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Research Article

Cotylenin A--A Plant Growth Regulator as a Differentiation-inducing Agent Against Myeloid Leukemia

Pages 1169-1178 | Published online: 01 Jul 2009

  • Ichikawa, Y. (1969) "Differentiation of a cell line of myeloid leukemia". J Cell Physiol. 74, 223-234.
  • Mintz. B. and Illmensee. K. (1975) "Normal genetically mosaic mice produced from malignant teratocarcinoma cells". Proc. Natl Acad. Sci. USA 72, 3585-3589.
  • Gootwine. E., Webb. G. and Sachs. L. (1982) "Participation of myeloid leukemic cells injected into embryos in hematopoietic differentiation in adult mice". Nature 299, 63- 65.
  • Ichikawa. Y. (1970) "Further studies on the differentiation of a cell line of myeloid leukemia". J. Cell. Physiol 76, 175-184.
  • Hozumi. M. (1983) "Fundamentals of chemotherapy of myeloid leukemia by induction of leukemia cell differentiation". Adv. Cancer Res. 38, 121-169.
  • Honma, Y., Kasukabe. T. and Hozumi. M. (1978) "Relationship between leukemogenicity and in vivo inducibility of normal differentiation in mouse myeloid leukemia cells". J Natl Cancer Inst. 61, 837-841.
  • Honma, Y. Kasukabe. T., Okabe, J. and Hozumi. M. (1979) "Prolongation of survival time of mice inoculated with myeloid leukemia cells by inducers of normal differentiation", Cancer Res 39, 3167-3171.
  • Huan, M., Ye. Y. Chen. S., Chai. J., Lu. J., Lin. Z. Gu. L. and Wang, Z. (1988) "Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia". Blood 72, 567-572.
  • Castaigne. S., Chomienne. C., Daniel. M.T. Ballerini, P., Berger. R., Fenaux. P. and Degos. L. (1990) "All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results". Blood, 1704-1709.
  • Warrell, R.P., Frankel. S.R., Miller, W.H., Scheinberg. D.A., Itn. L.M., Hittleman, W.N., Vyas. R., Andreff. M., Tafuri. A., Jakubowsky. A., Gabrilove, J., Gordon. M.S. and Dmitrovsky. E. (1991) "Differentiation therapy of acute prornyelocytic leukemia with tretinoin (all-trans--retinoic acid)". N. Engl. J. Med. 324. 1385-1393.
  • Collins. S.J., Gallo. R.C. and Gallagher. R.E. (1977) "Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture", Nature 270, 347-349.
  • Pegoraro. L., Abrahm. J., Cooper. R.A., Levis. A., Lange. B., Meo. P. and Rovers, G. (1980.) "Differentiation of human leukemias in response to 12-O-tetradecanoylphorbol-13-acetate in vitro", Blood 55, 859-862.
  • Honma, Y. Fujita. Y. Kasukabe, T., Hozumi, M., Sampi. K., Sakurai, M., Tsushima. S. and Nomura, H. (1983) "Induction of differentiation of human acute non-lymphocytic leukemia cells in primary culture by inducers of differentiation of human myeloid leukemia cell line HL-60". Eur. J. Cancer Clin. Oncol. 19, 251-261.
  • Ohta, M., Saito, M., Suda, K., Sakamoto. S., Kitagawa. S., Miura, Y. and Takaku, F. (1983) "Differentiation of human leukemia cells and its usefulness for clinical diagnosis". Leuk. Res. 7, 363-374.
  • Okabe. J., Honma. Y. and Hozumi, M. (1977) "Inhibition of RNA and protein synthesis makes non-differentiating mouse myeloid leukemia cells sensitive to a factor(s) stimulating differentiation". Int. J. Cancer 20, 933-940.
  • Honma. Y. Honma. C. and Bloch. A (1986) "Mechanism of interaction between antineoplastic agents and natural differentiation factors in the induction of human leukemic cell maturation". Cancer Res. 46, 6311-6315.
  • Tomida, M., Yamamoto, Y and Hozumi. M. (1982) "Stimulation by interferon of induction of differentiation of human promyelocytic leukemia cells". Biochem. Biophys. Res. Commun. 104, 30-37.
