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Leukemia & Lymphoma Volume 44, 2003 - Issue 10
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Research Article

The CC Genotype of the C825T Polymorphism of the G Protein β3 Gene (GNB3) is Associated with a High Relapse Rate in Patients with Chronic Lymphocytic Leukaemia

Holger Nückel Department of Haematology, University of Essen Medical School, Hufelandstrasse 55, 45122 Essen, Germany
,
Ulrich Frey Institute of Pharmacology, University of Essen Medical School, Essen, Germany
,
Nese Aral Institute of Pharmacology, University of Essen Medical School, Essen, Germany
,
Jan Dürig Department of Haematology, University of Essen Medical School, Hufelandstrasse 55, 45122 Essen, Germany
,
Ulrich Dührsen Department of Haematology, University of Essen Medical School, Hufelandstrasse 55, 45122 Essen, Germany
&
Winfried Siffert Department of Haematology, University of Essen Medical School, Hufelandstrasse 55, 45122 Essen, Germany
Pages 1739-1743 | Published online: 16 Nov 2010

References

  • Houlston, R.S. Catovsky, D. and Yuille, M.R. (2002) "Genetic susceptibility to chronic lymphocytic leukaemia". Leukemia 16, 1008–1014.
  • Döhner, H., Stilgenbauer, S., Benner, A., Leupolt, E., Krober, A., Bullinger, L., Dohner, K., Bentz, M. and Lichter, P. (2000) "Genomic aberrations and survival in chronic lymphocytic leukemia", N. EngL J. Med. 343, 1910–1916.
  • Offermanns, S. and Simon, M.I. (1996) "Organization of transmembrane signalling by heterotrimeric G proteins", Cancer Sum 27, 177–198.
  • Bourne, H.R. (1997) "How receptors talk to trimeric G proteins", Cuff, Opin. Cell Biol. 9, 134–142.
  • Siffert, W., Rosskopf, D., Siffert, G., Busch, S., Moritz, A., Erbel, R., Sharma, A.M., Ritz, E., Wichmann, H.E., Jakobs, K.H. and Horsthemke, B. (1998) "Association of a human G-protein beta3 subunit variant with hypertension", Nat. Genet. 18, 45–48.
  • Siffert, W. (2001) "Molecular genetics of G proteins and atherosclerosis risk", Basic Res. CardioL 96, 606–611.
  • Siffert, W., Forster, P., Jöckel, Ku., Mvere, D.A., Brinkmann, B., Naber, C., Crookes, R., Du, P.H., Epplen, J.T., Fridey, J., Freedman, B.1., Miller, N., Stolke, D., Sharma, A.M., Al Moutaery, K., Grosse-Wilde, H., Buerbaum, B., Ehrlich, T., Ahmad, H.R., Horsthernke, B., Du Toit, E.D., Tiilikainen, A., Ge, J., Wang, Y. and Rosskopf, D. (1999) "Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese and Black African individuals", .1. Am. Soc. NephroL 10, 1921–1930.
  • Virchow, S., Ansorge, N., Rtibben, H., Siffert, G. and Siffert, W. (1998) "Enhanced tMLP-stimulated chemotaxis in human neu-trophils from individuals carrying the G protein beta3 subunit 825 T-allele", FEES Len. 436, 155–158,
  • Virchow, S., Ansorge, N., Rosskopf, D., Riibben, H. and Siffert, W. (1999) "The G protein beta3 subunit splice variant Gbeta3-s causes enhanced chemotaxis of human neutrophils in response to interleukin-8", Naunyn Schmiedebergs Arch. Phannacol. 360, 27–32.
  • Lindemann, M., Virchow, S., Ramann, F., Barsegian, V., Kreuzfelder, E., Siffert, W., Muller, N. and Grosse-Wilde, H. (2001) "The G protein beta3 subunit 825T allele is a genetic marker for enhanced T cell response", FEBS Lett. 495, 82–86.
  • Rosskopf, D., Manthey, I. and Siffert, W. (2002) "Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit", Pharmacogenetics 12, 209–220.

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