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Leukemia & Lymphoma Volume 44, 2003 - Issue 5
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Research Article

Recent Advances in the Treatment of Infant Acute Myeloid Leukemia

Eiichi Ishii Department of Pediatrics, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan
,
Hajime Kawasaki Department of Pediatrics, Mie University, Tsu, Japan
,
Keiichi Isoyama Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Japan
,
Minenori Eguchi-Ishimae Leukaemia Research Fund Centre, London, UK
&
Mariko Eguchi Leukaemia Research Fund Centre, London, UK
Pages 741-748 | Published online: 01 Jul 2009

  • Pui, C-H., Kane, J.R. and Crist, W.M. (1995) "Biology and treatment of infant leukemias", Leukemia 9, 762-769.
  • Greaves, MF. (1996) "Infant leukaemia biology, aetiology and treatment", Leukemia 10, 372-377.
  • lshii, E., Okamura. J., Tsuchida, M., Kobayashi, M., Akiyama. Y., Nakahata, T. Kojimsu S., Hanada, R., Horibe. K., Sato, T., Komada. Y., Kimura. K., Sakaguchi. C., Hosoya, R., Oda, M., Tsunematsu, Y., Kawa, K., Konishi. S., Tsukimoto. I., Matsuyama, K. and Ueda, K. (1991) "Infant leukemia in Japan: clinical and biological analysis of 48 cases", Med. Pediatr. Oncol. 19, 28-32.
  • Kawasaki, H., hoyama, K., Eguchi, M., Hibi. S., Kinukawa, N., Kosaka, Y. Oda, T., Oda. M., Nishimura, S., Imaizumi M., Okamura, T., Hongo, T., Okuwa, H., Mizutani. S, Hayashi, Y, Tsukimoto. I., Kamada, N. and lshii. E. (2001) "A superior outcome of infant acute myeloid leukemia with intensive chemotherapy: results of the Japan Infant Leukemia Study Group", Blood 98. 3589-3594.
  • Woods, W.G., Neudorf, S., Gold, S., Sanders, J., Buckley, J.D., Barnard, D.R., Dusenbery, K., DeSwarte, J., Arthur, D.C., Lange. BJ. and Kobrinsky, N.L. (2001) "A comparison of allogeneic bone marrow transplantation, autologous bone marrow transplantation, and aggressive chemotherapy in children with acute myeloid leukemia in remission: a report from the Children's Cancer Group", Blond 97, 56-62.
  • Loeb, D.M. and Arceci, R.J. (2002) "Treatment and outcome of infants with acute myeloid leukemia", Blood 99, 2626-2627.
  • lshii, E., Hibi, S., Mizutani, S., Kinukawa, N., Eguchi, H., Migita, M., Kawakami. K., Gushiken, T. Matusmoto, K., Inamitsu, T, Ikuno, Y, Nibu, K., Miyake. K., Horii, Y. Suenobu. S., Takeda, T., Nose, Y. and Miyazaki, S. (1997) "Epidemiological study of infant leukemia on Kyushu Island between 1990-1994 (abstract in English)", Jpn. J. Pediatr, Hematol. 11, 167-173.
  • Pui, C-H., Raimondi, S.C., Murphy, S.B., Ribeiro, R.C., Kalwinsky, O.K., Dahl, G.V., Crist, W.M. and Williams, D.L. (1987) "An analysis of leukemic cell chromosomal features in infants", Blood 69, 1289-1293.
  • Koller, U., Haas, O.A., Ludwig. W.-D., Bartman, C.R., Harbott, J., Panzer-Grumayer. R., Hansen-Hagge. T. Ritter. J., Creutzig. U., Knapp. W. and Gadner. H. (1989) "Phenotypic and genotypic heterogeneity in infant acute leukemia. II. Acute nonlymphoblastk leukemia", Leukemia 3, 708-714.
  • Nakamura, T., Alder, H., Gu. Y., Prasad, R., Canaani. O., Kamada. N., Gale, R.P., Lange. B., Crist, W.M., Nowell, P.C., Crocc. C.M. and Canaani, E. (1993) "Genes on chromosome 4. 9, and 19 involved in I Iq23 abnormalities in acute leukemia share sequence homology and/or common motif ', Proc. Nail Acad. Sci. USA 90. 4631-4635.
  • Rubnitz, J.E., Behm. F.G. and Downing. J.R. (1996) 11q23 rearrangements, in acute leukemia", Leukemia 10, 74-82.