  • Kamijo. R., Takeda. K., Nagumo, M. and Konno, K. (1990) "Effects of combinations of transforming growth factor-ßl and tumor necrosis factor on induction of differentiation of human myelogenous leukemic cell lines". J. Immunol. 144, 1311-1316.
  • Makishima. M., Kanatani, Y, Yamamoto-Yamaguchi. Y. and Honma. Y. (1996) "Enhancement of activity of 1a 25-dihydroxyvitamin D3 for growth inhibition and differentiation induction of human myelomonocytic leukemia cells by tretinoin tocoferil. an a-tocopherol ester of all-trans retinoic acid". Blood 87, 3384-3394.
  • Kanatani. Y. Makishima. M., Ishikawa, I., Ogasawara, Y. Kawahara, N., Motoyoshi, K., Nagata. K. and Honma. Y. (1998) "A novel uracil analog 6-chloro-5-(2-propenyl)uracil preferentially enhances growth inhibition and differentiation of myeloid leukemia cells induced by 1a. 25-dihydroxyvitamin D3". Exp Hematol. 26, 198-206.
  • Thaller, C. and Eichele, G (1987) "Identification and spatial distribution of retinoids in the developing chick limb bud". Nature 327, 625-628.
  • Marshall, H., Morrison, A., Studer. M., Popperl. H. and Krumlauf. R. (1996) "Retinoids and Hox genes", FASAB J 10, 969-978.
  • Honma. Y, Takenaga. K., Kasukabe. T. and Hozumi. M. (1980) "Induction of differentiation of cultured human promyelocytic leukemia cells by retinoids". Biochem. Biophys. Res. Commun. 95, 507-512.
  • Breitman, T., Selonick, S.E. and Collins. S.J. (1980) "Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid", Proc. Natl Acad. Sci. USA 77. 2936 -2940.
  • Eto. Y. Tsuji, T. Takezawa. M., Takano, S., Yokogawa. Y. and Shibai. H. (1987) "Purification and characterization of erythroid differentiation factor (EDF) isolated from human leukemia cell line THP-I", Biochem. Biophys. Res. Commun. 142, 1095-1103.
  • Asashima. M., Nakano. H., Uchiyama, IL. Sugino. H., Nakamura. T., Eto. Y. Ejima, D., Nishimaisu, S., Ueno. N. and Kinoshita. K. (1991) "Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis", Proc. Natl Acad. Sci. USA 88, 6511- 6514.
  • Asahi. K., Sakurai. A., Takahashi, N., Kubohara. Y. Okamoto. K. and Tanaka, Y. (1995) "DIF. morphogen of Dictyostelium dixoideum, induces the erythroid differentiation in murine and human leukemia cells", Biochem. Biophys. Res. Commun. 208. 1036-1039.
  • Oka. H., Asahi, K., Morishima. H., Sanada. M., Shiratori. K. Iimura, Y, Sakurai, T, Uzawa, J., Iwadare. S. and Takahashi. N. (1985) "Differanisole A, a new differentiation inducing substance". J. Antibior. 38, 1100-1102.
  • Kubohara. Y., Okamoto. K., Tanaka. Y., Asahi. K., Sakurai. A. and Takahashi. N. (1993) "Differanisole A. an inducer of the differentiation of Friend leukemic cells, induces, stalk cell differentiation in Dictvostrelium discoideum". FEBS Lett 322, 73-75.
  • Sassa. T. (1971) "Cotylenins. leaf growth substances produced by a fungus". Agric. Biol. Chem. 35, 1415-1418.
  • Siissa. T and Togashi. M. (1973) "Isolation and structure of cotylenin E". Agric. Biol. Chem. 37, 1505-1506.
  • Sassa. T., Togashi. M. and Kilaguchi. T. (1975) "The structures of cotylenins A. B. C. D and E". Agric Biol. Chem. 39, 1735- 1744.
  • Bottalico. A., Granity. A. and Lerario. P. (1978) "Further investigation on the biological activity of some fusicoccins and cotylenins". Phytopathol. Mediterr: 17, 127-134.
