Advanced search
Publication Cover
Leukemia & Lymphoma Volume 44, 2003 - Issue 5
Submit an article Journal homepage
32
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Predicting Long-term Survival in Multiple Myeloma Patients Following Autotransplants

Athanasios B.-T. Fassas Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AK 72205, USA
,
Frits Van Rhee Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AK 72205, USA
&
Guido Tricot Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AK 72205, USA
Pages 749-758 | Published online: 01 Jul 2009

  • Barlogie, B., Epstein, J., Selvanayagam, P. and Alexanian, R. (1989) "Plasma cell myeloma--new biological insights and advances in therapy", Blood 73, 865-879.
  • Kyle, R.A. (1994) "Why better prognostic factors for multiple myeloma are needed", Blood 83, 1713-1716.
  • The Intergroupe Français du MyélomeAttal, M., Harousseau, J.L., Stoppa, A.M., Sotto, J.-J., Fuzibet, J.-G., Rossi, J.-F., Casassus, P., Maisonneuve, H., Facon, T., Ifrah, N., Payen, C. and Bataille, R. (1996) "A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma", New England Journal of Medicine 335, 91-97.
  • Barlogie, B., Jagannath, S., Vesole, D., Naucke, S., Cheson, B., Mattox, S., Bracy, D., Salmon, S., Jacobson, J., Crowley, J. and Tricot, G. (1997) "Superiority of tandem autologous transplantation over standard therapy for previously untreated multiple myeloma", Blood 89, 789-793.
  • Lenhoff, S., Hjorth, M., Holmberg, E., Turesson, I., Westin, J., Nielsen, J.L., Wislöff, F., Brinch, L., Carlson, K., Carlsson, M., Dahl, I.-M., Gimsing, P., Hippe, E., Johnsen, H., Lamvik, J., Löfvenberg, E., Nesthus, I. and Rödjer, S. (2000) "Impact on survival of high dose therapy with autologous stem cell supporting patients younger than 60 years with newly diagnosed multiple myeloma: a population based study", Blood 95, 7-11.
  • Alexanian, R., Barlogie, B. and Tucker, S. (1990) "VAD-based regimens as primary treatment for multiple myeloma", American Journal of Hematology 33, 86-89.
  • Anderson, H., Scarffe, J.H., Ranson, M., Young, R., Wieringa, G.S., Morgenstern, G.R., Fitzsimmons, L. and Ryder, D. (1995) "VAD chemotherapy as remission induction for multiple myeloma", British Journal of Cancer 71, 326-330.
  • Raje, N., Powles, R., Kulkarni, S., Milan, S., Middleton, G., Singhal, S., Mehta, J., Millar, B., Viner, C., Raymond, J., Treleaven, J., Cunningham, D. and Gore, M. (1997) "A comparison of vincristine and doxorubicin infusional chemotherapy with methylprednisolone (VAMP) with the addition of weekly cyclophosphamide (C-VAMP) as induction treatment followed by autografting in previously untreated myeloma", British Journal of Haematology 97, 153-160.
  • Siegel, D.S., Desikan, K.R., Mehta, J., Singbal, S., Passas, A., Munshi, N., Anaissie, E., Naucke, S., Ayers, D., Spoon, D., Vesole, D., Tricot, G. and Barlogie, B. (1999) "Age is not a prognostic variable with autotransplants for multiple myeloma", Blood 93, 51-54.
  • Badros, A., Barlogie, B., Siegel, E. Roberts, J., Langmaid, C., Zangari, M., Desikan, R., Shaver, M.J., Fassas, A., McConnell, S., Muwalla, F., Barri, Y., Anaissie, E., Munshi, N. and Tricot, G. (2001) "Results of autologous stem cell transplant in multiple myeloma patients with renal failure", British Journal of Haematology 114, 822-829.
  • Harousseau, J.-L. and Attal, M. (2002) "The role of stem cell transplantation in multiple myeloma", Blood Reviews 16, 245-253.
