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Research Article

Quantitative Analysis of Cell-free Epstein-Barr Virus Genome Copy Number in Patients with EBV-associated Hemophagocytic Lymphohistiocytosis

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Pages 173-179 | Published online: 01 Jul 2009

  • Pagano, J.S. (1999) "Epstein-Barr virus: the first human tumor virus and its role in cancer", Proc. Assoc. Am. Physicians 111, 573-580.
  • Imashuku, S., Tabata, Y., Teramura, T. and Hibi, S. (2000) "Treatment strategies for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH)", Leukemia & Lymphoma 39, 37-49.
  • Henter, J.I., Elinder, G. and Ost, A. (1991) "Diagnostic guidelines for hemophagocytic lymphohistiocytosis. The FHL Study Group of the Histiocyte Society", Sem. Oncol. 18, 29-33.
  • Imashuku, S., Hibi, S., Tabata, Y., Sako, M., Sekine, Y., Hirayama, K., Sakazaki, H., Maeda, N., Kito, H., Shichino, H. and Mugishima, H. (1998) "Biomarker and morphological characteristics of Epstein-Barr virus- related hemophagocytic lymphohistiocytosis", Med. Pediatr. Oncol. 31, 131-137.
  • Imashuku, S., Hibi, S., Fujiwara, F., Ikushima, S. and Todo, S. (1994) "Haemophagocytic lymphohistiocytosis, interferon-gamma-naemia and Epstein-Barr virus involvement", Br. J. Haematol. 88, 656-658.
  • Lay, J.D., Tsao, C.J., Chen, J.Y., Kadin, M.E. and Su, I.J. (1997) "Upregulation of tumor necrosis factor-alpha gene by Epstein-Barr virus and activation of macrophages in Epstein-Barr virus-infected T cells in the pathogenesis of hemophagocytic syndrome", J. Clin. Invest. 100, 1969-1979.
  • Ho, J.W., Liang, R.H. and Srivastava, G. (1999) "Differential eytokine expression in EBV positive peripheral T cell lymphoma", Mol. Pathol. 52, 269-274.
  • Rooney, C.M., Smith, C.A., Ng. C.Y., Liftin, S., Li, C., Krance, R.A., Brenner, M.K. and Heslop, H.E. (1995) "Use of genemodified virus-specific T lymphocytes to control Epstein- Barr- virus-related lymphoproliferation", Lancet 345, 9-13.
  • Rooney, C.M., Roskrow, M.A., Suzuki, N., Ng, C.Y., Brenner, M.K. and Heslop, H. (1998) "Treatment of relapsed Hodgkin's disease using EBV-specific cytotoxic T cells", Annal. Oncol. 9(suppl 5), S129-S132.
  • Fontan, J., Bassignot, A., Mougin, C., Chan, J.Y., and Lab.M. (1998) "Detection of Epstein-Barr virus DNA in serum of transplanted patients: a new diagnostic guide for lymphoroliferative diseases [letter]", Leukemia 12, 772.
  • Mutirangura, A., Pornthanakaserm, W., Theamboonlers, A., Sriuranpong, V., Lertsanguansinchi, P., Yenrudi, S., Vorvaud, N., Supiyaphun, P. and Poovorawan, Y. (1998) "Epstein-Barr viral DNA in serum of patients with nasopharyangeal carcinoma", Clin. Cancer Res. 4, 665-669.
  • Kanegane, H., Bhatia, K., Gutierrez, M., Kaneda, H., Wada, T., Yachyie, A., Seki, H., Arai, T., Kagimoto, S., Okazaki, M., Oh-ishi, T., Moghaddam, A., Wang, F. and Tosato, G. (1998) "A syndrome of peripheral blood T-cell infection with Epstein-Barr virus (EBV) followed by EBV-positive T-cell lymphoma", Blood 91, 2085-2091.
  • Yamamoto, M., Kimura, H., Hironaka, T., Hirai, K., Hasegawa, S., Kuzushima, K., Shibata, M. and Morishima, T. (1995) "Detection and quantification of virus DNA in plasma of patients with Epstein-Barr virus-associated diseases", J. Clin. Microbiol. 33, 1765-1768.
  • Zingg, W., Bossart, W., Berli, E. and Nadal, D. (1999) "Detection and quantification of cell-free Epstein-Barr virus by polymerase chain reaction and subsequent DNA enzyme immunoassay", J. Virol. Meth. 79, 141-148.
  • Gan, Y.J., Sullivan, J.L., and Sixbey, J.W. (1994) "Detection of cell-free Epstein-Barr virus DNA in serum during acute infectious mononucleosis", J. Infect. Dis. 170, 436-439.
  • Gallagher, A., Armstrong, A.A., MacKenzie, J., Shield, L., Khan, G., Lake, A., Proctor, S., Taylor, P., Clements, G.B. and Jarrett, R.F. (1999) "Detection of Epstein-Barr virus (EBV) genomes in the serum of patients with EBV-associated Hodgkin's disease", Int. J. Cancer 84, 442-448.
  • Mouritsen, C.L., Wittwer, C.T., Reed, G., Khan, T., Martins, T.B., Jaskowski, T.D., Litwin, C.M. and Hill, H.R. (1997) "Detection of Epstein-Barr viral DNA in serum using rapid-cycle PCR", Biochem. Mol. Med. 60, 161-168.
