289
Views
100
CrossRef citations to date
0
Altmetric
Research Article

Activity of a Novel Anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against Human Lymphoma is Superior to Methotrexate and Correlates with Tumor RFC-1 Gene Expression

, , , , &
Pages 1027-1035 | Published online: 01 Jul 2009

  • DeVita, V., Hellman, S. and Rosenberg, S. (2001) Cancer: Principles and Practice of Oncology. 6th ed. (Lippincott Williams and Wilkins, Philadelphia).
  • Howe, H.L., Wingo, P.A., Thun, M.J., Ries, L.A., Rosenberg, H.M., Feigel, E.G. and Edwards, B.K. (2001) "Annual report to the nation on the status of cancer (1973-1998), featuring cancers with recent increasing trends". J Natl Cancer Inst. 93, 824-842.
  • DeVita, V.T.J., Hellman, S. and Rosenberg, S.A., eds (1995) Biologic Therapy of Cancer (Lippincott Williams & Wilkins, Philadelphia).
  • Dhaliwal, H.S., Rohatiner, A.Z., Gregory, W., Richards, M.A., Johnson, P.W., Whelan, J.S., Gallagher, C.J., Matthews, J., Ganesan, T.S., Barnett, M.J., et al. (1993) "Combination chemotherapy for intermediate and high grade non-Hodgkin's lymphoma". Br. J. Cancer 68, 767-774.
  • Dorigo, A., Mansberg, R. and Kwan, Y.L. (1993) "Lomustine, etoposide, methotrexate and prednisone (LEMP) therapy for relapsed and refractory non-Hodgkin's lymphoma". Eur. J. Haematol. 50, 37-40.
  • Sarris, A.H., Phan, A., Duvic, M., Romaguera, J., McLaughlin, P., Mesina, O., King, K., Medeiros, L.J., Rassidakis, G.Z., Samuels, B. and Cabanillas, F. (2002) "Trimetrexate in relapsed T-cell lymphoma with skin involvement". J. Clin. Oncol. 20, 2876-2880.
  • McGrath, I., Adde, M., Shad, A., Venzon, D., Seibel, N., Gootenber, J., Neely, J., Arndt, C., Neider, M., Jaffe, E., Wittes, R.A. and Horal, I.D. (1996) "Adults and children with small non-cleaved-cell lymphoma have a similar excellent outcome when treated with the same chemotherapy regimen". J. Clin. Oncol. 12, 925-934.
  • DeGraw, J.I., Colwell, W.T., Piper, J.R. and Sirotnak, F.M. (1993) "Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin". J. Med. Chem. 36, 2228-2231.
  • Sirotnak, F.M., DeGraw, J.I., Moccio, D.M., Samuels, L.L. and Goutas, L.J. (1984) "New folate analogs of the 10-deazaaminopterin series. Basis for structural design and biochemical and pharmacologic properties". Cancer Chemother. Pharmacol. 12, 18-25.
  • Sirotnak, F.M., DeGraw, J.I., Schmid, F.A., Goutas, L.J. and Moccio, D.M (1984) "New folate analogs of the 10-deazaaminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models". Cancer Chemother. Pharmacol. 12, 26-30.
  • Schmid, F.A., Sirotnak, F.M., Otter, G.M. and DeGraw, J.I. (1985) "New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice". Cancer Treat. Rep. 69, 551-553.
  • Sirotnak, F.M., Schmid, F.A., Samuels, L.L. and DeGraw, J.I. (1987) "10-Ethyl-10-deaza-aminopterin: structural design and biochemical, pharmacologic, and antimmor properties". NCI Monogr. 5, 127-131.
  • Sirotnak, F.M., DeGraw, J.I., Colwell, W.T. and Piper, J.R. (1998) "A new analogue of 10-deaza-aminopterin with markedly enhanced curative effects against human tumor xenografts in mice". Cancer Chemother. Pharmacol. 42, 313-318.
  • Krug, L.M., Ng, K.K., Kris, M.G., Miller, V.A., Tong, W., Heelan, R.T., Leon, L., Leung, D., Kelly, J., Grant, S.C. and Sirotnak, F.M. (2000) "Phase 1 and pharmacokinetic study of 10-propargyl-10-deaza-aminopterin, a new antifolate". Clin. Cancer Res. 6, 3493-3498.
