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Research Article

Seventy-Two Hour Continuous Infusion Flavopiridol in Relapsed and Refractory Mantle Cell Lymphoma

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Pages 793-797 | Published online: 01 Jul 2009

  • Argatoff, L., Connors, J., Klasa, R., Horsman, D. and Gascoyne, R. (1997) "Mantle cell lymphoma: a clinicopathologic study of 80 cases", Blood. 2067-2078.
  • Berger, F., Fetman, P., Sonet, A., Salles, G., Bastion, Y., Bryon, P.A. and Coiffier, B. (1994) "Nonfollicular small B-cell lymphomas: a heterogeneous group of patients with district clinical features and outcome", Blood 83, 2829-2850.
  • Bosch, F., Lopez-Guillermo, A., Campo, E., Ribera, J., Conde, E., Piris, M., Vallespi, T., Woessner, S. and Montserrat, E. (1998) "Mantle cell lymphoma: presenting features, response to therapy, and prognastic factors", Cancer 82, 567-575.
  • Fisher, R., Dahlberg, S., Nathwani, B., Banks, P., Miller, T. and Grogan, T. (1995) "A clinical analysis of two indolent lymphoma entities: mantle cell lymphoma and marginal zone lymphoma (including the mucosa-associated lymphoid tissue and monocytoid B-cell subcategories): a Southwest Oncology Group study", Blood 85, 1075-1082.
  • Samaha, H., Dumontet, C., Ketterer, N., Moullet, I., Thieblemont, C., Bouafia, F., Callet Bauchu, E., Felman, P., Berger, P., Salles, G., et al. (1998) "Mantle cell lymphoma: a retrospective study of 121 cases", Leukemia 12, 1281-1287.
  • Velders, G., Kulin-Nelemans, J., De Boer, C., Hermans, J., Noordijk, E., Schuuring, E., Kramer, M., Van Deijk, W., Rahder, J., Kluin, P., et al. (1996) "Mantle-cell lymphoma: a population-based clinical study", J. Clin. Oncol. 14, 1269-1274.
  • Weisenburger, D. and Armitage, J. (1996) "Mantle cell lymphoma--an entity comes of age", Blood 87, 4483-4494.
  • Weisenburger, D., Vose, J., Greiner, T., Lynch, J., Chan, W., Bierman, P., Dave, B., Sanger, W. and Armitage, J. (2000) "Mantle cell lymphoma. A clinicopathologic study of 68 cases from the Nebraska Lymphoma Study Group", Am. J. Hematol. 64, 190-196.
  • Zucca, E., Stein, H. and Coiffier, B. (1994) "European Lymphoma Task Force (ELTF): report of the workshop on mantle cell lymphoma (MCL)", Ann. Oncol. 5, 508-511.
  • Zucca, E. Roggero, E., Pinotti, G., Pedrinis, E. Cappella, C., Venco, A. and Cavalli, F. (1995) "Patterns of survival in mantle cell lymphoma", Ann. Oncol. 6, 257-262.
  • Khouri, I., Lee, M., Romaguera, J., Mirza, N., Kantarjian, H., Korbling, M., Albitar, M., Giralt, S., Samuels, B., Anderlini, P., et al. (1999) "Allogeneic hematopoietic transplantation for mantle cell lymphoma: molecular remissions and evidence of graft-versus-malignancy", Ann. Oncol., 1293-1299.
  • Khouri, I., Romaguera, J., Kantarjian, H., Palmer, J., Pugh, W., Korbling, M., Hagemeister, F., Samuels, B., Rodriguez, A., Giralt, S., et al. (1998) "Hyper-CVAD and high-dose methotrexate/cytarabine followed by stem-cell transplantation: an active regimen for aggressive mantle-cell lymphoma", J. Clin. Oncol. 16, 3803-3809.
