Advanced search
Publication Cover
Leukemia & Lymphoma Volume 43, 2002 - Issue 2
Submit an article Journal homepage
75
Views
19
CrossRef citations to date
0
Altmetric
Research Article

Angiogenic and Lymphangiogenic Molecules in Hematological Malignancies

Arto Orpana Departments of Clinical Chemistry and Medical Genetics, Helsinki University Central Hospital, Helsinki, Finland
&
Petri Salven Division of Hematology-Oncology, Weill Medical College of Cornell University, New York, NY 10021, USA
Pages 219-224 | Published online: 01 Jul 2009

  • Reynolds, L.P., Killilea, S.D. and Redmer, D.A. (1992) "Angiogenesis in the female reproductive system", FASEB J. 6, 886-892.
  • Folkman, J. (1995) "Angiogenesis in cancer, vascular, rheumatoid and other disease", Nat. Med. 1, 27-31.
  • Risau, W. (1995) "Differentiation of endothelium", FASEB J. 9, 926-933.
  • Hanahan, D. and Folkman, J. (1996) "Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis", Cell 86, 353-364.
  • Yancopoulos, G.D., Davis, S., Gale, N.W., Rudge, J.S., Wiegand, S.J. and Holash, J. (2000) "Vascular-specific growth factors and blood vessel formation", Nature 407, 242-248.
  • Griffioen, A.W. and Molema, G. (2000) "Angiogenesis: potential for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, chronic inflammation,", Pharmacol. Rev. 52, 238-262.
  • Wolf, J.E. and Hubler, W.R. (1975) "Tumour angiogenic factor associated with subcutaneous lymphoma", Br. J. Dermatol. 92, 273-277.
  • Perez-Atayde, A.R., Sallan, S.E., Tedrow, U., Connors, S., Allred, E. and Folkman, J. (1997) "Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia", Am. J. Pathol. 150, 815-821.
  • Hussong, J.W., Rodgers, G.M. and Shami, P.J. (2000) "Evidence of increased angiogenesis in patients with acute myeloid leukemia", Blood 95, 309-313.
  • Padro, T., Ruiz, S., Bicker, R., Burger, H., Steins, M., Kienst, J., Buchner, T., Berdel, W.E. and Mesters, R.M. (2000) "Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia", Blood 95, 2637-2644.
  • Aguayo, A., Kantarjian, H., Mansbouri, T., Gidel, C., Eatey, E., Thomas, D., Koller, C., Estrov, Z., O'Brien, S., Keating, M., Freireich, E. and Albitar, M. (2000) "Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes", Blood 96, 2240-2245.
  • Pruneri, G., Bertolini, F., Soligo, D., Carboni, N., Cortelezzi, A., Ferrucci, P.F., Buffa, R., Lambertenghi-Deliliers, G. and Pezzella, F. (1999) "Angiogenesis in myelodysplastic syndromes", Br. J. Cancer 81, 1398-1401.
  • Ribatti, D., Vacca, A., Nico, B., Fanelli, M., Roncali, L. and Dammacco, F. (1996) "Angiogenesis specturm in the stroma of B-cell non-Hodgkin's lymphomas. An immunohistochemical and ultrastructural study", Eur. J. Haematol, 56, 45-53.
  • Vacca, A., Ribatti, D., Ruco, L., Giacchetta, F. Nico, B., Quondamatteo, F., Ria, Iurlaro, M. and Dammacco, F. (1999) "Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas", Br. J. Cancer 79, 965-970.
  • Ribatti, D., Vacca, A., Nico, B., Quondamatteo, F., Ria, R., Minischetti, M., Marzullo, A., Herken, R., Roncali, L. and Dammacco, F. (1999) "Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma", Br. J. Cancer 79, 451-455.
  • Rajkumar, S.V., Leong, T., Roche, P.C., Fonseca, R., Dispenzieri, A., Lacy, M.Q., Lust. J.A., Witzig, T.E., Kyle, R.A., Gertz, M.A. and Greipp. P.R. (2000) "Prognostic value of bone marrow angiogenesis in multiple myeloma", Clin. Cancer Res. 6, 3111-3116.