  • Ford, A.M., Ridge. S.A., Cabrera. M.E., Mahrnoud. H., Steel. C.M., Chan. L.C. and Greaves. M. (1993) "In utero rearrangements in the trithorax-related oncogene in infant leukemias", Nature 363. 358-360.
  • Gale, K.B., Ford, A.M., Repp. R., Borkhardt, A., Keller. C. Eden, O.B., Moffo, M. and Greaves. M.F. (1997) "Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots", Proc. Nat! Acad. Sci. USA 94, 13950-13954.
  • Strissel Broeker, P.L., Gill Super, H., Thirman, M.J., Pomykala, H., Yonebayashi, Y., Tanabe. S., Zeteznik-Le, N. and Rowley, J.D. (1996) "Distribution of Ilq23 breakpoints within the MLL breakpoint cluster region in de nova acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffolf attachment regions and lopoisomerase II consensus binding sites", Blood 87, 1912-1922.
  • Cimino, G., Rapanotti. M.C., Biondi. A., EIia, L., Lo Coco. F., Price. C., Rossi, V., Rivolta, A., Canaani. E., Croce. C.M., Mandelli. F. and Greaves, M. (1997) "Infant acute leukemias show the same biased distribution of ALLl gene breaks as lopoisomerase II related secondary acute leukemia", Cancer Res. 57, 2879-2883.
  • Apian, P.D., Chervinsky, D.S., Stanulla, M. and Burhans, W.C. (1996) "Site-specific DNA cleavage within the MIJ. breakpoint cluster region induced by topoisomerase II inhibitors", Blood 87, 2649-2658.
  • Strick, R., Strissel, PL., Borgers, S., Smith, S.L. and Rowley, ;.D. (2000) "Dietary bioflavonoids induce cleavage in the MLl. gene and may contribute to infant leukemia", Proc. Natl Acad. Sci. USA 97, 4790-4795.
  • Ishii, E., Eguchi, M., Eguchi-Ishimac, M., Yoshida, N., Oda, M., Zaitsu, M., Fujita, I., Miyazalci, S., Hamasaki, Y. and Mizutani. S. (2002) 'Vn vim cleavage of the MLL gene by topoisomerase Il inhibitor (etoposide) in normal cord and peripheral blood mononuclear cells", Int. J. Hematol. 76, 74-79.
  • DiMartino, J.F. and Cleary, M.L. (1999) "MLL rearrangements in haematological malignancies: lessons from clinical and biological studies", Br. J. Haematol. 106, 614-626.
  • Alexander, P.E., Patheal. S.L., Biondi. A., Brandalise. S., Cabrera, M.-E., Chan. L.C., Chen, Z., Cimino, G., Cordoba. J-C, Gu, L.-J., Hussein, H., Ishii, E, Kamel, A.M., Ubra, 55., Magalhaes, I.Q., Mizutani, S., Petridou, E., Pombo. 0.M-. Yuen, P., Wiemels. J.L. and Greaves, MJ. (2001) 'Transplaccntal chemical exposure and risk of infant leukemia with MLL gene fusion", Cancer Res. 61. 2542-2546.
  • Felix, CA. (1998) "Secondary leukemias induced by topoisomerase-targeted drags", Biochim. Biophys. Acta 1400, 233-255.
  • Ishii, E. and Miyazaki, S. (1996) "Secondary leukemia in children. Incidence and clinical aspects", Int. J. Pediatr. Hematol J Oncol. 13, 467-481.
  • Hunger, S.P., McGavran, L., Meltesen. L., Parker, N.B., Kassenbrock, CK and Bitter, M.A. (1998) "Oncogenesis in utew: fetal death due to acute myclogenous leukaemia with an. WLL translocation", Br. J. Haematol. 103,539-542.
  • Ross, J.A., Potter. J.D. and Robinson. LL. (1994) "Infant leukemia, topoisomerasse n inhibitors, and the MLL gene", J. Natl Cancer lnst. 86, 1678-1680.
  • Greaves, M. (1999) "Molecular genetics, natural history and the demise of childhood leukaemia", Eur. J. Cancer 35, 1941 1953.
  • Corral, J., Lavenir, I., Impey, H., Warren. A.J., Forster, A., Larson, T.A., Bell, S., McKenzie, A.N., King, U. and Rabbits, T.H. (1996) "An M11-AF9 Fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes", Cell 85, 853-861.
