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Research Article

Aminopeptidase Inhibitors Inhibit Proliferation and Induce Apoptosis of K562 and STI571-resistant K562 Cell Lines Through the MAPK and GSK-3ß Pathways

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Pages 1987-1996 | Published online: 01 Jul 2009

References

  • Umezawa, H., Aoyagi, T., Suda, H., Hamada, M. and Takeuchi, T. (1976) �Ubenimex, an inhibitor of aminopeptidase B, produced by actinomycetes�, J. Antibiot. 29, 97�99.
  • Scornik, O.A. and Botbol, V. (2001) �Bestatin as an experimental tool in mammals�, Curr. Drug Metab. 2, 67�85.
  • Urabe, A., Mutoh, Y., Mizoguchi, H., Takaku, F. and Ogawa, N. (1993) �Ubenimex in the treatment of acute nonlymphocytic leukemia in adults�, Ann. Hematol. 67, 63�66.
  • Yamada, M., Sukenaga, Y., Fujii, H., Abe, F. and Takeuchi, T. (1994) �Purification and characterization of a ubenimex (Bestatin)-sensitive aminopeptidase B-like enzyme from K562 human chronic myeloid leukemia cells�, FEBS Lett. 342, 53�56.
  • Look, A.T., Ashmun, R.A., Shapiro, L.H. and Peiper, S.C. (1989) �Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N�, J. Clin. Investig. 83, 1299�1307.
  • Sekine, K., Fujii, H. and Abe, F. (1999) �Induction of apoptosis by ubenimex (bestatin) in human leukemic cell lines�, Leukemia 13, 729�734.
  • Druker, B.J., Tamura, S., Buchdunger, E., Ohno, S., Segal, G.M., Fanning, S., Zimmermann, J. and Lydon, N.B. (1996) �Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr- Abl positive cells�, Nat. Med. 2, 561�566.
  • Druker, B.J., Sawvers, C.L., Kantarjian, H., Resta, D.J., Reese, S.F., Ford, J.M., Capdeville, R. and Talpaz, M. (2001) �Activity of aspecific inhibitor of BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with Philadelphia chromosome�, N. Engl. J. Med. 344, 1038�1042.
  • Gorre, M.E., Mohammed, M., Ellwood, K., Hsu, N., Paquette, R., Rao, N. and Sayers, C.L. (2001) �Clinical resistance to STI571 cancer therapy caused by BCR-ABL gene mutation or amplification�, Science 293, 876�880.
  • le Coutre, P., Tassi, E., Varella-Garcia, M., Barni, R., Mologni, L., Cabrita, G., Marchesi, E., Supino, R. and Gambacorti-Passerini, C. (2000) �Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification�, Blood 95, 1758�1766.
  • Mahon, F.X., Deininger, M.W., Schultheis, B., Chabrol, J., Reiffers, J., Goldman, J.M. and Melo, J.V. (2000) �Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance�, Blood 96, 1070�1079.
  • Weisberg, E. and Griffin, J.D. (2000) �Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABLtransformed hematopoietic cell lines�, Blood 95, 3498�3505.
  • Fang, G., Kim, C.N., Perkins, C.L., Ramadevi, N., Winton, E., Wittmann, S. and Bhalla, K.N. (2000) �CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Ablpositive human leukemia cells to apoptosis due to antileukemic drugs�, Blood 96, 2246�2253.
  • Pap, M. and Cooper, G.M. (1998) �Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway�, J. Biol. Chem. 273, 19929�19932.
  • Diehl, J.A., Cheng, M., Roussel, M.F. and Sherr, C.J. (1998) �Glycogen synthase kinase-3b regulates cyclin D1 proteolysis and subcellular localization�, Genes Dev. 12, 3499�3511.
  • Somervaille, T.C., Linch, D.C. and Khwaja, A. (2001) �Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax�, Blood 98, 1374�1381.
  • Ota, K., Kurita, S., Yamada, K., Masaoka, T., Uzuka, Y. and Ogawa, N. (1986) �Immunotherapy with bestatin for acute nonlymphocytic leukemia in adults�, Cancer Immunol. Immunother. 23, 5�10.
  • Kobayashi, T., Miyawaki, S., Tanimoto, M., Kuriyama, K., Murakami, H., Yoshida, M., Minami, S., Minato, K., Tsubaki, K., Ohmoto, E., Oh, H., Jinnai, I., Sakamaki, H., Hiraoka, A., Kanamaru, A., Takahashi, I., Saito, K., Naoe, T., Yamada, O., Asou, N., Kageyama, S., Emi, N., Matsuoka, A., Tomonaga, M. and Ohno, R. (1996) �Randomized trials between behenoyl cytarabine and cytarabine in combination induction and consolidation therapy, and with or without ubenimex after maintenance/intensification therapy in adult acute myeloid leukemia. The Japan Leukemia Study Group�, J. Clin. Oncol. 14, 204�213.
  • Grujic, M. and Renko, M. (2002) �Aminopeptidase inhibitors bestatin and actinonin inhibit cell proliferation of myeloma cells predominantly by intracellular interactions�, Cancer Lett. 182, 113�119.
  • Deininger, M.W., Goldman, J.M. and Melo, J.V. (2000) �The molecular biology of chronic myeloid leukemia�, Blood 96, 3343�3356.
  • Kobayashi, T. and Cohen, P. (1999) �Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositidedependent protein kinase-1 (PDK1) and PDK2�, Biochem. J. 339, 319�328.
  • Koyama, M., Hashimoto, M., Asakawa, N., Ishibashi, M. and Miyazaki, H. (1980) �Simultaneous determination of bestatin and p-hydroxybestatin, a major metabolite, in human serum by gas chromatography mass spectrometry. Utilization of quantitative selected ion monitoring and deuterium labeled internal standard�, Biomed. Mass Spectrom. 7, 372�376.
  • Murata, M., Kubota, Y., Tanaka, T., Iida-Tanaka, K., Takahara, J. and Irino, S. (1994) �Effect of ubenimex on the proliferation and differentiation of U937 human histiocytic lymphoma cells�, Leukemia 8, 2188�2193.
  • Rosenzwajg, M., Tailleux, L. and Gluckman, J.C. (2000) �CD13/ N-aminopeptidase is involved in the development of dendritic cells and macrophages from cord blood CD34(�) cells�, Blood 95, 453�460.
  • Xu, Y., Lai, L.T., Gabrilove, J.L. and Scheinberg, D.A. (1998) �Antitumor activity of actinonin in vitro and in vivo�, Clin. Cancer Res. 4, 171�176.

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