51
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Depletion of Host Reactive T Cells by Photodynamic Cell Purging and Prevention of Graft Versus Host Disease

&
Pages 1871-1879 | Published online: 01 Jul 2009

References

  • Gale, R.P., et al. (1994) "Identical twin bone marrow transplants for leukemia", Annals of Internal Medicine 120, 646.
  • Barrett, A.J., et al. (2000) "Effect of nucleated marrow cell dose on relapse and survival in identical twin bone marrow transplants for leukemia", Blood 95, 3323.
  • Schlegel, P.G., Aharoni, R., Smilek, D.E., et al. (1994) "Prevention of GVHD by peptides binding to class II major histocompatibility complex molecules", Blood 84(8), 2802.
  • Guery, J.C., Sette, A., Leighton, J., et al. (1992) "Selective immunosuppression by administration of major histocompatibility complex (MHC) class II binding peptides. I. Evidence for in vivo MHC blockade preventing T cell activation", Journal of Experimental Medicine 175, 1345.
  • Perreault, C., Decary, F., Brochu, S., et al. (1990) "Minor histocompatibility antigens", Blood 76, 1269.
  • Roopenian, D.C., Christianson, G.J., Davis, A.P., et al. (1993) "The genetic origin of minor histocompatibility antigens", Immunogenetics 38, 131.
  • Hamilton, B.L. (1987) "L3T4 positive cells participate in the induction of GVHD in response to minor histocompatibility antigens", Journal of Immunology 139, 2511.
  • (2001) "Adoptive transfer of minor histocompatibility antigenspecific T lymphocytes eradicates leukemia cells without causing graft-versus-host disease", Nature Medicine 7(7), 789.
  • Champlin, R. (1990) "T-cell depletion to prevent graft-versus-host disease after bone marrow transplantation", Hematology Oncology Clinics of North America 4, 687–698.
  • Aversa, F., Tabilio, A., Velardi, A., et al. (1998) "Treatment of high risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype", NEJM 339, 1186–1193.
  • Bortin, M.M. and Saltzstein, E.C. (1969) "Graft versus host inhibition: fetal liver and thymus cells to minimize secondary disease", Science 164, 316.
  • Storb, R. and Thomas, E.D. (1983) "Allogeneic bone marrow transplantation", Immunological Reviews 71, 77.
  • Thomas, E.D., Storb, R., et al. (1975) "Bone marrow transplantation", NEJM 292, 832.
  • Thomas, E.D. (1983) "Marrow transplantation for malignant diseases", JCO 1(9), 517.
  • Kansu, E., Gooley, T., Flowers, M.E.D., et al. (2001) "Administration of cyclosporine for 24 months compared with 6 months for prevention of chronic GVHD: a prospective randomized clinical trial", Blood 98(13), 3868.
  • Ruutu, T., Volin, L., Parkkali, T., et al. (2000) "Cyclosporin, methotrexate, and methylprednisolone compared with cyclosporine and methotrexate for the prevention of GVHD in bone marrow transplantation from HLA-identical sibling donor: a prospective randomized study", Blood 96(7), 2391.
  • Nash, R.A., Antin, J., Karanes, C., et al. (2000) "Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute GVHD after marrow transplantation from unrelated donors", Blood 96(6), 2062.
  • Ratanatharathorn, V., Nash, R.A., Przepiorka, D., et al. (1998) "Phase III study comparing methotrexate and tacrolimus with methtrexate and cyclopsorin for GVHD prophylaxis after HLA-identical sibling bone marrow transplantation", Blood 92(7), 2303.
  • Yu, C., Seidel, K., Nash, R.A., et al. (1998) "Synergism between mycophenolate mofetil and cyclosporin in preventing GVHD among lethally irradiated dogs given DLA-nonidentical unrelated marrow grafts", Blood 91(7), 2581.
  • Deeg, H.J., Lin, D., Leisenring, W., Boeckh, M., et al. (1997) "Cyclosporine or cyclosporine plus methylprednisolone for prophylaxis of GVHD: a prospective, randomized trial", Blood 89(10), 3880.