  • Wiemels, J.L., Pagnamenta, A., Taylor. G.M., Eden, O.B., Alexander. F.E. and Greaves, M.F. (1999) "A lack of a functional NAD(P)H:Quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions", Cancer Res. 59, 4095-4099.
  • Gane, S., Taioli, E., Crosti. F., Sainati, L., Barisone, E., Luciani, M., Jaukovic, M. and Biondi, A.G. (2000) "Deletion of parental GST genes as a possible susceptibility factor in the etiology of infant leukemia", Leuk. Res 14, 971-974.
  • Ross, J.A. (2000) "Dietary flavonoids and the MLL gene: a pathway to infant leukemia?", Proc. Nail Acad. Sci. USA 97, 4411 -4413.
  • Ford, A.M., Bennett. C.A., Price, C.M., Bruin, M.C.A., Wering, E.R. and Greaves. M.F. (1998) "Fetal origin of the TEL-AMLI fusion gene", Proc. Natl Acad. Sci. USA 95, 4584-4588.
  • Ford, A.M., Pombo de Oliveira, M.S., McCarthy, K.P., McLean. J.M., Carrico, K., Vincent. R.E. and Greaves. M. (1997) "Monoclonal origin of concordant T-cell malignancy in identical twins", Blood 89, 281-285.
  • Pui, C-H., Kalwinsky. O.K., Schell, M.J., Mason, C.A., Mirro. J. Jr. and Dahl, G.V. (1988) "Acute nonlymphoblastic leukemia in infants: clinical presentation and outcome", J. Clin, Oncol. 6. 1008-1013.
  • Pui, C-R, Dahl. G.V., Kalwinsky. O.K., Look, A.T., Mirro. J., Dodge, R.K. and Simone, J.V. (1985) "Central nervous system leukemia in children with acute nonlyinphoblasuc leukemia", Blood 66. 1062-1067.
  • Ishii, E., Eguchi, M., Matsuzaki, A., Zaizen, Y., Yoshidomi. S., Kirnura, N., Takcshita, M., Tashiro, S., Kamada, N., Suita, S., Ueda, K. and Miyazaki. S. (1995) "Granulocytic sarcoma in infant with MLL rearrangement preceding acute monoblastic leukemia with t(10;l l)(pl I;q23)", Leukemia 9, 1970-1974.
  • Sorensen, P.H.B. Chen, C.-S., Smith, P.O., Arthur. D.C., Domer, P.M., Bernstein, I.D., Korsmeyer. S.J., Hammond. G.D. and Kersey. J.H. (1994) "Molecular rearrangements of the MLL gene are present in most cases of infant acute myetoid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes",.J Clin. Inveaig. 93,429-437'
  • Hilden, J.M., Frestedl, J.I., and Kersey, J.H. (1997) "Molecular analysis of infant acute leukemia", Leuk. Lymphoma 25, 191-199.
  • Cimino, G. Rapanotti. M.C., Elia. L., Biondi. A., Fizzotti. M., Testi, A.M., Tosti, S., Croce, C.M., Canaani, E., Mandelli, F. and l-o Coco, F. (1995) "AU.-I gene rearrangements in acute mycloid leukemia: association with M4-M5 French -American-British classification subtypes and young age", Cancer Res. 55. 1625-1628.
  • Bower. M., Parry. P., Carter, M., Lillington, D.M., Amess, J., Lister, TA., Evans, G. and Young, B.D. (1994) "Prevalence and clinical correlations of MLL gene rearrangements in AML-M4/5", Blood 84, 3776-3780.
  • Lion, T-. Haas. O.A., Hoarbott, J., Bannicr, E., Ribberbach. J., Jankovic, M., Fink, F.M., Stojimirovic, A., Herrmann, J., Riehm, HJ., Lampen, F., Ritter. J., Koch, H. and Gadner, H. (1992) "The rranslocation t(l ;22)(pl3;ql3) is a nondandom marker specifically associated with acute megakaryocytic leukemia in young children", Blood 79, 3325-3330.
  • Carroll, A., Civin, C., Schneider, N., Dahl, G., Pappo, A., Bowman, P., Emami, A., Gross, S., Alvarado, C., Phillips. C., Krischer. J., Crist, W., Head, D., Gresik, M., Ravmdranach. Y. and Weinstein, H. (1991 ) "The t (1 ;22)(p 13 ;q 13) is nonrandom and restricted to infants with acute megakaryocytic leukemia: á Pediatric Oncology Group Study", Blood 78, 748 752.