  • Pulvertaft, R. (1964) "Cytology of Burkitt's tumour (African lymphoma)". Lancet 1, 238-240.
  • Beckwith, M., Longo, D.L., O'Connell, C.D., Moratz, C.M. and Urba, W.J. (1990) "Phorbol ester-induced, cell-cycle-specific, growth inhibition of human B-lymphoma cell lines". J Natl Cancer Inst. 82, 501-509.
  • Amstein, P., Taylor, D.O., Nelson-Rees, W.A., Huebner, R.J. and Lennette, E.H. (1974) "Propagation of human tumors in antithymocyte serum-treated mice". J Natl Cancer Inst. 52, 71-84.
  • Ohsugi, Y., Gershwin, M.E., Owens, R.B. and Nelson-Rees, W.A. (1980) "Tumorigenicity of human malignant lymphoblasts: comparative study with unmanipulated nude mice, antilymphocyte serum-treated nude mice, and X-irradiated nude mice". J. Natl Cancer Inst. 65, 715-718.
  • Goy, A., Gilles, F., Remache, Y., Filippa, D., Portlock, C.S., Jhanwar, S.C. and Zelenetz, A.D. (2001) "Establishment of a human cell line (SKI-DLCL-1) with a t(1:14)(q21;q32) translocation from the ascites of a patient with diffuse large cell lymphoma". Leuk. Lymphoma 40, 419-423.
  • Gilles, F., Goy, A., Remache, Y., Shue, P. and Zelenetz, A.D. (2001) "MUCI dysregulation as the consequence of a t(1:14)(q21:q32) translocation in an extranodal lymphoma". Blood 95, 2930-2936.
  • Sirotnak, F.M., Wendel, H.G., Bornmann, W.G., Tong, W.P., Miller, V.A., Scher, H.I. and Kris, M.G. (2000) "Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo". Clin. Cancer Res. 6, 3705-3712.
  • Khokhar, N.Z., She, Y., Rusch, V.W. and Sirotnak, F.M. (2001) "Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases. and combined therapy with platinums". Clin. Cancer Res. 7, 3199-3205.
  • Eads, C.A., Danenberg, K.D., Kawakami, K., Saltz, L.B., Danenberg, P.V. and Laird, P.W. (1999) "CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression". Cancer Res. 59, 2302-2306.
  • Rots, M.G., Willey, J.C., Jansen, G., Van Zantwijk, C.H., Noordhuts, P., DeMuth, J.P., Kuiper, E., Veerman, A.J., Pieters, R. and Peters, G.J. (2000) "mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method". Leukemia 14, 2166-2175.
  • Shultz, L.D., Schweitzer, P.A., Christianson, S.W., Gott, B., Schweitzer, I.B., Tennent, B., McKenna, S., Mobraaten, L., Rajan, T.V., Greiner, D.L., et al. (1995) "Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice". J. Immunol. 154, 180-191.
  • Shultz, L.D., Lang, P.A., Christianson, S.W., Gott, B., Lyons, B., Umeda, S., Leiter, E., Hesselton, R., Wagar, E.J., Leif, J.H., Kollet, O., Lapidot, T. and Greiner, D.L. (2000) "NOD/LtSz-Rag I null mice: an immunodeficient and radio resistant model for engraftment of human hematolymphoid cells. HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells". J. Immunol. 164, 2496-2507.
  • Piacibello, W., Sanavio, F., Severino, A., Dane, A., Gammaitoni, L., Fagioli, F., Perissinotto, E., Cavalloni, G., Kollet, O., Lapidot, T. and Aglietta, M. (1999) "Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34(+) cord blood cells after ex vivo expansion: evidence for the amplification and self-renewal of repopulating stem cells". Blood 93, 3736-3749.
  • Kollet, O., Peled, A., Byk, T, Ben-Hur, H., Greiner, D., Shultz, L. and Lapidot, T. (2000) "Beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function". Blood 95, 3102-3105.
  • Hudson, W.A., Li, Q., Le, C. and Kersey, J.H. (1998) "Xenotransplantation of human lymphoid malignancies is optimized in mice with multiple immunologic defects". Leukemia 12, 2029-2033.