  • Przepiorka, D., Ippoliti, C., Khouri, I., et al. (1996) "Tacrolimus and minidose methotrexate for prevention of acute GVHD after matched unrelated donor marrow transplantation", Blood 88(11), 4383.
  • Nash, R.A., Wingard, J.R., Antin, J.H., et al. (1996) "FK506 in combination with methotrexate for the prevention of GVHD after marrow transplantation from matched unrelated donors", Blood 88(9), 3634.
  • Nash, R.A., Etzioni, R., Storb, R., et al. (1995) "Tacrolimus alone or in combination with methrotrexate or methylprednisolone for the prevention of acute GVHD after marrow transplantation from HLA matched siblings: a single center study", Blood 85(12), 3746.
  • Jacobsohn, D.A. and Vogelsang, G.B. (2002) "Novel pharmacotherapeutic approaches to prevention and treatment of GVHD", Drugs 62(6), 879.
  • Vogelsang, G.B. and Arai, S. (2001) "Mycophenolate mofetil for the prevention and treatment of GVHD following stem cell transplantation: preliminary findings", Bone Marrow Transplantation 27, 1255.
  • Winston, D.J., Antin, J.H., Wolff, S.N., et al. (2001) "A multicenter, randomized, double blind comparison of different doses of IV immunoglobulin for prevention of GVHD and infection after allogeneic bone marrow transplantation", Bone Marrow Transplantation 28, 187.
  • Chao, N.J., Schmidt, G.M., Niland, J.C., et al. (1993) "Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prophlaxis of acute graft-versushost disease", NEJM 329 (17), 1225.
  • Arai, S. and Vogelsang, G.B. (2000) "Management of graft-versushost disease", Blood Reviews 14, 190.
  • Hows, J.M., Yin, J.L., Marsh, J., et al. (1986) "Histocompatible unrelated volunteer donors compared with HLA nonidentical family donors in marrow transplantation for aplastic anemia and leukemia", Blood 68(6), 1322.
  • Gingrich, R.D., Ginder, G.D., Goeken, N.E., et al. (1988) "Allogeneic marrow grafting with partially mismatched, unrelated marrow donors", Blood 71(5), 1375.
  • Anasetti, C., Amos, D., Beatty, P.G., et al. (1989) "Effect of HLA compatibility on engraftments of bone marrow transplants in patients with leukemia and lymphoma", NEJM 320(4), 197.
  • Gajewski, J.L., Ho, W.G., Feig, S.A., et al. (1990) "Bone marrow transplantation using unrelated donors for patients with advanced leukemia or bone marrow failure", Transplantation 50(2), 244.
  • Ash, R.C., Horowitz, M.M., Gale, R.P., et al. (1991) "Bone marrow transplantation from related donors other than HLAidentical siblings: effect of T cell depletion", Bone Marrow Transplantation 7, 443.
  • Weisdorf, D., Hakke, R., Blazar, B., et al. (1991) "Risk factors for acute GVHD in histocompatible donor bone marrow transplantation", Transplantation 51, 1197.
  • Nash, R.A., et al. (1992) "Acute GVHD: analysis of risk factors after allogeneic marrow transplantation and prophylaxis with cyclosporine and methotrexate", Blood 80(7), 1838.
  • Przepiorka, D., Smith, T.L., Follodor, J., et al. (1994) "Risk factors for acute GVHD after allogeneic blood stem cell transplantation", Blood 94(4), 1465.
  • Atkinson, K., Farrelly, H., Cooley, M., et al. (1987) "Human marrow T cell dose correlates with severity of subsequent acute GVHD", Bone Marrow Transplantation 2, 51.
  • Kernan, N.A., Collins, N.H., Juliano, L., et al. (1986) "Clonable T lymphocytes in T cell-depleted bone marrow transplants correlate with development of GVHD", Blood 68(3), 770.
  • Sullivan, K., Agura, E. and Anasetti, C. (1991) "Chronic GVHD in other late complications of bone marrow transplantation", Seminars in Hematology 28, 250.
  • Atkinson, K., Horowiitz, M.M., Gale, R.P., et al. (1990) "Risk factors for chronic GVHD after HLA-identical sibling bone marrow transplantation", Blood 75, 2459.