  • Thirman, MJ., Gill, HJ., Bumetl, R.C., Mbangkollo, D., McCabe. N.R., Kobayashi. H., Ziemin-van der Poel. S., Kaneko. Y. Morgan, R, Sandberg, A.A., Chaganti, R.S.K.,Larson, R.A., Lc Beau. M.M., Diaz, M.O. and Rowley, J.D. (1993) "Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias withI Iq23 chromosomal translocations",iV. Engt. J. Med. 329, 909-914.
  • Cimino, G., Lo Coco, K, Biondi, A., Elia, L., Luciano. A., Croce. C.M., Masera, G., Mandelli, F. and Canaani. E. (1993) "ALL-1 gene at chromosome 1 Iq23 is consistently altered in acute leukemia of early infancy", Blood 82, 544-546.
  • Caligiuri, M.A., Schichman, S.A., Strout. M.P., Mrozek, K., Bacr. M.R., Frankel. S.R., Barcos, M., Herzig. G.P., Croce, C.M. and Bloomfield, C.D. (1994) "Molecular rearrangement of the ALL-I gene in acute myeloid leukemia without cytogenetic evidence ofII q23 chromosomal translocations", Cancer Res. 54, 370-373.
  • Caligiuri, M.A., Strout. M.P., Lawrence. D., Arthur, D.C., Baer. M.R., Yu. F., Knuutila, S., Mrozek, K., Oberkircher, A.R., Marcucci. G., de la Chapelle. A., Elonen, E., Block, A.W., Rao. P.N., Herzig, O.P., Powell, B.L., Ruutu. T., Schiffer. C.A. and Bloomfield, C.D. (1998) "Rearrangement of ALLl (MLL) in acute myeloid leukemia with normal cytogenctics", Cancer Res. 58. 55-59.
  • Martincz-Climent, J.A., Thirman, M.J., Espinosa. R.E. III. Le Beau. M.M. and Rowley, J.D. (1995) "Detection of 11q23/MLL rearrangements in infant lcuekmias with fluorescence in situ hybridization and molecular analysis", Leukemia 9. 1299-1304.
  • Yamamoto, K., Seto, M., Iida, S., Komatsu, H., Kamada, N., Kojima, S., Kodera, Y., Nakazawa, S., Saito, H., Takahashi, T. and Ueda, R. (1994) "A reverse transcriptase-polyrnerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 1 Iq23 abnormalities", Blood 83, 2912-2921.
  • Maihew, S., Behrn, F.G., Dallon, J. and Raimondi. S.C. (1999) "Comparison of cytogenetics, Southern blotting, and fluorescence in situ hybridization as methods for detecting Ml.L gene rearrangements in children with acute leukemia and with Ilq23 abnormalities", Leukemia 13, 1713-1720.
  • Isoyama, K., Kguchi, M, Hibi, S., Kinukawa, N., Ohkawa. H., Kawasaki. H., Kosaka, Y. Oda, T., Oda. M., Okamura. T., Nishiraura, S., Hayashi, Y. Mori, T., Lmaizumi. M., Mizutani. S., Tsukimoto, I., Kamada, N. and Ishii, E. (2002) "Risk-directed treatment of infant acute lymphoblastic leukemia based on early assessment of MLL gene status: results of the Japan Infant [-eukcmia Study (MIJ.96)", Hr J. Haematol., 118, 999-1010.
  • Ida, K., Taki. T., Bessho. F. Kobayashi. M., Taira. R. Hanada, R., Yamamoto, K., Okimoto, Y. Seto. M., Ueda, R. and Hayashi, Y (1997) "Detection of chimeric mRNAs by reverse transcriptasepolymerase chain reaction for diagnosis and monitoring of acute leukemia? with Ilq23 abnormalities", Med. Pediatr. Oncol. 28, 325-332.
  • Repp, R., Borkhardt, A., Haupt. R., Kreuder. J., Brettreich. S., Hammermann. J., Nishida, K., Harbott. J. and Lampen, F. (1995) "Detection of four different 1 Iq23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis", Leukemia 9, 210-215.
  • Strehl, S., Konig, M., Mann, G. and Haas. O.A. (2001) "Multiplex reverse transcriptase-polymerase chain reaction screening in childhood acute myeloblastic leukemia", Blood 97, 805-808.