  • Cavo, M.,Tosi, P., Zamagni, E., Cellini, C., Ronconi, S., De Vivo, A., Cangini, D., Baccarani, M. and Tura, S. (2002) "The 'Bologna 96' clinical trial of single vs. double autotransplants for previously untreated multiple myeloma patients", Blood. Abstract # 669.
  • Bataille, R., Dune, B.G., Grenier, J. and Sany, J. (1986) "Prognostic factors and staging in multiple myeloma", Journal of Clinical Oncology 4, 80-87.
  • Greipp, P.R., Lust, J.A., O'Fallon, W.M., Katzmann, J.A., Witzig, T.E. and KyIe, R.A. (1993) "Plasma cell labeling index an ß2-microglobulin predict survival independent of thymidine kinase and c-reactive protein in multiple myeloma", Blood 81. 3382-3387.
  • Fenaux, P., Preudhomme, C., Lai, J.L., Morel, P., Beuscart, R. and Bauters, F. (1989) "Cytogenetics and their prognostic value in de novo acute myeloid leukaemia: a report on 283 cases", British Journal of Haematology 73, 61-67.
  • Secker-Walker, L.M. (1990) "Prognostic and biological importance of chromosome findings in acute lymphoblastic leukemia", Cancer Genetics and Cytogenetics 49, 1-13.
  • Drach, J., Schuster, J., Nowotny, H., Angerler, J., Rosenthal, F., Fiegl, M., Rothermundt, C., Gsur, A., Jager, U. and Heinz, R. (1995) "Multiple myeloma: high incidence of chromosomal aneuploidy as detected by interphase fluorescence in situ hybridization", Cancer Research 55, 3854-3859.
  • Latreille, J., Barlogie, B., Johnston, D., Drewinko, B. and Alexanian, R. (1982) "Ploidy and proliferative characteristics in monoclonal gammopathies", Blood 59, 43-46.
  • Zandecki, M., Obein, V. Bernardi, F., Soenen, V, Flactif, M., Lai, J.L., Francois, M. and Facon, T. (1995) "Monoclonal gammopathy of undetermined significance: chromosome changes are a common finding within bone marrow plasma cells", British Journal of Haematology 90, 693-696.
  • Drach, J., Angerler, J., Schuster, J., Rothermundt, C., Thalhammer, R., Haas, O.A., Jager, U., Fiegl, M., Geissler, K. and Ludwig, H. (1995) "Interphase fluorescence in situ hybridization identifies chromosomal abnormalities in plasma cells from patients with monoclonal gammopathy of undetermined significance", Blood 86, 3915-3921.
  • Tricot, G., Sawyer, J.R., Jagannath, S., Desikan, R.K., Siegel, D., Naucke, S., Mauox, S., Bracy, D., Munshi, N. and Barlogie, B. (1997) "Unique role of cytogenetics in the prognosis of patients with myeloma receiving high-dose therapy and autotransplants", Journal of Clinical Oncology 15, 2659-2666.
  • Desikan, R., Barlogie, B., Sawyer, J., Ayers, D., Tricot, G., Badros, A., Zangari, M., Munshi, N., Anaissie, E., Spoon, D., Siegel, D., Jagannath, S., Vesole, D., Epstein, J., Shaughnessy, J., Passas, A., Lim, S., Roberson, P. and Crowley, J. (2000) "Results of high-dose therapy for 1000 patients with multiple myeloma: durable complete remissions and superior survival in the absence of chromosome 13 abnormalities", Blood 95, 4008-4010.
  • Seong, C., Delasalle, K., Hayes, K., Weber, D., Dimopoulos, M., Swantkowski, J., Huh, Y., Classman, A., Champlin, R. and Alexanian, R. (1998) "Prognostic value of cytogenetics in multiple myeloma", British Journal of Haematology 101, 189-194.
  • Weh. H.J., Gutensohn, K., Selbach, J., Knise, R., Wacker-Backhaus, G., Seeger, D., Fielder, W., Fett, W. and Hossfeld, D.K. (1993) "Karyorype in multiple myeloma and plasma cell leukemia", European Journal of Cancer 29A, 1269-1273.