  • Uphoff, D.E. (1958) "Preclusion of secondary phase of irradiation by inoculation of fetal hematopoietic tissue following lethal total body X-irradiation", JNCI 20, 625.
  • Bortin, M.M. and Saltzstein, E.C. (1969) "Graft versus host inhibition: fetal liver and thymus cell minimize secondary disease", Science 164, 316.
  • Dicke, K.A., van Hooft, J.I.M. and van Beekum, D.W. (1968) "The selective elimination of immunology competent cells from bone marrow and lymphatic cell mixtures. II. Mouse spleen cell fractionation on a discontinuous albumin gradient", Transplantation 6, 562.
  • Rodt, H., Kolb, H.J., Netzel, B., et al. (1981) "Effect of anti-T-cell globulin on graft versus host disease in leukemia patients treated with BMT", Transplantation Proceedings 13, 257.
  • Prentice, H.G., Janossy, G., Price-Jones, L., et al. (1984) "Depletion of T lymphocytes in donor marrow prevents significant graft-versus-host disease in matched allogeneic leukaemic marrow transplant recipients", Lancet, 472.
  • Martin, P.J., Hansen, J.A., Buckner, D., et al. (1985) "Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts", Blood 66(3), 664.
  • Patterson, J., Prentice, H.G., Brenner, M.K., et al. (1986) "Graft rejection following HLA matched T-lymphocyte depleted bone marrow transplantation", BJH 63, 221.
  • Mitsuyasu, R.T., Champlin, R.E., Gale, R.P., et al. (1986) "Treatment of donor bone marrow with monoclonal anti-T-cell antibody and complement for the prevention of GVHD", Annals of Internal Medicine 105, 20.
  • Martin, P.J., Hansen, J.A., Torok-Storb, B., et al. (1988) "Graft failure in patients receiving T cell depleted HLA-identical allogeneic marrow transplants", Bone Marrow Transplantation 3, 445.
  • Youle, R.J. and Neville, D.M. (1980) "Anti-Thy 1-2 monoclonal antibody linked to ricin is a potent cell type specific toxin", Proceedings of the National Academy of Science USA 77, 5483.
  • Filipovich, A.H., Youle, R.J., Neville, D.M., et al. (1984) "Ex vivo treatment of donor bone marrow with anti-T-cell immunotoxins for prevention of GVHD", Lancet, 469–471.
  • Filipovich, A.H., Vallera, D.A., Youle, R.J., et al. (1987) "Graftversus- host disease prevention in allogeneic bone marrow transplantation from histocompatible siblings", Transplantation 44(1), 62.
  • Martin, P.J., Hansen, J.A., Torok-Storb, B., et al. (1988) "Effects of treating marrow with a CD3 specific immunotoxin for prevention of acute GVHD", Bone Marrow Transplantation 3, 437.
  • Laurent, G., Maraninchi, D., Gluckman, E., et al. (1989) "Donor bone marrow treatment with T101 Fab fragment-ricin A-chain immunotoxin prevents GVHD", Bone Marrow Transplantation 4, 367.
  • Antin, J.H., Bierer, B., Smith, B.R., et al. (1991) "Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for GVHD in patients with hematologic malignancies", Blood 78(8), 2139.
  • O'Reilly, R.J., Collins, N.H., Kernan, N., et al. (1985) "Transplantation of marrow depleted T cells by soybean lectin agglutination and E-rosette depletion: major histocompatibility complex related graft resistance in leukemic transplant recipients", Transplantation Proceedings 17(1), 455.
  • Fischer, A., Durandy, A., de Villartay, J.P., et al. (1986) "HLAhaploidentical bone marrow transplantation for severe combined immunodeficiency using E rosette fractionation and cyclosporine", Blood 67(2), 444.
  • Bordignon, C., Keever, C.A., Small, T.N., et al. (1989) "Graft failure after T cell depleted HLA identical marrow transplants for leukemia: II. In vitro analyses of host effector mechanisms", Blood 74(6), 2237.
  • Young, J.W., Papadopoulos, E.B., et al. (1992) "T cell depleted allogeneic bone marrow transplantation in adults with acute nonlymphocytic leukemia in first remission", Blood 79(12), 3380.