  • Pui, C-H., Raimondi. S.C., Srivastava. O.K., Tong, X., Behm. E.G., Razzouk, B., Rubnitz, J.E. Sandlund, J.T., Evans, W.E. and Ribeira, R. (2000) "Prognostic factors in infants with acute myeloid leukemia", leukemia 14, 684-687.
  • Creutzig, U., Zimmermann, M., Ritter, J., Henze, G., Graf, N., Loffler. H. and ScheUong. G. (1999) "Definition of a standard-risk group in children with AML", Br. J. Haematol. 104, 630-639.
  • Stevens, R.F, Hann. I.M., Wbeatley. K. and Gray. R. (1998) "Marked improvement in outcome with chemotherapy alone in paediatric acute myeloid leukaemia: results of the United Kingdom Medical Research Council's 10th AML trial", Br. J. Haematol. 101, 130-140.
  • Ravinrdanath, Y. Steuber, C.P., Krischer. J., Civin, C.I., Ducore, J., Vega. R., Pitel. P., lnoue, S., Bleher. E., Sexauer. C., Hutter. J. and Vietri. T. (1991) "High-dose cytarabine for intensification of early therapy of childhood acute myeloid leukemia: a Pediatric Oncology Group study", J. Clin. Oncol. 9, 572-580.
  • Lie, S.O., Jonmundsson, G., Mcllander. L., Sumes. M.A., Yssing. M. and Gustafsson. G. (1996) "A population-based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome m girls, infants, and children with Down's syndrome", Br. J. Haematol. 94, 82-88.
  • Hilden, I.M., Smith, P.O., Frestedt, J.L., McGlennen, R., Howells. W.B., Sorensen, P.H.B.,. Arthur. D.C., Woods, W.G., Bucktey, J., Bernstein, I.D. and Kersey, J.H. (1997) "MLL gene rearrangement, cytogenetic I Iq23 abonormalities. and expression of the NG2 molecule in infant acute myeloid leukemia", Blood V), 3801 -3805.
  • Satake, N., Maseki, N., Nishiyama. M., Kobayashi, H., Sakurai, M., lnaba. H., Katano, N, Horikoshi. Y, Eguchi, H., Miyake, M., Seto. M. and Kaneko. Y. (1999) "Chromosome abnormalities and MLL rearrangements in acute myeloid leukemia of infants", Leukemia 13, 1013-1017.
  • Byrd, J.C., Dodge. R.K., Carroll. A., Baer. M.R., Edwards. C, Stamberg, J., Qumsiyeh. M., Moore, J.O., Mayer, R.J., Davey. R.J., Schiffer, C.A. and Btoomneld, C.D. (1999) "Patients with t(8:2l)(q22;q22) and acute myeloid leukemia have superior failure-free and overall survival when repetitive cycles of highdose cytarabine are administered", J. Clin. Oncol. 17, 3767-3775.
  • Cassileth, P.A., Harringlou, O.P., Appelbaum. F.R., l Lazanis. H.M., Rowe, J.M., Paietta. E., Willman, C., Kurd, D.D., Bennett, J.M., Blume. K.G., Head, D.R. and Wieraik, PH (1998) "Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission", N. Engl. J. Med. 339, 1649-1656.
  • Loeb, D.M., Bowers. D.C., Civin, C.I. and Friedman. A.D. (2001) "Intensive timed sequential remission induction chemotherapy withhigh-dose cytarabine for childhood acute myeloid leukemia", Med. Pediatr. Oncol. 37, 365-371
  • Odora, L.F. and Gordon. EM. (1984) "Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin", Blood 64, 875-882.
  • Nishikawa, A., Nakamura. Y., Nobori. U., Aoki. T., Higashino. H., Matsui. T., Kobayashi, Y, Yamashita, M. and Unishi, G. (1987) "Acute monocytic leukemia in children: response to VP-16-213 as a single agent", Cancer 60. 2146-2149.
  • Kigasawa, H., Akiyama, Y. Ohira. M., Tsukimoto, I. and Nagao, T. (1998) "Prospective comparison between postinduction chemotherapy and various types of stem cell transplants for childhood acute myeloid leukemia using Japan cooperative protocol ANI.L91 (abstract)", Med. Pediatr. Oncol. 33, 225.
