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Leukemia & Lymphoma Volume 43, 2002 - Issue 2
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Research Article

Apoptosis and Prognostic Factors in Myelodysplastic Syndromes

K. Shimazaki Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jonanku, Fukuoka 814-01, Japan
,
K. Ohshima Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jonanku, Fukuoka 814-01, Japan
,
J. Suzumiya Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jonanku, Fukuoka 814-01, Japan
,
C. Kawasaki Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jonanku, Fukuoka 814-01, Japan
&
M. Kikuchi Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jonanku, Fukuoka 814-01, Japan
Pages 257-260 | Published online: 01 Jul 2009

  • Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A., Gralnick, H.R. and Sultan, C. (1982) "Proposals for the classification of the myelodysplastic syndromes", Br. J. Haematol. 51, 189-199.
  • Greenberg, P., Cox, C., Lebeau, M.M., Fenaux, P., Morel, P., Sanz, G., Sanz, M., Vallespi, T., Hamblin, T., Oscier, D., Ohyashiki, K., Toyama, K., Aul, C., Mufti, G. and Benett, J. (1997) "International scoring system for evaluating prognosis in myelodysplastic syndromes", Blood 89, 2079-2088.
  • Raza, A., Mundle, S., Iftikhar, A., Gregory, S., Marcus, B., Khan, Z., Alvi, S., Nadir Ali, S. and Preisler, H. (1995) "Simultaneous assessment of cell kinetics and programmed cell death in bone marrow biopsies of myelodysplastics reveals extensive apoptosis as the probable basis for ineffective hematopoiesis", Am. J. Hematol. 48, 143-154.
  • Raza, A., Grezer, S., Mundle, S., Gao, X.Z., Alvi, S., Borok, R., Rifkin, S., Iftikhar, A., Shetty, V. and Parcharidou, A. (1995) "Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes", Blood 86, 268-276.
  • Lepelley, P., Campergue, L., Grardel, N., Preudhomme, C., Cosson, A. and Fenaux, P. (1996) "Is apoptosis a massive process in myelodysplastic syndromes?", Br. J. Hematol. 95, 368-371.
  • Bouscary, D., De Vos, J., Guesnu, M., Jondeau, K., Viguier, F., Melle, J., Picard, F., Dreyfus, F. and Fontenay-Roupie, M. (1997) "Fas/Apo-1 (CD95) expression and apoptosis in patients with myelodyplastic syndromes", Leukemia 11, 839-845.
  • Hellström-Lindberg, E., Kanter-Lewensohn, L. and Öst, Å. (1997) "Morphological changes and apoptosis in bone marrow from patients with myelodysplastic syndromes treated with granulocyte-CSF and erythropoietin", Leukemia Res. 21, 415.
  • Shimazaki, K., Ohshima, K., Suzumiya, J., Kawasaki, C. and Kikuchi, M. (2000) "Evaluation of apoptosis as a prognostic factor in myelodysplastic syndromes", Br. J. Hematol. 110, 584-590.
  • Orazi, A., Kahsai, M., John, K. and Neiman, R.S. (1996) "p53 overexpression in myeloid leukemic disorder is associated with increased apoptosis of hematopoietic marrow cells and ineffective hematopoiesis", Modern Pathol. 9, 48-52.
  • Lai, J-L, Preudhomme, C., Zandecki, M., Flactif, M., Vanrumbeke, M., Lepelley, P., Wattel, E. and Fenaux, P. (1995) "Myelodysplastic syndromes and acute myeloid leukemia with 17p deletion. An entity characterized by specific dysgranulopoiesis and a high incidence of p53 mutations", Leukemia 9, 370-381.
  • Ohyashiki, J.H., Iwama, H., Yahata, N., Ando, K., Hayashi, S., Shay, J.W. and Ohyashiki, K. (1999) "Telomere stability is frequently impaired in high-risk groups of patients with myelodysplastic syndromes", Clin. Cancer Res. 5, 1155-1160.
  • Rajapaska, R., Ginzton, N., Rott, L.S. and Greenberg, P.L. (1996) "Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells", Blood 88, 4275-4287.
  • Bouscary, D., De Vos, J., Guesnu, M., Jondeau, K., Viguier, F., Melle, J., Picard, F., Dreyfus, F. and Fontenay-Roupie, M. (1997) "Fas/Apo-1 (CD95) expression and apoptosis in patients with myelodyplastic syndromes", Leukemia 11, 839-845.
