuals". Tissue Antigens 44, 166-173.
  • Okamoto, T., Okada, M., Yamada, S., Takatsuka, H., Wada, H., Tamura, A., Fujimori, Y., Takemoto, Y. and Kakishita, E. (2000) "Good response to cyclosporine therapy in patients with myelodysplastic syndromes having the HLA-DRB1*1501 allele". Leukemia 14, 344-346.
  • Rosse, W.F (1997) "Paroxysmal nocturnal hemoglobinuria as a molecular disease". Medicine (Baltimore) 76, 63-93.
  • Lewis, S.M. and Dacie, J.V. (1967) "The aplastic anaemiaparoxysmal nocturnal hemoglobinuria syndrome". British Journal of Haematology 13, 236-251.
  • Kinoshita, T., Inoue, N. and Takeda, J. (1996) "Role of phosphatidylinositol-Linked proteins in paroxysmal nocturnal hemoglobinuria pathogenesis". Annual Review of Medicine 47, 1-10.
  • Rosse, W.F. and Ware, R.E. (1995) "The molecular basis of paroxysmal nocturnal hemoglobinuria". Blood 86, 3277-3286.
  • Dunn, D.E., Tanawattanacharoen, P., Boccuni, P., Nagakura, S., Green, S.W., Kirby, M.R., Kumar, M.S.A., Rosenfeld, S. and Young, N.S. (1999) "Paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure syndromes". Annals of Internal Medicine 131, 401-408.
  • Maciejewski, J.P., Follmann, D., Nakamura, R., Saunthararajah, Y., Rivera, C.E., Simonis, T., Brown, K.E., Barrett, J.A. and Young, N.S. (2001) "Increased frequency of HLA-DR2 in patients with paroxysmal nocturnal hemoglobinuria and the PNH/aplastic anemia syndrome". Blood 98, 3513-3519.
  • Arden, B., Clark, S.P., Kabelitz, D. and Mak, T.W. (1995) "Human T-cell receptor variable gene segment families". Immunogenetics 42, 455-500.
  • Wei, S., Charmley, P., Robinson, M.A. and Concannon, P. (1994) "The extent of the human gemline T-cell receptor Vß gene segment repertoine". Immunogenetics 40, 27-36.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.