  • Creutzig, U., Ritter, J., Zinimermann. M., Hermann. RJ., Berthold. F., Henze. G., Jurgens. H., Kabisch, H., Havers, W., Reiter, A., Kluba. U., Niggli. F. and Gadner, H. (2001) "Improved treatment resulte in high-risk pediatrie acule myeloid leukemia patients after intensification with high-dose cytarabine ami mitoxantrone: results of study acute myeloid leukemia-Berlin-Frankfurt-Munster 93", J. Clin. Oncol. 19, 2705-2713.
  • Woods, W.G., Kobrinsky. N., Buckley. J.D., Lee, J.W., Sander;. J., Neudorf, S., Gold. S., Barnard. D.R., DeSwarte, J., Dusenbery. K., Kalousek, D., Arthur, D.C. and Lange. B.J. (1996) "Timedsequential induction therapy improves postrcmission outcome in acute myeloid leukemia: a report from the Children's Cancer Group", Blood 87, 4979-4989.
  • Pui. C-H., Ribeiro. R.C., Campana, D., Raimondi. S.C., Hancock. ML., Behm, F.G., Sandlund, J.T, Rivera, O.K., Evans. W.E., Grist. W.M. and Krance. R. (1996) "Prognostic factors in the acute lymphoid and myeloid teukemias of infants", Leukemia 10. 952-956.
  • Creutzig, U, Ritter, J. and Schellong, G. (1990) "Identification of two risk groups in childhood acute myelogenous leukemia after therapy intensification in study AML-BFM-83 as compared with study AML-BFM-78", Blood 75, 1932 1940.
  • Rubnitz, JE., Raimondi. S.C., Tong, X., Srivastava. O.K., Razzouk. B.I., Shurteff. S.A., Downing. J.R., Pui. C.-H., Ribeiro, R.C. and Behm, F.G. (2002) "Favorable impact of the t(9;l I) in childhood acute myeloid leukemia", J. CWn. Oncol. 20. 2302-2309.
  • Martinez-Climent, J.A., Lane. N.J., Rubin, C.M., Morgan. E., Johnstoae, U.S., Mick, R., Murphy. S.B., Vardiman. J.W., Larson. R.A., Le Beau. M.M. and Rowley. J.D. (1995) "Clinical and prognostic significance of chromosomal abnormalities in childhood acute myeloid leukemia de nova", Leukemia 9, 95-101.
  • Mrozek, K., Heinonen, K., Lawrence. D., Carroll. AJ., Koduru. P.R.K., Rao, K.W., Strout. M.P., Hutchinson. R.E., Moore, J.O., Mayer. RJ., Schiffer, C.A. and Bloomfield, C.D. (1997) "Adult patients with de novo acute myeloid leukemia and 1(9; 11 )(p22:q23) have a superior outcome to patients with other translocations involving band I Iq23: a Cancer and Leukemia Group B study", Blood 90, 4532-4538.
  • Biondi, A., Cimino. G., Pieters, R. and Pui, C.-H. (2000) "Biological and therapeutic aspects of infam leukemia", Blood 96. 24-33.
  • Tien, R-K. Hsiao, C.-H., Tang, J.-L., Tsay. W., Hu. C.-H., Kuo. Y.Y. Wang, C.-H., Chen, Y-C., Shen, M.-C, Lin, D. T., Lin. K.-H. and Lin, K.-S. (2000) "Characterization of acute myeloid leukemia with MLL rearrangements -no increase in the incidence of coexpression of lymphoid-associated antigens on leukemic blasts", Uukemia14, 1025 1030.
  • Johnson, F.L., Sander. J.E., Ruggiero, M., Chard. Jr., RL. and Thomas. ED. (1988) "Bone marrow transplantation for the treatment of acute nonlymphoblastic leukemia in children aged less than 2 years", Blood 71, 1277-1280.
  • Emminger, W., Emminger-Schmidtneier, W., Haas. O.A., Urban, C., Ambros. P., Peters, C., Mann, G., Fink, F.H., Ferell, G. and Hocker. D. (1992) "Treatment of infant leukemia with busulfan, cyclophophamide +/- etoposidc and bone marrow transplantation", Bone Marrow Transplant. 9, 313-318.
  • Woolfrey. A.E., Gooley.T.A., Sievers, E.L., Milner. L.A., Andrews, R.G., Walters, M., Hoffmeister, P., Hansen, J.A., nasetti, C., Bryant, E., Appelbaum, F.R. and Sanders. J.E. (1998) "Bone marrow transplantation for children less than 2 years of age with acute rayelogenous leukemia or myelodysplastic syndromes", Bhtfd 2, 3546-3556.