  • Ballio. A., DeMichelis. M.I., Lado. P. and Randazzo. G. (1981) "Fusicoccin structure-activity relationships: stimulation of growth by cell enlargement and promotion of seed germination". Physiol. Plantanim 52, 471-475.
  • Asahi. K., Honma, Y. Hazeki. K., Sassa. T., Kubohara. Y., Sakurai. A. and Takahashi. N. (1997) "Cotyienin, A. a plant-growth regulator, induces the differentiation in marine and human myeloid leukemia cells". Biochem Biophvs. Res. Commun. 238, 718-763.
  • Yarnamoto-Yamaguchi. Y., Yamada. K., lshii, Y., Asahi. K., Tomoyasu. S. and Honma, Y. (2001) "Induction of the monocytic differentiation of myeloid leukaemia cells by colylenin A. a plant growth regulator". Br. J. Haematol. 112, 697-705.
  • Yen. A., Roberson. M.S., Varvayanis, S. and Lee. A.T. (1998) "Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60cell differentiation and growth arrest". Cancer Res. 58, 3163-3172.
  • Bertagnolo. V. Neri. L.M., Marchisio. M., Mischiati, C. and Capitani. S. (1999) "Phosphoinositide 3-kinase activity is essential for all-trans retinoic acid-induced granulocytic differentiation of HL-60 cells". Cancer Res. 59, 542-546.
  • Tonetti. D.A., Henning Chubb. C., Yamanishi. D.T. and Huberman. K. (1994) "Protein kinase C-ß is required for macrophage differentiation of human HL-60 leukemia cells''. J. Biol. Chem. 269, 23230-23235.
  • Martell, R.E., Simpson, R.U. and Hsu, T. (1981 "Effects of protein kinase inhibitors 1(5-isoquinolinesulfonyl)-2-methylpiperazinedihydrochloride (H-7) and N-[2-guanidinoethyl]-5-isoquinolinesulfonamidehydrochloride (HA1004) on calcitriol-induced differentiation of HL-60 cells". Bioche.m Pharmacol 37, 635-640.
  • Simpson. R.L'., Hsu. T., Wendt. M.D, and Taylor. J.M. (1989) "25-Dihydroxyvitamin D3 regulation of c-myc protooncogene transcription. Possible involvement of protein kinase C". J. Biol Client. 264, 19710-19715.
  • Koeffler. H.P. (1983) "Induction of differentiation of human acute myelogenous leukeumia cells therapeutic implications", Blood 62, 709-721.
  • Yamuda, K., Honma. Y., Asahi. K., Sassa. T., Hino. K. and Tomoyasu, S. (2001) "Differentiation of human acute myeloid leukaemia cells in primary culture in response to colylenin A. a plant growth regulator". Br. J. Haematol. 114, 814-821.
  • Levin. A.A., Sturzenhecker. I.J., Kazmer. S., Boiakowski. T., Huselton. C., Allenby. G., Speck. J., Kratzeisen. C., Rosenberger. M., Lovey, A. and Grippo. J.F. (1992) "9-cis Retinoic acid stereoisonier binds and activates the nuclear receptor RXRa", Nature 355, 359-361.
  • Han. Z.T., Zhu. X.X. Yang, R.Y., Sun. J.7., Tian. G.F., Liu. X.J., Cao. G.S., Newmark. H.L. Conney. A.H. and Chang. R.L. (1998) "Effect of intravenous infusion of 12-O-tetradecanoylphorbol13-acetale (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity". Proc. Nutl Acad. Sci. USA 95, 5357-5361.
  • The leukemia Study Group of the Ministry of Health and WelfareOhno. R., Naoe. T., Hirano. M., Kobayashi. M., Hirat. H., Tubaki. K. and Oh. H. (1993) "Treatment of myelodysplastic syndromes with all-trans retinoic acid". Blood 81, 1152-1154.
  • Charrad. R.-S., Li. Y., Delpech. B., Balitrand. N., Clay. D., Jasmin. C'., Chomienne. D, and Smadja-Joffe. E (1999) "Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia". Nat. Med. 5, 669-676.