  • La, J.L., Zandecki, M., Mary, J.Y., Bernardl, P., Izydorczyk, V., Flactif, M., Morel, P., Jouet, J.P., Bauters, F. and Facon, T. (1995) "Improved cytogenetics in multiple myeloma: a study of 151 patients including 117 patients at diagnosis", Blood 85, 2490-2497.
  • Smadja, N.-V. Fruchart, C., Isnard, F., Louvet, C. Dutel, J.-L., Cheron, N., Grange, M.-J., Monconduit, M. and Bastard, C. (1998) "Chromosomal analysis in multiple myeloma: cytogenetic evidence of two different diseases", Leukemia 12, 960-969.
  • Heerema, N.A., Nachman, J.B., Sather, H.N., Sensel, M.G., Lee, M.K., Hutchinson, R., Lange, B.J., Steinherz, P.G., Bostrom, B., Gay non, P.S. and Uckun, F. (1999) "Hypodiploidy with less than 45 chromosomes confers adverse risk in childhood acute lymphoblastic leukemia: a report from the children's cancer group", Blood 94, 4036-4404.
  • Pujol, J.L., Simony, J., Jolimony, G., Jaffuel, D., Demoly, P., Quanlin, X., Marty-Ane, C., Boher, J.M., Charpentier, R. and Michel, F.B. (1996) "Hypodiploidy, Ki-67 growth fraction and prognosis of surgically resected lung cancers", British Journal of Cancer 74, 964-970.
  • Rubio Bueno, P., Naval Gias, L., Garcia Delgado, R., Domingo Cebollada, J. and Diaz Gonzalez, F.J. (1998) "Tumor DNA content as prognostic indicator in squamous cell carcinoma of the oral cavity and tongue base", Head and Neck 20, 232-239.
  • Perez Simon, J.A., Garcia-Sanz, R., Tabemero, M.D., Almeida, J., González, M., Hernández-Calvo, J., More, M.J., Heraández, J.M., San Miguel, J.P. and Orfäo, A. (1998) "Prognostic value of numerical chromosome aberrations in multiple myeloma: a FISH analysis of 15 different chromosomes'. Blood 91, 3366-3371.
  • Latreille, J., Barlogie, B., Dosik, G., Johnsion, D.A., Drewinko, B. and Alexanian, R. (1980) "Cellular contents as a marker of human multiple myeloma", Blood 55, 403-408.
  • Tafuri, A., Meyers, J., Lee, B.J. and Andreeff, M. (1991) "DNA and RNA flow cytometric study in multiple myeloma: clinical correlations", Cancer 67, 449-454.
  • Barlogie, B., Alexanian, R., Dixon, D., Smith, L., Smallwood, L. and Delasalle, K. (1985) "Prognostic implications of tumor cell DNA and RNA content in multiple myeloma", Blood 66, 338-341.
  • Garcia-Sanz, R., Ortao, A., Gonzalez, M., Moro, M.J., Hernandez, M., Onega, P., Borrego, D., Carnero, M., Casanova, F., Jimënez, R., Portero, J. A. and San Miguel, J.P. (1995) "Prognostic implications of DNA aneuploidy in 156 untreated multiple myeloma patients", British Journal of Haematology 90, 106-112.
  • Greipp, P.R., Trendle, M.C., Leong, T., Oken, M.M., Kay, N.E., Van Ness, B. and KyIe, R.A. (1999) "Is flow cytometric DNA content hypodiploidy prognostic in multiple myeloma?", Leukemia and Lymphoma 35, 83-89.
  • Calasanz, M.J., Cigudosa, J.C., Odero, M.D., Garcia-Poncillas, J., Marin, J., Ardanaz, M.T., Rocha, B. and Gallon, A. (1997) "Hypodiploidy and 22q11 rearrangements at diagnosis are associated with poor prognosis in patients with multiple myeloma", British Journal of Haematology 98, 418-425.
  • Smadja, N.-V, Bastard, C., Brigaudeau, C., Leroux, D. and Fnichan, C. (2001) "Hypodiploidy is a major prognostic factor in multiple myeloma", Blood 98, 2229-2238.