  • Ferrara, N. and Alitalo, K. (1999) "Clinical applications of angiogenic growth factors and their inhibitors", Nat. Med. 5, 1359-1964.
  • Bertolini, P., Fusetti, L., Mancuso, P., Gobbi, A., Corsini, C., Ferrucci, P.F., Martinelli, G. and Pruneri, G. (2000) "Endostatin, an antiangiogenic drug, induces tumor stabilization after chemotherapy or anti-CD20 therapy in a NOD/SCID mouse model of human high-grade non-Hodgkin lymphoma", Blood 96, 282-287.
  • Browder, T., Butterfield, C.E., Kraling, B.M., Shi, B., Marshall, B., O'Reilly, M.S. and Folkman, J. (2000) "Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer", Cancer Res. 60, 1878-1886.
  • Dvorak, H.F., Brown, L.F., Detmar, M. and Dvorak, A.M. (1995) "Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis", Am. J. Pathol. 146, 1029-1039.
  • Ferrara, N. and Davis-Smyth, T. (1997) "The biology of vascular endothelial growth factor", Endocr. Rev. 18, 4-25.
  • Senger, D.R., Galli, S.J., Dvorak, A.M., Perruzzi, C.A., Harvey, V.S. and Dvorak, H.F. (1983) "Tumor cells secrete a vacular permeability factor that promotes accumulation of ascits fluid", Science 219, 983-985.
  • Ferrara, N., Carver Moore, K., Chen, H., Dowd, M., Lu, L., O'Shea, K.S., Powell Braxton, L., Hillan, K.J. and Moore, M.W. (1996) "Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene", Nature 380, 439-442.
  • Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., Declercq, C., Pawling, J., Moons, L., Collen, D., Risau, W. and Nagy, A. (1996) "Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele", Nature 380, 435-439.
  • Ferrara, N., Winer, J., Burton, T., Rowland, A., Siegel, M., Phillips, H.S., Terrell, T., Keller, G.A. and Levinson, A.D. (1993) "Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells", J. Clin. Invest. 91, 160-170.
  • Zhang, H.T., Craft, P., Scott, P.A., Ziche, M., Weich, H.A., Harris, A.L. and Bicknell, R. (1995) "Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells", J. Natl. Cancer Inst. 87, 213-219.
  • Dvorak, H.F., Sioussat, T.M., Brown, L.F., Berse, B., Nagy, J.A., Sotrel, A., Manseau, E.J., Van de Water, L. and Senger, D.R. (1991) "Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels", J. Exp. Med. 174, 1275-1278.
  • Salven, P., Lymboussaki, A., Heikkila, P., Jaaskela-Saari, H., Enholm, B., Aase, K., von Euler, G., Eriksson, U., Alitalo, K. and Joensuu, H. (1998) "Vasuclar endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors", Am. J. Pathol. 153, 103-108.
  • Foss, H.D., Araujo, I., Demel, G., Klotzbach, H., Hummel, M. and Stein, H. (1997) "Expression of vascular endothelial growth factor in lymphomas and Castleman's disease", J. Pathol. 183, 44-50.
  • Fiedler, W., Graeven, U., Ergun, S., Verago, S., Kilie, N., Stockschlader, M. and Hossfeld, D.K. (1997) "Vascular endothelial growth factor, possible paracrine growth factor in human acute myeloid leukemia", Blood 89, 1870-1875.
  • Aguayo, A., Estey, E., Kantarjian, H., Mansouri, T., Gidel, C., Keating, M., Giles, F., Estrov, Z., Barlogie, B. and Albitar, M. (1999) "Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid laukemia", Blood 94, 3717-3721.
  • Fusetti, L., Pruneri, G., Gobbi, A., Rabascio, C., Carboni, N., Peccatori, F., Martinelli, G. and Bertolini, F. (2000) "Human myeloid and lymphoid malignancies in the non-obese diabetic/severe combined immunodeficiency mouse model: frequency of apoptotic cells in solid tumors and efficiency and speed of engraftment correlate with vascular endothelial growth factor production", Cancer Res. 60, 2527-2534.
  • Dankdar, B., Padro, T., Leo, R., Feldmann, B., Kropff, M., Mesters, R.M., Serve, H., Berdel, W.E. and Kienast, J. (2000) "Vascular endothelial growth factor in interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma", Blood 95, 2630-2636.