  • Inai, K., Tsuiani. H., Yamauchi. T., Fukushima. T., Iwasaki. H., Imamura. S., Wano. Y. Nemoto. Y., Naiki. H. and Ueda, T. (2000) "Differentiation induction in non-lymphocytic leukemia cells upon treatment with mycophenolate inofetil". Leuk. Res. 24, 761-768.
  • Sassa. T., Tojyo. T. and Munakata. K. (1970) "Isolation of a new plant growth substance with cytokinin-like activity". Nature 227. 379.
  • Shaw. G. (1994) "Chemistry of adenine cytokinins". In: Mok. D.W.S. and Mok. M.C., eds. Cytokinins Chemistry. Activity and Function (CRC Press, Boca Raton, FL), pp 15-34.
  • Tanimoto. S. and Harada. H (1982) "Effect of cytokinin and anticytokininon the initial stage of adventitious bud differentiation in the epidermis of Torenia stem segments". Plant Cell Physiol. 23, 1371-1376.
  • Fajkus. J., Fulneckova. J., Hulanova. M. Berkova. K., Riha. K. and Malyasek. R. (1998) "Plant cells express telomerase activity upon transfer to callus culture, without extensively changing telomere lengths". Mol. Gen. Genet. 260, 470-474.
  • Coliins. S.J., Ruscetti. F.W., Gallagher, R.E. and Gallo. R.C. (1978) "Terminal differentiation of human promyelucytic leukemia cells induced by dimethyl sulfoxide and other polar compounds", Proc. Natl Acad. Sci. USA 75, 2458-2462.
  • Collins. S.J., Bodner. A., Ting. R. and Gallo. R.C. (1980) "Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL-60) by compounds which induce differentiation of murinc leukemia cells". Int. J. Cancel 25, 213-218.
  • Haces. A., Breitman. T.R. and Driscoll. J.S. (1987) "Chemical differentiating agents. Differentiation of HL-60 cells by hexamethylenebis(acetamide) analogues". J. Med. Chem. 30. 405-409.
  • Hodner. A.J., Ting, R.C. and Gallo. R.C. (1981) "Induction of differentiation of human promyelocytic leukemia cells (HL-60) by nucleosides and methotrexate". J. Nail Corner Inst. 67. 1025- 1030.
  • Prytz. S., Loennechen. T., Johansson. A., Larsen. L.B., Slordal. L. and Aarbakke. J. (1989) "Effects of 3-deazaadenosine, an inducer of HL-60 cell differentiation, on human blood cells in vitro". Pediatr. Hematol Oncol. 6, 173 -179.
  • Munroe, D.M., Sugiura. M., Ciriffin. J. and Kufe. D. (1984) "Effect of ara-A on differentiation and proliferation of HL-60 cells". Leuk. Res. 8, 335-361.
  • Niitsu. N., Umeda. M. and Honma. Y (1997) "Induction of differentiation of human leukemia cells by 2'-deoxycoformycin in combination with 2'-deoxyadenosine". Biochem. Biophys, Res. Commun. 238, 100-106.
  • Niitsu. N., Umeda, M. and Honma. Y. (2000) "Myeloid and monocytoid leukemia cells have different sensitivity to differentiation-inducing activity of deoxyadenosine analogs", Leuk. Res 24, 1-9.
  • Niitsu. N., Yamamoto-Yamaguchi. Y., Kanatani. Y., Shuto. S., Matsuda. A., Umeda. M. and Honma. Y. (1997) "Neplanocin A. a potent inhibitor of 5-adenosythomocysleim: hydrolase. potentiates granulocytic differentiation of acute promyelocytic leukemia cells induced by all-trans retinoic acid", Exp. Hematol. 25, 1296- 1303.
  • Honma. Y., Ikuta. T., Kasukabe. T., Hozumi. M., Itob, T. und Ogura. H. (1988) "Inhibition of proliferation and induction of differentiation of human myeloid leukemia cells by novel nucleoside analogs". Anticancer Res. 8, 695-699.
  • Makishima. M., Honma. Y. Hozumi. M. Sampi. K., Hattori. M., Ishikawa. I, Ogura. H. Kawahara. N., Kanaiwa. T. and Motoyoshi. K. (1991) "Inducuon of differentiation of human myeloid leukemia HL-60 cells by novel pyrimidine nucleoside analogs". Biochem. Biophys. Acta 1094, 1-7.