  • Howard, O., Gribben, J., Neuberg, D., Grossbard, M., Kim, H., Poor, C., Janicek, M. and Shipp, M. (2000) "Rituxiinab and CHOP induction therapy for newly diagnosed mantle cell lymphoma: molecular complete responses are not predictive of progression-free survival", J. Clin. Oncol., in press.
  • Decaudin, D., Brousse, N., Brice, P., Haioun, C., Bourhis, J., Morel, P., Van Hoof, A., Souleau, B., Quesnel, B. and Gisselbrecht, C. (2000) "Efficacy of autologous stem cell transplantation in mantle cell lymphoma: a 3-year follow-up study", Bone Marrow Transplant. 25, 251-256.
  • Freedman, A., Neuberg, D., Gribben, J., Mauch, P., Soiffer, R., Fisher, D., Anderson, K., Andersen, N., Schlossman, R., Kroon, M., et al. (1998) "High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission", J. Clin. Oncol. 16, 13-18.
  • Ketterer, N., Salles, G., Espinouse, D., Dumontet, C., Neidbardt-Berard, E., Moullet, I., Bouafia, F., Berger, F, Felman, P and Coiffier, B (1997) "Intensive therapy with peripheral stein cell transplantation in 16 patients with mantle cell lymphoma", Ann Oncol. 8, 701-704.
  • Milpied, N., Gaillard, F. Moreau, P., Mahe, B., Souchet, J., Rapp, M., Bulabois, C., Morineau, N. and Harousseau, J. (1998) "High dose therapy with stem cell transplantation for mantle cell lymphoma: results and prognostic factors, a single center experience", Bone Marrow Transplant. 22, 645-650.
  • Vose, J., Bierman, P., Weisenburger, D., Lynch, J., Bociek, Y., Chan, W., Greiner, T. and Armitage, I/ (2000) "Autologous hematopoietic stem cell transplantation for mantle cell lymphoma", Biol. Blood Marrow Transplant. 6, 640-645.
  • Leroux, D., LeMarc'Hadour, F., Gressin, R., Jacob, M., Keddari, E., Monteil, M, Caillot, P., Jalbert, P. and Scotto, J. (1991) "Non-Hodgkin's lymphomas with t(11;14)(q13:q32): a subset of mantle zone/intermediate lymphocytic lymphoma?", Br. J. Haematol. 77, 346-353.
  • Vanderberghe, E., DeWolf Peeters, C., Wlodarska, I., Stul, M., Louwagie, A., Verhoef, G., Thomas, J., Criel, A., Cassiman, J. and Mecucci, C. (1992) "Chromosome 11q rearrangements in B non-Hodgkin's lymphoma", Br. J. Haematol. 81, 212-217.
  • Weisenburger, D., Linder, J., Daley, H. and Armitage, J. (1987) "Intermediate lymphocytic lymphoma: an immunohistologic study with comparison to other lymphocytic lymphomas", Hum. Pathol. 18, 781-790.
  • Sausville, E., Johnson, J., Alley, M., Zaharevitz, D. and Senderowicz, A. (2000) "Inhibition of CDKs as a therapeutic modality", Ann. NY Acad. Sci. 910, 207-222.
  • Senderowicz, A. and Sausville, E. (2000) "Preclinical and clinical development of cyclin-dependent kinase modulators", J. Natl Lancer Inst. 92, 376-387.
  • Carlson, B., Dubay, M., Sausville, E., Brizuela, L. and Worland, P. (1996) "Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK)2 and CDK4 in human breast carcinoma cells", Cancer Res. 56, 2973-2978.
  • Carlson, B., Lahusen, T., Singh, S., Loaiza-Perez, A., Worland, P., Pestell, R., Albanese, C., Sausville, E. and Senderowicz, A. (1999) "Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol", Cancer Res. 59, 4634-4641.
  • Kaur, G., Stetler-Stevenson, M., Sehers, S., Worland, P., Sedlacek, H., Myers, C. Czech, J., Naik, R. and Sausville, K. (1992) "Growth inhibition with reversible cell cycle arrest carcinoma cells by flavone", J. Null. Cancer Inst. 84, 1736-1740.