  • Frizzera, G. (1992) "Atypical lymphoproliferative disorders", In: Knowles, D.M., ed, Neoplastic Hematopathology (Baltimore: Williams and Wilkins), pp. 459-496.
  • Fukumura, D., Xavier, R., Sugiura, T., Chen, Y., Park, E.C., Lu, N., Selig, M., Nielsen, G., Taksir, T., Jain, R.K. and Seed, B. (1998) "Tumor induction of VEGF promoter activity in stromal cells", Cell 94, 715-725.
  • Freeman, M.R., Schneck, F.X., Gagnon, M.L., Corless, C., Soker, S., Niknejad, K., Peoples, G.E. and Klagsbrun, M. (1995) "Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis", Cancer Res. 55, 4140-4145.
  • Salven, P., Heikkila, P., Anttonen, A., Kajanti, M. and Joensuu, H. (1997) "Vascular endothelial growth factor in squamous cell head and neck carcinoma: expression and prognostic significance", Mod. Pathol, 10, 1128-1133.
  • Salven, P., Orpana, A. and Joensuu, H. (1999) "Leukocytes and platelets of patients with cancer contain high levels of vascular endothelial growth factor", Clin. Cancer Res. 5, 487-491.
  • Salven, P., Anttonen, K., Repo, H., Joensuu, H. and Orpana, A. (2001) "Endotoxins induce and interferon-a suppresses vascular endothelial growth factor (VEGF) production in human peripheral blood mononuclear cells", FASEB J., 101096/fj00-1010627fje.
  • Wartiovaara, U., Salven, P., Mikkola, H., Lassila, R., Kaukonen, J., Joukov, V., Orpana, A., Ristimaki, A., Heikinheimo, M., Joensuu, H., Alitalo, K. and Palotie, A. (1998) "Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation", Thromb. Haemost. 80, 171-175.
  • Gaudry, M., Bregerie, O., Andrieu, V. El Benna, J., Pocidalo, M.A. and Hakim, J. (1997) "Intracellular pool of vascular endothelial growth factor in human neutrophils", Blood 90, 4153-4161.
  • Mohle, R., Green, D., Moore, M.A., Nachman, R.L. and Rafii, S. (1997) "Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets", Proc. Natl. Acad. Sci. USA 94, 663-668.
  • Salven, P.A., Teerenhovi, L. and Joensuu, H. (1997) "A high pretreatment serum vascular endothelial growth factor concentration is associated with poor outcome in non-Hodgkin's lymphoma", Blood 90, 3167-3172.
  • Salven, P., Orpana, A., Teerenhovi, L. and Joensuu, H. (2000) "Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin lymphoma: a single-institution study of 200 patients", Blood 96, 3712-3718.
  • Bertolini, F., Paolucci, M., Peccatori, F., Cinieri, S., Agazzi, A., Ferrucci, P.F., Cocorocchio, E., Goldhirsch, A. and Martinelli, G. (1999) "Angiogenic growth factors and endostatin in non-Hodgkin's lymphoma", Br. J. Haematol. 106, 504-509.
  • Molica, S., Vitelli, G., Levato, D., Gandolfo, G.M. and Liso, V. (1999) "Incresed serum levels of vascular endothelial growth factor predict risk of progression in early B- cell chronic lymphocytic leukaemia", Br. J. Haematol. 107, 605-610.
  • Bellamy, W.T., Richter, L., Frutiger, Y. and Grogan, T.M. (1999) "Expression of vascular endothelial growth factor and its receptors in hematopoietic melignancies", Cancer Res. 59, 728-733.
  • Dias, S., Hattori, K., Zhu, Z., Heissig, B., Choy, M., Lane, W., Wu, Y., Chadburn, A., Hyjek, E., Gill, M., Hicklin, D.J., Witte, L., Moore, M.A. and Rafii, S. (2000) "Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration", J. Clin. Invest. 106, 511-521.
  • Dias, S., Shmelkov, S.V., Lam, G. and Rafii, S. (2000) "VEGF acts as a survival factor on leukemia by HSP90-mediated induction of BCL-2 expression", Blood 96, 502a, Abstract.