  • Makishima. M. Honma. Y. Hozumi, M., Sampi. K., Hailori. M., Ishikawa. I., Ogura, H. and Motoyoshi. K. (1992) "Effects of novel uracil analogs on proliferation and differentiation of human myeloid leukemia cells", Exp Hematol. 20, 879-885.
  • Honma. Y, Ishii. Y. Kasukabe. T., Okabe-Kado. J., YamamotoYamaguchi, Y. Kakegawa. T. and Awaya. A. (2001) "Induction of differentiation of human myeloid leukemia cells by novel synthetic neurotrophic pyrimidine derivatives". Exp. Hematol. 29, 194-201.
  • Goldstein. B.M., Leary. J.F., Farley. B.A. Marquez. V.E. Levy. P.C. and Rowley. P.T. (1991) "Induction of HL60 cell differentiation by tiazofurin and its analogues: characterization and efficacy". Blood 78, 593-598.
  • Sokoloski. J., Beardley, G.P. and Sartorelli, A.C. (1989) "Induction of HL-60 leukemia cell differentiation by the novel antifolate 5. 10-dideazatetrahydrofolic acid". Cancer Res. 49, 4824-4828.
  • Bernabei. P.A., Mini. E., Gattei. V., Agostino. F.C., Bezzini. R., Saccardi. R., Santini. V., Coronnello. M., Mazrei, T. and Rossi Herrini. P. (1989) "Induction of differentiation of HL-60 cells along the monocytic pathway by 5-methyltetrahydrofolate". J. Chemotlter. 1, 359-364.
  • Balzarini. J., Verstuyf, A., Hatse. S. Goebels. J., Sobis. H., Vandeputte. M. and DeClercq. E. (1995) "The human immunodeficiency virus (HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines". Int. J. Cancer 61, 130-137.
  • Tortora. G., Yokozaki. H., Pepe. S., Clair. T. and Cho-Chung. Y.S. (1991) "Differentiation of HL-60 leukemia by type 1 regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase". Proc. Natl Acad. Sci. USA 88, 2011 -2015.
  • Honma, Y., Kasukabe. T., Hozumi. M., Tsushima. S. and Nomura. H. (1981) "Induction of differentiation of cultured human and mouse mycloid leukemia cells by alkyl-lysophospholipids". Cancer Res. 41, 3211-3216.
  • Honma, Y., Kasukabe. T., Hozumi, M., Akimoto, H. and Numura. H. (1991) "Induction of differentiation of human myeloid leukemia HL-60 cells by novel ether non-phosphorus lipids", Lipids 26, 1445-1449.
  • Honma, Y., Kasukabe, T. Okabe-Kado, J., Hozumi. M., Tsushima. S. and Nomura, H. (1983) "Antileukemic effect of alkylphospholipids I. Inhibition of proliferation and induction of differentiation of cultured myetoid leukemia cells by alkylethyleneglycophospholipids". Cancer Chemother. Pharmacol. 11, 73-76.
  • Kasukabe. T. Honma. Y, Hozumi. M. and Nomura. H. (1990) "Inhibition of proliferation and induction of differentiation of human and mouse mycloid leukemia cells by new ethyleneglycoltype nonphosphorus alkyl ether lipids". Jpn. J. Cancer Res. 81, 807-812.
  • Nojiri. H., Takaku, F. Terui. Y. Miura, Y. and Saito. M. (1986) "Ganglioside GM3: an acidic membrane component that increases during macrophage-Iike cell differentiation can induce monocytic differentiation of human mycloid and monocytoid leukemic cell lines HL-60 and U937". Proc. Natl Acad. Sci. USA 83, 782-786.
  • Nojiri, H., Kitagawa, S., Nakamura. M., Kirtto. K., Enomoto. Y. and Saito. M. (1988) "Neolacto-series gangliosides induce granulocytic differentiation of human promyelocytic leukemia cell line HL-60". J. Biol. Chem. 263, 7443-7446.