  • Dewald, G., KyIe, R.A., Hicks, G.A. and Greipp, P.R. (1985) "The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia, or amyloidosis", Blood 66, 380-390.
  • Sawyer, J.R., Waldron, J.A., Jagannath, S. and Barlogie, B. (1995) "Cytogenetic findings in 200 patients with multiple myeloma", Cancer Genetics and Cytogenetics 82, 41-49.
  • Passas, A.B.-T. Spencer, T., Sawyer, J., Zangari, M., Lee, C.-K., Anaissic, E., Muwalla, F., Morris, C., Barlogie, B. and Tricot, G. (2002) "Both hypodiploidy and deletion of chromosome 13 independently confer poor prognosis in multiple myeloma", British Journal of Haematology 118, 1041-1047.
  • Barlogie, B., McCoy, J., Tricot, G., Shaughnessy, J., Epstein, J., Sawyer, J., Passas, A., Zangari, M., Jacobson, J. and Crowley, J. "Continuous absence of cytogenetic abnormalities especially of chromosome 13 and hypodiploidy assures long-term survival in multiple myeloma treated with total therapy A. Blood (Submitted).
  • Barlogie, B., Smallwood, L., Smith, T. and Alexanian, R. (1989) "High serum levels of lactic dehydrogenase identify a high-grade lymphoma-like myeloma", Annals of Internal Medicine 110, 521-525.
  • Passas, A.B., Desikan, K.R., Siegel, D., Golper, T.A., Munshi, N.C., Barlogie, B. and Tricot, G. (1999) "Tumor lysis syndrome complicating high-dose treatment in patients with multiple myeloma", British Journal of Haematology 105, 938-941.
  • Drach, J., Ackermann, J., Fritz, E., Krömer, E., Schuster, R., Gisslinger, H., DeSantis, M., Zojer, N., Fiegl, M., Roka, S., Schuster, J., Heinz, R., Ludwig, H. and Huber, H. (1998) "Presence of a p53 gene deletion in patients with multiple myeloma predicts for short survival after conventional-dose chemotherapy", Blood 92. 802-809.
  • Zojer, N., Königsberg, R., Ackermann, J., Fritz, E., Dallinger, S., Krömer, E., Kaufmann, H., Riedl, L., Gisslinger, H., Schreiber, S., Heinz, R., Ludwig, H., Huber, H. and Drach, J. (2000) "Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization", Blood 95, 1925-1930.
  • Königsberg, R., Zojer, N., Ackermann, J., Kromer, E., Kittler, H., Fritz, E., Kaufmann, H., Nosslinger, T., Riedl, L., Gisslinger, H., Jager, U., Simonitsch, I., Heinz, R., Ludwig, H., Huber, H. and Drach, J. (2000) "Predictive role of interphase cytogenetics for survival of patients with multiple myeloma", Journal of Clinical Oncology 18, 804-812
  • On behalf of the Intergroupe Francophone du Myelome (IFM)Facon, T., Avet-Loiseau, H., Guillerm, G., Moreau, P., Geneviève, F., Tandecki, M., Laï, J.-L., Lelue, X., Jouet, J.-P., Bauters, F., Harousseau, J.-L., Bataille, R. and Mary, J.-Y. (2001) "Chromosome 13 abnormalities identified by FISH analysis and serum ß2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy", Blood 97, 1566-1571.
  • The Intergroupe Francophone du MyélomeMoreau, P., Facon, T., Leleu, X., Monncau, N., Huyghe, P., Harousseau, J.-L., Bataille, R. and Avet-Loiseau, H. (2002) "Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy", Blood 100, 1579-1583.
  • Shaughnessy, J.,Tian, E., Sawyer, J., McCoy. J., Tricot, G., Jacobson, J., Anaissie, E., Zangari, M., Fassas, A., Muwalla, F., Morris, C. and Barlogie, B. "Prognostic impact of cytogenetic interphase FISH defined chromosome 13 deletion in multiple myeloma: early results of total therapy Il ", British Journal of Haematology (In press).