  • Kuramoto, K., Uesaks, T., Kimura, A., Kobayashi, M., Watanabe, H. and Katoh, O. (2000) "ZK7, a novel zinc finger gene, is induced by vascular endothelial growth factor and inhibits apoptotic death in hematopoietic cells", Cancer Res. 60, 425-430.
  • Joukov, V., Pajusola. K., Kaipainen, A., Chilov, D., Lahtinen,I., Kukk, E., Saksela, O., Kalkkinen, N. and Alitalo, K. (1996) "A novel vascular endothelial growth factor, VEGF-C, is a lignad for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases", Embo J. 15, 290-298.
  • Joukov, V., Sorsa, T., Kumar, V., Jeltsch, M., Claesson-Welsh, L., Cao, Y., Saksela, O., Kalkkinen, N. and Alitalo, K. (1997) "Proteolytic processing regulates receptor specificity and activity of VEGF-C", Embo J. 16, 3898-3911.
  • Pajusola, K., Aprelikova, O., Korhonen, J., Kaipainen, A., Pertovaarsa, L., Alitalo, R. and Alitalo, K. (1992) "FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines", Cancer Res. 52, 5738-5743.
  • Kaipainen, A.,Korhonen, J., Mustonen, T., van Hinsbergh, V.W., Fang, G.H., Dumont, D., Breitman, M. and Alitalo, K. (1995) "Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development", Proc. Natl. Acad. Sci. USA 92, 3566-3570.
  • Jussila, L., Valtola, R., Partanen, T.A., Salven, P., Heikkila, P., Matikainen, M.T., Renkonen, R., Kaipainen, A., Detmar, M., Tschachler, E., Alitalo, R. and Alitalo, K. (1998) "Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3", Cancer Res. 58, 1599-1604.
  • Valtola, R., Salven, P., Heikkila, P., Taipale, J., Joensuu, H., Rehn, M., Pihlajaniemi, T., Weich, H., deWaal, R. and Alitalo, K. (1999) "VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer", Am. J. Pathol. 154, 1381-1390.
  • Jeltsch, M., Kaipainen, A., Joukov, V., Meng, X., Lakso, M., Rauvala, H., Swartz, M., Fukumura, D., Jain, R.K. and Alitalo. K. (1997) "Hyperplasia of lymphatic vessels in VEGF-C transgenic mice", Science 276, 1423-1425.
  • Makinen, T., Jussila, L., Veikkola, T., Karpanen, T., Kettunen, M.I., Pulkkanen, K.J., Kauppinen, R., Jackson, D.G.,. Kubo, H., Nishikawa, S.I., Yla-Herttuala, S. and Alitalo, K. (2001) "Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3", Nat. Med. 7, 199-205.
  • Cao, Y., Linden, P., Farnebo, J., Cao, R., Eriksson, A., Kumar, V., Qi, J.H., Claesson-Welsh, L. and Alitalo, K. (1998) "Vascular endothelial growth factor C induces angiogenesis in vivo", Proc. Natl. Acad. Sci. USA 95, 14389-14394.
  • Mandriota, S.J., Jussila, L., Jeltsch, M., Compagni, A., Baetens, D., Prevo, R., Banerji, S., Huarte, J., Montesano, R., Jackson, D.G., Orci, L., Alitalo, K., Christofori, G. and Pepper, M.S. (2001) "Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis", Embo J. 20, 672-682.
  • Skobe, M., Hawighorst, T., Jackson, D.G., Prevo, R., Janes, L., Velasco, P., Riccardi, L., Alitalo. K., Claffey, K. and Detmar, M. (2001) "Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis", Nat. Med. 7, 192-198.
  • Veikkola. T., Jussila, L., Makinen, T., Karpanen, T., Jeltsch, M., Petrove, T.V., Kubo, H., Thurston, G., McDonald, D.M., Achen, M.G., Stacker, S.A. and Alitalo, K. (2001) "Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice", Embo J. 20, 1223-1231.
  • Fielder, W., Graeven U., Ergun, S., Verago, S., Kilic, N., Stockschlader, M. and Hossfeld, D.K. (1997) "Expression of FLT4 and its ligand VEGF-C in acute myeloid leukemia", Leukemia 11, 1234-1237.