  • Isoda. H., Shinmoto. H., Kilamoto. D., Matsumura. M. and Nakahara. T. (1997) "Differentiation of human promyelocytic leukemia cell line HLoO by microbial extracellular glycolipids". Lipids 32, 263 -271.
  • Makishima. M., Honma. Y, Hozumi. M., Sampi. K., Hattori. M., Umezawa. K. and Motoyoshi, K. (1991) "Effects of inhibitors of tyrosine kinase activity and/or phosphatidylinositol turnover on differentiation of some human myelomonocytic leukemia cells". Leuk. Res. 15, 701-708.
  • Makishima. M., Honma. Y. Hozumi. M., Sampi, K., Hattori. M. and Motoyoshi. K. (1991) "Induction of differentiation of human leukemia cells by inhibitors of myosin light chain kinase". FEBS Lett. 287, 175-177.
  • Yokoyama. A., Okabe-Kado. J., Uehara. Y. Oki, T., Tomoyasu. S., Tsuruoka. N. and Honma, Y. (1996) "Angelmicin B. a new inhibitor of oncogenic signal transduction. inhibits growth and induces myelomonocytic differentiation of human myeloid leukemia HL-60 cells". Leuk. Res. 20, 491-497.
  • Yamamoto-Yamaguchi, Y, Okabe-Kado, J., Kasukabe. T. and Honma. Y (2001) "Induction of differentiation of human mycloid leukemia cells by immunosuppressant macrolides (rapamycin and FK506) and calcium/calmodulin-dependent kinase inhibitors". Exp. Hematol. 29, 582-588.
  • Ishii. Y. Sakai. S. and Honma, Y. (2001) "Pyridinyl imidazole inhibitor SB2O3580 activates p44/42 mitogen-activated protein kinase and induces the differentiation of human myeloid leukemia cells", Leuk. Res. 25, 813-820.
  • Fischkoff. S.A. and Condon. M.E. (1985) "Switch in differentiation response to maturation inducers of human promyelocytic leukemia cells by prior exposure to alkaline conditions". Cancer Res. 45, 2065-2069.
  • Samid, D., Shack. S. and Sberman. L.T. (1992)"Phenylacetate: A. novel uontoxic inducer of tumor cell differentiation", Cancer Res. 52, 1988-1992.
  • Jenis. D.M., Keyes. S.R. and Sartorelli, A.C. (1987) "Induction of the differentiation of HL-60 promyelocytic leukemia cells by palmitoleic and myristoleic acids". Leuk. Res. 10, 935-939.
  • Nakayasu, M., Terada. M., Tamura. G. and Sugimura. T. (1980) "Induction of differentiation of human and murine myeloid leukemia cells in culture by tunicamycin", Proc:. Natl Acad. Sci. USA 77, 409-413.
  • Rovera, G., O'Brien. T.G. and Diamond. L. (1979) "Induction of differentiation in human promyelocytic leukemia cells by tumor promoters". Science 204, 868-870.
  • Huberman. E. and Callahan. M.E. (1979) "Induction of terminal differentiation in human promyelucytic leukemia cells by tumorpromoting agents". Proc. Natl Acad. Sci. USA 76, 1293-1297.
  • Stone. R.M., Sariban. E., Pettit, G.R. and Kufe. D.W. (1988) "Bryostatin-1 activates protein kinase C and induces monocytic differentiation of HL-60) cells", Blood 72, 208-213.
  • Kagechika. H., Kawachi. E., Hashimoto. Y. and Shudo. K. (1984) "New type inducers of differentiation of human HL-60 promyelocytic leukemia cells. Terephthalic anilides". Chem. Pharm. Bull. 32, 4209-4212.
  • Gross. M.D., Bishop. T.D., Belcher. J.D. and Jacobs. Jr. D.R. (1997) "Induction of HL-60 cell differentiation by carotenoids", Nutr: Cancer 27, 169-173.
  • Miyaura, C., Abe. E., Kuribayashi. T., Tanaka. H., Konno. K., Nishii. Y and Suda, T. (1981) "la.25-Dihydroxyvitamin D, induces differentiation of human myeloid leukemia cells". Biochem. Biophys. Res. Commun. 102, 937-943.