  • Reisner, Y., Kapoor, N., Kirkpatrick, D., et al. (1981) "Transplantation for acute leukemia with HLA-A and B nonidentical parental marrow cells fractionated with soybean agglutinin and sheep red blood cells", Lancet 2, 327.
  • Reisner, Y., Kapoor, N., et al. (1983) "Transplantation for severe combined immunodeficiency with HLA-A, B, D, DR incompatibility parental marrow cells fractionated by soybean agglutinin and sheep red blood cells", Blood 61, 341.
  • De Witte, T., Raymakers, R., Plas, A., et al. (1984) "Bone marrow repopulation capacity after transplantation of lymphocytedepleted allogeneic bone marrow using counterflow centrifugation", Transplantation 37(2), 151.
  • Noga, S.J., Donnenberg, A.D., Schwartz, C.L., et al. (1986) "Development of a simplified counterflow centrifugation elutriation procedure for depletion of lymphocytes from human bone marrow", Transplantation 41(2), 220.
  • Wagner, J.E., Donnenberg, A.D., Noga, S.J., et al. (1988) "Lymphocyte depletion of donor bone marrow by counterflow centrifugal elutriation: results of a phase I clinical trial", Blood 72(4), 1168.
  • Wagner, J.E., Santos, G.W., Noga, S.J., et al. (1990) "Bone marrow graft engineering by counterflow centrifugal elutriation: results of a phase I-II clinical trial", Blood 75(6), 1370.
  • De Witte, T., Koekman, E., Plas, A., et al. (1983) "Enrichment of myeloid clonogenic cells by isopycnic density equilibrium centrifugation in Percoll gradients and counterflow centrifugation", Stem Cells 2, 308.
  • Bunjes, D., Heit, W., Arnold, R., et al. (1987) "Evidence for the involvement of host-derived OKT8-positive T cells in the rejection of T-Depleted, HLA-identical bone marrow grafts", Transplantation 43(4), 501.
  • Hale, G., Cobbold, S., Waldmann, H., et al. (1988) "T cell depletion with Campath-1 in allogeneic bone marrow transplantation", Transplantation 45(4), 753.
  • Hale, G.,Waldmann, H., et al. (1994) "Control of graft versus host disease and graft rejection by T cell depletion of donor and recipient with Campath-1 antibodies. Results of matched sibling transplants for malignant diseases", Bone Marrow Transplantation 13, 597.
  • Hale, G., Waldmann, H., et al. (1996) "Recent results using Campath-1 antibodies to control GVHD and graft rejection", Bone Marrow Transplantation 17, 305.
  • Bozdech, M.J., Sondel, P.M., Trigg, M.E., et al. (1985) "Transplantation of HLA-haploidentical T cell depleted marrow for leukemia: addition of cytosine arabinoside to the pretransplant conditioning prevents rejection", Experimental Hematology 13, 1201.
  • Ash, R.C., Horowitz, M.M., Gale, R.P., et al. (1991) "Bone marrow transplantation from related donors other than HLAidentical siblings: effect of T cell depletion", Bone Marrow Transplantation 7, 443.
  • Howard, M.R., Hows, J.M., Gore, S.M., et al. (1990) "Unrelated donor marrow transplantation between 1977 and 1987 at four centers in the United Kingdom", Transplantation 49(3), 547.
  • Weiden, P., Flournoy, N., Thomas, E., Prentice, R., Fefer, A., Buckner, C.D. and Storb, R. (1979) "Antileukemic effect of graft versus host disese in human recipients of allogeneic marrow grafts", NDJM 300, 1068–1073.
  • Sullivan, K., Weiden, P., Storb, R., Witherspoon, R.P., Fefer, A., Fisher, L., Buckner, C.D., Anasetti, C., Appelbaum, F.R. and Badger, C. (1989) "Influence of acute and chronic graft versus host disease on relapse and survival after bone marrow transplantation from HLA identical siblings as treatment of acute and chronic leukemia", Blood 73, 1720–1728.
  • Horowitz, M., Gale, R., Sondel, P., Goldman, J.M., Kersey, J., Kolb, H.J., Rimm, A.A., Ringden, O., Rozman, C. and Speck, B. (1990) "Graft versus leukemia reactions after bone marrow transplantation", Blood 75, 555–562.