  • Parker, B., Kaur, G., Nieves-Neira, W., Taimi, M., Kohlhagen, G., Shimizu, T., Losiewicz, M., Pommier, Y., Sausville, E. and Senderowicz, A. (1998) "Early induction of apoptasis in hematopoietic cell lines after exposure to flavopiridol", Blind 91, 458-465.
  • Senderowicz, A., Headlee, D., Stinson, S., Lush, R., Kalil, N., Villalba, L., Hill, K., Steinberg, S., Figg, W., Tompkins, A., Aibuck, S.G. and Sausville, E.A. (1998) "Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms", J. Clin. Oncol. 16, 2986-2999.
  • Schwartz, G., Ilson, D., Saltz, U. O'Reilly, E., Tong, W., Maslak, P. Werner, J., Perkins, P., Stoltz, M. and Kelsen, D. (2001) "Phase II study of the cyclin-dependent kinase inhibitor flavopiridol administered to patients with advanced gastric carcinoma", J. Clin. Oncol. 19, 1985-1992.
  • Shapiro, G., Supko, J., Patterson, A., Lynch, C., Lucca, J., Zacarola, P., Muzikansky, A., Wright, J., Lynch, T. and Rollins, B (2001) "A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer", Clin. Cancer Res. 7, 1590-1599.
  • Stadler, W., Vogelzang, N., Amato, R., Sosman, J., Taber, D., Liebowitz, D. and Yokes, E. (2000) "Flavopiridol, a novel cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non small cell lung cancer", J. Clin. Oncol 18, 371-375.
  • Innocenti, F., Stadler, W., Iyer, L., Rameriz, J., Vokes, E. and Ratain, M. (2000) "Havopiridol metabolism in cancer patients is associated with the occurrence of diarrhea", Clin. Cancer Res. 6, 3400-3405.
  • Shinn, C., Larsen, D., Suarez, J., Buj, V., Petric, R., Pearson., M. Flinn, I., Levasseur, L., Greaver, M. and Byrd, J. (2000) "Flavopiridol sensitivity of chronic lymphocytic leukemia (CLL) cells in vitro varies based upon species drug protein binding", Blood 96, 294b.
  • Bible, K. and Kaufmann, S. (1997) "Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: the importance of sequence of administration", Cancer Res 57, 3375-3380.
  • Motwani, M., Delohery, T. and Schwartz, G. (1999) "Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-Created human gastric and breast cancer cells", Clin. Cancer Res. 5, 1876-1883.
  • Bunch, R. and Eastman, A. (1997) "7-Hydroxystauroosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S-phase arrest in Chinese hamster ovary cells", Cell Growth Differ. 8, 779-788.
  • Yu, L., Ortandi, L., Wang, P., Orr, M., Senderowicz, A., Sausville, E., Silvestrini, R., Watanabe, N., Piwnica-Worms, H. and O'Connor, P. (1998) "UCN-01 abrogates G2 arrest through a cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the cdc25c phosphatase", J. Biol. Chem. 273, 33455-33464.
  • Monks, A., Harris, E., Vaigro-Wolff, A., Hose, C., Connelly, J. and Sausville, C. (2000) "UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines", lnvest. New Drugs 18, 95-107.
  • Bunch, R. and Eastman, A. (1996) "Enhancement ot cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (LCN-01), a new 02 checkpoint inhibitor", Clin. Cancer Res. 2, 791-797.
  • Tsuhida, E. and Urano, M. (1997) "The effect of UCN-01(7-hydroxystaurosporine). a potent inhibitor of protein kinase C. on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma", Int. J. Radiat. Oncol. Biol. Phys. 39, 1153-1161.
  • Sausville, E., Arbuck, S., Messman, R., Headlee, D., Bauer, K., Lush, R., Murgo, A., Figg, W., Lahusen, T., Jaken, S., et al. (2001) "Phase 1 trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms", J Clin Oncol. 19, 2319-2333.

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