  • Asou. H., Koide, M., Elstner. E., Cambell. M., Le. J., Uskokovic. M.R., Kamada, N. and Koeffler. HP. (1998) "19-nor Vitamin-D analogs: a new class of potent inhibitors of proliferation and inducers of differentiation of human myeloid leukemia cell lines". Blood 92, 2441-2449.
  • Sato. K. Okamoto. Y., Ouchi. Y., Kaneki. M., Nakamura. T., Ikekawa, N. and Orimo, H. (1991) "Biological activity of 1a.25-dihydroxyvitamin D-derivatives-24-epi-1a.25-dihydroxyvitamin D-2 and 1a.25-dihydroxyvitamin D-7". Biochem. Biophys. Acta 1091, 188-192.
  • Zhang. L., Nakaya, K. Yoshida. T. and Kuroiwa. Y. (1992) "Induction by bufalin of differentiation of human leukemia cells HL6O, U937, and ML1 toward macrophage/monocyte-like cells and iLs potent synergistic effect on the differentiation of human leukemia cells in combination with other inducers". Cancer Res. 52,4634-4641.
  • Hirase. N., Yanase. T., Mu. Y., Muta. K., Urnemura. T., Takayanagi. R. and Nawata. H. (1999) "Thiazolidinedione induces apoptosis and monocytic differentiation in the promyelocytic leukemia cell line HL60". Oncology 57, 17-26.
  • Bronfman. M., Ponce. C., Rojas. S., Roth. A., Loyola. G., Vollrath. V. and Chianale. J. (1998) "Enhanced differentiation of HL-60 leukemia cells to macrophages induced by ciprofibrate". Eur. J. Cell Biol. 77, 214-219.
  • Tontonoz, P., Nagy. L., Alvarez., J.G A., Thomazy, V.A and Evans. R.M. (1998) "PPAR? promotes monocyte/macrophage differentiation and uptake of oxidized LDL". Cell 93, 241-252.
  • Takei. M., Takeda, K and Konno. K. (1984) "The role of interferon-? in induction of differentiation of human myeloid leukemia cell lines. ML-1 and HL-60". Biochem. Biophys. Res. Commun. 124, 100-105.
  • Kamijo. R., Takeda, K., Nagumo, M., Konno. K. Hasegawa. A., Inaka. K. and Ikehara. M. (1989) "Induction of differentiation of human monoblastic and myeloblastic leukemia cell lines by TNF muteins", Biochem. Biophys. Res Commun. 160, 820-827.
  • Hutt-Taylor. S.R., Hamish. D., Richardson. M., Ishizaka. T. and Denburg. A. (1988) "Sodium butyrate and a T lymphocyte cell line-derived differentiation factor induce hasophilic differentiation of the human promyelocytic leukemia cell line HL-60", Blood 71. 209-215.
  • Tsuda. T, Wong. D., Dolovich. J., Bienenstock. J., Marshall. J and Denburg. J.A. (1991) "Synergistic effects of nerve growth factor and granulocyte-macrophage colony-stimulating factor on human basophilic cell differentiation". Blood 77, 971-979
  • Denburg. J., Silver. J.E. and Abrams. J.S. (1991) "Interleukin-5 is a human basophilopoietin: induction of hi stamme content and basophilic differentiation of HL-60 cells and of peripheral blood basophil-eosinophil progenitors". Blood 77, 1462-1468.
  • Honma. Y., Fujita. Y, Okabe-Kado. J., Kasukabe, T. and Hozumi, M. (1980) "Induction of differentiation of human promyelocytic leukemia cells (HL-60) by arginase". Cancer Lett. 10, 287-292.
  • Maurer, H.R., Hozumi, M., Honma. Y. and Okabe-Kado, J. (1988) "Bromelain induces the differentiation of leukemic cells in vitro: an explanation for its cytostalic effect?". Planta Med. 5, 377-382.
  • Xu, W., Seiter. K., Feldman, E., Ahmed, T. and Chiao. J.W. (1996) "The differentiation and maturation mediator for human myeloid leukemia cells shares homology with neuroleukin or phosphoglucose isomerase", Blood 87, 4502-4506.