  • Dadmarz, R., Sgagias, N., Rosenberg, S., Schwartzentruber, D.J. and CD4�, T. (1995) "Lymphocytes infiltrating human breast cancer recognize autologous tumor in an MHC class II restricted fashion", Cancer Immunology and Immunotherapy 40, 1–9.
  • Van der Straaten, H.M., Funheer, R., Dekker, A.W., et al. (2001) "Relationship between GVHD and GVL in partial T cell depleted bone marrow transplantation", BJH 114, 31–35.
  • Goldman, J.M., Gale, R.P., Horowitz, M.M., et al. (1988) "Bone marrow transplantation for chronic myelogenous leukemia in chronic phase", Annals of Internal Medicine 108, 806.
  • Rocha, M., Umansky, V., Lee, K.H., Hacker, H.J., Benner, A. and Schirrmacher, V. (1997) "Differences between graft-versusleukemia and graft-versus-host reactivity. Interaction of donor immune T cells with tumor and/or host cells", Blood 89, 2189–2202.
  • Tsukada, N., Kobata, T., Aivawa, Y., et al. (1999) "Graft-versusleukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of bone marrow transplantation", Blood 93, 2738.
  • Hudson, J.G., Lawler,M. and Pamphilon, D.H. (1994) "Ultraviolet irradiation for the prevention of GVHD and graft rejection in bone marrow transplantation", Bone Marrow Transplantation 14, 511–516.
  • Pamphilon, D.H., Alnaqdy, A.A. and Wallington, T.B. (1991) "Immunomodulation by ultraviolet light: clinical studies and biological effects", Immunology Today 12, 119.
  • Del Rosario, M.L.U., Zucali, J. and Kao, K.J. (1999) "Prevention of GVHD by induction of immune tolerance with ultraviolet B irradiated leukocytes in H-2 disparate bone marrow donor", Blood 93(10), 3558.
  • Deeg, H.J. and Sigaroudinia, M. (1990) "Ultraviolet B induced loss of HLA class II antigen expression on lymphocytes is dose, time and locus dependent", Experimental Haematology 18, 916.
  • Gruner, S., Volk, H.D., Noack, F., Meffert, H. and Baehr, R. (1986) "Inhibition of HLA-DR antigen expression and of the allogeneic mixed leukocyte reaction by photochemical treatment", Tissue Antigens 27, 147.
  • Araneo, B., Dowell, T., Moon, H.B. and Daynes, R.A. (1989) "Regulation of murine lymphokine production in vivo", Journal of Immunology 143, 1737.
  • Kahn, R.A., Duffy, B.F. and Rodey, G.G. (1985) "Ultraviolet irradiation of platelet concentrates abrogates lymphocyte activation without affecting platelet function in vitro", Transfusion 25, 547.
  • Krutman, J.K., Kahn, I.U., Wallis, R.S., Zhang, F., et al. (1990) "Cell membrane is a major locus for ultraviolet B-induced alteration in accessory cells", Journal of Clinical Investigation 85, 1529.
  • Fujihara, M., Takahashi, T.A., et al. (1996) "Decreased inducible expression of CD80 and CD86 in human monocytes after ultraviolet-B irradiation: its involvement in inactivation of alloantigeneicity", Blood 87, 2385.
  • Del Rosario, M.L.U., Zucali, J. and Kao, K.J. (1999) "Prevention of GVHD by induction of immune tolerance with ultraviolet B irradiated leukocytes in H-2 disparate bone marrow donor", Blood 93(10), 3558.
  • Van Prooijen, H.C., Aarts-Riemens, M., et al. (1992) "Ultraviolet irradiation modulates MHC-alloreactive cytotoxic T cell precursors involved in the onset of GVHD", British Journal of Haematology 81, 73.
  • Pamphilon, D.H., Alnaqdy, A.A., et al. (1991) "Studies of allogeneic bone marrow and spleen cell transplantation in murine model using ultraviolet-B light", Blood 77, 2072.
  • Lin, L., Cook, D.N., Wiesehahn, G.P., Alfonso, R., et al. (1997) "Photochemical inactivation of viruses and bacteria in platelet concentrates by use of a novel psoralen and long-avelength ultraviolet light", Transfusion 37, 423.