  • Choy, M., Dias, S., Alitalo, R., Alitalo, K. and Rafii, S. (2000) "VEGR-C signalling through FLT-4 (VEGFR3) mediates leukemic cell proliferation and survival ", Blood 96, 502a-503b, Abstract.
  • Yonekura, H., Sakurai, S., Liu, X., Migita, H., Wang, H., Yamagishi, S., Nomura, M., Abedin, M.J., Unoki, H., Yamamoto, Y. and Yamamoto, H. (1999) "Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis", J. Biol. Chem. 274, 35172-35178.
  • Friesel, R.E. and Maciag, T. (1995) "Molecular mechanisms of angiogenesis: fibroblast growth signal transduction", Faseb J. 9, 919-925.
  • Bikfalvi, A., Klein, S., Pintucci, G. and Rifkin, D.B. (1997) "Biological roles of fibroblast growth factor-2", Endocr. Rev 18, 26-45.
  • Hori, A., Sasada, R., Matsutani, E., Naito, K., Sakura, Y., Fujita, T. and Kozai, Y. (1991) "Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor", Cancer Res. 51, 6180-6184.
  • Brunner, G., Nguyen, H., Gabrilove, J., Rifkin, D.B. and Wilson, E.L. (1993) "Basic fibroblast growth factor expression in human bone marrow and peripheral blood cells", Blood 81, 631-638.
  • Gu, X.F., Bikfalvi, A., Chen, Y.Z., Caen, J.P. and Han, Z.C. (1995) "Constitutive and selective expression of basic fibroblast growth factor in human leukaemia cell lines", Eur. J. Haematol. 55, 189-194.
  • Peoples, G.E., Blotnick, S., Takahashi, K., Freeman, M.R., Klagsbrun, M. and Eberlein, T.J. (1995) "T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparinbinding epidermal growth factor-like growth factor and basic fibroblast growth factor: a potential pathologic role", Proc. Natl. Acad. Sci. USA 92, 6547-6551.
  • Blotnick, S., Peoples, G.E., Freeman, M.R., Eberlein, T.J. and Klagshrun, M. (1994) "T lymphocytes synthesize and export heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor, mitogens for vascular cells and fibroblasts: differential production and release by CD4+ and CD8+ T cells", Proc. Natl. Acad. Sci. USA 91, 2890-2894.
  • Vacca, A.,. Ribatti, D., Iurlaro, M., Albini, A., Minischetti, M., Bussolilno, F., Pellegrino, A., Ria, R., Rusanti, M., Presta, M., Vincenti, V., Persico, M.G. and Daimacco, F. (1998) "Human lymphoblAstoid cells produce extracellular matrix-degrading enzymes and induce endothelial cell proliferation, migration, morphogenesis, angiogenesis", Int. J. Clin. Lab. Res. 28, 55-68.
  • Allouche, M., Bayard, F., Clamens, S., Fillola, G., Sie, P. and Amalric, F. (1995) "Expression of basic fibroblast growth factor (bFGF) and (FGF-receptors in human leukemic cells", Leukemia 9, 77-86.
  • Gruber, G., Schwarzmeier, J.D., Shehata, M., Hilgarth, M. and Berger, R. (1999) "Basic fibroblast growth factor is expressed by CD19/CD11c-positive cells in hairy cell leukemia", Blood 94, 1077-1085.
  • Menzel, T., Rahman, Z., Calleja, E., White, K., Wilson, E.L., Wider, R. and Gabrilove, J. (1996) "Elevated intracellular level of basic fibroblast growth correlates with stage of chronic lymphocytic leukemia and is associated with resistance to fludarabine", Blood 87, 1056-1063.
  • Salven, P., Teerenhovi, L. and Joensuu, H. (1999) "A high pretreatment serum basic fibroblast growth factor concentration is an independent predictor of poor prognosis in non-Hodgkin's lymphoma", Blood 94, 3334-3339.
  • Pepper, M.S., Ferrara, N., Orci, L. and Montesano, R. (1992) "Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro", Biochem. Biophys. Res. Commun. 189, 824-831.
  • Goto, F., Goto, K., Weindel, K. and Folkman, J. (1993) "Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels", Lab. Invest. 69, 508-517.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.