  • Lucas, K.G., Burton, R.L., Zimmerman, S.E., Wang, J., Cornetta, K.G., Robertson, K.A., Lee, C.H. and Emanuel, D.J. (1998) "Semiquantitative Epstein-Barr virus (EBV) polymerase chain reaction for the determination of patients at risk for EBV-induced lymphoproliferative disease after stem cell transplantation", Blood 91, 3654-3661.
  • Rowe, D.T., Qu, L., Reyes, J., Jabbouur, N., Yunis, E., Putnam, P., Todo, S. and Green, N. (1997) "Use of quantitative competitive PCR to measure Epstein-Barr virus genome load in the peripheral blood of pediatric transplant patients with lymphoproliferative disorders", J. Clin Microbiol. 35, 1612-1615.
  • Kimura, H., Morita, M., Yabuta, Y., Kuzushima, K., Kato, K., Kojima, S., Matsuyama, T. and Morishima, T. (1999) "Quantitative analysis of Epstein-Barr virus load by using a real-time PCR assay", J. Clin. Microbiol. 37, 132-136.
  • Lo, Y.M., Chan, L.Y., Lo, K.W., Leung, S.F., Zhang, J., Chan, A.T.C., Lee, J.C.K., Hjelm, N.M., Johnson, P.J. and Huang, D.J. (1999) "Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma", Cancer Res. 59, 118-1191.
  • Niesters, H.G., van, E.J., Fries, E., Wolthers, K.C., Cornelissen, J. and Osterhaus, A.D. (2000) "Development of a real-time quantitative assay for detection of Epstein-Barr virus", J. Clin. Microbiol. 38, 712-715.
  • Baldanti, F., Grossl, P., Furione, M., Simoncini, L., Sarasini, A., Comoli, P., Maccario, R., Fiocchi, R. and Gerna, G. (2000) "High levels of Epstein-Barr virus DNA in blood of solid-organ transplant recipients and their value in predicting post-transplant lymphopro-liferative disorders", J. Clin. Microbiol. 38, 613-619.
  • Lo, K.W., Lo, Y.M., Leung, S.F., Tsang, Y.S., Chan, L.Y.S., Johnson, P.J., Hjelm, N.M., Lee, J.C.K. and Huang, D.P. (1999) "Analysis of cell-free Epstein-Barr virus associated RNA in the plasma of patients with nasopharyngeal carcinoma", Clin. Chem. 45, 1292-1294.
  • Kogan, D.L., Burroughs, M., Emre, S., Fishbein, T., Moscona, A., Ramson, C. and Shneider, B.L. (1999) "Prospective longitudinal analysis of quantitative Epstein-Barr virus polymerase chain reaction in pediatric liver transplants recipients", Transplantation 67, 1068-1070.
  • Orentas, R.J. (1998) "Determination of Epstein-Barr virus (EBV) load by RT-PCR and cellular dilution", Mol. Cell Probes 12, 427-430.
  • Sumaya, C.V. and Ench, Y. (1985) "Epstein-Barr Virus infectious mononucleosis in children. II. Heterophil antibody an viral-specific responses", Pediatrics 75, 1011-1019.
  • Henter, J.I., Arico, M., Egeler, R.M., Elinder, G., Favara, B.E., Filipovich, A.H., Gadner, H., Imashuku, S., Janka-Schaub, G., Komp, D., Ladishch, S. and Webb, D. (1997) "HLH-94: a treatment protocol for hemophagocytic lymphohistiocytosis. HLH study Group of the Histiocyte Society", Med. Pediatr. Oncol. 28, 342-347.
  • Imashuku, S., Hibi, S., Kuriyama, K., Tabata, Y., Hashida, T., Iwai, A., Kato, M., Yarnashita, N., Oda, M., Uchida, M., Kinugawa, N., Sawada, M. and Kono, M. (2000) "Management of severe neutropenia with cyclosporin during initial treatment of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis", Leukemia & Lymphoma 36, 339-346.
  • Heid, C.A., Stevens, J., Livak, K.J. and Williams, P.M. (1996) "Real Time quantitative PCR", Genome Res. 6, 986-994.
  • Raab-Traub, N. and Flynn, K. (1986) "The structure of the termini of the Epstein Barr virus as a marker of clonal cellular proliferation", Cell 47, 883-889.
  • Hibi, S., Ikushima, S., Fujiwara, F., Hashida, T., Tsunamoto, K., Todo, S. and Imashuku, S. (1995) "Serum and urine beta-2-mircoglobulin in hemophagocytic syndrome", Cancer 75, 1700-1705.
  • Lei, K.I.K., Chan, L.Y.S., Chan, W.Y., Johnson, P.J. and Lo, Y.M.D. (2000) "Quantitative analysis of circulating cell-free Epstein-Barr virus(EBV) DNA levels in patients with EBV-associated lymphoid malignancies", Br. J. Haematol 111, 239-246.
  • Steven, S.J., Verschuuren, E.A., Pronk, I., van Der Bij., W., Harmsen, M.C., The, Meijer, C.J., van Den Brule, A.J. and Middeldrop, J.M. (2000) "Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of post-transplant lymphoproliferative disease in high-risk patients", Blood 97, 1165-1171.
  • Imashuku, S., Kuriyama, K., Teramura, T., Ishii, E., Kinugawa, N., Kato, M., Sako, M. and Hibi, S. (2001) "Requirement for etoposide in the treatment of Epstein-Barr virus-associated hemophagocytic lymphohistiocytois", J. Clin. Oncol., 19, 2665-2673.

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