  • Kang, S.N., Lee. M.H., Kim. K.-M., Cho. D. and Kim. T.S. (2001) "Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by silibinin: involvement of protein kinase C', Biochem. Pharm. 61, 1487-1495.
  • Park. E.J., Park. H.R., Lee, J.S. and Kim. J. (1998) "Licochalcone A: an inducer of cell differentiation and cytotoxic agent from pogostcmon cablin". Planta Med. 64, 464- 466.
  • Kimoto, T., Hino. K., Koya-Miyata, S., Yamamoto. Y, Takeuchi. M., Nishizaki, Y. Micallef. M.J., Ushio. S., Iwaki, K., Ikeda. M. and Kurimoto, M. (2001) "Cell differentiation and apoptosis of monocytic and promyelocytic leukemia cells (U-937 and HL-60) by tryptanthrin an active ingredient of Polygonum tinctorium Lour". Pathol. Int. 51, 315-325.
  • Budhiraja, S.S., Cullum. M.E., Sioutis, S.S., Evangelista, L. and Habanova, S.T. (1999) "Biological activity of melaleuca alternifola (Tea Tree) oil component, tlerpinen-4-ol, in human myelocytic cell line HL-60", J. Manipulative Physiol. Ther. 22, 447-453.
  • Jing, Y. Nakaya. K. and Han. R. (1993) "Differentiation of promyelocytic leukemia cells HL-60 induced by daidzein in vitro and in vivo". Anticancer Res. 13, 1049-1054.
  • Wang. Z., Zhou. J., Ju. Y., Zhang. H., Liu, M. and Li, X. (2001) "Effects of two saponuis extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells". Biol. Pharm. BuIl. 24, 159-162.
  • Jing. Y., Nakajo, S., Xia, L., Nakaya. K., Fang. Q., Waxman. S. and Han. R. (1999) "Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines", Leuk. Res. 23, 43-50.
  • Sasaki. R., Furukawa, Y. Okada. K., Nakamura, M., Yamane. Y. Miura, Y. and Eguchi. M. (1997) "Chloroquine induces basophilic differentiation of HL-60 cells". Leukemia 11(Suppl. 3). 478-479.
  • Bae. K.A. and Choung. S. Y. (1996) "Differentiation inducing effects of 2-chloro-3-amino-1.4-naphthoquinone on human leukemia HL-60", Biol. Pharm. Bull. 19, 824-827.
  • Mendelsohn. N, Michl, J., Gilbert. H.S., Acs, G. and Christiman. JK (1980) "L-Ethionine as an inducer of differentiation in human promyelocytic leukemia cells", Cancer Res. 40, 3206-3210.
  • Barrera. G., DiMauro, C., Muraca, R., Ferroro. D., Cavalli. G., Fazio. V.M., Paradisi, I., and Dianzani. M.U. (1991) "Induction of differentiation inhuman HL-60 cells by 4-hydroxynonenal. a product of lipid peroxidation", Exp. Cell Res, 197, 148-152.
  • Kohroki, J., Muto. N., Tanaka. T., Itoh. N., Inada, A. and Tanaka. K. (1998) "Induction of differentiation and apoptosis by dithizone in human myeloid leukemia cell lines", Leuk. Res. 22, 405-412.
  • Li. Y.Y., Liang. N.C., Jiang. I.,. Wu, T. and Lin, X.Y. (2000) "Dimethylamiloride-induced differentiation of HL-60 cells". Acta Pharmacol Sin. 21, 445-449.
  • Calderon. T.M., Schneiderman, N., Michl. J. and Christman. J.K. (1989) "5.5'-Diniethyloxazolidine-2,4-dione is a strong inducer of differentiation of human promyelocytic leukemia (HL-60) cells". Cell Differ. Dev. 26, 181-190.
  • Pae. H.O.,Seo. W.G., Kim, N.Y. Oh.G.S., Kim. G.E., Kim, Y.H. Kwak. H.J., Yun. Y.G., Jun, CD. and Chung. HT. (2001) "Induction of granulocytic differentiation in acute promyelocytic leukemia cells (HL-60) by water-soluble chitosan oligomer". Leuk Res. 25, 339-346.

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