  • Marco. F., Bureo. E., Onega. J.J., Badell. L. Verdaguer. A., Martinez. A., Munoz, A., Madero. L., Olive. T., Cubells, J., Castcl, V., Sastre. A., Maldonado, M.S. and Diaz. M.A. (2000) "High survival rale in infant acute leukemia treated with early high-dose chemotherapy and stem-cell support", J. Clin. Oncol. 18. 3256-3261.
  • Woods, W.O., Kobrinsky, N., Buckley, J., Neudorf. S., Sanders. J., Miller. L., Barnard. D., Benjamin. D., DeSwarte, J., Kalousek. D., Shina, D., Hammond, G.D. and Lange. BJ. (1993) "Intensively timed induction therapy followed by autologous or allogeneic bone marrow transplantation for children with acute myeloid leukemia or myelodysplasitc syndrome: a Chidren's Cancer Group pilot study", J. Clin. Oncol. 11,1448-1457.
  • Ravindranach. Y., Yeager. A.M., Chang, M.N., Steuber, C.P., Krischer, J., Graham-Pole, i., Carrall, A., moue, S., Camilla, B. and Weinstein, H.J. (1996) "Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood", Af. Engl. J. Med. 334, 1428-1434.
  • Cesaro, S., Meloni. G., Messina, C., Pillon, M., Proglia. A., Lanino. E., Caniggia, M., Baguulo, S., Pession, A. and Locatelli, F. (2001) "High-dose melphalan with autologous hematopoietic stem cell transplantation for acute myeloid leukemia: results of a retrospective analysis of the Italian Pediatric Group for Bone Marrow Transplantation", Bone Marrow Transplant. 28, 131- 136.
  • Tiedemann. K., Waters, K.D., Tauro. O.P., Tucker, D. and Ekert, H. (1993) "Results of intensive therapy in childhood acule myeloid leukemia, incorporating high-dose melpnalan and autologous bone marrow transplantation in first complete remission", Blood 82, 3730-3738.
  • Gluckman, E. (2000) "Current status of umbilical cord blood hcmatopoictic stem cell transplantation", Ex/7. Hematol. 28, 1197 1205.
  • Backer, J.N., Davies. S.M., DcFor. T., Ramsay. N.K.C., Weisdorf, D.I. and Wagner. J.E. (2001) "Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrowresults of a matched-pair analysis", Blood 97, 2957-2961.
  • Rocha, V., Cornish. J., Sievers, E.L., Filipovich. A., Locatelli, E. Peters, C., Ramberger. M., Michel, G., Arccse, W., Dallorso, S., Tiederaann, K., Busca. A., Chan, K.-W., Kalo, S., Onega, J, Vowels, M., Zander, A., Souillet, G., Oakill, A., Woolfrey, A., Pay, A.L., Green, A., Gamier. F., Ionescu, 1., Wernel, P., Sirchia. G., Rubinstein. P., Chevret, S. and Gluckman, E. (2001) "Compan son of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia", Hlood 97. 2962-2971.
  • Johnson, F.L. and Rubin, C.M. (1992) "Allogeneic marrow transplantation in the treatment of infants with cancer", Br. J. Cancer 66(Suppl. XVIII), S76-S79.
  • Gorin, N.C. (1998) "Autologous stem cell transplantation in acute myelocyTIc leukemia", Blood 92, 1073-1090.
  • Liesner, R.J., Leiper, A.D., Hann. I.M. and Chessells. I.M. (1994) "Late effects of intensive treatment for acute myeloid leukemia and myelodysplasia in childhood", J. Clin. Oncol 12, 916-924.
  • Venditti, A., Buccisano. F., Del Poeta, G., Maurillo, L., Tamburini, A., Cox, C., Battaglia. A., Catalane. G., Del Moro, B., Cudillo, L., Postorino. M., Masi, M. and Araadori, S. (2000) "Level of minimal residual disease after consolidation therapy predicts outcome in acute myeloid leukemia", Blood 96. 3948-3952.
  • Minerbauer. G., Zimmer. C., Fonatsch, C., Haas, O.A., Thalbammer-Scherrer, R., Schwarzinger, I., Kalhs. P., Jaeger, U., Lechner. K. and Mannhalter. C. (1999) "Monitoring of minimal residual leukemia in patients with MLL-AF9 positive acute myeloid leukemia by RT-PCR", Leukemia 13. 1519-1524.

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