  • Raza, A., Bokhari, J., Yousuf, N., Mehdi, A., Mazawski, C., Khan, S., Baker, V. and Lampkin, B. (1991) "Cell cycle kinetic studies in human cancers. Development of three DNA-specific labels in three decades", Arch. Pathol. Lab. Med. 115, 873.
  • Raza, A., Yousef, N., Bokhari, S.A.J., Sheikh, Y., Akhtar, S., Chugutai, S., Umerani, A., Mehdi, S.A., Miller, M.A. Materson, M. and Lampkin, B. (1992) "In situ cell cycle kinetics in bone marrow biopsies following sequential infusions of IudR/BrdU in patients with hematopoietic malignancies", Anticancer Res. 12, 403.
  • Oriani, A., Annaloro, C., Soligo, D., Pozzoli, E., Cortelezzi, A. and Lambertenghi Deliliers, G. (1996) "Bone marrow histology and CD34 immunostaining in the prognostic evaluation of primary myelodysplastic syndromes", Br. J. Haematol. 92, 360-364.
  • Tricot, G., De, Wolf-Peeters, C., Vlietinck, R. and Verwilghen, R.L. (1984) "Bone marrow histology in myelodysplastic syndromes. II Prognostic value of abnormal localization of immature precursors in MDS", Br. J. Haematol. 58, 217-225.
  • Mufti, G.J., Stevens, J.R., Oscier, D.G., Hamblin, T.J. and Machin, D. (1985) "Myelodysplastic syndromes: a scoring system with prognostic significance", Br. J. Haematol. 59, 425-433.
  • Sanz, G.F., Sanz, M.A. and Greenberg, P.L. (1998) "Prognostic factors and scoring systems in myelodysplastic syndromes", Haematologica 83, 358-368.
  • Morel, P., Hebbar, M., Lai, J.L., Duhamel, A., Preudhomme, C., Wattel, E., Bauters, F. and Fenaux, P. (1993) "Cytogenetic analysis has strong independent prognostic value in de novo myelodysplastic syndromes and can be incorporated in a new scoring system: a report on 408 cases", Leukemia 7, 1315-1323.
  • Cunningham, I., MacCallum, S.J., Nicholls, M.D., Byth, K., Hewson, J.W., Arnold, B., Motum, P.I., Mulligan, S.P. and Crane, G.G. (1995) "The myelodysplastic syndromes: an analysis of prognostic factors in 226 cases from a single institution", Br. J. Haematol. 90, 602-606.
  • Balduini, C.L., Guarnone, R., Pecci, A., Centenara, E., Invernizzi, R. and Ascari, E. (1999) "The myelodysplastic syndromes: predictive value of eight prognostic systems in 143 cases from a single institution", Haematologica 84, 12-16.
  • Rosati, S., Mick, R., Xu, F., Stonys, E., Le Beau, M.M., Larson, R. and Vardiman, J.W. (1996) "Refractory cytopenia with multilineage dysplasia: further characterization of an unclassifiable myelodysplastic syndrome", Leukemia 10, 20-26.
  • Third MIC Cooperative Study Group (1988) "Recommendations for a morphologic, immunologic, and cytogenetic (MIC) working classification of the primary and therapy-related myelodysplastic disorders. Report of the workshop held in Scottsdale, Arizona, USA, on February 23-25, 1987", Cancer Genet. Cytogenet. 32, 1-10.
  • Varela, B.L., Chuang, C., Woll, J.E. and Benett, J.M. (1985) "Modifications in the classification of primary myelodysplastic syndromes: the addition of a scoring system", Hematol Oncol. 3, 55-63.
  • Anderson, J.E. (2000) "Bone marrow transplantation for myelodysplasia", Blood Rev. 14, 63-77.
  • Beran, M. (2000) "Intensive chemotherapy for patients with high-risk myelodysplastic syndrome", Int. J. Hematol. 72, 139-150.
  • Bowen, D., Culligan, D. and Jacobs, A. (1991) "The treatment of anemia in the myelodysplastic syndromes", Br. J. Haematol. 77, 419-423.
  • Mantovani, L., Lentini, G., Hentschel, B., Wickramanayake, P.D., Loeffler, M., Diehl, V. and Tesch, H. (2000) "Treatment of anaemia in myelodysplastic syndromes with prolonged administration of recombinant human granulocyte colony-stimulating factor and erythropoietin", Br. J. Haematol. 109, 367-375.

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