  • Alizadeh, A.A., Eisen, M.B., Davis, R.E., Ma, C., Lossos, I.S., Rosenwald, A., Boldrick, J.C., Sabet, H., Tran, T., Yu, X., Powell, J.I., Yang, L., Marti, G.E., Moore, T., Hudson, J., Lu, L., Lewis, D.B., Tibshirani, R., Sherlock, G., Chan, W.C., Greiner, T.C., Weisenburger, D.D., Armitage, J.O., Warnke, R., Staudt, L.M., et al. (2000) "Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling". Nature 403, 503-511.
  • Shipp, M.A., Ross, K.N., Tamayo, P., Weng, A.P., Kutok, J.L., Aguiar, R.C., Gaasenbeek, M., Angelo, M., Reich, M., Pinkus, G.S., Ray, T.S., Koval, M.A., Last, K.W., Norton, A., Lister, T.A., Mesirov, J., Neuberg, D.S., Lander, E.S., Aster, J.C. and Golub, T.R. (2002) "Diffuse large B cell lymphoma outcome prediction by gene expression profiling and supervised machine learning". Nature Med. 8, 68-74.
  • Sierra, E.E. and Goldman, I.D. (1999) "Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates". Semin. Oncol. 26, 11-23.
  • Kamen, B. (1997) "Folate and antifolate pharmacology". Semin. Oncol. 24, S18-30-S18-39.
  • Sirotnak, F.M. and Tolner, B. (1999) "Carrier-mediated membrane transport of folates in mammalian cells". Annu. Rev. Nutr. 19, 91-122.
  • Mauritz, R., Peters, G.J., Priest, D.G., Assaraf, Y.G., Drori, S., Kathmann, I., Noordhuis, P., Bunni, M.A., Rosowsky, A., Schornagel, J.H., Pinedo, H.M. and Jansen, G. (2002) "Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemic cells and their implications for folate homeostasis". Biochem. Pharmacol. 63, 105-115.
  • Lenz, H.J., Danenberg, K., Schnieders, B., Goeker, E., Peters, G.J., Garrow, T., Shane, B., Bertino, J.R. and Danenberg, P.V. (1994) "Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction: marked variation of expression among leukemia patients". Oncol. Res. 6, 329-335.
  • Whitehead, V.M., Vuchich, M.I., Lauer, S.J., Mahoney, D., Carroll, A.J., Shuster, J.J., Esseltine, D.W., Payment, C., Look, A.T., Akabutu, J., et al. (1992) "Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group study". Blood 80, 1316-1323.
  • Whitehead, V.M., Payment, C., Cooley, L., Lauer, S.J., Mahoney, D.H., Shuster, J.J., Vuchich, M.J., Bernstein, M.L., Look, A.T., Pullen, D.J. and Camitta, B. (2001) "The association of the TELAMI.I chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study". Leukemia 15, 1081-1088.
  • Gorlick, R., Goker, E., Trippett, T., Steinherz, P., Elisseyeff, Y., Mazumdar, M., Flintoff, W.F. and Bertino, J.R. (1997) "Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression". Blood 89, 1013-1018.
  • Rhee, M.S., Wang, Y., Nair, M.G. and Galivon, J. (1993) "Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity". Cancer Res. 53, 2227-2230.
  • Mantadakis, E., Smith, A.K. and Kamen, B.A. (2000) "Ratio of methotrexate to folate uptake by lymphoblasts in children with B-lineage acute lymphoblastic leukemia: a pilot study". J. Pediatr. Hematol. Oncol. 22, 221-226.
  • Ding, B.C., Whetstine, J.R., Witt, T.L., Schuetz, J.D. and Matherly, L.H. (2001) "Repression of human reduced folate carrier gene expression by wild type p53". J. Biol. Chem. 276, 8713-8719.
  • Drori, S., Jansen, G., Mauritz, R., Peters, G.J. and Assaraf, Y.G. (2000) "Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake". J. Biol. Chem. 275, 30855-30863.
  • Whetstine, J.R., Gifford, A.J., Witt, T. Liu, X.Y., Flatley, R.M., Norris, M., Haber, M., Taub, J.W., Ravindranath, Y. and Matherly, L.H. (2001) "Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carries". Clin. Cancer Res. 7, 3416-3422.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.