  • Tricot, G., Spencer, T. Sawyer, J., Spoon, D., Desikan, R., Fassas, A., Badros, A., Zangari, M., Munshi, N., Anaissie, E., Tour, A. and Barlogie, B. (2002) "Predicting long-term (= 5 years) eventfree survival in multiple myeloma patients following planned tandem autotransplant", British Journal of Haemotology 116. 211-217.
  • Tricot, G., Vesole, D., Jagannath, S., Hilton, J., Munshi, N. and Barlogie, B. (1996) "Graft-versus-myeloma effect: proof of principle", Blood 87, 1196-1198.
  • Gahrton, G., Svensson, H., Björkstrand, B., Apperley, J., Carlson, K., Cavo, M., Ferrant, A., Fouillard, L., Gratecos, N., Gratwohl, A., Guilhot, F., Lambertenghi Deliliers, G., Ljungman, P., Masszi, T., Milligan, D.W., Powles, R.L., Reiffers, J., Samson, J.D., Stoppa, A.M., Vernant, J.P., Volin, L. and Wallvik, J. (1999) "Syngeneic transplantation in multiple myeloma-a case-matched comparison with autologous and allogeneic transplantation", Bone Marrow Transplantation 24, 741-745.
  • Björkstrand, B., Ljungman, P., Svensson, H., Hermans, J., Alegre, A., Apperley, J., Blade, J., Carlson, K., Cavo, M., Ferrant, A., Goldstone, A.H., de Laurenzi, A., Majolino, I., Marcus, R., Prentice, H.G., Remes, K., Samson, D., Sureda, A., Verdonck, L.F., Volin, L. and Gahrton, G. (1996) "Allogeneic bone marrow transplantation versus autologous stem cell transplantation in multiple myeloma: a retrospective case-matched study from the European group for blood and marrow transplantation", Blood 88, 4711-4718.
  • Corandini, P., Voena, C., Tarella, C., Astolfi, M., Ladetto, M., Palumbo. A., Van Lint, M.T., Badgalupo, A., Santoro, A., Musso, M., Majolino, I., Boccadoro, M. and Pileri, A. (1999) "Molecular and clinical remissions in multiple myeloma: role of autologous and allogeneic transplantation of heinatopoietic cells", Journal of Clinical Oncology 17, 208-215.
  • Gahrton, G., Tura, S., Ljungman, P., Blade, J., Brandt, L., Cavo, M., Facon, T., Gratwohl, A., Hagenbeek, A. and Jacobs, P. (1995) "Prognostic factors in allogeneic bone marrow transplantation for multiple myeloma", Journal of Clinical Oncology 13, 1312-1322.
  • Badros, A., Barlogie, B., Morris, C., Desikan, R., Martin, S., Munshi, N., Zangari, M., Mehta, J., Toor, A., Cottler-Fox, M-. Fassas, A., Anaissie, E., Schichman, S., Tricot, G. and Anaissie, E. (2001) "High response rate in refractory and poor-risk multiple myeloma after allotransplantation using a nonmycloablative conditioning regimen and donor lymphocyte infusions", Blood 97, 2574-2579.
  • Kroger, N., Schwerdtfeger, R., Keihl, M., Sayer, H.G., Renges, H., Zabelina, T., Fehse, B., Togel, F., Wiukowsky, G., Kruse, R. and Zander, A.R. (2002) "Autologous stem cell transplantation followed by a dose-reduced allograft induces high complete remission rate in multiple myeloma", Blood 100. 755-760.
  • Than, F., Hardin, J., Bumm, K., Zheng, M., Tian, E., Sanderson, R., Yang, Y., Wilson, C., Zangari, M., Anaissie, E., Morris, C., Muwalla, F., van Rhee, F., Fassas, A., Tricot, G., Crowley, J., Barlogie, B. and Shaughnessy, J. (2002) "Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance and normal bone marrow plasma cells", Blood 99, 1745-1757.
  • Wu, K., Orme, L., Shaughnessy, J., Bumm, K., Barlogie, B. and Moore, M.A.S. (2001) "Telomerase expression and telomerase length in purified myeloma colls: a study of 158 cases", Blood 98. 347A, Abstract #1574.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.