  • Grass, J.A., Hei, D.J., Metchette, K., et al. (1998) "Inactivation of leukocytes in platelet concentrates by photochemical treatment with psoralen plus UVA", Blood 91(6), 2180.
  • Grass, J.A., Wafa, T., Reames, A., et al. (1999) "Prevention of transfusion-associated graft-versus-host-disease by photochemical treatment", Blood 93(9), 3140.
  • Luban, N.L.C. (2001) "Prevention of transfusion-associated graft versus host disease by inactivation of T cells in platelet components", Seminars in Hematology 38(4)\(Suppl. 11), 34–45.
  • Okamoto, K., Kamano, H. and Sakata, I. (2000) "Development of a novel LED apparatus for photodynamic purging of leukemia cells in hematopoietic stem cell transplantation", Transplantation Proceedings 32, 2444.
  • Roy, D.C., Boileau, J., Laplante, J., et al. (2000) "Phase I study of autologous progenitor cell transplantation (PCT) purged with a photodynamic approach for patients with chronic myelogenous leukemia", Blood 96\(Suppl. 1), 583a, Abstract 2504, 2000.
  • Roy, D.C., Dallaire, N., et al. (2000) "Photodynamic therapy of B-lineage non-Hodgkins lymphoma and chronic lymphocytic leukemia", Blood 96\(Suppl. 1), 185a, Abstract 793, 2000.
  • Brasseur, N., Menard, I., Forget, A., et al. (2000) "Eradication of multiple myeloma and breast cancer cells by TH9402-mediated photodynamic therapy: implication for clinical ex vivo purging of autologous stem cell transplants", Photochemistry and Photobiology 72(6), 780–787.
  • Chen, B.J., Cui, X., Liu, C. and Chao, N. (2002) "Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process", Blood 99(9), 3083.
  • Guimond, M., Balassy, A., Barrette, M., et al. (2002) "P-glycoprotein targeting: a unique strategy to selectively eliminate immunoreactive T cells", Blood 100(2), 375.
  • Villeneuve, L. (1999) "Ex vivo photodynamic purging in chronic myelogenous leukemia and other neoplasias with rhodamine derivatives", Biotechnology and Applied Biochemistry 30, 1–17.
  • Fontaine, P., Roy-Proulx, G., Knafo, L., Baron, C., Roy, D.C. and perreault, C. (2001) "Adoptive transfer of minor histocompatibility antigen specific T lymphocytes eradicates leukemia cells without causing graft versus host disease", Nature Medicine 7, 789–794.
  • Pal, P., Zeng, H., Durocher, G., et al. (1996) "Phototoxicity of some bromine substituted rhodamine dyes: synthesis, phophysical properties and application as photosensitizers", Photochemistry and Photobiology 63, 161.
  • Chaudhary, P.M., Mechetner, E.B. and Roninson, I.B. (1992) "Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes", Blood 80, 2735.
  • Ludeshcer, C., Pall, G., Irschick, E.U. and Gastl, G. (1998) "Differential activity of P-glycoprotein in normal blood lymphocyte subsets", British Journal of Haematology 101, 722.
  • Pilarski, L.M., Paine, D., et al. (1995) "Multidrug transporter P-glycoprotein 170 as a differentiation antigen on normal human lymphocytes and thymocytes: modulation with differentiation stage and during aging", American Journal of Hematology 49, 323.
  • Coon, J.S., Wang, Y.Z., Bines, S.D., et al. (1991) "Multidrug resistance activity in human lymphocytes", Human Immunology 32, 134.
  • Champlin, R., Ho, W., Gajewski, J., et al. (1990) "Selective depletion of CD8� T lymphocytes for prevention of GVHD after allogeneic bone marrow transplantation", Blood 76, 418.
  • Soiffer, R.J., Fairclough, D., Robertson, M., et al. (1997) "CD6 depleted allogeneic bone marrow transplantation for acute leukemia in first complete remission", Blood 89, 3039.
  • Roy, D.C., Tantravachi, R., Murray, C., et al. (1990) "Natural history of mixed chimerism after bone marrow transplantation with CD6-depleted allogeneic marrow: a stable equilibrium", Blood 75, 296.
  • Montagna, D., Yvon, E., Calcaterra, V., Comoli, P., Locatelli, F., et al. (1999) "Depletion of alloreactive T Cells by a specific anti-interleukin-2 receptor p55 chain immunotoxin does not impair in vitro antileukemia and antiviral activity", Blood 93(10), 3550.
  • Valteau-Couanet, D., Cavazzano-Calvo, M., Le Deist, F., et al. (1993) "Functional study of residual T lymphocytes after specific elimination of alloreactive T cells by a specific antiinterleukin- 2 receptor Bk chain immunotoxin", Transplantation 56(6), 1574.
  • Cavazzana-Calvo, M., Fromont, C., Le Deist, F., et al. (1990) "Specific elimination of alloreactive T cells by an anti-interleukin- 2 receptor B chain-specific immunotoxin", Transplantation 50(1), 1–7.
  • Rencher, S.D., Houston, H.A., Lockey, T.D. and Hurwitz, J.L. (1996) "Eliminating graft-versus-host potential from T cell immunotherapeutic populations", Bone Marrow Transplantation 18, 415.
  • Mavroudis, D.A., Dermime, S., Molldrem, J., et al. (1998) "Specific depletion of alloreactive T cells in HLA-identical siblings: a method for separating graft-versus-host and graftversus- leukaemia reactions", British Journal of Haematology 101, 565.
  • Van Dijk, A.M.C., Kessler, F.L., Stadhouders-Keet, S.A.E., et al. (1999) "Selective depletion of major and minor histocompatibility antigen reactive T cells: towards prevention of acute graft-versushost disease", British Journal of Haematology 107, 169.
  • Mavroudis, D.A., Jiang, Y.Z., Hensel, N., et al. (1996) "Specific depletion of alloreactivity against haplotype mismatched related individuals by a recombinant immunotoxin: a new approach to graft-versus-host disease prophylaxis in haploidentical bone marrow transplantation", Bone Marrow Transplantation 17, 793.
  • Cavazzana-Calvo, M., Stephan, J.L., Sarnacki, S., et al. (1994) "Attenuation of graft-versus-host disease and graft rejection by ex vivo immunotoxin elimination of alloreactive T cells in an H-2 haplotype disparate mouse combination", Blood 83(1), 288.
  • Koh, M.B., Prentice, H.G. and Lowdell, M.W. (1999) "Selective removal of alloreactive cells from haematopoietic stem cell grafts: graft engineering for GVHD prophylaxis", Bone Marrow Transplantation 23, 1071.
  • Garderet, L., Snell, V., Przepiorka, D., et al. (1999) "Effective depletion of alloreactive lymphocytes from peripheral blood mononuclear cell preparations", Transplantation 67, 124.
  • Fehse, B., Frerk, O., Goldmann, M., et al. (2000) "Efficient depletion of alloreactive donor T lymphocytes based on expression of two activation-induced antigens (CD25 and CD69)", British Journal of Haematology 109, 644.
  • Cohen, J.L., Boyer, O. and Klatzman, D. (2001) "Suicide gene therapy of graft-versus-host disease: immune reconstitution with transplanted mature T cells", Blood 98(7), 2071.
  • Cohen, J.L., Boyer, O., Salomon, B., et al. (1997) "Prevention of graft-versus-host disease in mice using a suicide gene expressed in T lymphocytes", Blood 89(12), 4636.
  • Gribben, J.G., Guinan, E.C., Boussiotis, V.A., et al. (1996) "Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate GVHD and extend the donor pool", Blood 87(11), 4887–4893.
  • Taylor, P.A., Friedman, T., Korngold, R., Noelle, R.J. and Blazar, B. (2002) "Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell", Blood 99(12), A4601.
  • Drobyski, W.R. and Majewski, D. (1996) "Treatment of donor mice with an alphabeta T-cell receptor monoclonal antibody induces prolonged T-cell nonresponsiveness and effectively prevents lethal graft-versus-host disease in murine recipients of major histocompatibility complex (MHC)- matched and MHC-mismatched donor marrow grafts", Blood 87(12), 5355.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.